| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 546255000 | Plural pyridine or partially hydrogenated pyridine rings | 70 |
| 20080269496 | Method for Producing Optically Active Hydroxymethylated Compounds - The present invention presents a catalyst that allows asymmetric hydroxymethylation reactions to progress with excellent asymmetric selectivity and a production method for optically active hydroxymethylated compounds using the catalyst. Optically active hydroxymethylated compounds are obtained with excellent asymmetric selectivity by using a catalyst obtained by mixing chiral ligands (for example, chemical formula 4) | 10-30-2008 |
| 20110065924 | PREPARATION OF ASYMMETRIC ANTHRACENE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME - Provided is a method of preparing asymmetric anthracene derivative, more particularly, a method for high-yield production of an anthracene derivative in which an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group or a heteroaryl group is introduced at position 2 of anthracene, and an aryl group or a heteroaryl group is introduced at each of positions 9 and 10 of the anthracene. | 03-17-2011 |
| 20120178938 | PROCESS FOR MAKING ORGANIC COMPOUNDS AND THE ORGANIC COMPOUNDS MADE THEREFROM - A compound of formula II is prepared by: reacting a compound of formula F with | 07-12-2012 |
| 20130035491 | 1,2,4, 5-SUBSTITUTED PHENYL COMPOUND, METHOD FOR PRODUCING SAME AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME AS CONSTITUENT - A 1,2,4,5-substituted phenyl compound represented by the formula (1): | 02-07-2013 |
| 20130217882 | ORGANIC COMPOUNDS - A compound of formula IV: | 08-22-2013 |
| 20130310566 | ORGANIC AMINE DIMMER AND METHOD FOR SYNTHESIZING THE SAME - An organic amine dimmer and a method for synthesizing the same are disclosed. The method comprises the following steps: (A) mixing an iron-containing compound (e.g., Fe | 11-21-2013 |
| 20160035982 | NOVEL FUSED POLYCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING ELEMENT INCLUDING THE SAME - The present invention provides a novel fused polycyclic compound suitably used for a blue light emitting element and an organic light emitting element including the fused polycyclic compound. | 02-04-2016 |
| 546256000 | Additional hetero ring containing | 27 |
| 20080214826 | PROCESSES FOR THE MANUFACTURE OF A PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVE - The invention is concerned with processes for the manufacture of the pyrrolidine-3,4-dicarboxamide derivative of formula (I), | 09-04-2008 |
| 20080275244 | HETEROCYCLE-SUBSTITUTED PYRIDINE DERIVATIVE'S SALT OR CRYSTAL THEREOF - There is provided a heterocycle-substituted pyridine derivative's salt or a crystal thereof. The present invention provides an acid addition salt of 3-(3-( | 11-06-2008 |
| 20080306275 | NOVEL HETEROARYL DERIVATIVE - A heteroaryl derivative of the formula (1): | 12-11-2008 |
| 20090221831 | Method for Producing N,N-Bis(Pyridin-2Ylmethyl)-1,1-Bis(Pyridin-2-Yl)-1-Aminoalkane Compounds and Metal Complex Salts Containing These Compounds - The invention relates to a method for producing the compositions cited in the title. According to this method: dipyridyl ketone is reacted with hydroxylamine; the oxime obtained thereby is reduced without intermediate isolation to form 1,1-di-(2-pyridyl)-methylamine, and; this amine is firstly reacted with 1 to 1.5 molar equivalent of picolyl chloride and then with another 1 to 1.5 molar equivalent of picolyl chloride to form the amine of formula (1). | 09-03-2009 |
| 20090259046 | Cyclic Amine Compounds and Agents for Pest Control - Agents for pest control comprising cyclic amine compounds represented by the formula (1) | 10-15-2009 |
| 20100056795 | NOVEL INTERMEDIATE AND PROCESS USEFUL IN THE PREPARATION OF -(2-CHLOROPHENYL)-METHANONE - The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: (I) The present invention further relates to novel processes for preparing a crystalline compound, which is {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, Form IV | 03-04-2010 |
| 20100174086 | ELECTRON-TRANSPORTING MATERIALS AND PROCESSES FOR MAKING THE SAME - Compound of formula C is made by reacting a compound of formula A with an pyridyl boronic acid or pyridyl borate ester to form a compound of formula B; and | 07-08-2010 |
| 20100331547 | PROCESS FOR MAKING ORGANIC COMPOUNDS AND THE ORGANIC COMPOUNDS MADE THEREFROM - An organic compound of formula E is made from a process comprising: | 12-30-2010 |
| 20100331548 | SOLID-STATE FORM OF AMG 706 AND PHARMACEUTICAL COMPOSITIONS THEREOF - The anti-angiogenic drug AMG 706 is provided in amorphous form. Also provided is AMG 706 drug substance wherein the AMG 706 is present, in at least a detectable amount, as amorphous AMG 706. Also provided is an AMG 706-crystallization inhibitor composite comprising particles of amorphous AMG 706 or a AMG 706 drug substance of the invention in intimate association with one or more crystallization inhibitors, for example polymers. Also provided is a pharmaceutical composition comprising such an AMG 706-crystallization inhibitor composite and one or more excipients. Also provided are processes for preparing amorphous AMG 706, AMG 706 drug substance of the invention, an AMG 706-crystallization inhibitor composite of the invention, and a pharmaceutical composition of the invention. Also provided is a method of treating a medical condition or disorder in a subject where treatment with an anti-angiogenic is indicated, comprising administering, for example orally, a composition of the invention in a therapeutically effective amount. | 12-30-2010 |
| 20110098475 | FLUORESCENT PROBES - A fluorescent probe which is represented by the following formula (wherein R | 04-28-2011 |
| 20110184181 | ELECTROCHROMIC MATERIALS AND ELECTROCHROMIC DEVICES USING THE SAME - Disclosed herein are novel electrochromic materials. The electrochromic materials are viologens into which an imidazole derivative is asymmetrically introduced. The electrochromic materials can be used in a variety of electrochromic displays, including electrochromic windows and smart windows. Also disclosed herein are electrochromic devices that use the electrochromic materials. | 07-28-2011 |
| 20110196158 | TRIS(ARYLBENZOXAZOLE)BENZENE AND TRIS(ARYLBENZTHIAZOLE)BENZENE AND DERIVATIVES THEREOF AS ORGANIC ELECTRON-TRANSPORT MATERIALS - A compound represented by a Formula 1: | 08-11-2011 |
| 20120004415 | Chiral Synthesis of Pyrrolidine Core Compounds en route to Neuronal Nitric Oxide Synthase Inhibitors - A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable. | 01-05-2012 |
| 20120220779 | Novel Processes - The present invention provides processes useful for preparing 5-lipoxygenase activating protein (FLAP) inhibitors and their intermediates. In particular, processes for preparing 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, the anhydrous Form C polymorph of sodium 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionate, and intermediates useful in said processes are provided. | 08-30-2012 |
| 20120226046 | COMPOUNDS FOR POROUS FILMS IN LIGHT-EMITTING DEVICES - Compounds useful in porous films for light extraction and/or light scattering in electronic devices, such as light-emitting devices, are described herein. These compounds may be represented by Formula 1, as described herein. | 09-06-2012 |
| 20120259123 | AMINOPYRIDINE COMPOUND - The present invention relates to a compound represented by the formula (I): | 10-11-2012 |
| 20120277439 | PYRIDINE DERIVATIVES SUBSTITUTED WITH HETEROCYCLIC RING AND y-GLUTAMYLAMINO GROUP, AND ANTIFUNGAL AGENTS CONTAINING SAME - The present invention provides an antifungal agent which has excellent antifungal action, and which is also excellent in terms of its properties, and in particular its solubility in water and safety. The present invention discloses a compound represented by the following formula (I) or a salt thereof: | 11-01-2012 |
| 20120309974 | Bianthracene compounds substituted by aromatic ring and their uses for luminescence materials - The present invention relates to Aromatic ring substituted dianthracene compounds and pertains to the field of synthesis of organic light-emitting materials. Aromatic ring substituted dianthracene compounds in the formula (I) present high glass transition temperature and solution efficiency, which can be used as effective blue-light emitting host materials. | 12-06-2012 |
| 20130317227 | PROCESS FOR MAKING A SOLID-STATE FORM OF AMG 706 - The anti-angiogenic drug AMG 706 is provided in amorphous form. Also provided is AMG 706 drug substance wherein the AMG 706 is present, in at least a detectable amount, as amorphous AMG 706. Also provided is an AMG 706-crystallization inhibitor composite comprising particles of amorphous AMG 706 or a AMG 706 drug substance of the invention in intimate association with one or more crystallization inhibitors, for example polymers. Also provided is a pharmaceutical composition comprising such an AMG 706-crystallization inhibitor composite and one or more excipients. Also provided are processes for preparing amorphous AMG 706, AMG 706 drug substance of the invention, an AMG 706-crystallization inhibitor composite of the invention, and a pharmaceutical composition of the invention. Also provided is a method of treating a medical condition or disorder in a subject where treatment with an anti-angiogenic is indicated, comprising administering, for example orally, a composition of the invention in a therapeutically effective amount. | 11-28-2013 |
| 20130338368 | METHOD FOR ANALYSIS OF PROTEIN AND ANALYTICAL REAGENT - An object of the present invention is to provide a reagent for protein analysis that has still greater 1) rapidity and 2) high operability, that can be detected with 3) high sensitivity, and that can be detected using 4) a gel imager that carries out excitation with visible light or a detecting device having a highly versatile UV light source (UV transilluminator), and a method for protein analysis. | 12-19-2013 |
| 20140066627 | ORGANIC LIGHT EMITTING HOST MATERIALS - Polyphenylene compounds such as compounds represented by Formulas 1-28 may be used in electronic devices such as organic light-emitting devices. For example, the compounds may be used as host material in an emissive layer. | 03-06-2014 |
| 20140163232 | METHOD OF PRODUCING AROMATIC AMINO COMPOUNDS - A method of producing an aromatic amino compound by using a primary or secondary amine compound having an aromatic ring group and a halogenated aromatic compound as starting materials, reacting the amine compound with the halogenated aromatic compound in the presence of a copper catalyst and a base so as to produce the aromatic amino compound having a structure in which an aromatic ring group derived from the halogenated aromatic compound is coupled to the amino group of the amine compound, wherein the amine compound and the halogenated aromatic compound are reacted together under a condition where an aromatic oxycarboxylic acid having a hydroxyl group and a hydroxycarbonyl group that are bonded to neighboring carbon atoms, is made present together with the copper catalyst and the base. | 06-12-2014 |
| 20140163233 | ELECTRON TRANSPORTING COMPOUNDS AND ORGANIC ELECTROLUMINESCENT DEVICES USING THE SAME - The present invention discloses a novel compound of Formula 1, and an organic electroluminescent device using the same. In Formula 1, X and Y independently represents an aromatic or a hetero aromatic hydrocarbon having a carbon number of from 5 to 10. Ar | 06-12-2014 |
| 20140206877 | NOVEL INTERMEDIATE AND PROCESS USEFUL IN THE PREPARATION OF -(2-CHLOROPHENYL)-METHANONE - The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: | 07-24-2014 |
| 20140303376 | CLASS OF NEAR INFRARED MOLECULAR PROBES FOR BIOLOGICAL APPLICATIONS - Methods for preparing 2,5-Bis(benzoxazol-2′-yl)benzene-1,4-diol derivatives (Zinhbo derivatives) are provided. Zinhbo derivatives are used to detect zinc ions and have particular application in vivo and in vitro. Zinhbo derivatives upon excitation give a florescence response emission that can be used to determine the presence of zinc cation in solution. Zinhbo derivatives complexed with zinc cations upon excitation can produce a florescence response emission in the visible and near infrared range. Zinhbo derivatives complexed with zinc cations exhibit a large stoke shift between the excitation and emission wavelengths. | 10-09-2014 |
| 20150057448 | INTERMEDIATES FOR THE PREPARATION OF PYRIDIN-2-YL-AMINO-1,2,4-THIADIAZOLE DERIVATIVES - Provided are intermediates having the formulas | 02-26-2015 |
| 20160060250 | NOVEL INTERMEDIATE AND PROCESS USEFUL IN THE PREPARATION OF -(2-CHLOROPHENYL)-METHANONE - The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: | 03-03-2016 |
| 546257000 | Pyridine or partially hydrogenated pyridine rings are bonded directly to each other | 13 |
| 20090054654 | SALT OF 1,2-DIHYDROPYRIDINE COMPOUND - An acid addition salt of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one or a hydrate thereof, wherein the acid is selected from the group consisting of benzenesulfonic acid, p-toluenesulfonic acid, hydrochloric acid, hydrobromic acid, sulfuric acid, methanesulfonic acid, fumaric acid, tartaric acid, succinic acid and benzoic acid. | 02-26-2009 |
| 20090062548 | NOVEL PYRIDINE OXIDE COMPOUND, AND PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE AND OPTICALLY ACTIVE CARBOXYLIC ACID DERIVATIVE WITH THE USE OF THE SAME - The invention relates to a pyridine oxide compound represented by formula (I), an optically active compound thereof, a salt thereof and a hydrate thereof, and, in the presence of the compound as a catalyst, performing 1) a method for producing an ester compound or an amide compound from a carboxylic acid equivalent and an alcohol or an amine, 2) an asymmetric esterification reaction or 3) an asymmetric amidation reaction. In formula (I), each R | 03-05-2009 |
| 20090088574 | CRYSTAL OF 1,2-DIHYDROPYRIDINE COMPOUND (TYPE IV) - A crystal of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one characterized in having a diffraction peak at a diffraction angle (2θ±0.2°) of 15.4° in a powder X-ray diffraction or others. | 04-02-2009 |
| 20100324297 | METHOD FOR PRODUCING 1, 2-DIHYDROPYRIDINE-2-ONE COMPOUND - The present inventions provide a method for commercially producing a 1,2-dihydropyridine-2-one compound represented by the following formula (III-a) | 12-23-2010 |
| 20140142314 | Methods and Compositions for Production of Blue Pigment Indigoidine - The present disclosure provides for an expression system for the production of blue pigment indigoidine. The system comprises a heterologous host cell, a DNA sequence encoding a Sc-IndB protein, and a DNA sequence encoding a Sc-IndC protein. The system may be configured for the co-expression of the Sc-IndB and Sc-IndC. DNA sequences encoding the Sc-IndB and Sc-IndC may be provided on at least one vector. Alternatively, the DNA sequences encoding the Sc-IndB and Sc-IndC may optionally be integrated into the genome of the heterologous host genome. The expression system may further comprise a sfp gene or a PPTase. | 05-22-2014 |
| 20140142315 | METHOD FOR PRODUCING 1,2-DIHYDROPYRIDINE-2-ONE COMPOUND - The present inventions provide a method for commercially producing a 1,2-dihydropyridine-2-one compound represented by the following formula (III-a) | 05-22-2014 |
| 546258000 | Halogen containing or process utilizing halogen or halogen containing compound | 6 |
| 20090082570 | METHOD OF MANUFACTURING BIPYRIDINIUM COMPOUND AND SYNTHETIC INTERMEDIATE OF THE SAME, METHOD OF MANUFACTURING DYE COMPOUND, AND NOVEL BIPYRIDINIUM COMPOUND AND NOVEL DYE COMPOUND COMPRISING THE SAME - Provided is a method of manufacturing a bipyridinium compound denoted by general formula (A). | 03-26-2009 |
| 20150011771 | PROCESS FOR THE SYNTHESIS OF ETORICOXIB - The present invention relates to a process for the synthesis of the anti-inflammatory agent 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridine, referred to as compound of formula (1) or etoricoxib, which is a pharmaceutically active ingredient inhibiting cyclooxygenase-2. In particular, the application concerns a novel process of making the compound of formula (1) by oxidizing a compound of formula (4). | 01-08-2015 |
| 20160176842 | PROCESS FOR THE PREPARATION OF PERAMPANEL | 06-23-2016 |
| 546259000 | Metal containing catalyst utilized | 3 |
| 20130041155 | CARBON NANORING, METHOD FOR PRODUCING SAME, COMPOUND SUITABLE AS STARTING MATERIAL FOR PRODUCING THE CARBON NANORING, AND METHOD FOR PRODUCING THE COMPOUND - This invention provides: a compound for accurately forming a carbon nanoring that contains a specific number of organic rings and has a definite diameter; a method for producing the compound; a method for efficiently producing a carbon nanoring; and a cycloparaphenylene obtained by the production method. The carbon nanoring of the present invention is a compound obtained by bonding a specific number of organic ring groups. The method for producing a carbon nanoring of the present invention comprises a modification step wherein a halogen atom in a U-shaped compound is modified into a boron compound, and a coupling step wherein the U-shaped compound is subjected to a coupling reaction. The U-shaped compound is a novel compound that has cyclohexane rings, benzene rings, and specific organic ring groups. | 02-14-2013 |
| 20130102785 | METHOD OF MAKING COUPLED HETEROARYL COMPOUNDS VIA REARRANGEMENT OF HALOGENATED HETEROAROMATICS FOLLOWED BY OXIDATIVE COUPLING - The inventions disclosed and described herein relate to new and efficient generic methods for making a wide variety of compounds having Formulas (I) and (II) as shown below (Formulas (I) and (II)) wherein HAr is an optionally substituted five or six membered heteroaryl ring, and Hal is a halogen, and Y is a bridging radical, such as S, Se, NR | 04-25-2013 |
| 20130245272 | PROCESS FOR CYCLOOXYGENASE-2 SELECTIVE INHIBITOR - The present invention describes a process for preparing a cyclooxygenase-2 selective inhibitor. It provides a synthetic procedure for the said substance namely 5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine of formula (I). The invention also relates to preparation of a new intermediate of formula (IV) and a process to prepare it. Furthermore, the invention describes a process for preparing another key intermediate of formula (II). Compounds of formula (IV) and formula (II) are useful intermediates in synthesis of the said cyclooxygenase-2 inhibitor. | 09-19-2013 |
| 546260000 | Metal containing catalyst utilized | 1 |
| 20130109862 | METHODS FOR PREPARING INTERMEDIATES OF PERAMPANEL | 05-02-2013 |
| 546261000 | Chalcogen bonded directly to ring carbon of pyridine or partially hydrogenated pyridine ring | 13 |
| 20110295015 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER - Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or an activated carboxylic acid compound thereof, to provide a compound of Formula (IV); and (b) converting said protected amine group attached to said compound of Formula (IV) to an amine group to provide said compound of Formula (I); wherein PAm is a protected amine group. Processes to prepare the compounds of Formulae (II), (III), and (IV) are also disclosed. | 12-01-2011 |
| 20120022261 | Colorant Compositions Containing an Oxonol Dye - The present invention relates to an oxonol dye of formula (I) | 01-26-2012 |
| 20120116088 | 2-[[[2-[(HYDROXYACETYL)AMINO]-4-PYRIDINYL]METHYL]THIO]-N-[4-(TRIFLUOROMETH- OXY)PHENYL]-3-PYRIDINECARBOXAMIDE BENZENESULFONATE, CRYSTAL OF SAME, CRYSTAL POLYMORPH THEREOF, AND METHODS FOR PRODUCTION THEREOF - In the course of developing 2-[[[2-[(hydroxyacetyl)amino]-4-pyridinyl]methyl]thio]-N-[4-(trifluoromethoxy)phenyl]-3-pyridinecarboxamide (compound A), there are the multiple problems: 1) compound A or its salt is difficult to be recrystallized, the storage stability largely differs depending on the kind of the salt, and it is very difficult to obtain a salt of compound A having excellent storage stability; 2) in a crystallization process of compound A, it is very difficult to control a crystal polymorph, and 3) compound A (free body) causes mineral deposition in the stomach when it is orally administered repeatedly. For solving these problems, we made examination focusing on the kind of the salt and, as a result, found that 1) benzenesulfonate of compound A does not decompose by light, humidity and other factors in a 1-week preliminary stability test (severe test), and has no problem in its storage stability, 2) a method of selectively producing two kinds of crystal forms of benzenesulfonate of compound A, and that 3) no mineral deposition in the stomach is observed even after a 4-week repeated oral administration. | 05-10-2012 |
| 20120184747 | ANILINE COMPOUND - This is to provide a novel aniline compound represented by the following formula (I) having an excellent broncho dilatory action based on potent EP2 agonistic action. | 07-19-2012 |
| 20140256951 | STABILIZED POLYMERIC THIOL REAGENTS - Disclosed are water soluble polymeric thiol reagents. Also disclosed are uses for the polymeric thiol reagents and methods for preparing the polymeric thiol reagents. | 09-11-2014 |
| 20140303377 | AGRICULTURAL/HORTICULTURAL INSECTICIDE AND METHOD FOR USING THESAME - An object of the present invention is to provide insecticides having high effectiveness. The present invention provides compounds represented by formula (1): | 10-09-2014 |
| 20150065719 | PHARMACEUTICAL COMPOSITIONS COMPRISING N-(4-(2-AMINO-3-CHLOROPYRIDIN-4-YLOXY)-3-FLUOROPHENYL)-4-ETHOXY-1-(4-FLUO- ROPHENYL)-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE - Disclosed are salts and crystalline forms of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide and salts thereof. Also disclosed are at least one pharmaceutical composition comprising at least one crystalline form of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, at least one method of using at least one crystalline form of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide to treat cancer and/or other proliferative diseases, and processes to prepare crystalline forms of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide and salts thereof. | 03-05-2015 |
| 20150291560 | 2-[[[2-[(HYDROXYACETYL)AMINO]-4-PYRIDINYL]METHYL]THIO]-N-[4-(TRIFLUOROMETH- OXY)PHENYL]-3-PYRIDINECARBOXAMIDE BENZENESULFONATE, CRYSTAL OF SAME, CRYSTAL POLYMORPH THEREOF, AND METHODS FOR PRODUCTION THEREOF - In the course of developing 2-[[[2-[(hydroxyacetyl) amino]-4-pyridinyl]methyl]thio]-N-[4-(trifluoromethoxy) phenyl]-3-pyridinecarboxamide(compound A), there are the multiple problems: 1) compound A or its salt is difficult to be recrystallized, the storage stability largely differs depending on the kind of the salt, and it is very difficult to obtain a salt of compound A having excellent storage stability; 2) in a crystallization process of compound A, it is very difficult to control a crystal polymorph, and 3) compound A (free body) causes mineral deposition in the stomach when it is orally administered repeatedly. For solving these problems, we made examination focusing on the kind of the salt and, as a result, found that 1) benzenesulfonate of compound A does not decompose by light, humidity and other factors in a 1-week preliminary stability test (severe test), and has no problem in its storage stability, 2) a method of selectively producing two kinds of crystal forms of benzenesulfonate of compound A, and that 3) no mineral deposition in the stomach is observed even after a 4-week repeated oral administration. | 10-15-2015 |
| 20150307474 | PROCESS FOR PREPARING 4-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLORO-1-OXIDO-4-PYRIDYL)-5-METHOXYPYRIDI- NE-2-CARBOXAMIDE - The present invention relates to a novel process for preparing the compound 4-(cyclopropylmethoxy)-N-(3,5-di-chloro-1-oxido-4-pyridyl)-5-methoxypyridine-2-carboxamide of formula (1), in base or hydrate form or in the form of pharmaceutically acceptable salts, and also to several novel synthetic intermediates that are useful in this preparation process. | 10-29-2015 |
| 20150368201 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors - Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity. | 12-24-2015 |
| 20160060221 | SUBSTITUTED BIARYL COMPOUND - The present invention provides a substituted biaryl compound of general formula (I): | 03-03-2016 |
| 20160159743 | FUSED HETEROCYCLIC COMPOUND - There is provided a compound having an excellent controlling effect on pests represented by the formula (1): | 06-09-2016 |
| 20160251314 | 2-[[[2-[(HYDROXYACETYL)AMINO]-4-PYRIDINYL]METHYL]THIO]-N-[4-(TRIFLUOROMETH- OXY)PHENYL]-3-PYRIDINECARBOXAMIDE BENZENESULFONATE, CRYSTAL OF SAME, CRYSTAL POLYMORPH THEREOF, AND METHODS FOR PRODUCTION THEREOF | 09-01-2016 |
| 546262000 | Having -C(=X)-, wherein X is chalcogen, bonded directly to pyridine or partially hydrogenated pyridine ring | 4 |
| 20100016604 | PROCESS FOR THE MANUFACTURE OF HI-6 DIMETHANESULFONATE - The invention provides a process for the manufacture of H1 6 dimethanesulfonate comprising contacting an O-protected pyridine aidoxime compound with bis(methylsulphonoxymethyl)ether in a suitable solvent to form an intermediate compound, contacting said intermediate compound with isonicotinamide to form an O-protected HI 6 product precursor, and de-protecting the precursor to form HI 6 dimethanesulfonate. | 01-21-2010 |
| 20110098476 | PROCESS FOR PREPARING BIS(THIOHYDRAZIDE AMIDES) - Disclosed herein are methods of preparing a bis(thio-hydrazide amides) compounds of the following structural formula: wherein R | 04-28-2011 |
| 20150099888 | 2-Anilinonicotinyl Based Chalcones Useful As Potential Anticancer Agents and Process for Preparation Thereof - The present invention provides a compound of general formulae A useful as potential antitumor agents against human cancer cell lines and a process for the preparation thereof. | 04-09-2015 |
| 20150299168 | PROCESS FOR ACYLATING AMINES - The present invention is concerned with the formation of amide bonds. More specifically, the present invention, relates to processes for the manufacture of organogellant compounds (OG) as depicted below wherein L is selected from C | 10-22-2015 |
| 546264000 | Acyclic nitrogen attached directly or indirectly to pyridine or partially hydrogenated pyridine ring by nonionic bonding | 6 |
| 20150141653 | PROCESS FOR PRODUCING SUBSTITUTED METHYLAMINE COMPOUND AND TRIAZINE DERIVATIVE - The present invention provides a process that enables a substituted methylamine compound which is useful as an intermediate for the production of agricultural chemicals and medicines, to be produced easily, with good yield, and at low cost, and also provides a production intermediate thereof. The process comprises a step of reacting a hexamethylenetetraammonium salt compound represented by a formula (I) with a base to obtain an N-methylidene-substituted methylamine oligomer represented by a formula (II) or a mixture of two or more of the oligomers, and a step of hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II) or the mixture of two or more of the oligomers in the presence of an acid. | 05-21-2015 |
| 20150329773 | NOVEL LUMINESCENT MATERIALS - The invention provides photoluminescent compounds, reactive intermediates used to synthesize photoluminescent compounds, and methods of synthesizing and using photoluminescent compounds, among others. The compounds comprise phenanthrene and dipyridylamine moieties. The compounds are colored and fluoresce upon excitation. Methods are included for using the compounds to detect metal ions by spectral changes of wavelength shift or a change in fluorescence intensity. Compositions in polymers and solvents are provided for use as a film, paint, reflective surfaces, and electroluminescent devices are provided. | 11-19-2015 |
| 546265000 | Having -C(=X)-, wherein X is chalcogen, bonded directly to the acyclic nitrogen | 4 |
| 20100099881 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR - An object of the invention is to provide a novel sphingosine compound with an inhibitory activity against sphingomyelinase, and a method for producing the sphingosine compound. | 04-22-2010 |
| 20100331549 | Novel compounds useful for modulating abnormal cell proliferation - There is described compounds of Formulæ I, II, III, IV and V. The compounds of Formulæ I, II, III, IV and/or V are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools. | 12-30-2010 |
| 20130281703 | Small Molecules Modulator of Epigenetic Regulation and Their Therapeutic Applications - Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof. | 10-24-2013 |
| 20140213791 | METHOD FOR PRODUCING PEST CONTROL AGENT - To supply a derivative having a 2-acyliminopyridine structure and being represented by the following formula (I) in an amount required as a pest control agent stably and at a low cost, provided is a method comprising the steps of: acylating an amino group at position 2 of a compound represented by formula (A) by use of an acylating agent, to thereby produce a compound represented by formula (B); and further alkylating a nitrogen atom at position 1 of the compound represented by formula (B): | 07-31-2014 |
