| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 546139000 | Isoquinolines (including hydrogenated) | 73 |
| 20080200682 | Process of Producing Bleach Boosters - This invention relates to a process of producing compounds, which are useful as bleach boosters, as well as to the compounds, which are obtainable using said process, and to their use. | 08-21-2008 |
| 20090209765 | PROCESS FOR PRODUCTION OF 4-FLUOROISOQUINOLINE-5-SULFONYL HALIDE OR SALT THEREOF - To provide an effective and simple process for producing 4-fluoroisoquinoline-5-sulfonyl halide or a salt thereof, and a simple method for separating for purification of the product from a by-produced position isomer thereof. | 08-20-2009 |
| 20090247756 | Process for the Preparation of Hexahydroisoquinolines from 1,2,3,4-Tetrahydroisoquinolines - The present invention is directed to processes for the synthesis of morphinans. In particular, a process for the asymmetric reduction of an imine moiety in a 3,4-dihydroisoquinoline to produce a tetrahydroisoquinoline, followed by a Birch reduction to produce a hexahydroisoquinoline. In various embodiments, the 3,4-dihydroisoquinoline contains a phenol moiety protected with a labile protecting group. In other embodiments, the imine reduction reaction mixture contains silver tetrafluoroborate. | 10-01-2009 |
| 20100063290 | Preparation of 3,4-Dihydroisoquinolines from an Acid and an Amine - The present invention is directed to processes for the synthesis of morphinans. In particular, a process for coupling a carboxylic acid compound with an amine compound to form an amide product that can then be isolated or the crude amide product can be cyclized to form a 3,4-dihydroisoquinoline. In one embodiment, the carboxylic acid contains a phenol moiety protected with a labile protecting group. The protected phenol reduces reaction times, simplifies work-up of the product, and reduces the amount of cyclizing agent, POCl | 03-11-2010 |
| 20140288309 | PROCESS OF PRODUCING BLEACH BOOSTERS - This invention relates to a process of producing compounds, which are useful as bleach boosters, as well as to the compounds, which are obtainable using said process, and to their use. | 09-25-2014 |
| 546140000 | Plural isoquinoline ring systems attached directly or indirectly to each other by nonionic bonding | 9 |
| 20100016596 | PROCESS FOR THE PURIFICATION OF NEUROMUSCULAR BLOCKING AGENTS - A process for the preparation of neuromuscular blocking agents with isoquinoline structure, such as atracurium besylate, doxacurium chloride, mivacurium chloride and gantacurium chloride, by chromatographic purification of their mixtures of isomers using a silica modified by treatment with a tertiary amine of formula NR | 01-21-2010 |
| 20100087650 | (1R,1'R)-ATRACURIUM SALTS SEPARATION PROCESS - Provided is a method for separating cisatracurium from a mixture of atracurium isomers, which method includes eluting from a Reverse Phase (RP) stationary phase with a mobile phase in which the isomers are stable. The method of the present invention can be conveniently and inexpensively scaled up. | 04-08-2010 |
| 20100099878 | (1R, 1'R)-ATRACURIUM SALTS SEPARATION PROCESS - The present invention provides an improved method of chromatographically separating the isomers of (1R,rR)-atracurium salts by high-performance liquid chromatography (HPLC), in the absence of a strong acid. The separation is preferably performed on a silica gel HPLC column using an eluent containing an organic solvent, a polar aprotic co-solvent and a weak organic acid. | 04-22-2010 |
| 20100168431 | NOVEL ISOQUINOLINIUM COMPOUNDS USEFUL IN THE PREPARATION OF CISATRACURIUM AND ASSOCIATED INTERMEDIATES - The present invention provides novel isoquinolinium compounds, methods of producing the isoquinolinium compounds, and methods for converting them into cisatracurium, e.g., cisatracurium besylate. The isoquinolinium compounds of the present invention can be obtained in the form of solids, which can be purified using simple techniques and can be used to afford pure cisatracurium besylate without HPLC purification | 07-01-2010 |
| 20100174082 | (1R,1'R)-ATRACURIUM SALTS SEPARATION PROCESS - The present invention provides an improved method for obtaining cisatracurium besylate, which preferably chromatographically separating cisatracurium besylate from a mixture of (1R,1′R)-atracurium isomers via flash chromatography | 07-08-2010 |
| 20100234602 | NOVEL R,R`-ATRACURIUM SALTS - The present invention provides R,R′-atracurium salts processes for producing and purifying such salts, and methods of using such salts to produce highly pure cisatracurium besylate. | 09-16-2010 |
| 20130041154 | PROCESS FOR PRODUCING CISATRACURIUM AND ASSOCIATED INTERMEDIATES - The present invention provides a process of producing cisatracurium compounds, e.g., cisatracurium besylate, from isoquinolinium salts of the structural formula (VIIA) wherein X | 02-14-2013 |
| 20130245269 | Synthesis of Tripodal Catechol Derivatives Having an Adamantyl Basic Framework for Functionalizing Surfaces - The present invention describes tripodal catechol derivatives with an adamantyl basic framework for the functionalisation of surfaces, methods for their production and use. The remaining fourth bridgehead position is easily suitable to be further functionalised via so-called click reactions, by way of example with biomolecules, dyes, radiomarkers, polyethylene glycol or active agents. | 09-19-2013 |
| 20150318494 | Fluorescent Isoindoline Dyes - The present invention provides a new class of excited state intramolecular charge transfer (ESIPT) dye compounds based on mono or dihydroxy substituted 1,3-bisiminoisoindole motif and metal complexes containing such compounds as ligands. The present invention also provides OLEDs containing the compound and/or metal complex as the emissive material. | 11-05-2015 |
| 546141000 | Chalcogen attached directly to the six-membered hetero ring by nonionic bonding | 19 |
| 20090076276 | ISOQUINOLINE COMPOUND AND PHARMACEUTICAL USE THEREOF - The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. | 03-19-2009 |
| 20090156823 | Sulfonamide compound and crystal thereof - (S)-1-(4-Chloro-5-isoquinolinesulfonyl)-3-(methylamino)pyrrolidine monohydrochloride and a crystal thereof, and a crystal of the aforementioned monohydrochloride having a major peak or peaks at one or more positions selected from the group consisting of positions where 2θs are about 13.9°, 21.5°, 21.7°, 22.4°, 22.8°, 24.5° and 35.0° in a powder X-ray diffraction spectrum, which have excellent properties as active ingredient of a medicament for prophylactic and/or therapeutic treatment of glaucoma and the like. | 06-18-2009 |
| 20090171090 | METHOD FOR PRODUCING BENZAZEPINONE - It is an object of the present invention to provide 2-iminocarboxylic acid derivatives, and a practically suitable industrial method for producing benzazepinones in a short process under mild conditions. The present invention provides a method for producing a benzazepinone or a salt thereof, which comprises opening a ring of an isoquinoline derivative and subsequently converting the thus generated amine into a benzazepinone through lactamization reaction. | 07-02-2009 |
| 20100056792 | Process for Synthesizing Substituted Isoquinolines - The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process. | 03-04-2010 |
| 20110021779 | PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES - The present invention relates to a process for making 6-substituted-1-(2H)-isoquinolinone derivatives of formula (I) | 01-27-2011 |
| 20110137037 | CASPASE INHIBITOR PRODRUGS - This invention relates to prodrugs of caspase inhibitors comprising of a furo[3,2-d]oxazolin-5-one moiety which, under specific conditions, can convert into biologically active compounds, particularly caspase inhibitors. | 06-09-2011 |
| 20120220774 | Process for Synthesizing Substituted Isoquinolines - The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process. | 08-30-2012 |
| 20120330019 | Hepatitis C Virus Inhibitors - Hepatitis C virus inhibitors are disclosed having the general formula: | 12-27-2012 |
| 20130012711 | SUBSTITUTED PHENYL COMPOUNDS - The present invention relates to novel substituted phenyl compounds of the formula | 01-10-2013 |
| 20130123503 | Process for Synthesizing Substituted Isoquinolines - The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process. | 05-16-2013 |
| 20130267712 | AROMATIC KETONE SYNTHESIS WITH AMIDE REAGENTS AND RELATED REACTIONS - A method of preparing an aryl carbonyl or aryl thiocarbonyl compound, comprises reacting an N-(nitroaryl)-amide or N-(nitroaryl)-thioamide with an aromatic ring, with a superacid catalyst, to produce the aryl carbonyl or aryl thiocarbonyl compound. The superacid is present in an amount of at most 8 equivalents in proportion to the N-(nitroaryl)-amide or N-(nitroaryl)-thioamide. A method of preparing aryl amide or aryl thioamide, comprises reacting an N-(nitroaryl)-carbamide or N-(nitroaryl)-thiocarbamide with an aromatic ring, with a superacid catalyst, to produce the aryl amide or aryl thioamide. | 10-10-2013 |
| 20130267713 | Hepatitis C Virus Inhibitors - Hepatitis C virus inhibitors are disclosed having the general formula: | 10-10-2013 |
| 20130310565 | NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF - The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. | 11-21-2013 |
| 20140221656 | CRYSTALLINE SOLVATES OF 6-(PIPERIDIN-4-YLOXY)-2H-ISOQUINOLIN-1-ONE HYDROCHLORIDE - The present invention relates to crystalline solvates of 6-(Piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride, processes for their preparation and the use thereof. | 08-07-2014 |
| 20150322015 | CRYSTALLINE FORMS OF A PROLYL HYDROXYLASE INHIBITOR - The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof. | 11-12-2015 |
| 20160039723 | STEREODYNAMIC CHEMOSENSORS - The present invention relates to multifunctional chemosensors that can measure the concentration, enandomeric excess (ee), and absolute configuration of chiral compounds. The chemosensors described herein may contain a backbone moiety that is bonded to a fluorescent moiety and a moiety for bonding a chiral compound. Backbone moieties may include aromatic groups, for example, naphthyl. The chemosensors described herein are useful for measuring concentration, enandomeric excess, and absolute configuration of organic molecules in areas such as high throughput screening. | 02-11-2016 |
| 20160194285 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | 07-07-2016 |
| 546142000 | Plural chalcogens attached directly to the six-membered hetero ring by nonionic bonding | 2 |
| 20120077981 | N[S(4-ARYL-TRIAZOL-3-YL)ALPHA-MERCAPTOACETYL]-P-AMINO BENZOIC ACIDS AS HIV REVERSE TRANSCRIPTASE INHIBITORS - A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. | 03-29-2012 |
| 20140163231 | Hepatitis C Virus Inhibitors - Hepatitis C virus inhibitors are disclosed having the general formula: | 06-12-2014 |
| 546143000 | Nitrogen, other than as nitro or nitroso, attached directly to the isoquinoline ring system by nonionic bonding | 1 |
| 20100022775 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS - The present invention is directed to practical high-yielding synthetic processes to prepare compounds of general Formula III, IV, V, VII, VIII, IX, X, XII, XIV, and XV. Such compounds are useful as final products or can be used as intermediates and be further modified to prepare other desired products such as rho-kinase inhibitors. The present invention is also directed to certain novel compounds and/or novel solid forms of certain compounds. | 01-28-2010 |
| 546144000 | Unsaturated ring attached directly to the six-membered hetero ring by nonionic bonding | 7 |
| 20080275242 | 3-(Dihydro(Tetrahydro)Isoquinolin-1-Yl)Quinoline Compound - The invention provides compounds which exert excellent fungicidal activities against various plant diseases and are useful as active ingredients of pesticides permitting the control of rice blast and so on even in low dosages. Compounds represented by the general formulae (1a) to (1d) or salts thereof: (1a) (1b) (1c) (or) (1d) wherein R | 11-06-2008 |
| 20090306390 | CHIRAL LIGANDS, THEIR PREPARATION AND USES THEREOF IN ASYMMETRIC REACTIONS - A novel class of chiral ligands represented by a structure of Formula (I): wherein R | 12-10-2009 |
| 20110130568 | Acylsulfonamides and Processes for Producing the Same - The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide. | 06-02-2011 |
| 20110201815 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES - The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal plasma uric acid level and the like. The present invention relates to fused heterocyclic derivatives represented by the following formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of plasma uric acid level, prodrugs thereof, salts thereof or the like. In the formula (I), T represents trifluoromethyl, nitro or cyano; ring Q represents heteroaryl; X | 08-18-2011 |
| 20130281700 | PALLADIUM CATALYST, METHOD FOR ITS PREPARATION AND ITS USE - The invention relates to palladium(0)-tris{tri-[3,5-bis(trifluoromethyl)-phenyl]-phosphine} complex of formula (I), as well as to its preparation and use. | 10-24-2013 |
| 20140235862 | METHOD FOR PRODUCING 4, 4-DIFLUORO-3,4-DIHYDROISOQUINOLINE DERIVATIVES - Provided is a simple and efficient method for the large-scale production of a 4,4-difluoro-3,4-dihydroisoquinoline derivative. In the method for producing a 4,4-difluoro-3,4-dihydroisoquinoline derivative represented by general formula (1): | 08-21-2014 |
| 20160039786 | METHOD FOR PRODUCING 3,4-DIHYDROISOQUINOLINE DERIVATIVES AND PRODUCTION INTERMEDIATES OF SAME - Provided are an efficient method for producing 3,4-dihydroisoquinoline derivatives and useful production intermediates thereof. Provided is a method for producing 3,4-dihydroisoquinoline derivatives represented by general formula (1), comprising converting a compound represented by general formula (3) in the presence of acid after reacting with an aniline derivative, or converting a compound represented by general formula (3) by reacting with an aniline derivative in the presence of an acid. | 02-11-2016 |
| 546146000 | Having -C(=X)-, wherein X is chalcogen, attached directly or indirectly to the isoquinoline ring system by nonionic bonding | 20 |
| 20080312445 | Novel Crystalline Forms Of Nelfinavir Mesylate - The present invention provides novel crystalline forms of Nelfinavir mesylate, Form-A, Form-B, Form-C, Form-D and the process for their preparation without the use of any special equipment such as a spray drier, avoiding the use of highly flammable solvents such as ethers. The crystalline form can be tailored with the selection of the ante solvent and appropriate conditions for the process. | 12-18-2008 |
| 20090221829 | 3,4-Dihydroisoquinolinium Salt Derivatives - The present invention relates to 3,4-dihydroisoquinolinium salt derivatives. More specifically, the present invention relates to 3,4-dihydroisoquinolinium salt derivatives of the following chemical formula (I). | 09-03-2009 |
| 20100010226 | TRISUBSTITUTED 3,4-DIHYDRO-1H-ISOQUINOLIN COMPOUND, PROCESS FOR ITS PREPARATION, AND ITS USE - The present invention relates to the compound of formula 7*acetate (see below), a process for its preparation, and its use | 01-14-2010 |
| 20100217003 | 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EFFECTS OF PREVENTING AND TREATING DEGENERATIVE AND INFLAMMATORY DISEASES - Provided are 7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline derivatives and synthesis methods thereof. The compounds significantly inhibit the production of nitrogen monoxide (NO) and superoxide in an activated microglial cell and expressions of TNF-α, IL-1β inducive NO synthase and cyclooxygenase-2 genes. They also prevent NF-kB shift to a nucleus, decrease reactive oxygen species (ROS), inhibit expression of GTP cyclohydrolase I gene and over-production of tetrahydrobiopterin (BH | 08-26-2010 |
| 20110071299 | One-Pot Preparation of Hexahydroisoquinolines from Amides - The present invention provides an efficient process for the preparation of hexahydroisoquinolines from amides. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines. | 03-24-2011 |
| 20110092707 | Crystalline Pharmaceutical and Methods of Preparation and Use Thereof - Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in this invention. | 04-21-2011 |
| 20120041207 | Compound - A compound having Formula I | 02-16-2012 |
| 20120330020 | METHOD FOR PREPARING TETRAZOLE METHANESULFONIC ACID SALTS, AND NOVEL COMPOUND USED IN SAME - According to the present invention, a method for preparing tetrazole methanesulfonic acid salts comprises an acylation reaction using a novel 4-iodine-4H-chromene-2-carbothionic acid S-benzothiazole-2-yl ester. The method of the present invention can shorten a reaction time and improve safety as compared to conventional methods, and can prepare high-purity tetrazole methanesulfonic acid salts at a high yield rate without using a column chromatography method. | 12-27-2012 |
| 20130150585 | Crystalline Pharmaceutical and Methods of Preparation and Use Thereof - Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in this invention. | 06-13-2013 |
| 20130289280 | NOVEL PHARMACEUTICAL FORMS, AND METHODS OF MAKING AND USING THE SAME - Crystalline salts, polymorphs, solvates, and hydrates of bicalutamide, 5-fluorouracil, donepezil, anastrozole, nelfinavir, mirtazapine, lansoprazole, and tamsulosin, or derivatives thereof are provided by the subject invention. Methods of making and using the same are also provided. | 10-31-2013 |
| 20150031892 | SPHINGOLIPID METABOLITE MIMETICS - Sphingolipid metabolite mimetics and methods of synthesizing them are provided. The sphingolipid metabolite mimetics are shown to be effective at inducing apoptosis in various types of tumor cells. Further, the sphingolipid metabolite mimetics are shown to be effective at sensitizing multiple types of tumor cells to TRAIL-induced apoptosis. Formulations containing one or more sphingolipid metabolite mimetics and, optionally, one or more cell death receptor agonists are provided. Methods of treating cancer in a subject in need thereof are provided using one or more sphingolipid metabolite mimetics. | 01-29-2015 |
| 546147000 | The -C(=X)- is part of a -C(=X)X- group, wherein the X's are the same or diverse chalcogens | 9 |
| 20080306269 | INTERMEDIATES USEFUL FOR MAKING TETRABENAZINE COMPOUNDS - A method of preparing a tetrabenazine compound (TBZ compound) having structure I comprising the steps of reacting a nucleophilic alkenyl species with aldehyde compound II and oxidizing the resultant allylic alcohol to provide enone III. The protecting group P | 12-11-2008 |
| 20100094014 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS - The present invention provides novel compounds of Formula (I) and Formula (I(a)), or the pharmaceutically acceptable salts thereof; methods for treating neurological disorders and neurodegenerative diseases, particularly pain and migraine, comprising administering a compound of Formula (I) or Formula (I(a)); and processes for preparing compounds of Formula (I) or Formula (I(a)). | 04-15-2010 |
| 20100184988 | PROCESS FOR PRODUCING CISATRACURIUM COMPOUNDS AND ASSOCIATED INTERMEDIATES - The present invention provides processes for producing isoquinolinium compounds, and for converting them into cisatracurium salts, e.g., cisatracurium besylate | 07-22-2010 |
| 20100298570 | PROCESS FOR THE RESOLUTION OF ISOQUINOLINE DERIVATIVES - A process for the resolution of racemic tetrahydropapaverine with optically active arylpropionic acids is described. | 11-25-2010 |
| 20130096310 | ISOQUINOLINE DERIVATIVE - A compound represented by formula (I) or a pharmaceutically acceptable salt thereof has an effect of inhibiting CRTH2 and, therefore, is useful as a pharmaceutical. | 04-18-2013 |
| 20130137874 | One-Pot Preparation of Hexahydroisoquinolines from Amides - The present invention provides an efficient process for the preparation of hexahydroisoquinolines from amides. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines. | 05-30-2013 |
| 20130144063 | Crystalline Pharmaceutical and Methods of Preparation and Use Thereof - Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in this invention. | 06-06-2013 |
| 20160016971 | Inhibitors of Retroviral Replication - Methods for preventing or treating retroviral infection, such as human immunodeficiency virus, in vivo utilize transcriptional inhibitory compounds. These include cortistatin A and analogs of the cortistatin family. | 01-21-2016 |
| 20160090361 | CONTINUOUS FLOW CARBOXYLATION REACTION - The present invention is related to a two-step carboxylation reaction of an aryl group using continuous flow reaction conditions. This process permits large scale synthesis of useful reaction products in high yield. | 03-31-2016 |
| 546148000 | Unsaturated hetero ring attached indirectly to the isoquinoline ring system by nonionic bonding | 2 |
| 20100105915 | CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS - Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert effects characteristic of antagonists to the CXCR4 receptor. | 04-29-2010 |
| 20160152590 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Synthase Inhibitors | 06-02-2016 |
| 546149000 | Unsaturated carbocyclic ring attached indirectly to the six-membered hetero ring through an acyclic hydrocarbon chain | 4 |
| 20090247757 | LIGANDS, THEIR PREPARATION AND USES THEREOF IN ASYMMETRIC REACTIONS - Novel chemical agents are described herein. More a ligand of general Formula I: | 10-01-2009 |
| 20100022776 | Preparation of Hexahydroisoquinolines from Dihydroisoquinolines - The present invention is directed to processes for the synthesis of morphinans. In particular, a process for the asymmetric reduction of an imine moiety in a 3,4-dihydroisoquinoline to produce a tetrahydroisoquinoline, followed by a Birch reduction to produce a hexahydroisoquinoline. In various embodiments, the 3,4-dihydroisoquinoline contains a phenol moiety protected with a labile protecting group. In other embodiments, the imine reduction reaction mixture contains silver tetrafluoroborate. | 01-28-2010 |
| 20100305325 | PROCESS FOR THE PREPARATION OF AN ENANTIOMERIC TRISUBSTITUTED 3,4-DIHYDRO-ISOQUINOLINE DERIVATIVE - The present invention relates to a process for the preparation of the compound of formula (7) which process comprises the hydrogenation of the compound of formula (4) using bis[chloro-1,5-cyclooctadiene-iridium], (S)-i-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]-ferrocene as a catalyst. | 12-02-2010 |
| 20110201816 | METHODS OF SCREENING FOR COMPOUNDS THAT INHIBIT THE BIOSYNTHESIS OF GPI IN MALARIA PARASITES - The present inventors succeeded in isolating GWT1 (PfGWT1), which is one of the enzymes involved in GPI biosynthesis in the malaria parasite | 08-18-2011 |
| 546150000 | Single bond between 3,4-positions | 4 |
| 20110071300 | One-Pot Preparation of Hexahydroisoquinolines from Dihydroisoquinolines - The present invention provides an efficient process for the preparation of hexahydroisoquinolines from dihydroisoquinolines. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines. | 03-24-2011 |
| 20130245270 | Synthesis of Trivalent Flexible Frameworks with Ligands Comprising Catechol Units for Functionalizing Surfaces - The present invention describes tripodal catechol derivatives with a flexible basic framework for the functionalisation of surfaces, and methods for their production and use. The central atom of the flexible framework is hereby a tertiary aliphatic carbon atom. The remaining fourth bridgehead position is easily suitable to be further functionalised via so-called click reactions, e.g. with biomolecules, dyes, radiomarkers, polyethylene glycol or active agents. | 09-19-2013 |
| 20150031893 | AN H3 RECEPTOR ANTAGONIST FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE - This disclosure relates to methods of using 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide in a disease modifying therapy of Alzheimer's disease, other tauopathies and related neurodegenerative diseases. | 01-29-2015 |
| 20150105559 | PRODUCTION METHOD FOR COMPOUND COMPRISING AMINO GROUP AND/OR HYDROXYL GROUP - Disclosed is a method for producing a compound having an amino group and/or a hydroxyl group from a substrate compound having an atomic group containing CO or CS by eliminating such atomic group. The substrate compound, having an atomic group containing CO or CS (for example, an amide, a carbamate, or the like), is allowed to react with a compound expressed by formula (I) below, at a temperature of 120° C. or lower, preferably in the presence of an ammonium salt, to eliminate such atomic group containing CO or CS. In formula (I) A may not be present, and in a case where A is present, A represents an alkyl group having 1 to 6 carbon atoms. H | 04-16-2015 |
| 546151000 | N-alkyl or N-alkenyl isoquinoliniums which are otherwise unsubstituted or alkyl or alkenyl substituted only | 2 |
| 20110319622 | PROCESS OF PRODUCING BLEACH BOOSTERS - This invention relates to a process of producing compounds, which are useful as bleach boosters, as well as to the compounds, which are obtainable using said process, and to their use. | 12-29-2011 |
| 20150073151 | SUPERCRITICAL FLUID EXTRACTION OF BIS-BENZYL ISOQUINOLINES - An improved process for obtaining at least one bis-benzyl isoquinoline alkaloid from botanical material involves contacting the botanical material with a supercritical fluid having as a major component one or more aliphatic hydrocarbon compounds, such as alkanes, alkenes, cyclic aliphatic hydrocarbons, or a combination of these compounds. | 03-12-2015 |
