| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 540593000 | Bicyclo ring system which contains the hetero ring as one of the cyclos | 29 |
| 20110040088 | FUSED HETEROCYCLIC COMPOUNDS - Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases. | 02-17-2011 |
| 20110172416 | AMIDINE DERIVATIVE - Provision of a novel amidine derivative or a pharmaceutically acceptable salt thereof having an activated blood coagulation factor X-inhibitory activity. A compound represented by the formula (I) | 07-14-2011 |
| 20120016117 | INDAZOLEPROPIONIC ACID AMIDE COMPOUND - Disclosed is a compound which is useful in preventing and treating cardiac arrhythmia such as atrial fibrillation. A compound represented by formula (1) or a pharmaceutically acceptable salt of the same. | 01-19-2012 |
| 20120029190 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF - Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, psychiatric disorders, neuro-muscular disorders, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds provided herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein. | 02-02-2012 |
| 20120226034 | PROCESS FOR PREPARING BENZAZEPINE COMPOUNDS OR SALTS THEREOF - This invention provides a process for preparing benzazepine compounds of the formula (1): | 09-06-2012 |
| 20130190490 | PROCESS FOR PREPARING TOLVAPTAN INTERMEDIATES - The present invention provides a novel process for the preparation of 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one. The present invention also provides an improved process for the preparation of 7-chloro-1-(2-methyl-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine. The present invention further provides an improved process for the preparation of 7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine. | 07-25-2013 |
| 20140066619 | PROCESS FOR THE PREPARATION OF 1 - (2-METHYL-4- (2,3,4,5-TETRAHYDRO-1-BENZAZEPIN-1-YLCARBONYL) BENZYLCARBAMOYL) - L - PROLINE - N, N-DIMETHYLAMIDE - The present invention relates to a new process for the preparation of a crystalline polymorph of a vasopressin V | 03-06-2014 |
| 20150112059 | PROCESS FOR THE PREPARATION OF A BENZAZEPINE DERIVATIVE - Provided is an industrially scalable process for the preparation of a benzazepine derivative, namely, 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methyl benzoyl amino) benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine (generically referred as Tolvaptan). | 04-23-2015 |
| 20150141641 | METHOD FOR PRODUCING 4,4,7-TRIFLUORO-1,2,3,4-TETRAHYDRO-5H-1-BENZAZEPINE COMPOUND AND INTERMEDIATE USED IN THE METHOD - The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art. | 05-21-2015 |
| 20150291533 | NOVEL BENZOAZEPINE DERIVATIVE AND MEDICAL USE THEREOF - A compound having a V2 receptor agonistic activity is provided. Providing a pharmaceutical composition which contains, as an active ingredient, a compound represented by general formula (I) described below: | 10-15-2015 |
| 540594000 | 3-Benzazepines (including hydrogenated) | 19 |
| 20080207897 | 6-Substituted-2,3,4,5-Tetrahydro-1H-Benzo[D] Azepines as 5-Ht2c Receptro Agonists - The present invention provides 6-substituted 2,3,4,5-tetrahydro- | 08-28-2008 |
| 20090143576 | Processes for the Preparation of 8-Chloro-1-Methyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine and Intermediates Related Thereto - The present invention provides processes, methods and intermediates for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, salts, hydrates and crystal forms thereof which are useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity. | 06-04-2009 |
| 20100016580 | Process for the preparation of functionalised benzocyclobutenes, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid - Process for the preparation of compounds of formula (IV): | 01-21-2010 |
| 20100145040 | Benzazepine Derivatives For The Treatment of Neurological Disorders - The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders. | 06-10-2010 |
| 20100197908 | Pyridazine Derivatives with MCH Antagonistic Activity and Medicaments Comprising These Compounds - The present invention relates to compounds of general formula I | 08-05-2010 |
| 20100216989 | METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES - The disclosure describes method of synthesis of substituted benzazepine derivatives. Preferred methods according to the disclosure allow for large-scale preparation of benzazepine compounds having low levels of metal impurities. In some embodiments, preferred methods according to the disclosure also allow for the preparation of benzazepine derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry. | 08-26-2010 |
| 20100305316 | PROCESSES FOR PREPARING (R)-8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND INTERMEDIATES THEREOF - The present invention provides processes and intermediates for the preparation of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and salts thereof which are useful as serotonin-2C (5-HT2C) receptor agonists for the treatment of, for example, obesity. | 12-02-2010 |
| 20110201805 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid - Process for the synthesis of ivabradine of formula (I): | 08-18-2011 |
| 20120283431 | PROCESSES FOR THE PREPARATION OF 8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND INTERMEDIATES RELATED THERETO - The present invention provides processes, methods and intermediates for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, salts, hydrates and crystal forms thereof which are useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity. | 11-08-2012 |
| 20130165648 | PROCESSES FOR PREPARING 3-BENZAZEPINES - The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity. | 06-27-2013 |
| 20130178619 | PROCESSES FOR THE PREPARATION OF 8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND INTERMEDIATES RELATED THERETO - The present invention provides processes, methods and intermediates for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, salts, hydrates and crystal forms thereof which are useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity. | 07-11-2013 |
| 20130178620 | PROCESSES FOR PREPARING 3-BENZAZEPINES - The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity. | 07-11-2013 |
| 20140005382 | NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND | 01-02-2014 |
| 20140336375 | ALLOSTERIC MODULATORS OF 5-HYDROXYTRYPTAMINE 2C RECEPTOR (5-HT2CR) - The disclosure is directed to compounds identified as allosteric modulators of 5-HT 2CR, as well as pharmaceutical compositions and methods using the same. Certain embodiments also include methods of identifying and methods of synthesizing the compounds. Optimization and development of allosteric 5-HT 2CR modulators that bind sites other than the primary ligand binding site generate novel, highly selective, and potent ligands of 5-HT2CR. Such molecules can be used as small molecule probes for the nervous system and as effective therapeutics for a variety of diseases. | 11-13-2014 |
| 20150038701 | PROCESSES FOR THE PREPARATION OF 8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND INTERMEDIATES RELATED THERETO - The present invention provides processes, methods and intermediates for the preparation of 8-chloro-1-methyl-2, 3,4,5-tetrahydro-1H-3-benzazepine, salts, hydrates and crystal forms thereof which are useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity. | 02-05-2015 |
| 20150045552 | 5HT2C RECEPTOR MODULATORS - The present invention relates to novel compounds of Formula (I): | 02-12-2015 |
| 20160024014 | 5HT2C RECEPTOR MODULATORS - The present invention relates to novel compounds of Formula (I): | 01-28-2016 |
| 20160185729 | PROCESSES FOR PREPARING 3-BENZAZEPINES - The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity. | 06-30-2016 |
| 540595000 | Benzene ring bonded directly to ring carbon of the hetero ring | 1 |
| 20140296514 | ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN - The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): | 10-02-2014 |
