| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 546015000 | Spiro | 80 |
| 20080262231 | Processes for Preparing Morphinans and Intermediates Thereof - The present invention is directed to processes for the synthesis of morphinans. In particular, a process for cyclizing a β,γ-bicyclic ketone compound to form a nordihydrothebainone product using the Grewe cyclization reaction is improved by forming a reaction mixture comprising a β,γ-bicyclic ketone compound, a cyclizing acid and a water scavenging cyclization additive. In one embodiment, the Grewe transformation occurs in the presence of an acid anhydride as the cyclization additive. Further, the present invention is directed to processes for converting α,β-bicyclic ketone compounds (e.g., by-products of the Grewe cyclization reaction) to β,γ-bicyclic ketone compounds, wherein the β,γ-bicyclic ketone compounds may be recovered to further undergo Grewe cyclization and form the nordihydrothebainone product. | 10-23-2008 |
| 20090005563 | CONVERSION OF THEBAINE TO MORPHINE DERIVATIVES - The present invention provides methods for the conversion of thebaine to a morphine derivative, such as hydrocodone. Novel ketal intermediates of the conversion are provided. A one-pot procedure for the conversion comprises treating thebaine with an acid in the presence of a metal catalyst. | 01-01-2009 |
| 20090203911 | BENZIMIDAZOLE COMPOUND - A novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases is provided, which has an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by | 08-13-2009 |
| 20090216022 | CYCLOPAMINE ANALOGS - The invention provides novel derivatives of cyclopamine having the following formula: | 08-27-2009 |
| 20100125140 | AMINOTETRALIN-DERIVED UREA MODULATORS OF VANILLOID VR1 RECEPTOR - This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals. | 05-20-2010 |
| 20100145050 | ORTHOGONALLY FIXED COMPOUNDS FOR ELECTROOPTICAL APPLICATIONS - The present invention relates to chemical compounds that can be used in electrooptical applications. The electrically conductive and optical properties of these compounds, e.g. hole transporting, electron transporting and/or light emitting properties can be predetermined by substituting the core structure of these compounds with respective residues. The core structure ( | 06-10-2010 |
| 20100197921 | Preparation of N-Alkylated Opiates by Reductive Amination - The present invention is directed to the reduction of an N-imine moiety or a hemiaminal moiety of a morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source. | 08-05-2010 |
| 20100261903 | PHOSPHONATE FLUORESCENT DYES AND CONJUGATES - Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates. | 10-14-2010 |
| 20110087027 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS - This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. | 04-14-2011 |
| 20110105754 | NOVEL RHODAMINE DYES - There are described novel rhodamine color-forming compounds. The rhodamine color-forming compounds exhibit a first color when in a crystalline form and a second color, different from the first color, when in an amorphous form. | 05-05-2011 |
| 20110152526 | METHOXATIN DERIVATIVES - The present invention provides for compounds of Formula I and II: | 06-23-2011 |
| 20110160457 | METHODS FOR OBTAINING CYCLOPAMINE - The present invention relates to a process for extracting, purifying and isolating cyclopamine from cyclopamine-containing biomass comprising the steps of contacting cyclopamine-containing organic matter with an extractant (e.g., aqueous extractant) capable of extracting cyclopamine, separating the extracted organic matter from the cyclopamine/extract solution, concentrating the cyclopamine/extract solution leaving a concentrated aqueous solution, contacting the concentrated aqueous solution with an organic extractant capable of selectively extracting cyclopamine from the aqueous phase, concentrating the cyclopamine-containing organic phase, providing an enriched extract containing cyclopamine, separating cyclopamine from the enriched extract using column chromatography, providing at least one fraction containing cyclopamine, and crystallizing select chromatography fractions to provide purified cyclopamine. | 06-30-2011 |
| 20110166353 | Cyclopamine Analogues and Methods of Use Thereof - The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers. | 07-07-2011 |
| 20110275819 | ORGANIC COMPOUNDS AND THEIR USES - The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases. | 11-10-2011 |
| 20110295009 | STREPTOSPIROLE DERIVATIVES - The invention relates to streptospirole derivatives of the general formula (I), wherein R | 12-01-2011 |
| 20120010412 | Process for the Synthesis of Substituted Morphinans - The present invention relates to a process for the synthesis of a compound of formula I: | 01-12-2012 |
| 20120035366 | N-Demethylation of 6-Keto Morphinans - The present invention provides processes for the demethylation of an N-methyl morphinan comprising a ketone functional group. In particular, the invention provides methods for the protection of the ketone functional group such that impurities are not generated during the demethylation of the N-methyl morphinan. | 02-09-2012 |
| 20120046464 | Cyclic Diones and Their Use as Insecticides, Acaricides and/or Fungicides - The present invention relates to the use of compounds of Formula (I) | 02-23-2012 |
| 20120065399 | Transfer Hydrogenation of Cyclopamine Analogs - Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of | 03-15-2012 |
| 20120065400 | Transfer Hydrogenation of Cyclopamine Analogs - Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of | 03-15-2012 |
| 20120083607 | Enzymatic Transamination of Cyclopamine Analogs - Provided are processes for the synthesis of amino analogues from ketone starting materials. | 04-05-2012 |
| 20120302754 | PRODUCTION OF ALKALOIDS BY LILIACEAE CELL CULTURE - The present invention relates to the production of alkaloids from Liliaceae cell culture. | 11-29-2012 |
| 20120309972 | TETRAZOLYLOXIME DERIVATIVE OR SALT THEREOF AND FUNGICIDE - There are provided a tetrazolyloxime derivative, a salt thereof, and a fungicide, that have excellent control effects against plant diseases. The fungicide contains, as an active ingredient, at least one selected from the group consisting of tetrazolyloxime derivatives represented by formula (6) and salts thereof. In formula (6), X represents a halogen atom, A represents a tetrazolyl group, R represents a halogen atom or the like, D represents a single bond or an oxygen atom, E represents a single bond or an alkylene chain, R | 12-06-2012 |
| 20130072686 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS - This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. | 03-21-2013 |
| 20130225821 | SYNTHESIS OF THIOHYDANTOINS - A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52. | 08-29-2013 |
| 20130338364 | IODOARENE DERIVATIVE, METHOD FOR MANUFACTURING OPTICALLY ACTIVE SPIROLACTONE COMPOUND BY USING THE SAME, AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE CYCLOADDUCT - An optically active spirolactone compound is highly enantioselectively produced by using an iodoarene derivative which can be synthesized easily and which is not racemized easily. A hypervalent iodine compound precursor (iodoarene derivative) which was able to be designed flexibly was synthesized from 2,6-dihydroxyiodoarene by using 1,2-aminoalcohol as a chiral source in short steps, a hypervalent iodine compound was prepared in a reaction system (in situ) by using a catalyst quantity of the resulting precursor in the presence of a stoichiometric quantity of m-CPBA, and a spirolactonization reaction of 3-(1-hydroxy-2-naphthyl)propionic acid was induced. As a result, a corresponding spirolactone compound was obtained at a high enantiomeric excess. | 12-19-2013 |
| 20140081027 | FUNGICIDAL AZOCYCLIC AMIDES - Disclosed are compounds of Formulae 1, 1A, 1B and 1C including all geometric and stereoisomers, N-oxides, and salts thereof, | 03-20-2014 |
| 20140235860 | METHOD OF PREPARING BUPRENORPHINE - An improved process for preparing buprenorphine and a method for increasing the yield of buprenorphine or a derivative thereof. | 08-21-2014 |
| 20140303371 | Process for the Synthesis of Substituted Morphinans - The present invention relates to a process for the synthesis of a compound of formula I: | 10-09-2014 |
| 20150065714 | PRODUCTION OF ALKALOIDS BY LILIACEAE CELL CULTURE - The invention relates to the production of alkaloids from Liliaceae cell culture. | 03-05-2015 |
| 20150112067 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS - The disclosure encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, having less steps and improved yields as compared to previous synthetic methods for making these compounds, which are CGRP receptor antagonists, useful for the treatment of migraine. Conditions for an amide bond formation between an acid and amine include for example reacting the compounds of Formulae B (after salt break) and C with an amide coupling reagent and optionally an additive and an acid and/or a base in a non-reactive solvent. | 04-23-2015 |
| 20160130273 | Process for Making CGRP Receptor Antagonists - The invention encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, which are CGRP receptor antagonists useful for the treatment of migraine. | 05-12-2016 |
| 20160168193 | Isolation of Cyclopamine | 06-16-2016 |
| 20160176844 | PROCESSES FOR THE PREPARATION OF A DIARYLTHIOHYDANTOIN COMPOUND | 06-23-2016 |
| 20160176845 | PROCESS FOR THE PREPARATION OF A DIARYLTHIOHYDANTOIN COMPOUND | 06-23-2016 |
| 20160194331 | METHOD FOR PRODUCING SPIROOXINDOLE DERIVATIVE | 07-07-2016 |
| 546016000 | The spiro includes the six-membered hetero ring | 44 |
| 20090099362 | Process for the preparation of gabapentin hydrochloride - A process for preparation of gabapentin hydrochloride by converting 1,5-dicyano-2,4-dioxo-3-azaspiro[5,5]-undecane into 1,5-diaminoformyl-2,4-dioxo-3-azaspiro[5,5]-undecane at a temperature of 65° C. to 85° C. in the presence of a strong acid, and then carrying out Hofmann rearrangement under an alkaline condition. The starting material of the process is readily available. The process is simple, and can reduce the purification procedure of intermediates, reduce production cost, and obtain product with higher purity. | 04-16-2009 |
| 20090187020 | Process And Intermediate For Preparation Of Donepezil - The invention relates to new compounds of formula (III): | 07-23-2009 |
| 20100076190 | METHOD FOR SYNTHESIS OF NITROXYL RADICAL - The problem to be solved by the present invention is to provide a highly-versatile method for producing a nitroxyl radical derivative, in which position-2 and position-6 in a TEMPO-based compound can be easily substituted, and further, a method for producing a nitroxyl radical derivative, in which a nitrogen nucleus is labeled with | 03-25-2010 |
| 20100099874 | TRANSANNULAR REARRANGEMENT OF ACTIVATED LACTAMS - The disclosure relates to a method for the synthesis of a compound of the following formula (I) in which: R1 and R2 are independently an N-protective group; R3 is a hydrogen atom, a C | 04-22-2010 |
| 20110230660 | METHOD FOR PREPARING A SPIROINDOLINE AND A PRECURSOR THEREOF - The present invention relates to a method comprising the step of contacting a protected N,N-bis(2-X-ethyl)amine with a (2-fluorophenyl)acetonitrile in the presence of a water-soluble phase transfer reagent, concentrated aqueous base, and an immiscible organic solvent, and under such conditions to form a 4-(2-fluorophenyl)-4-piperidinecarbonitrile in at least a 70% yield, wherein X is a leaving group. The 4-(2-fluorophenyl)-4-piperidinecarbonitrile is useful in preparing spiroindolines, which can be used as precursors of compounds that are modulators of CCR2 receptor. | 09-22-2011 |
| 20120101280 | COMPOUND HAVING SPIRO-BONDED CYCLIC GROUP AND USE THEREOF - The invention relates to a compound represented by formula (I): | 04-26-2012 |
| 20120238757 | SUBSTITUTED TETRAHYDROPYRAN SPIRO PYRROLIDINONE AND PIPERIDINONE, PREPARATION AND THERAPEUTIC USE THEREOF - The present disclosure relates to a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I): | 09-20-2012 |
| 20130211087 | 7-AZA-SPIRO[3,5]NONANE-7-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF - The present invention is directed to 7-aza-spiro[3.5]nonane-7-carboxylate derivatives of the Formula I. The compounds of the invention are inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The invention also relates to processes for the preparation of compounds of the Formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them. | 08-15-2013 |
| 20130296569 | PROCESS FOR THE PREPARATION OF PHOSPHORIC ACID MONO-(1--4-METHOXYMETHYL-PIPERIDIN-4-YL) ESTER - The invention relates to a process to prepare pharmacologically active phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluoro phenyl}-4-methoxy methyl-piperidin-4-yl)ester. | 11-07-2013 |
| 20140005400 | NEW AZACYCLIC COMPOUNDS | 01-02-2014 |
| 20140024834 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 8-[-METHYL]-8-PHENYL-1,7-DIAZA-SPIRO[4.5]DECAN-2-ONE COMPOUNDS - This application discloses a process to synthesize 8-({1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-pheny-1.7-diaza-spiro[4.5]decan-2-one comprising reacting a compound of the Formula 27a-sulfonate with zinc in the presence of acetic acid. | 01-23-2014 |
| 20140031549 | Process and Intermediates for the Synthesis of 8-[-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one Compounds - This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes. | 01-30-2014 |
| 20140371455 | Chemical compounds - Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts. | 12-18-2014 |
| 20160024092 | INTRAVENOUS FORMULATIONS OF NEUROKININ-1 ANTAGONISTS - Pharmaceutical compositions for intravenous administration comprising the compound of Formula I | 01-28-2016 |
| 20160145256 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 8-[-METHYL]-8-PHENYL-1,7-DIAZA-SPIRO[4.5]DECAN-2-ONE COMPOUNDS - This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes. | 05-26-2016 |
| 20160159799 | NOVEL PROCESS FOR THE PREPARATION OF SPIROHETEROCYCLIC PYRROLIDINE DIONES - A process for making certain spiroheterocyclic pyrrolidine dione derivatives. | 06-09-2016 |
| 546017000 | Polycyclo ring system having one of the two rings which form the spiro as one of the cyclos | 23 |
| 20080281103 | AZASPIRO DERIVATIVES - The present invention is concerned with novel indol-3-yl-carbonyl-azaspiropiperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of anxiety and depressive disorders and other diseases. In particular, the present invention is concerned with compounds of the general formula (I) | 11-13-2008 |
| 20130030181 | N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors - The invention provides a compound of Formula (I) | 01-31-2013 |
| 20140296524 | HALOGENATED COMPOUNDS FOR PHOTODYNAMIC THERAPY - Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes. The polymethine dyes are characterized by enhanced properties, e.g., brightness, photostability, sensitivity and/or selective affinity that make them useful to target cancer cells, pathogenic microorganisms, and/or other biological materials, in applications such as photodynamic therapy, photodynamic antimicrobial chemotherapy (PACT), cancer treatment, selective removal or attachment of biological materials, antimicrobial coating materials, and other diagnostic, theranostic, spectrum shifting, deposition/growth, and analytic applications. | 10-02-2014 |
| 20140323730 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS - The invention provides a compound of Formula (I) | 10-30-2014 |
| 20150112068 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS - The invention provides a compound of Formula (I) | 04-23-2015 |
| 20150336958 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS - The invention provides a compound of Formula (I) | 11-26-2015 |
| 546018000 | Polycyclo ring system having the six-membered hetero ring as one of the cyclos | 17 |
| 20090143587 | INTERMEDIATES FOR ALPHA-FLUOROALKYL TETRABENAZINE AND DIHYDROTETRABENAZINE IMAGING AGENTS AND PROBES - The present invention provides novel fluorophilic compounds having structure VII | 06-04-2009 |
| 20090182146 | Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3')quiniclidine hydrochloride - An industrially acceptable process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine from a cisitrans mixture of isomers. Treatment of the mixture with an organic sulfonice acid generates a less soluble acid addition salt that is enriched in the cis-isomer. Recrystallization or pulping using various organic solvents allows for enrichment of the cis-isomer by filtration. These new sulfonic acid salts of the cis-isomer of 2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine prepared according to the present invention could be further converted into the hydrochloride salt by any known procedures such as treatment with a base and then hydrochloric acid salt formation or exchange of the sulfonic acid salt with hydrochloric acid. | 07-16-2009 |
| 20100048903 | Method For Producing Azoniaspironortropine Esters And Nortropan-3-One Compounds - The present technology relates to an improved one-stage method for producing azoniaspironortropine esters such as trospium chloride by reacting an endonortropine compound with an organic dihalogen compound and an a-hydroxycarboxylic acid in the presence of a base and 1,1′ carbonyldiimidazole or 1,1′ thiocarbonyldiimidazole or thionyldiimidazole. The present technology also relates to an improved method for producing nortropan-3-one compounds or their hydrohalides (such as N-benzyltropanone hydrochloride) by reacting an amine and a protected dialdehyde with a basic aqueous solution of 1,3-acetone dicarboxylic acid. | 02-25-2010 |
| 20100240897 | Spirocyclic Cyclohexane Compounds - Spirocyclic cyclohexane compounds corresponding to formula I | 09-23-2010 |
| 20100286396 | NOVEL ISOQUINOLINE DERIVATIVES - The invention provides novel compounds of formula (I) | 11-11-2010 |
| 20110301352 | PROCESS FOR THE PREPARATION OF CIS-2-METHYLSPIRO (1, 3-OXATHIOLANE 5-3') QUINUCLIDINE - Methods are provided for making pharmaceutical-grade cis-2-methylspiro(1,3-oxathiolane-5,3′)quinuclidine and pharmaceutically acceptable salts thereof by isomerizing racemic 2-methylspiro(1,3-oxathiolane-5,3′)quinuclidine to cis-2-methylspiro(1,3-oxathiolane-5,3′)quinuclidine and subsequent purification of the C-MSOQ by salt formation with inexpensive and commercially available material such as sulfuric acid. Purification methods are disclosed which employ an organic solvent/water system and recrystallization with an organic solvent such as acetone. | 12-08-2011 |
| 20110306765 | STEREOSELECTIVE HYDROGENATION OF A KETONE - The present invention relates to a method comprising reducing a ketone of formula I: | 12-15-2011 |
| 20130060036 | PROCESS FOR PRODUCTION OF QUINUCLIDINE COMPOUNDS - Provided is a production method for a cis-QMF, which has a low environmental burden and is industrially advantageous. Specifically provided is a production method for a cis-type 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine hydrochloride, including: reacting a cis-trans isomer mixture of 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine with p-nitrobenzoic acid; resolving the resultant product to produce a cis-type 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine p-nitrobenzoate; and converting the p-nitrobenzoate into a hydrochloride. | 03-07-2013 |
| 20130237707 | CIS-2-METHYLSPIRO 1, 3-OXATHIOLANE 5-3 QUINUCLIDINE - Pharmaceutical-grade compounds containing cis-2-methylspiro(1,3-oxathiolane-5,3′)quinuclidine having a purity >99.0% by HPLC with less than 0.5% of trans-2-methylspiro(1,3-oxathiolane-5,3′)quinuclidine are provided. | 09-12-2013 |
| 20130267710 | (1R,4R) 7-OXO-2-AZABICYCLO[2.2.2]OCT-5-ENE AND DERIVATIVES THEREOF - This invention provides novel (1R,4R) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof, preferably in substantially enantiomerically enriched forms, intermediates thereto, and processes of their synthesis. | 10-10-2013 |
| 20130274474 | 1,3-OXATHIOLANE DERIVATIVES, PROCESS FOR THE PREPARATION OF 1,3-OXATHIOLANE DERIVATIVES AND INTERMEDIATES THEREOF - This invention relates to 1,3-oxathiolane derivatives (I), processes for the preparation of 1,3-oxathiolane derivatives and intermediate compounds thereof. | 10-17-2013 |
| 20140288307 | Crystalline cis-(E)-4-(3-Fluorophenyl)-2',3',4',9'-tetrahydro-N,N-dimethyl-2'-(1-oxo-- 3-phenyl-2-propenyl)-spiro[cyclohexane-1,1'[1H]-pyrido[3,4-b]indol]-4-amin- e - The present invention relates to crystalline forms of cis-(E)-4-(3-Fluorophenyl)-2′,3′,4′,9′-tetrahydro-N,N-dimethyl-2′-(1-oxo-3-phenyl-2-propenyl)-spiro[cyclohexane-1,1′[1H]-pyrido[3,4-b]indol]-4-amine, pharmaceutical compositions and medicaments comprising these modifications, the use of these modifications as well as to a process for making the crystalline forms. | 09-25-2014 |
| 20140357868 | METHODS FOR STEREOSELECTIVE REDUCTION - The invention is directed to a method to reduce a C—C double bond of an enone of a steroidal compound to produce a mixture of β ketone product and α ketone product, comprising treating a solution or suspension of the steroidal compound in a solvent with hydrogen gas in the presence of a catalyst and a substituted pyridine. | 12-04-2014 |
| 20140371456 | Enzymatic Transamination of Cyclopamine Analogs - Provided are processes for the synthesis of amino analogues from ketone starting materials. | 12-18-2014 |
| 20140371457 | PROCESS FOR PRODUCTION OF QUINUCLIDINE COMPOUNDS - Provided is a production method for a cis-QMF, which has a low environmental burden and is industrially advantageous. Specifically provided is a production method for a cis-type 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine hydrochloride, including: reacting a cis-trans isomer mixture of 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine with p-nitrobenzoic acid; resolving the resultant product to produce a cis-type 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine p-nitrobenzoate; and converting the p-nitrobenzoate into a hydrochloride. | 12-18-2014 |
| 20150322080 | Process for Preparing Spirocyclic Cyclohexane Compounds, Compositions Containing Such Compounds and Method of Using Such Compounds - Spirocyclic cyclohexane compounds corresponding to formula I | 11-12-2015 |
| 20160168163 | PROCESS FOR THE MANUFACTURE OF SPIROCYCLIC SUBSTITUTED BENZOFUROQUINOLIZINES | 06-16-2016 |
| 546019000 | At least three ring hetero atoms in the two rings which form the spiro | 5 |
| 20100305322 | Process for the Oxidation of Secondary Amines into the Corresponding Nitroxides - The invention relates to a process for the preparation of secondary nitroxide radicals from their corresponding secondary amines by oxidation with an organic peracid, comprising the steps a) adding to a reaction vessel a secondary amine, optionally together with an organic solvent and in one batch a base selected from the group consisting of alkali metal, alkaline earth metal or ammonium bicarbonates and alkaline earth metal or ammonium carbonates or mixtures thereof in the form of a solid together with water or as an aqueous slurry; b) dosing a peracid under stirring to the reaction mixture in an amount of 1.0 to 2.5 mol per mol of secondary amine; and c) isolating the organic phase. | 12-02-2010 |
| 20150065715 | AMIDOPYRIDINE DERIVATIVE AND USE THEREOF - The present invention relates to novel amidopyridine derivatives. More specifically, the present invention provides a medicinal agent which is useful as a prophylactic or therapeutic agent for diseases based on the production of cytokines from T cells, comprising as the active ingredient an amidopyridine derivative or a pharmacologically acceptable salt thereof. Provided are an amidopyridine derivative of the following general formula (I): | 03-05-2015 |
| 546020000 | At least three ring nitrogens in the two rings which form the spiro | 3 |
| 20090187021 | INDANE COMPOUNDS AS CCR5 ANTAGONISTS - The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS). | 07-23-2009 |
| 20110092704 | Preparation of triazospiro compounds - The present invention relates to processes for producing triazospiro compounds having the formula (IV): | 04-21-2011 |
| 20140303372 | SULFONYLPYRAZOLE AND SULFONYLPYRAZOLINE CARBOXAMIDINE DERIVATIVES AS 5-HT6 ANTAGONISTS - This invention concerns compounds of the general formula (1): | 10-09-2014 |
