| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 544124000 | Six-membered ring consisting of one nitrogen and five carbons (e.g., pyridine, etc.) | 81 |
| 20090182143 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, their pharmaceutically acceptable solvates and their pharmaceutical compositions containing them. The present invention more particularly relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the Formula (1), their analogs, tautomers, enantiomers, diasteromers, regioisomers, stereoisomers, polymorphs, pharmaceutically acceptable salts, appropriate N-oxide, pharmaceutically acceptable solvates and the pharmaceutical compositions containing them. | 07-16-2009 |
| 20090240052 | NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF - An anthranilic acid derivative represented by the general formula (X) [wherein R | 09-24-2009 |
| 20090292121 | Cyanopyridine derivative and use thereof as medicine - A therapeutic drug for cancer containing a substance selected from the group consisting of a novel cyanopyridine derivative, a pharmaceutically acceptable salt, a hydrate, a water adduct and a solvate as an active ingredient can be provided. | 11-26-2009 |
| 20130231477 | NOVEL METHOD OF PREPARING BENZOIMIDAZOLE DERIVATIVES - This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production. | 09-05-2013 |
| 20150329503 | SUBSTITUTED BENZAMIDES AND THEIR USES - Provided herein are Substituted Benzamides, compositions, and method of their manufacture and use. | 11-19-2015 |
| 20160016905 | STILBAZOLIUM DERIVATIVE AND NONLINEAR OPTICAL MATERIAL USING THE SAME - Provided is a stilbazolium derivative represented by the general formula (I): | 01-21-2016 |
| 20160122333 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN - There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin. | 05-05-2016 |
| 544125000 | The additional six-membered hetero ring is one of the cyclos in a polycyclo ring system | 23 |
| 20110009628 | Compounds and Compositions for Modulating Lipid Levels and Methods of Preparing Same - The present technology relates to compounds of Formulas I-VI and methods of making and using such compounds. Methods of use include prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. Compounds disclosed herein also increase HDL-C, lower total cholesterol, LDL-cholesterol, and triglycerides and increase hepatic LDL receptor expression, inhibit PCSK9 expression, and activate AMP-activated protein kinase. | 01-13-2011 |
| 20120165522 | CAMPTOTHECIN DERIVATIVES - Various 14-Nitro, 14-amino, and 14-substituted amino camptothecin derivatives are useful in the treatment of cancer and other hyperproliferative diseases. Various 14-nitro camptothecin derivatives are conveniently prepared by reacting a camptothecin derivative with fuming nitric acid, optionally employing acetic anhydride as a solvent. | 06-28-2012 |
| 20140031543 | (+)-6-Hydroxy-Morphinan or (+)-6-Amino-Morphinan Derivatives - The present invention provides (+)-morphinanium compounds comprising substituted 6-hydroxy or 6-amine groups. The invention also provides methods for inhibiting microglial activation by administering the compounds of the invention. | 01-30-2014 |
| 544126000 | The additional six-membered hetero ring is one of the cyclos in a tricyclo ring system | 3 |
| 20080312434 | PROCESS FOR IMIDAZO [4,5-C] PYRIDIN-4-AMINES - A process and intermediates for preparing 1H-imidazo[4,5-c]pyridin-4-amines are disclosed. The process includes providing a 7H-imidazo[4,5-c]tetrazolo[1,5-a]pyridine and converting a 7H-imidazo[4,5-c]tetrazolo[1,5-a]pyridine to a 1H-imidazo[4,5-c]pyridin-4-amine. | 12-18-2008 |
| 20120289697 | NOVEL SULFONIC ACID DERIVATIVE COMPOUND AND NOVEL NAPHTHALIC ACID DERIVATIVE COMPOUND - Disclosed are a novel sulfonic acid derivative compound and a novel naphthalic acid derivative compound with high solubility in organic solvents, good photosensitivity, and suitability as a photoacid generator and a polymerization initiator. The sulfonic acid derivative compound is represented by the formula (I) | 11-15-2012 |
| 20140031544 | ARYL-AND HETEROARYLCARBONYL DERIVATIVES OF HEXAHYDROINDENOPYRIDINE AND OCTAHYDROBENZOQUINOLINE - The present invention relates to compounds defined by formula I | 01-30-2014 |
| 544127000 | The additional six-membered hetero ring is one of the cyclos in a bicyclo ring system | 17 |
| 20090306373 | 4,7-DIHYDROTHIENO[2,3-B]PYRIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS - This invention relates generally to compounds and pharmaceutical compositions for the treatment of myosin heavy chain (MyHC)-mediated conditions, and in particular, cardiovascular conditions. | 12-10-2009 |
| 20100234593 | Imidazo[4,5-B]Pyridine-7-Carboxamides 704 - The present invention relates to new compounds of formula (I) as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy. | 09-16-2010 |
| 20110028717 | AZAINDOLE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY - The present invention creates an azaindole derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further providing a therapeutic agent for treating allergic diseases. | 02-03-2011 |
| 20110282056 | PROTEIN KINASE INHIBITORS AND USE THEREOF - Disclosed are compounds according to Formula I: | 11-17-2011 |
| 20120041195 | Heterocyclic compounds - The invention is directed to certain novel compounds, methods for producing them and methods for treating or ameliorating a kinase-mediated disorder. More particularly, this invention is directed to substituted triazolopyridine compounds useful as selective kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase-mediated disorder. In particular, the methods relate to treating or ameliorating a kinase-mediated disorder including cardiovascular diseases, diabetes, diabetes-associated disorders, inflammatory diseases, immunological disorders, cancer and diseases of the eye such as retinopathies or macular degeneration or other vitreoretinal diseases, and the like. | 02-16-2012 |
| 20120130070 | COMPOUNDS HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY - This invention provides a compound of the formula (I): | 05-24-2012 |
| 20130165652 | NOVEL HETEROCYCLIC COMPOUND, AND COMPOSITION FOR TREATING INFLAMMATORY DISEASES USING SAME - The heterocyclic compound according to the present invention may treat and prevent inflammatory diseases and heal skin wounds, and particularly, have effects of recovering damaged skin barrier, reducing inflammation and pruritus in inflammatory skin diseases. In addition, the composition containing the compound according to the present invention as an active ingredient may be used to alleviate various inflammatory diseases and diseases in which PAR-2 is excessively expressed, and particularly, the composition may inhibit activity of PAR-2 in skin, such that the composition may be used as a composition having anti-inflammatory function in inflammatory skin diseases including atopic dermatitis, or the like. | 06-27-2013 |
| 20130296555 | BETA-LACTAMASE INHIBITORS - Aryl substituted diazabicyclooctanes (DBO) compounds that inhibit β-lactamases of class A, class C or class D and potentiate β-lactam antibiotics are disclosed. In particular, this disclosure provides DBO compounds that, when used in the disclosed Synergy MIC Assay with a β-lactam antibiotic at a fixed concentration have an MIC of 8 μg/mL or less against one or more isogenic β-lactamase expressing bacterial strains. | 11-07-2013 |
| 20140128600 | METHODS FOR PREPARING NAPHTHYRIDINES - The present invention provides methods of synthesizing compounds of formula (1) and intermediates thereto. The present invention also provides intermediates useful in the synthesis of compounds of formula (1). | 05-08-2014 |
| 20140316133 | BETA-LACTAMASE INHIBITORS - Aryl substituted diazabicyclooctanes (DBO) compounds that inhibit β-lactamases of class A, class C or class D and potentiate β-lactam antibiotics are disclosed. In particular, this disclosure provides DBO compounds that, when used in the disclosed Synergy MIC Assay with a β-lactam antibiotic at a fixed concentration have an MIC of 8 μg/mL or less against one or more isogenic β-lactamase expressing bacterial strains | 10-23-2014 |
| 20140323721 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein. | 10-30-2014 |
| 20140330009 | Substituted 4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridines, Their Use as Medicament, and Pharmaceutical Preparations Comprising Them - The invention relates to substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines of formula (I), their use as medicament, and pharmaceutical preparations comprising them. The compounds of formula (I) act on the TASK-1 potassium channel. The compounds are particularly suitable for the treatment or prevention of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter. | 11-06-2014 |
| 20150038703 | IMIDAZO[1,2-a]PYRIDINE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS - The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC). | 02-05-2015 |
| 20160046628 | Pd-CATALYZED COUPLING OF PYRAZOLE AMIDES - A novel process for the preparation of imidazo[1,2-a]pyridine compounds of the formula | 02-18-2016 |
| 20160122337 | 2-HETEROARYL CARBOXAMIDES - The invention relates to novel 2-heteroaryl carboxamides and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory. | 05-05-2016 |
| 20160128989 | PYRAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF BLADDER CANCER - The invention relates to the use of compounds corresponding to formula (I), or a pharmaceutically acceptable salt thereof, for preparing a medicament for the treatment of bladder cancer. | 05-12-2016 |
| 20160176865 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | 06-23-2016 |
| 544129000 | Piperidine ring | 31 |
| 20090111983 | Cycloalkylcarbonylamino Acid Derivative and Process For Producing The Same - Cycloalkylcarbonylamino acid derivatives, which are raw material intermediates of a novel cycloalkane carboxamide derivative that selectively inhibits cathepsin K, and a production process thereof, are provided. | 04-30-2009 |
| 20090318690 | Benzisoxazole Compound - Disclosed is a compound represented by the general formula (I) or a salt thereof: | 12-24-2009 |
| 20100137587 | Heterocyclic compound and use thereof - Compounds represented by the formulas | 06-03-2010 |
| 20110295000 | PRODUCTION METHOD - The present invention relates to a process for preparing compounds of general formula I | 12-01-2011 |
| 20130281691 | HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS - Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active. | 10-24-2013 |
| 20160176906 | Chemical Compounds | 06-23-2016 |
| 544130000 | Double bonded divalent chalcogen containing | 25 |
| 20080255352 | Cyclic amide derivative, and its production and use - The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I): | 10-16-2008 |
| 20090118501 | Dicycloalkyl Urea Glucokinase Activators - Dicycloalkyl urea glucokinase activators compounds are glucokinase inhibitors useful for the treatment of diabetes. | 05-07-2009 |
| 20090137799 | Cycloalkylcarbonylamino Acid Ester Derivative and Process for Producing The Same - Cycloalkylcarbonylamino acid ester derivatives, which are raw material intermediates for a novel cycloalkane carboxamide derivative having an action that selectively inhibits cathepsin K, and a production process thereof, are provided. | 05-28-2009 |
| 20090156805 | Cycloalkane Carboxamide Derivatives and Production Process of Same - Novel cycloalkane carboxamide derivatives having an action that selectively inhibits cathepsin K, and a production process thereof, are provided. | 06-18-2009 |
| 20090281310 | CINNAMIDE COMPOUND - The present invention relates to a process for preparing a compound of formula (6a): | 11-12-2009 |
| 20100113776 | PYRAZOLE DERIVATIVE - A novel pyrazole derivative of the following formula having a histamine H3 receptor antagonistic effect: | 05-06-2010 |
| 20100145043 | 2,4-Disubstituted-5-Aminocarbonyl-1,3-Thiazole Derivatives For Therapeutic Agent Of Antiinflammatory Disease, Method Thereof For Preparation, Therapeutic Agent For Antiinflammatory Disease Induced By SPC Activity Containing The Same - Disclosed herein are 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives, a preparation method thereof, and a therapeutic agent for treating inflammatory diseases induced by SPC, which contains the derivative as an active ingredient. The anti-inflammatory effect of the 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives was analyzed through a test employing human dermal cells and an animal test using mice and, as a result, it was found that the derivatives showed excellent inhibitory activity on SPC receptor compared to thiazole derivatives known in the prior art. Thus, the 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives or pharmaceutically acceptable salts thereof are useful as active ingredients in therapeutic agents for treating inflammatory diseases, such as inflammation, pruritus and skin infection, which appear in atopic dermatitis and other diseases induced by SPC activity. | 06-10-2010 |
| 20100168420 | Taxol Derivatives With Antitumor Activity - Taxol derivatives or their salts having the formula as following: Wherein, R | 07-01-2010 |
| 20100168421 | A NEW PEPTIDE DEFORMYLASE INHIBITOR COMPOUND AND MANUFACTURING PROCESS THEREOF - The present invention relates to the novel antibacterial compounds having potent antibacterial activity as inhibitors of peptide deformylase. This invention further relates to pharmaceutically acceptable salts thereof, to processes for their preparation, and to pharmaceutical compositions containing them as an active ingredient. | 07-01-2010 |
| 20100267950 | Novel Stabilizing Ligands For Regulation of Protein Function - The invention pertains to novel compounds of Formula (I) wherein R | 10-21-2010 |
| 20100324286 | BENZOTHIAZOLE DERIVATIVES - Provided are compounds and their pharmaceutically acceptable salts that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance. | 12-23-2010 |
| 20110098468 | NK1 ANTAGONISTS | 04-28-2011 |
| 20110152520 | NITROGENOUS HETEROCYCLIC DERIVATIVE AND MEDICINE CONTAINING THE SAME AS AN ACTIVE INGREDIENT - A compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof: | 06-23-2011 |
| 20120083604 | BENZOTHIAZOLE DERIVATIVES - Provided are compounds of formula I or II that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods oftreating patients suffering from or susceptible to at least one symptom of abuse of dependence on, or withdrawal from at least one substance. | 04-05-2012 |
| 20130085275 | NITROGENOUS HETEROCYCLIC DERIVATIVE AND MEDICINE CONTAINING THE SAME AS AN ACTIVE INGREDIENT - A compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof: | 04-04-2013 |
| 20130317219 | Benzothiazole Derivatives - Provided are compounds and their pharmaceutically acceptable salts that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance. | 11-28-2013 |
| 20140011996 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS - Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1). | 01-09-2014 |
| 20140046057 | SALTS AND SOLID FORMS OF (S)-3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDIN- E-2,6-DIONE AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME - Salts and solid forms of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a stereoisomer thereof, are disclosed. Compositions comprising and methos of using the salts and solid forms are also disclosed. | 02-13-2014 |
| 20140046058 | PROCESSES FOR THE PREPARATION OF (S)-3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDIN- E-2,6-DIONE AND PHARMACEUTICALLY ACCEPTABLE FORMS THEREOF - Provided are processes for the preparation of enantiomerically enriched or enantiomerically pure 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a pharmaceutically acceptable form thereof. | 02-13-2014 |
| 20140046059 | PROCESS FOR THE PREPARATION OF MORPHOLINO SULFONYL INDOLE DERIVATIVES - The present invention relates to a process for the preparation of the compounds of formula (I) which are morpholino sulphonyl indole derivatives. The compounds of formula (I) are capable of inhibiting, modulating or regulating Insulin-Like-Growth Factor I Receptors or Insulin Receptors. The present invention also relates to the processes for preparation of the pharmaceutically acceptable salts of the compounds of formula (I). | 02-13-2014 |
| 20140330010 | PHENYLPYRROLE DERIVATIVE - Provided are novel compounds that are useful in the prevention or treatment of such diseases as dementia, Alzheimer's disease, attention-deficient hyperactivity disorder, schizophrenia, epilepsy, central convulsion, obesity, diabetes mellitus, hyperlipidemia, narcolepsy, idiopathic hypersomnia, behaviorally induced insufficient sleep syndrome, sleep apnea syndrome, circadian rhythm disorder, parasomnia, sleep related movement disorder, insomnia, and depression, or allergic rhinitis, or pharmaceutically acceptable salts of such compounds. Specifically, there are provided phenylpyrrole compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof: | 11-06-2014 |
| 20150045553 | PHENYLTRIAZOLE DERIVATIVE - Provided are novel compounds that are useful in the prevention or treatment of such diseases as dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, epilepsy, central convulsion, obesity, diabetes mellitus, hyperlipidemia, narcolepsy, idiopathic hypersomnia, behaviorally induced insufficient sleep syndrome, sleep apnea syndrome, circadian rhythm disorder, parasomnia, sleep related movement disorder, insomnia, depression, or allergic rhinitis, or pharmaceutically acceptable salts of such compounds. Specifically, there are provided phenyltriazole derivatives represented by the following formula (I) or pharmaceutically acceptable salts thereof: | 02-12-2015 |
| 20150361066 | PROCESSES FOR THE PREPARATION OF ISOTOPOLOGUES OF 3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,- 6-DIONE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF - Provided are processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoin-dolin-2-yl)piperidine-2,6-dione, or a pharmaceutically acceptable salt thereof. | 12-17-2015 |
| 20160052915 | ROHITUKINE ANALOGS AS CYCLIN-DEPENDENT KINASE INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF - The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc. [insert Formula A here] wherein, n=0 or 1, when n=1, the dotted line indicates the double bond. | 02-25-2016 |
| 20160251333 | PROCESSES FOR THE PREPARATION OF (S)-3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDIN- E-2,6-DIONE AND PHARMACEUTICALLY ACCEPTABLE FORMS THEREOF | 09-01-2016 |
| 544131000 | Double bonded divalent chalcogen containing | 20 |
| 20090023918 | PROCESS FOR PREPARING 3-ACYLAMINOBENZOFURAN-2-CARBOXYLIC ACID DERIVATIVE - The present invention provides a process of preparing a compound of the formula [I]: | 01-22-2009 |
| 20090270616 | ARYL SULFONAMIDES - Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists. | 10-29-2009 |
| 20100234594 | INHIBITOR OF BINDING OF S1P1 - A compound represented by formula (I) or a pharmaceutically acceptable salt thereof: | 09-16-2010 |
| 20100286392 | PROCESS FOR THE MANUFACTURING OF THE COMPOUND 2-HYDROXY-3-[5-(MORPHOLIN-4-YLMETHYL)PYRIDIN-2-YL]1H-INDOLE-5-CARBONITRIL- E 701 - The present invention relates to a new process for the manufacture of the compound 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile as a free base and pharmaceutically acceptable salts thereof, particularly the 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile citrate, and to new intermediates prepared in said process suitable for large scale manufacturing of said compound. | 11-11-2010 |
| 20110269960 | TRIAZOLE DERIVATIVE - An object of the present invention is to provide a compound having an action of inhibiting binding between S1P and its receptor, Edg-1 (S1P | 11-03-2011 |
| 20120022255 | SUBSTITUTED 3-HYDROXY-4-PYRIDONE DERIVATIVE - This invention provides compounds having antiviral activities especially inhibiting activity for influenza virus, more preferably provides substituted 3-hydroxy-4-pyridone derivatives having cap-dependent endonuclease inhibitory activity. | 01-26-2012 |
| 20120220767 | AMINOTHIAZOLE DERIVATIVE - A compound represented by formula (1) or a pharmaceutically acceptable salt thereof, which has a PI3 kinase γ inhibitory effect and is useful as a prophylactic or therapeutic agent for articular rheumatism, Crohn's disease, irritable colitis, Sjoegren's syndrome, multiple sclerosis, systemic lupus erythematosus, asthma, atopic dermatitis, arteriosclerosis, organ transplant rejection, cancer, retinopathy, psoriasis, arthrosis deformans, age-related macular degeneration, type II diabetes, insulin resistance, obesity, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hyperlipemia, etc. | 08-30-2012 |
| 20120226036 | SUBSTITUTED CARBONYL COMPOUND - This is to provide a novel substituted carbonyl compound represented by the following formula (I) having an excellent bronchodilatory action based on potent EP2 agonistic action and useful for treatment of respiratory diseases. | 09-06-2012 |
| 20120259113 | DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS - In one aspect, the invention relates to compounds having the formula: | 10-11-2012 |
| 20130079513 | N-Thio-anthranilamid compounds and their use as pesticides - N-Thio-anthranilamid compounds of formula (I) | 03-28-2013 |
| 20130324718 | PROCESSES AND REAGENTS FOR MAKING DIARYLIODONIUM SALTS - This invention relates to processes and reagents for making diaryliodonium salts, which are useful for the preparation of fluorinated and radiofluorinated aromatic compounds. | 12-05-2013 |
| 20140005385 | TETRAZOYLOXIME DERIVATIVE AND PLANT DISEASE CONTROL AGENT | 01-02-2014 |
| 20140114064 | P38 MAP KINASE INHIBITORS - There are provided inter alia compounds of formula (I) | 04-24-2014 |
| 20140336377 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS - The present invention relates to arylamide derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved. | 11-13-2014 |
| 20150299177 | Novel Polymorphs and Salts - The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity. | 10-22-2015 |
| 20150336944 | Sodium Channel Blockers, Preparation Method Thereof and Use Thereof - The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and the use thereof. A compound represented by formula 1 according to the invention, or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof may be effectively used for the prevention or treatment of pain, for example, acute pain, chronic pain, neuropathic pain, post-surgery pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, or paroxysmal extreme pain disorder (PEPD). | 11-26-2015 |
| 20160024009 | Novel Sulfonamide TRPA1 Receptor Antagonists - The invention discloses compounds of Formula (I). The compounds of formula (I) are TRPA1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of TRPA1 receptors. | 01-28-2016 |
| 20160075697 | HETEROCYCLIC SUBSTITUTED-3-HETEROARYLIDENYL-2-INDOLINONE DERIVATIVE - Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, R | 03-17-2016 |
| 20160130228 | Novel Heterocyclic Compounds as Bromodomain Inhibitors - The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy. | 05-12-2016 |
| 20160376280 | Substituted 7-Azabicycles And Their Use As Orexin Receptor Modulators - The present invention is directed to compounds of Formula I: | 12-29-2016 |
