| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 544343000 | Tetracyclo ring system having the diazine ring as one of the cyclos (e.g., benzophenazines, etc.) | 31 |
| 20090131667 | POLYMORPHIC FORMS OF TADALAFIL - Polymorphic forms of tadalafil, and processes for their preparation. | 05-21-2009 |
| 20090312548 | MODIFIED PICTET-SPENGLER REACTION AND PRODUCTS PREPARED THEREFROM - A method of introducing a second stereogenic center into a tetrahydro-β-carboline have two stereogenic centers using a modified Pictet-Spengler reaction is disclosed. The method provides a desired cis- or trans-isomer in high yield and purity, and in short processes times. | 12-17-2009 |
| 20090318695 | PROCESSES FOR THE PREPARATION OF VARENICLINE AND INTERMEDIATES THEREOF - The invention provides an improved process for the preparation and purification of Varenicline and intermediates for the preparation of Varenicline. | 12-24-2009 |
| 20100004451 | VARENICLINE TOSYLATE, AN INTERMEDIATE IN THE PREPARATION PROCESS OF VARENICLINE L-TARTRATE - Crystalline forms of Varenicline Tosylate, processes for preparing those crystalline forms of Varenicline Tosylate, and processes for obtaining high purity Varenicline base using Varenicline Tosylate are provided. | 01-07-2010 |
| 20100010221 | PROCESSES FOR PURIFYING VARENICLINE L-TARTRATE SALT AND PREPARING CRYSTALLINE FORMS OF VARENICLINE L-TARTRATE SALT - Processes for purifying Varenicline base or the L-tartrate salt thereof and for preparing Varenicline L-tartrate crystalline forms A and B are provided. | 01-14-2010 |
| 20100069636 | Quinoxaline Derivative, and Organic Semiconductor Device, Electric Field Light Emitting Device, and Electronic Device Which Have the Same - Target is to provide an organic compound material having a bipolar character. | 03-18-2010 |
| 20100113781 | SUBSTITUTED HETEROCYCLE GAMMA-CARBOLINES SYNTHESIS - The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines. | 05-06-2010 |
| 20100228030 | PROCESS FOR THE PREPARATION OF INTERMEDIATES OF TETRACYCLIC COMPOUNDS - The present invention relates to a process for the preparation of cis-intermediates of Formula II, (Formula II) wherein R1 represents hydrogen, (un)substituted alkyl, alkenyl, aryl, and X represents a leaving group, which are useful synthetic intermediates in the preparation of tetracyclic compounds having phosphodiesterase inhibitory activity. | 09-09-2010 |
| 20110105750 | Salts of a Pyrazino[2,3-h][3]Benzazepine Derivative - This invention provides novel dicarboxylic acid salt forms of varenicline, wherein the acid is selected from maleic acid, fumaric acid, adipic acid, galactaric acid and malic acid. This invention provides also a carboxylic acid salt form of varenicline, wherein the acid is S-2-pyrrolidinon-5-carboxylic acid. This invention also provides methods for making these salt forms. | 05-05-2011 |
| 20110105751 | CONVERSION OF TRYPTOPHAN INTO BETA-CARBOLINE DERIVATIVES - The invention belongs in the field of organic chemistry and relates to a new shortened Pictet-Spengler type reaction for preparing isomerically pure β-carboline compounds useful for the synthesis of tadalafil. | 05-05-2011 |
| 20110124866 | PROCESS FOR PREPARATION OF TADALAFIL - Process for the preparation of tadalafil of high pharmaceutical purity is characterized in that the sequence of reactions comprising acetylation of methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate with chloro acetyl chloride and cyclisation of the formed intermediate with methyl amine, is performed as a ‘one-pot’ process, without isolating the intermediate methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2-(chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate. | 05-26-2011 |
| 20110224437 | PROCESS FOR PREPARING VARENICLINE, VARENICLINE INTERMEDIATES, AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF - Provided herein is an improved, convenient, commercially viable and environmentally friendly process for the preparation of varenicline or a pharmaceutically acceptable salt thereof comprising reacting 1-(4,5-diamino-10-aza-tricyclo[6.3.1.0 | 09-15-2011 |
| 20120197020 | HETEROCYCLIC COMPOUND - Provided is a novel heterocyclic compound which can be used for a light-emitting element, as a host material of a light-emitting layer in which a light-emitting substance is dispersed. A heterocyclic compound represented by a general formula (G1) is provided. In the formula, A represents any of a substituted or unsubstituted dibenzothiophenyl group, a substituted or unsubstituted dibenzofuranyl group, and a substituted or unsubstituted carbazolyl group, R | 08-02-2012 |
| 20120209000 | CHEMICAL COMPOUNDS - The present invention is directed to a compound of the formula: | 08-16-2012 |
| 20120232272 | PROCESS FOR PRODUCING v-COELENTERAZINE COMPOUNDS - A simple process for producing v-coelenterazine compounds has been desired. Described is a process for producing a v-coelenterazine compound represented by general formula (II) comprising (1) the step of reacting a compound of general formula (VIII) with a methyltriphenylphosphonium salt in the presence of a base to give a compound represented by general formula (IX), (2) the step of performing a ring-closing metathesis reaction on any one selected from the group consisting of the compound represented by general formula (IX) and a compound of general formula (X) which is the compound of general formula (IX) wherein the amino is protected with R | 09-13-2012 |
| 20120277433 | PROCESS FOR THE PREPARATION OF SUBSTITUTED QUINOXALINES - The present invention is directed to an improved process for the preparation of substituted quinoxalines by cyclization of the corresponding dianiline in the presence of ion exchange resin. | 11-01-2012 |
| 20130030179 | PROCESS FOR THE PREPARATION OF VARENICLINE - It is disclosed a process for the preparation of a compound of formula (I) or a salt thereof, comprising: | 01-31-2013 |
| 20130060033 | LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, LIGHTING DEVICE, AND HETEROCYCLIC COMPOUND - Provided is a novel heterocyclic compound which has excellent heat resistance and can be used as a host material for a light-emitting substance (a substance emitting fluorescence or a substance emitting phosphorescence). A light-emitting element includes a heterocyclic compound which includes one dibenzo[f,h]quinoxaline ring, one ring having a hole-transport skeleton, and two to eight benzene rings. Note that in the above structure, the molecular weight of the heterocyclic compound is greater than or equal to 564 and less than or equal to 1000. | 03-07-2013 |
| 20130072682 | PROCESS FOR PREPARING VARENICLINE, VARENICLINE INTERMEDIATES, AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF - Provided herein is an improved, convenient, commercially viable and environmentally friendly process for the preparation of varenicline or a pharmaceutically acceptable salt thereof comprising reacting 1-(4 ,5-diamino-10-aza-tricyclo[6.3.1.0 | 03-21-2013 |
| 20130172559 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY - The present invention is to provide a novel compound (I) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. | 07-04-2013 |
| 20130324729 | Method of Synthesizing Pyrazine Derivative, and Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device - A novel method in which a pyrazine derivative is synthesized without a synthetic pathway of a pyrazine halide derivative, which is a synthetic intermediate, whose pytazine skeleton is halogenated is provided. Furthermore, a light-emitting element, a light-emitting device, an electronic device, or a lighting device with high emission efficiency by using a pyrazine derivative obtained by the above synthesizing method as an EL material is provided. In the method, a pyrazine derivative is synthesized without a synthetic pathway of a pyrazine halide derivative, which is a synthetic intermediate, whose pytazine skeleton is halogenated. Specifically, a 2-arylpyrazine derivative having an aryl group or a heteroaryl group as a substituent is synthesized. | 12-05-2013 |
| 20130324730 | PROCESS FOR OBTAINING COMPOUNDS DERIVED FROM TETRAHYDRO-beta-CARBOLINE - The invention relates to a process for obtaining compounds derived from tetrahydro-β-carboline, specifically tadalafil and intermediate products from the synthesis, comprising the reaction between piperonal and an alkyl ester of D-tryptophan as a salt, and in the absence of any other component, followed by haloacetylation and a final cyclization with methylamine. | 12-05-2013 |
| 20140094605 | SYNTHESIS OF CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS AND INTERMEDIATES - A synthesis approach providing an early ring attachment via a bromination to compound I-I yielding compound II-II: | 04-03-2014 |
| 20140128606 | ANTIPRURITIC AGENT - An antipruritic which exerts an antipruritic effect based on a novel action mechanism and is effective for pruritus. The antipruritic contains as an effective ingredient a compound which activates a central type nicotinic acetylcholine receptor. | 05-08-2014 |
| 20140142309 | PROCESS FOR THE PREPARATION OF AN INTERMEDIATE OF TADALAFIL - The present invention relates to a process for the preparation of a cis-intermediate compound of Formula II | 05-22-2014 |
| 20140206868 | PROCESS FOR PRODUCING v-COELENTERAZINE COMPOUNDS - A simple process for producing v-coelenterazine compounds has been desired. Described is a process for producing a v-coelenterazine compound represented by general formula (II) comprising (1) the step of reacting a compound of general formula (VIII) with a methyltriphenylphosphonium salt in the presence of a base to give a compound represented by general formula (IX), (2) the step of performing a ring-closing metathesis reaction on any one selected from the group consisting of the compound represented by general formula (IX) and a compound of general formula (X) which is the compound of general formula (IX) wherein the amino is protected with R | 07-24-2014 |
| 20140330017 | Heterocyclic Compound, Light-Emitting Element, Display Module, Lighting Module, Light-Emitting Device, Display Device, Lighting Device, and Electronic Device - Provided is a heterocyclic compound that can be used for a carrier-transport material, a host material, or a light-emitting material in a light-emitting element. The heterocyclic compound has an indolo[3,2,1-jk]carbazole skeleton and a dibenzo[f,h]quinoxaline skeleton which are linked to each other through an arylene group. The wide band gap of the heterocyclic compound allows excitation of a green-emissive phosphorescent material, which contributes to the formation of a highly efficient light-emitting element. | 11-06-2014 |
| 20140364609 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES SYNTHESIS - The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines. | 12-11-2014 |
| 20150073147 | Organic Compound, Light-Emitting Element, Display Module, Lighting Module, Light-Emitting Device, Display Device, Electronic Appliance, and Lighting Device - A novel organic compound is provided. In addition, a novel organic compound with high heat resistance is provided. In the organic compound, a dibenzoquinoxaline skeleton and a 4,4-bidibenzofuran skeleton or a 4,4′-bidibezothiophene skeleton are connected to each other through an arylene group. | 03-12-2015 |
| 20150080574 | Dibenzo[f,h]Quinoxaline Derivative, Method of Synthesizing the Same, Light-Emitting Element, Light-Emitting Device, Electronic Appliance, and Lighting Device - A dibenzo[f,h]quinoxaline derivative in which impurities are reduced and a novel method of synthesizing the dibenzo[f,h]quinoxaline derivative in which impurities are reduced are provided. In addition, a light-emitting element, a light-emitting device, an electronic appliance, or a lighting device with high emission efficiency and high reliability in which the dibenzo[f,h]quinoxaline derivative is used as an EL material is provided. In the synthesis method, a 2-(chloroaryl)dibenzo[f,h]quinoxaline derivative is used as a synthetic intermediate in a synthetic pathway so that an impurity contained in a final product can be removed easily by purification by sublimation. | 03-19-2015 |
| 20160194326 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES SYNTHESIS | 07-07-2016 |
