| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 546121000 | Ring nitrogen is shared by the two cyclos | 40 |
| 20080200680 | Polymorph Transformation of Zolpidem in Tablet Matrix - A method for converting polymorphs of Zolpidem hemitartrate, the method comprising treating tablets comprising Zolpidem hemitartrate with heat and/or moisture. | 08-21-2008 |
| 20080293946 | Process for Preparing Zolpidem Hemitartrate and Tartrate Polymorphs - A method for preparing a polymorph of a hemitartrate salt of a compound having the structure: comprising dissolving a free base form of the compound in a liquid medium comprising an alcohol and a tartrate derivative to form a solution comprising the compound, the alcohol, and the tartrate derivative; heating the solution to a temperature sufficient to dissolve the compound and the tartrate derivative; and cooling the solution to a temperature sufficient to precipitate the hemitartrate salt of the compound. | 11-27-2008 |
| 20080293947 | Method of Preparation for Imidazolepyridines - The present invention relates to an improved process for preparing imidazo[1,2-a]pyridine-3-acetamides and more particularly, 6-methyl-2-p-tolylH-imidazo[1,2-a]pyridine. | 11-27-2008 |
| 20090118512 | Process for Preparing 6,7-Dihydro-5H-Imidazo[1,5-A]Pyridin-8-One - 6,7-Dihydro-5H-imidazo[1,5-a]pyridin-8-one (I), is obtainable in high yields by: 1) a process which proceeds from a suitably protected C-(3-hydroxypyridin-2-yl)methylamine whose amine is converted to the formamide which is then cyclized to the imidazo[1,5-a]pyridine and hydrogenated to the 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one, and suitably protected C-(3-hydroxypyridin-2-yl)methylamines can be prepared either in 2 steps proceeding from commercially available 3-hydroxy-2-cyanopyridine [932-35-4] or in 3 steps proceeding from commercially available 2-hydroxymethylpyridin-3-ol [14173-30-9]; 2) a process for preparing 4-hydroxy-1-(1H-imidazol-4-yl)butan-1-one, an intermediate from the synthesis of 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one (formula I), as described in WO 2002/040484, proceeding from N,N-dimethyl-2-(trialkylsilanyl)imidazole-1-sulphonamide by lithiation and subsequent reaction with a suitably protected 4-hydroxybutyraldehyde, followed by oxidation of the secondary alcohol, acid-induced deprotection of the imidazole and deprotection of the alcohol functionality; 3) a process which proceeds from 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine [38666-30-7], which is oxidized. | 05-07-2009 |
| 20090247755 | Process for Preparing a Substituted Imidazopyridine Compound - The present invention provides a new process for large-scale preparation of substituted imidazopyridine compound of formula (I) wherein R | 10-01-2009 |
| 20100036129 | PROCESS FOR THE PREPARATION OF IMIDAZOPYRIDINES - A process for the preparation of imidazopyridines of formula (I), comprising reacting 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine with oxalyl chloride, followed by conversion of the chloride to oxoacetic acid, and further to compound of Formula (I). | 02-11-2010 |
| 20100056791 | Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same - A novel pyrazolopyridine carboxamide derivative is provided that is useful as a pharmaceutical drug having phosphodiesterase inhibitory activity. | 03-04-2010 |
| 20100069640 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID - A compound represented by the following formula or a salt thereof: | 03-18-2010 |
| 20100087648 | NOVEL NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIBACTERIAL DRUGS - The invention relates to nitrogen-containing heterocyclic compounds of general formula (I) | 04-08-2010 |
| 20100121067 | PREPARATION AND UTILITY OF SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS WITH HYPNOTIC EFFECTS - The present disclosure is directed to modulators of GABA | 05-13-2010 |
| 20100217001 | METHOD FOR PRODUCING PYRAZOLE FUSED RING DERIVATIVE - Disclosed is a commercially advantageous method for producing a pyrazole fused ring derivative (such as a 7-phenylpyrazolo[1,5-a]pyridine derivative). Specifically disclosed is a method for producing a compound (I) represented by the formula (I) below or a salt thereof, which comprises a step A wherein a hydroxy group in a compound (IV) represented by the formula (IV) below is converted into a methoxy group, thereby obtaining a compound (I) or a salt thereof: | 08-26-2010 |
| 20100249418 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID - A compound effective as a probe targeting amyloid for image diagnosis and a reagent comprising the compound for detecting amyloid deposited on a biological tissue are provided. Provided are a compound represented by the following formula (1): | 09-30-2010 |
| 20100249419 | UTILIZATION OF NOVEL COMPOUNDS WITH AMYLOID AFFINITY AND METHOD OF PRODUCING THE SAME - The invention provides a reagent for detecting amyloid deposited in a biological tissue which can detect amyloid in vitro and in vivo with high sensitivity using a compound which has affinity with amyloid and is suppressed in toxicity such as mutagencity. The reagent for detecting amyloid deposited in a biological tissue comprises a compound represented by the following formula (1) or a salt thereof: | 09-30-2010 |
| 20100292479 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID - A compound effective as a probe targeting amyloid for image diagnosis and a reagent comprising the compound for detecting amyloid deposited on a biological tissue are provided. Provided are a compound represented by the following formula (1): | 11-18-2010 |
| 20110040094 | 1,3,4-TRISUBSTITUTED BENZENES - Compounds that are 1,3,4-trisubstituted benzenes which modulate (e.g., inhibit) the activity of γ-secretase. The compounds are expected to reduce the level of Aβ42 in patients and be useful in the treatment of diseases (e.g., Alzheimer's disease) characterized by elevated levels of Aβ42 and/or the formation of Aβ plaques. | 02-17-2011 |
| 20110288301 | AZA-INDOLES AND RELATED COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY - The present invention provides compounds are disclosed herein having the formula: | 11-24-2011 |
| 20120010414 | GLYCINE TRANSPORTER INHIBITING SUBSTANCES - The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsory disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, and sleep disorder: | 01-12-2012 |
| 20120165533 | OPTICALLY ACTIVE DIAZABICYCLOOCTANE DERIVATIVES AND PROCESS FOR PREPARING THE SAME - Provided are an optically active diazabicyclooctane derivative defined by formula (F) below, which is useful as a pharmaceutical intermediate for β-lactamase inhibitor, and a process for preparing the same. | 06-28-2012 |
| 20120277436 | PHENYLHYDRAZONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS - A compound of general formula (I) a process for preparing the same, a pharmaceutical composition comprising said compound comprising such compound and its use for treating or preventing diseases related to the metabolic syndrome such as hepatic and cardiovascular diseases. | 11-01-2012 |
| 20120323010 | PROCESSES FOR PREPARING HETEROCYCLIC COMPOUNDS INCLUDING TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE AND SALTS THEREOF - The present invention relates to compounds and processes for preparing compounds of Formula (I), | 12-20-2012 |
| 20130150584 | 5-ANILINOIMIDAZOPYRIDINES AND METHODS OF USE - The invention relates to a method of inhibiting abnormal cell growth or treating a hyperproliferative disorder in a mammal comprising administering to said mammal a therapeutically effective amount of an imidazopyridine of formula I with anti-hyperproliferative activity. | 06-13-2013 |
| 20130178631 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS - The present invention relates to novel compounds of formula I wherein W, n, X and W′ are defined in the description; invention compounds are modulators of metabotropic glutamate receptors—subtype 5 (“mGluR5”) which are useful for the treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors. | 07-11-2013 |
| 20130274475 | BETA-LACTAMASE INHIBITORS - Substituted bicyclic beta-lactams of Formula I: | 10-17-2013 |
| 20140088309 | NEMATOCIDAL SULFONAMIDES - Disclosed are compounds of Formula 1, N-oxides, and salts thereof, | 03-27-2014 |
| 20140121377 | NOVEL COMPOUND WITH AMYLOID AFFINITY - A compound represented by the following formula (1), or a salt thereof: | 05-01-2014 |
| 20140163230 | PROCESSES FOR PREPARING HETEROCYCLIC COMPOUNDS INCLUDING TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE AND SALTS THEREOF - The present invention relates to compounds and processes for preparing compounds of Formula (I), | 06-12-2014 |
| 20140187786 | 1,3,4-TRISUBSTITUTED BENZENES - Compounds that are 1,3,4-trisubstituted benzenes which modulate (e.g., inhibit) the activity of γ-secretase. The compounds are expected to reduce the level of Aβ42 in patients and be useful in the treatment of diseases (e.g., Alzheimer's disease) characterized by elevated levels of Aβ42 and/or the formation of Aβ plaques. | 07-03-2014 |
| 20140296526 | NITROGEN CONTAINING COMPOUNDS AND THEIR USE - Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed. | 10-02-2014 |
| 20150094472 | B-LACTAMASE INHIBITOR PICOLINE SALT - Provided herein are intermediates useful in the synthesis of β-lactamase inhibitors, and methods of making said intermediates and β-lactamase inhibitors. | 04-02-2015 |
| 20150112070 | PROCESSES FOR PREPARING HETEROCYCLIC COMPOUNDS INCLUDING TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE AND SALTS THEREOF - The present invention relates to compounds and processes for preparing compounds of Formula (I), | 04-23-2015 |
| 20150322067 | NITROGEN CONTAINING COMPOUNDS AND THEIR USE - Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed. | 11-12-2015 |
| 20150368239 | PREPARATION OF NEMATOCIDAL SULFONAMIDES - Disclosed is a method for preparing a compound of Formula 1 by coupling of intermediates of Formula 2 and Formula 3 in the presence of an aluminum reagent of Formula 4 | 12-24-2015 |
| 20160002233 | (2S, 5R)- Sulfuric acid mono- ester - A process for preparation of (2S, 5R)-Sulfuric acid mono-{[(4-aminopiperidin-4-yl) carbonyl]-7-oxo-1,6-diaza-bi-cyclo[3.2.1]-oct-6-yl} ester is disclosed which comprises reacting a compound of Formula (II) with a compound of Formula (III) to Cobtain a compound of Formula (IV). | 01-07-2016 |
| 20160002234 | A process for preparation of (2S, 5R)-7-oxo-6-sulphooxy-2-[((3R)-pyrrolidine-3-carbonyl)-hydrazino carbonyl]-1,6-diaza-bicyclo[3.2.1]octane - A process for preparation of (2S,5R)-7-oxo-6-sulphooxy-2-[((3R)-pyrrolidine-3-carbonyl)-hydrazino carbonyl]-1,6-diaza-bicyclo[3.2.1]octane is disclosed comprising reacting a compound of Formula (II) with a compound of Formula (III) to obtain a compound of Formula (IV). The crystalline end-product is als claimed. | 01-07-2016 |
| 20160002235 | A process for preparation of (2S, 5R)-7-oxo-6-sulphooxy-2-[((3R)-piperidine-3-carbonyl)-hydrazino carbonyl]-1,6-diaza-bicyclo [3.2.1]-octane - A process for preparation of (2S,5R)-7-oxo-6-sulphooxy-2-[((3R)-piperidine-3-carbonyl)-hydrazino carbonyl]-1,6-diaza-bicyclo[3.2.1]octane of Formula (I) is disclosed which is comprising reacting a compound of Formula (II) with a compound of Formula (III) to obtain a compound of Formula (IV). Crystalline compounds of Formula (I) are claimed. | 01-07-2016 |
| 20160002236 | Sodium salt of (2S, 5R)-6-benzyloxy-7-oxo-1,6-diaza-bicyclo [3.2.1] octane-2-carboxylic acid and its preparation - Sodium salt of (2S,5R)-6-benzyloxy-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carboxylic acid and a process for its preparation is disclosed. | 01-07-2016 |
| 20160016955 | A process for sodium salt of (2S, 5R)-2-carboxamido-7-oxo-6-sulfooxy -1,6-diaza-bicyclo[3.2.1]octane - A process for preparation of a sodium salt of (2S, 5R)-2-carboxamido-7-oxo-6-sulfooxy-1,6-diaza-bicyclo[3.2.1]octane is disclosed which is comprising the amidation of a compound of Formula (II) to obtain a compound of Formula (III). | 01-21-2016 |
| 20160137645 | COMPOUNDS USEFUL FOR PRODUCING AN OPTICALLY ACTIVE DIAZABICYCLOOCTANE COMPOUND - An optically active (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid compound defined by the following formula (F): | 05-19-2016 |
| 20170233393 | BETA-LACTAMASE INHIBITOR AND PROCESS FOR PREPARING THE SAME | 08-17-2017 |
| 20190144404 | PROCESS FOR PRODUCING ORGANIC COMPOUND | 05-16-2019 |
