| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 546207000 | The additional ring is a hetero ring | 38 |
| 20080312447 | Process for Isolation of Crystalline Tacrolimus - The invention is a simple process for separation of tacrolimus and its analogues, ascomycin and tsucubamycin B and preparation of enough pure crystalline tacrolimus. The process takes advantage of surprising properties of tacrolimus and involves extraction, purification and crystallization to produce purified crystalline tacrolimus. | 12-18-2008 |
| 20100137603 | DIALKYLPHENYL COMPOUNDS HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY - This invention relates to compounds of formula I: | 06-03-2010 |
| 20100331545 | REGULATOR FOR SIGNALING TOLL-LIKE RECEPTOR, WHICH COMPRISES CATHEPSIN INHIBITOR AS ACTIVE INGREDIENT - [Problems] To provide a modulator for signaling of TLR | 12-30-2010 |
| 546208000 | Ring nitrogen in the additional hetero ring | 29 |
| 20110172431 | PROCESS FOR PRODUCING 1-SUBSTITUTED TRANS-4-(SUBSTITUTED AMINO) PIPERIDIN-3-OL - A process is provided for producing a 1-substituted trans-4-(substituted amino)piperidin-3-ol represented by formula (III-1): | 07-14-2011 |
| 20160002165 | SALT OF PYRROLIDIN-3-YL ACETIC ACID DERIVATIVE AND CRYSTALS THEREOF - An organic carboxylic acid salt of 2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(cyclohex-1-en-1-ylmethyl) piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid and a crystal thereof. | 01-07-2016 |
| 546209000 | Ring sulfur or ring oxygen in the additional hetero ring | 8 |
| 20090005568 | Substituted 2-aminothiazoles for treating neurodegenerative diseases - The invention relates to substituted 2-aminothiazole derivatives useful in treating disorders that are mediated by A | 01-01-2009 |
| 20100197927 | Protein Tyrosine Phosphatase 1B Inhibitor, Preparation Methods and Uses Thereof - PTP1B inhibitors with the following structure (formula I). Experiments indicate that these inhibitors can effectively inhibit the activity of protein tyrosine phosphatase 1B (PTP1B). They can be used as insulin sensitisers. They can be used to prevent, delay or treat diseases which are related to insulin antagonism mediated by PTP1B, especially diabetes type II and obesity. The invention also provides methods for preparing these inhibitors. | 08-05-2010 |
| 20120010416 | PYRROLIDINONE BENZENESULFONAMIDE DERIVATIVES AS MODULATORS OF ION CHANNELS FOR THE TREATMENT OF PAIN - The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 01-12-2012 |
| 20120302757 | SYNTHETIC INTERMEDIATE OF OXAZOLE COMPOUND AND METHOD FOR PRODUCING THE SAME - An object of the present invention is to provide a method for producing an oxazole compound in a high yield. | 11-29-2012 |
| 20140031553 | Thiazol-4-Carboxylic Acid Esters and Thioesters as Plant Protection Agents - The use of thiazole-4-carboxylic esters and thioesters of the formula (I) | 01-30-2014 |
| 20140148600 | THIAZOLE COMPOUNDS, METHODS FOR PREPARATION AND USE THEREOF - The present invention relates to thiazole compounds of formula I, the method for preparation and use thereof. More specifically, the present invention relates to novel derivatives of natural product largazole, the method for preparing them and their uses for treatments against tumor and multiple sclerosis as inhibitors of histone deacetylase. | 05-29-2014 |
| 20140336388 | Nitrofurfuryl Substituted Phenyl Linked Piperidino-Oxadiazoline Conjugates As Anti-Tubercular Agents And Process For The Preparation Thereof - The present invention provides nitrofurfuryl substituted phenyl linked piperidino-oxadiazolone compounds of general formula (A) as anti-tubercular agents; wherein G=formula (B); X═H, F; R═H, CH | 11-13-2014 |
| 20160108085 | TUBULYSINS AND PROCESSES FOR PREPARING - Processes are described for the preparation of tubulysins. The processes are useful for preparing predetermined mixtures of tubulysins, preparing single tubulysins from mixtures of tubulysins, and for converting one tubulysin into a different tubulysin. The tubulysins described herein are useful in treating diseases and disease states that include pathogenic cell populations. | 04-21-2016 |
| 546210000 | Plural ring nitrogens in the additional hetero ring | 19 |
| 20080306272 | ONE-POT METHODS FOR PREPARING CINNAMIDE DERIVATIVES - A compound represented by the following formula ( | 12-11-2008 |
| 20090048448 | SALTS OF CYNNAMIDE COMPOUND OR SOLVATES THEREOF - The invention provides crystals of dihydrochloride monohydrate of the compound of the following formula having an Aβ production inhibiting effect which crystals are characterized by exhibiting a diffraction peak at an angle of diffraction (2θ±0.2°) of 10.9° in powder X-ray diffractometry. Further, the invention also provides the compound in the form of various salts, crystal forms and amorphous forms which are suitable for the development of drugs. | 02-19-2009 |
| 20090143591 | SCALABLE SYNTHESIS OF IMIDAZOLE DERIVATIVES - Imidazole derivatives, compositions containing them, methods of preparing them, including regioselective scale-up synthetic methods, and methods of using them. | 06-04-2009 |
| 20090203916 | Amorphous object of cinnamide compound - An amorphous object of (3E)-1-[l(s)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4methyl-1H-imidazol-1-yl)benzylidene]piperidine-2-one, which is represented by the formula (1) and has Aβ-production inhibitory activity. The amorphous object has such satisfactory properties that it has excellent solubility, is stable, does not readily become a crystalline form, and has low hygroscopicity. It is hence suitable for use in pharmaceutical preparations. | 08-13-2009 |
| 20090240056 | METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS - Methods, composition, and intermediates are disclosed that are useful for making 4-Tetrazolyl-4-phenylpiperidine Compounds according to Formula I, | 09-24-2009 |
| 20130150586 | PROCESS FOR PRODUCING 1-TRIAZOLE-2-BUTANOL DERIVATIVES - An object is to provide a process for producing the compound of formula 1 in higher yield by the ring-opening addition reaction of epoxytriazole with amine under mild conditions without using a large excess of 4-methylenepiperidine. The process for producing (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol or an acid addition salt thereof comprises reacting (2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane with an acid addition salt of 4-methylenepiperidine in a reaction solvent in the presence of a hydroxide of an alkali metal or an alkaline earth metal selected from the group consisting of lithium, sodium, calcium, and strontium, or a hydrate thereof. | 06-13-2013 |
| 20140296532 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF MALARIA - The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided. | 10-02-2014 |
| 20140364616 | ANTI-VIRAL COMPOUNDS - The present invention relates to anti-HCV compounds, compositions comprising the same and methods of using the same to treat HCV infection. | 12-11-2014 |
| 20140364617 | ANTI-VIRAL COMPOUNDS - The present invention relates to anti-HCV compounds, compositions comprising the same and methods of using the same to treat HCV infection. | 12-11-2014 |
| 20150065717 | NIPECOTIC ACID DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES - A compound has an sEH-inhibiting activity and provides a pharmaceutical having a therapeutic effect and a prophylactic effect on chronic renal disease and pulmonary hypertension based on the sEH-inhibiting action. The nipecotic acid derivatives are represented by the chemical formula below and pharmaceutically acceptable salts thereof. | 03-05-2015 |
| 20160185751 | METHOD FOR PREPARING BENZAMIDE DERIVATIVE, NOVEL INTERMEDIATE USED IN PREPARATION OF BENZAMIDE, AND METHOD FOR PREPARING NOVEL INTERMEDIATE - The present invention relates to a method for preparing N-[[1-{3-(1,2,3-triazol-1-yl)propyl}piperidin-4-yl]methyl]-4-amino-5-chloro-2-methoxybenzamide, which is a novel benzamide derivative as a 5-HT4 receptor agonist, or a pharmaceutically acceptable salt thereof; to a novel intermediate capable of being used in the preparation of the compounds; and to a method for preparing the same. The preparation methods of the present invention can be useful for mass production since a low-priced reagent and intermediate are used and the number of reaction processes is decreased, thereby saving preparation costs and improving the yield. | 06-30-2016 |
| 20160376253 | PROCESS FOR THE PREPARATION OF PIPERIDINE COMPOUNDS - The present invention relates to a process for the preparation of efinaconazole. | 12-29-2016 |
| 546211000 | 1,2-diazole (including hydrogenated) | 7 |
| 20090048449 | RIMONABANT MONOHYDRATE, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME - The present invention relates to rimonabant monohydrate, to the process for preparing it and to the pharmaceutical compositions containing it. | 02-19-2009 |
| 20100076197 | PROCESS FOR RIMONABANT - The present invention provides an improved and commercially viable process for the preparation of rimonabant substantially free of amide impurity, namely 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl-4-methyl-pyrazole-3-carboxamide and its pharmaceutically acceptable acid addition salts thereof. Thus, for example, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl-4-methyl-pyrazole-3-carboxylic acid chloride is reacted with 1-aminopiperidine in the presence of a base and optionally a phase transfer catalyst is used such as tetra-butylammonium bromide in a biphasic reaction medium containing water and a water-immiscible solvent to obtain pure rimonabant. | 03-25-2010 |
| 20100190988 | PROCESS FOR PREPARATION OF PYRAZOLE DERIVATIVES - A process for preparation of Pyrazole derivatives adapted for one pot reaction involving the use of a pyclizing agent and involving the step of amidation in the presence of a catalyst. The steps for isolation and purification of found Pyrazole derivatives are also disclosed. | 07-29-2010 |
| 20110137040 | SYNTHESIS OF 3,4-DIARYL-4,5-DIHYDRO-(H)-PYRAZOLE-1-CARBOXAMIDINE DERIVATIVES - The invention relates to a novel chemical route to 3,4-diaryl-4,5-dihydro-(1H)-pyrazole-1-carbox-amidine derivatives, known as potent cannabinoid-CB | 06-09-2011 |
| 20110144345 | SULFOXYIMINO-SUBSTITUTED BENZOYL DERIVATIVE AND HERBICIDE - The benzoyl derivative of the present invention is represented by formula (I) | 06-16-2011 |
| 20130060041 | SYNTHESIS OF SUBSTITUTED PYRAZOLINE CARBOXAMIDINE DERIVATIVES - This invention relates to organic chemistry, in particular to processes for the preparation of pyrazoline carboxamidine derivatives of formula (I), known as potent 5-HT6 antagonists. The invention also relates to novel intermediates of these compounds. wherein the symbols have the meanings given in the description. | 03-07-2013 |
| 20150291556 | FUNGICIDAL AZOCYCLIC AMIDES - Disclosed are compounds of Formulae 1, 1A, 1B and 1C including all geometric and stereoisomers, N-oxides, and salts thereof, | 10-15-2015 |
| 546212000 | The additional hetero ring consists of one sulfur and four carbons | 5 |
| 20080269495 | Process for Preparation of Piperidine Carboxylic Acid - A process for preparing pure tiagabine, which is a piperidine carboxylic acid compound, via pharmaceutically acceptable salts of tiagabine ester is provided. Also, L(+) tartaric acid, oxalic acid and dibenzoyl L(+) tartaric acid salts of tiagabine esters are provided. Further, process for preparing acid addition salts of tiagabine esters is provided. | 10-30-2008 |
| 20100305328 | PROCESS FOR PREPARATION OF PIPERIDINE CARBOXYLIC ACID - Processes for preparing pure tiagabine, a piperidine carboxylic acid, using pharmaceutically acceptable acid addition salts of tiagabine esters are provided. L(+)-tartaric acid, oxalic acid and dibenzoyl L(+)-tartaric acid addition salts of tiagabine esters are also provided. Further, processes for preparing acid addition salts of tiagabine esters are provided. | 12-02-2010 |
| 546213000 | Carbocyclic ring containing | 3 |
| 20100137604 | METHOD OF MAKING PIPERIDINE DERIVATIVES - The present invention relates to a process for the preparation of piperidine derivatives including sufentanil, and their pharmaceutically acceptable salts, such as the citrate salt | 06-03-2010 |
| 20120059170 | THIOPHENE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS - Compounds represented by formula I: | 03-08-2012 |
| 20120071659 | Process for the Preparation of Sufentanil Base and Related Compounds - The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously utilizes more cost effective and/or less hazardous reagents, including a dispersion comprising between about 50% and about 70% by weight (based on the total weight of the dispersion) of an alkali metal hydride, such as sodium hydride, as well as eliminates the need for expensive and/or time consuming purification techniques. | 03-22-2012 |
| 546214000 | The additional hetero ring consists of one oxygen and four carbons | 1 |
| 20110015400 | PROCESS FOR THE PREPARATION OF TRYPTASE INHIBITORS - This invention is directed to processes for the preparation of a compound of the formula I or salt thereof, | 01-20-2011 |
