| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 544293000 |
Nitrogen bonded directly at 4-position
| 46 |
| 544284000 |
Additional nitrogen containing unsaturated hetero ring (e.g., thiazole, etc.)
| 24 |
| 544287000 |
Chalcogen bonded directly at 4-position
| 19 |
| 544292000 |
Nitrogen bonded directly at 2-position
| 9 |
| 544291000 |
Nitrogen bonded directly at 2- and 4-positions | 5 |
| 20080242861 | Synthesis of amino-protected cyclohexane-1,4-diyldimethanamine and its derivatives - This invention relates to methods of preparing the compounds of formula (V): | 10-02-2008 |
| 20090105477 | Quinazoline Protein Tyrosine Phosphatase Inhibitors - The present invention comprises aminoquinazoline compounds of the general formula I: | 04-23-2009 |
| 20120041199 | Process for the Preparation of Doxazosin and Salts Thereof - The present invention relates to a process for the preparation of doxazosin or salts thereof. | 02-16-2012 |
| 20120197016 | SCREENING METHODS OF MODULATING ADRENERGIC RECEPTOR GENE EXPRESSIONS IMPLICATED IN MELANOGENESIS - Embodiments of screening methods for determining test agents effective for modifying the appearance of pigmented skin are provided. The screening method may comprise the steps of contacting a cell, a cell culture, or bulk cells with the test agent, wherein the cell, the cell culture, or the bulk cells comprise ADRβ1 receptors, and determining based on the binding interaction of the test agent with the ADRβ1 receptors whether the test agent is an effective ADRβ1 receptor antagonist suitable for modifying the appearance of pigmented skin, wherein a test agent is considered to be an effective ADRβ1 receptor antagonist when it defines a half maximal inhibitory concentration of less than about 1000 ppm. | 08-02-2012 |
| 20160024551 | MULTI-TIERED, HIGH THROUGH-PUT SCREEN FOR COMPOUNDS EFFECTIVE AGAINST BACTERIAL BIOFILM COMPOUNDS EFFECTIVE FOR INHIBITING AND ERADICATING BACTERIAL BIOFILM - A high through-put screening method for identifying agents effective for inhibiting biofilm formation and/or killing established biofilm are disclosed. The method includes three tiers, and each tier includes three specific biological process assays. The tier levels are a primary screen, a confirmation screen, and a dose-response screen, and the biological process assays include as says for total bacterial growth, bacterial metabolic activity, and biofilm formation. | 01-28-2016 |
| 544285000 |
Chalcogen bonded directly at 2- and 4-positions | 3 |
| 20090326225 | Novel Process for the Preparation of Hexacyclic Compounds - This invention relates to novel processes for the preparation of compounds of the formula [1], | 12-31-2009 |
| 20100137593 | CRYSTALS OF PHENYLALANINE DERIVATIVES AND PRODUCTION METHODS THEREOF - The present invention provides crystals of phenylalanine derivatives of the formula (I): | 06-03-2010 |
| 20130066072 | CRYSTALS OF SALTS OF PHENYLALANINE DERIVATIVES - Provided is a crystal of a salt of the compound represented by formula (I), which is excellent in its solubility in water. In particular, also provided is a crystal of hydrochloride, hydrobromate, sulfate, nitrate, p-toluenesulfonate or methanesulfonate of the compound represented by formula (I). | 03-14-2013 |
| 544286000 |
Chalcogen bonded directly at 2-position | 1 |
| 20130066073 | PROCESS FOR THE PREPARATION OF DIHYDROQUINAZOLINES - The present invention relates to a process for the preparation of dihydroquinazolines, which are used for the production of medicaments. | 03-14-2013 |
| Entries |
| Document | Title | Date |
|---|
| 20080269487 | 4-ANILINO QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS - The invention concerns quinazoline derivatives of Formula (I) wherein each of Q | 10-30-2008 |
| 20090306375 | Process for production of 4(3H)-quinazolinone derivative - The present invention provides a process for producing a 4(3H)-quinazolinone derivative, which is useful as a medicinal substance, with better efficiency in an industrial scale. The process comprises the steps of reacting 4-hydroxy-N-tert-butoxycarbonylpiperidine with 4-fluoro-1-nitrobenzene in the presence of sodium hydride, reacting the resulting product with cyclobutanone, reducing the resulting product to give 4-(1-cyclobutyl-4-piperidinyl)oxyaniline, and reacting this compound with 2-methyl-5-trifluoromethyl-4H-3,1-benzoxazin-4-one to give 3-{4-[(1-cyclobutyl-4-piperidinyl)oxy]phenyl}-2-methyl-5-trifluoromethyl-4(3H)-quinazolinone. | 12-10-2009 |
| 20100016589 | Novel Anthranilic Acid Derivative as Potential Anticancer Agent and a Process for the Preparation Thereof - The present invention provides novel anthranilic acid derivative useful as potential anticancer agent. More particularly, the present invention relates novel anthranilic acid derivative of general formula (8), R′=alkyl-2-methoxyphenyl piperazine (or) benzyl, R=2 methoxy phenyl, piperazine, 2-pyridyl piperazine, 2-pyrimidyl piperazine, 4-quinazolinyl piperazine, 9H-9-fluorenylamine, 4-{(2{amino-5-(methoxy)-4-[(phenylmethyl)oxy]phenyl}carbonyl)hexahydro-1-pyrazinyl], and [(4[2 amino-4-(benzyloxy)-5-methoxybenzoyl]aminophenyl)sulfonyl]-4-benzamine; X═H (or) pyrazine-2-carbonyl. The present invention also provides a process for the preparation of novel anthranilic acid derivative of general formula (8), which is useful as potential anticancer agent. | 01-21-2010 |
