| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 546022000 | Phosphorus attached indirectly to the six-membered hetero ring by nonionic bonding | 49 |
| 20080281104 | Membrane-Anchoring Fluorescent Probe - A membrane anchoring-type fluorescent probe consisting of a compound comprising a phospholipid residue, a fluorescent probe compound residue, and a linker which binds the residues (e.g., the compound represented by the following formula). | 11-13-2008 |
| 20080300408 | Process for Preparing a Pure Polymorphic Form of 3-Pyridyl-1-Hydroxyethylidine-1, 1-Bisphosphonic Acid Sodium Salt - This process in general relates to the novel process for preparing polymorphic forms of 3-pyridyl-1-hydroxyethylidine-1,1-bisphosphonic acid sodium salt (Risedronate Sodium) in particular risedronate Form A and B employing a solvent system in an appropriate ratio. An improved process for preparation of risedronic acid is also disclosed in the present invention. | 12-04-2008 |
| 20090131671 | Novel phosphonic acid compounds as inhibitors of serine proteases - The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders. | 05-21-2009 |
| 20090137807 | Electrochromic material with improved lifetime - Disclosed are viologen derivatives as an electrochromic material having improved stability and lifetime, a metal oxide electrode including the same, and an electrochromic device using the viologen derivative as an electrochromic material. The viologen derivative includes a suitable regulator group capable of increasing ΔE that is a potential difference between E | 05-28-2009 |
| 20090182147 | PROCESS FOR THE PREPARATION OF PURE RISEDRONIC ACID OR SALTS - The present invention relates to an industrially advantageous process of making bisphosphonic acid or its salt in particular risedronic acid, [1-hydroxy-2(3-pyridinyl)ethylidene]bisphosphonic acid, having formula-(I) or its salts in high purity and high yields. | 07-16-2009 |
| 20090198062 | NOVEL PROCESS - The present invention relates to a process for the preparation of bisphosphonic acids and salts thereof, in particular monosodium salts thereof. The invention also relates to the conversion of the bisphosphonic acids to their sodium salts using an aqueous-organic solvent system. The present invention further relates to the conversion of variable hydrate forms of risedronic acid monosodium salt into a pharmaceutically acceptable hemipentahydrate form by crystallization using an aqueous-organic solvent system. | 08-06-2009 |
| 20090209763 | Novel Process For Making Bisphosphonic Acids Using Diluents Other Than Halogenated Hydrocarbons - Provided is a novel method of making bisphosphonic acids, e.g. risedronic acid, including the step of combining a carboxylic acid, phosphorous acid, and a halophosphorous compound in the presence of a diluent that is an aromatic hydrocarbon or a silicone fluid. When the diluent is an aromatic hydrocarbon, an inert support or ortho-phosphoric acid codiluent is advantageously included. | 08-20-2009 |
| 20090259042 | ELECTROCHROMIC COMPOUNDS - The invention concerns electrochromic compounds of the general formula I. These compounds may be used in electrochromic devices, especially electrochromic devices comprising nanostructured films. | 10-15-2009 |
| 20090281320 | PROCESS FOR THE PREPARATION OF [1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE] BISPHOSPHONIC ACID AND HEMIPENTAHYDRATE MONOSODIUM SALT THEREOF - The invention relates to a novel process for the preparation of [1-hydroxy-2-(3-pyridinyl)ethylidene] bisphosphonic acid and hemipentahydrate monosodium salt thereof comprising (a) reacting an aqueous solution of 3-pyridyl acetic acid hydrochloride with phosphorus trichloride; (b) removing unreacted phosphorus trichloride; (c) adding water and hydrolyzing; (d) isolating crystalline [1-hydroxy-2-(3-pyridinyl)ethylidene] bisphosphonic acid; (e) suspending said crystalline [1-hydroxy-2-(3-pyridinyl)ethylidene] bisphosphonic acid in water; (f) adding sodium hydroxide, filtering off, and washing; and (g) drying obtained hemipentahydrate monosodium salt of 1-hydroxy-2-(3-pyridinyl)ethylidene] bisphosphonic acid. | 11-12-2009 |
| 20090281321 | EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS - This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following: | 11-12-2009 |
| 20090312551 | Process for producing biphosphonic acids and forms thereof - Disclosed herein is a process for producing bisphosphonic acids and salts thereof. The process comprising reacting a carboxylic acid of Formula [I] with phosphorous acid and halophosphorus compound in the presence of a solvent selected from aliphatic hydrocarbon or water miscible cyclic ether. Further, the present invention also provides novel forms of bisphosphonic acids and process for preparation thereof. | 12-17-2009 |
| 20090326227 | Process for the Preparation of Biphosphonic Acids and Salts Thereof - A process for the preparation of biphosphonic acids and pharmaceutical acceptable salts thereof, comprises reacting a carboxylic acid with phosphorous trichloride and phosphorous acid in the presence of an aprotic polar solvent. Formula (I): | 12-31-2009 |
| 20100016592 | PROCESS FOR PREPARING SODIUM RISEDRONATE HEMIPENTAHYDRATE - A novel process for preparing risedronate sodium hemipentahydrate represented by the following formula 1 using 2-(3-pyridyl)-1-hydroxyethane-1,1-bisphosphonic acid (risedronic acid) and an aqueous solution of risedronate sodium is disclosed. | 01-21-2010 |
| 20100113786 | PHOSPHORAMIDE COMPOUND, METHOD FOR PRODUCING THE SAME, LIGAND, COMPLEX, CATALYST AND METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL - Disclosed is a method for highly efficiently obtaining an optically active alcohol from a carbonyl compound highly enantioselectively. Also disclosed is a ligand used in such a method. Specifically, an optically active alcohol is obtained by reacting a carbonyl compound and an organozinc compound by using a ligand (L) shown below. | 05-06-2010 |
| 20100121066 | Novel Process For Preparing Risedronic Acid - The present invention relates to a process for preparing risedronic acid comprising the step of combining a 3-pyridyl acetic acid or a salt thereof, phosphorous acid, and a halophosporous compound selected from PCl | 05-13-2010 |
| 20100137597 | SYNTHESIS Of DIETHYLPHOSPHONATE - This application discloses a novel process for the preparation of phosphonate esters useful as intermediates in the preparation of himbacine analogs, themselves useful as thrombin receptor antagonists. The chemistry taught herein can be exemplified by the following scheme: | 06-03-2010 |
| 20100317859 | Process for the Preparation of Risedronate Sodium - Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of risedronic acid or a pharmaceutically acceptable salt thereof, in high yield and purity. | 12-16-2010 |
| 20110092705 | Novel phosphonic acid compounds as inhibitors of serine proteases - The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders. | 04-21-2011 |
| 20110251392 | EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS - This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following: | 10-13-2011 |
| 20120296093 | EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS - This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following: | 11-22-2012 |
| 20130203998 | Synthesis of Drug Conjugates Via Reaction With Epoxide-Containing Linkers - The present invention relates to drug derivatives and linkers. The invention specifically relates to compounds and methods of phosphonates and linkers, that are useful as carriers for imaging agents and useful in the treatment of various bone diseases. | 08-08-2013 |
| 20130225822 | CHIRAL SPIRO-PYRIDYLAMIDOPHOSPHINE LIGAND COMPOUND, SYNTHESIS METHOD THEREFOR AND APPLICATION THEREOF - The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly characterized by having a chiral spiro-dihydro-indene skeleton in its structure. The chiral spiro-pyridylamidophosphine compound may be synthesized with optical active 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene or substituted 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene having a spiro-skeleton as chiral starting material. The chiral spiro-pyridylamidophosphine compound may be used as a chiral ligand in asymmetric hydrogenation of a carbonyl compound catalyzed by iridium, in which the reaction activity is very high, the amount of the catalyst may be 0.0001 mol %, and the enantioselectivity of the reaction is up to 99.9% ee. | 08-29-2013 |
| 20130303768 | METHOD AND SUBSTANCES FOR PREPARATION OF N-SUBSTITUTED PYRIDINIUM COMPOUNDS - A method for the synthesis of N-substituted 3-acylated pyridinium compounds by reacting a pentamethine precursor with a primary amine. | 11-14-2013 |
| 20140171644 | SUBSTITUTED PHENOXYETHYL (ISOPROPYL) ACYLOXYALKYL PHOSPHONATE COMPRISING PHOSPHORUSHETEROCYCLIC RING AND HAVING HERBICIDAL ACTIVITY, AND PREPARATION THEREFOR - A substituted phenoxyethyl(isopropyl)acyloxyalkyl phosphonate having phosphorusheterocyclic ring and having herbicidal activity, with a general formula of I, wherein R represents 5,5-dimethyl-1,3,2-dioxaphosphorinan-2-one-2-yl, or 1-oxo-1-phospha-2,6,7-trioxabicyclo[2,2,2]octan-4-yl, or 1-sulfo-1-phospha-2,6,7-trioxabicyclo 2,6,7-trioxabicyclo[2,2,2]octan-4-yl; R | 06-19-2014 |
| 20140256945 | PHOSPHONIC ACID COMPOUNDS AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORS - The present invention relates to novel derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors. | 09-11-2014 |
| 20140309422 | DIALKYL(2-ALKOXY-6-AMINOPHENYL)PHOSPHINE, THE PREPARATION METHOD AND USE THEREOF - The present invention relates to the compound of dialkyl(2-alkoxy-6-aminophenyl)phosphine and the preparation method thereof and the application in the palladium catalyzed coupling reactions of aryl chloride and ketone. The dialkyl(2-alkoxy-6-aminophenyl)phosphine of the present invention could coordinate with the palladium catalyst to highly selectively activate the inert carbon-chlorine bond, and to catalyze direct arylation reaction in the α-position of ketones to produce corresponding coupling compounds. The preparation method of the present invention is a simple one-step method which produces the air-stable dialkyl(2-alkoxy-6-aminophenyl)phosphine. Compared with the synthetic routes of ligands to be used in the activation of carbon-chlorine bonds in the prior arts, the preparation method of the present invention has the advantages of short route and easy operation. | 10-16-2014 |
| 20150298109 | BIFUNCTIONAL ORGANIC CATALYSTS - The present invention provides a bifunctional catalyst of the formula (1): wherein: each R | 10-22-2015 |
| 20150299231 | A PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES - The present invention provides a process for the preparation of mono- and bisacylphosphanes based on formula (I): | 10-22-2015 |
| 546023000 | Polycyclo ring system having the six-membered hetero ring as one of the cyclos | 19 |
| 20080312440 | SYNTHESIS OF DRUG CONJUGATES VIA REACTION WITH EPOXIDE-CONTAINING LINKERS - The present invention relates to drug derivatives and linkers. The invention specifically relates to compounds and methods of phosphonates and linkers, that are useful as carriers for imaging agents and useful in the treatment of various bone diseases. | 12-18-2008 |
| 20090082569 | NARCISTATIN PRODRUGS - The present invention provides prodrugs derived from the sparingly soluble anticancer isocarbostyril narciclasine, a component of various | 03-26-2009 |
| 20090131672 | SYNTHESIS OF SODIUM NARCISTATIN AND RELATED COMPOUNDS - The present invention involves use of the compounds narciclasine (2a) and 7-deoxy-narciclasine (2c), which are obtained via isolation from the medicinal plant species | 05-21-2009 |
| 20090137808 | PROCESS FOR MANUFACTURING BISPHOSPHONIC ACIDS - A manufacturing process for the preparation of bisphosphonic acids and in particular zoledronic acid is provided wherein diglyme, monoglyme, or a mixture thereof, is utilized to produce a homogenous, water soluble, solid reaction mass that upon cooling, dissolving in water and stripping results in a high purity product and comparatively good yield. wherein Ri is selected from the group consisting of | 05-28-2009 |
| 20100099876 | METHOD OF PREPARING MONTELUKAST AND INTERMEDIATES USED THEREIN - The present invention relates to a method for preparing montelukast, an inhibitor against leukotrienes, and an intermediate used therein. According to the inventive method, high-purity montelukast or its sodium salt can be prepared in a high yield. | 04-22-2010 |
| 20100160633 | KINASE INHIBITORS - Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: | 06-24-2010 |
| 20100240898 | CHIRAL PHOSPHORUS COMPOUND - The present invention relates to novel chiral phosphorus compounds which can be readily prepared from quinoline derivatives as inexpensive starting compounds and have the general formula (I) wherein R | 09-23-2010 |
| 20110282061 | Lipidated Imidazoquinoline Derivatives - The compounds of the subject invention are adjuvant molecules that comprise a imidazoquinoline molecule covalently linked to a phospho- or phosphonolipid group. The compounds of the invention have been shown to be inducers of interferon-a, IL-12 and other immunostimulatory cytokines and possess an improved activity profile in comparison to known cytokine inducers when used as adjuvants for vaccine antigens. | 11-17-2011 |
| 20110282062 | 1-(2H)-ISOQUINOLONE DERIVATIVE - The present invention provides a compound of the formula (I) or a pharmaceutically acceptable salt thereof: | 11-17-2011 |
| 20120004411 | CHIRAL PHOSPHORUS COMPOUND - The present invention relates to novel chiral phosphorus compounds which can be readily prepared from quinoline derivatives as inexpensive starting compounds and have the general formula (I) wherein R | 01-05-2012 |
| 20120088916 | OCTAHYDRO BIQUINOLINE COMPOUND - The present invention relates to an octahydro biquinoline compound. Provided is also a method of separating the octahydro biquinoline compound into enantiomers. The octahydro biquinoline compound is of the general formula (V): In formula (V) R | 04-12-2012 |
| 20120245354 | METHOD FOR THE MANUFACTURE OF AMINOHYDROXY DIPHOSPHONIC ACIDS - The technology of this invention concerns a method for the manufacture of hydroxy diphosphonic acids containing an amino moiety. The method specifically involves reacting a liquid P | 09-27-2012 |
| 20120264940 | CHIRAL PHOSPHORUS COMPOUND - The present invention relates to novel chiral phosphorus compounds which can be readily prepared from quinoline derivatives as inexpensive starting compounds and have the general formula (I) | 10-18-2012 |
| 20130150583 | CHIRAL PHOSPHORUS COMPOUND - Methods of making a chiral phosphorus compound of formula (X) are disclosed: | 06-13-2013 |
| 20140046065 | PROCESS FOR PREPARING AMINES FROM ALCOHOLS AND AMMONIA - The present invention provides novel ruthenium based catalysts, and a process for preparing amines, by reacting a primary alcohol and ammonia in the presence of such catalysts, to generate the amine and water. According to the process of the invention, primary alcohols react directly with ammonia to produce primary amines and water in high yields and high turnover numbers. This reaction is catalyzed by novel ruthenium complexes, which are preferably composed of quinolinyl or acridinyl based pincer ligands. | 02-13-2014 |
| 20140107342 | CAMPTOTHECIN DERIVATIVE, AND PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION AND APPLICATION - The present invention relates to a camptothecin derivative having a structure as represented by Formula (II), in which X | 04-17-2014 |
| 20140309423 | NOVEL ORGANOPHOSPHORUS COMPOUNDS BASED ON ANTHRACENETRIOL - The subject matter of the present invention is a plurality of products and the use thereof as a catalytically active composition in a method for producing aldehydes. | 10-16-2014 |
| 20140323731 | LIPIDATED IMIDAZOQUINOLINE DERIVATIVES - The compounds of the subject invention are adjuvant molecules that comprise an imidazoquinoline molecule covalently linked to a phospho- or phosphonolipid group. The compounds of the invention have been shown to be inducers of interferon-a, IL-12 and other immunostimulatory cytokines and possess an improved activity profile in comparison to known cytokine inducers when used as adjuvants for vaccine antigens. | 10-30-2014 |
| 20180022729 | Antioxidants and Methods to Maximize Performance | 01-25-2018 |
| 546024000 | Chalcogen bonded directly to ring carbon of the six-membered hetero ring | 2 |
| 20100317860 | CRYSTALLINE CINNAMIDE COMPOUNDS OR SALTS THEREOF - Disclosed are crystals of the compound represented by Formula (1), which has A□-production-reducing effects and is a prodrug of compounds effective in treating neural degenerative diseases of which A□ is the cause, for example, diseases such as Alzheimer's disease, Down syndrome, etc., and salts thereof or crystals of salts thereof. These are particularly useful as stock for pharmaceutical products. | 12-16-2010 |
| 546025000 | The phosphorus is bonded directly to the chalcogen | 1 |
| 20090023926 | Trityl Derivatives for Enhancing Mass Spectrometry - The present invention provides a compound of the formula: (IIa); having a reactive functional group M, capable of reacting with a biopolymer, BP, having at least one group capable of reacting with M to form a covalent linkage, to provide a biopolymer derivative of the formula: (IIIa). The biopolymer derivatives of the invention have enhanced ionisability with respect to free 10 biopolymer (Bp) enabling improved analysis of the biopolymer using mass spectrometry. The invention further provides specific examples of compounds formula (IIa), e.g. compounds of formula: (IIa-2 | 01-22-2009 |
