| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 540555000 | Polycyclo ring system which contains the hetero ring as one of the cyclos | 29 |
| 20090270612 | Therapeutic Agent for Osteoporosis Using a Retinoid X Receptor-Related Compound - It is an object of the present invention to provide a novel therapeutic agent for osteoporosis. | 10-29-2009 |
| 540556000 | Two of the cyclos share at least three ring members or a ring member is shared by three of the cyclos (e.g., bridged, peri-fused, etc.) | 1 |
| 20130211073 | SYNTHETIC VOACANGINE - Synthetic voacangine, including in substantially enantiomerically enriched forms, and derivatives thereof are provided. | 08-15-2013 |
| 540557000 | Tricyclo ring system which contains the hetero ring as one of the cyclos | 18 |
| 20080234479 | Novel Process For Preparation of a Pharmaceutically Pure Polymorphic Form I of Olanzapine - The invention is directed to a novel method for making crystalline Form I of Olanzapine, wherein crude olanzapine is dissolved in a water-miscible solvent in which it is freely soluble, from which substantially pure polymorphic Form I of Olanzapine is recovered by precipitation. | 09-25-2008 |
| 20080312433 | Novel process to Form-I of olanzapine - A process for obtaining crystalline Form-I olanzapine comprising the following:
| 12-18-2008 |
| 20080319189 | Processes for the synthesis of olanzapine - There is provided a process for the preparation of olanzapine comprising:
| 12-25-2008 |
| 20090131658 | Process for preparing Olanzapine form I - An improved for preparing Olanzapine Form I of Formula 1 in the presence of one solvent or a mixture of solvents. | 05-21-2009 |
| 20090318683 | METHOD FOR PREPARING A MIXED SOLVATE OF OLANZAPINE - An improved method is provided for preparing a mixed solvate of olanzapine/water/tetrahydrofuran in a proportion of 1:1:1/2. Said improvement is characterised in that said mixed solvate is basically prepared by means of methylation of the N-desmethylolanzapine with dimethyl sulphate, using tetrahydrofuran and water as solvents. | 12-24-2009 |
| 20100174066 | PROCESS FOR PREPARING CRYSTALLINE FORM I OF OLANZAPINE - A process for preparing olanzapine Form I comprises: a) cooling a concentrated solution of olanzapine; b) isolating wet crystals of olanzapine Form I; and c) drying wet crystals and recovering olanzapine Form 1. Drying can be conducted by stepwise increases in the drying temperatures, with extended holding times at each temperature condition. | 07-08-2010 |
| 20100234590 | PROCESS FOR THE PURIFICATION NE OF OLANZAPINE - The present invention relates to a novel process for the preparation of pharmaceutically pure olanzapine. The invention is also related to impurities obtained during the preparation of pharmaceutically pure olanzapine and methods for the detection of the impurities. | 09-16-2010 |
| 20100317849 | Process For Producing Pure And Stable Form Of 2-Methyl-4-(4-Methyl-1-Piperazinyl) -10H-Thieno[2,3-B] [1,5] Benzodiazepine - Disclosed is an improved process for producing pure and thermally color stable crystalline Form I of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine and product thereof. The process comprises of reacting 2-(2-aminoanilino)-5-methylthiophene-3-carbonitrile with N-methyl piperazine in conjunction with N-methylpiperazine acid salt, to produce 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine. Also disclosed is a process for obtaining the Polymorphic Form I of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][l,5J benzodiazepine by crystallizing the crude 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine in a mixture of solvents. Further the invention also provides a new polymorph of Olanzapine, dihydrate Form Ji and process for its preparation and a new hydrate Form J | 12-16-2010 |
| 20110319610 | DIAZEPINEDIONE DERIVATIVE - A diazepinedione derivative represented by the formula (I) or a pharmacologically acceptable salt thereof is used as a P2X | 12-29-2011 |
| 20160002258 | Process for Preparation of Olanzapine Pamoate - An improved process for preparation of Olanzapine pamoate monohydrate from Olanzpaine is disclosed which comprises mixing at room temperature a solution of olanzapine prepared in water in presence of an acid, with a solution of pamoic acid prepared in water in presence of a base; stirring and maintaining the reaction mixture for a sufficient time till precipitation of solid and drying the solid to obtain olazapine pamoate monohydrate. | 01-07-2016 |
| 540558000 | Nitrogen of the hetero ring is shared by an additional cyclo of the tricyclo ring system | 8 |
| 20110275799 | PROCESS FOR THE SYNTHESIS OF 4H-IMIDAZO [1,5-a] [1,4] BENZODIAZEPINES, IN PARTICULAR MIDAZOLAM AND SALTS THEREOF - The present invention refers to a process for the preparation of 4H-imidazo[1,5-a][1,4]benzodiazepines, in particular Midazolam, through an efficient and selective decarboxylation reaction of the derivative compound of the 5-aminomethyl-1-phenyl-1H-imidazole-4-carboxylic acid of formula (II) | 11-10-2011 |
| 540560000 | Chalcogen in the tricyclo ring system | 2 |
| 20090093629 | PROCESS FOR PREPARATION OF TRIAZOL-BENZODIAZEPINE DERIVATIVES - An improved process for preparation of triazol-benzodiazepine derivatives, such as alprazolam, triazolam, brotizolam and etizolam, is presented. The process comprises a cyclization reaction of compound Formula B in toluene with catalytic amount of p-toluene sulphonic acid to obtain the triazol-benzodiazepine derivative of Formula C: | 04-09-2009 |
| 20160176916 | METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES | 06-23-2016 |
| 540561000 | The additional cyclo consists of one nitrogen and four carbons (e.g., diazepinoindoles, etc.) | 1 |
| 20220135594 | METHODS OF SYNTHESIS AND INTERMEDIATES - A method of synthesising a compound of formula (I) from a compound of formula (II) wherein R | 05-05-2022 |
| 540562000 | The additional cyclo consists of two nitrogens and three carbons (e.g., imidazobenzodiazepines, etc.) | 3 |
| 20120330007 | PROCESS FOR PREPARING 3-[(4S)-8-BROMO-1-METHYL-6-(2-PYRIDINYL)-4H-IMIDAZO[1,2-A][1,4]BENZODIAZE- PINE-4-YL]PROPIONIC ACID METHYL ESTER OR THE BENZENE SULFONATE SALT THEREOF, AND COMPOUNDS USEFUL IN THAT PROCESS - The invention concerns a new process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]-propionic acid methyl ester | 12-27-2012 |
| 20140081018 | METHOD FOR PREPARATION OF FLUORINE-18-LABELED FLUMAZENIL USING DIARYLIODONIUM SALT PRECURSOR - Disclosed is the synthesis of [ | 03-20-2014 |
| 20160009680 | OXIDATION REACTION EXCELLENT IN CONVERSION RATE | 01-14-2016 |
| 540563000 | s-Triazolo(4,3-a)(1,4)-benzodi-azepines (including hydrogenated) | 1 |
| 540566000 | The unshared ring carbon of the triazolo ring is unsubstituted or alkyl substituted only | 1 |
| 20150299210 | Benzodiazepine Bromodomain Inhibitor - Benzodiazepine compounds of formula (I) | 10-22-2015 |
| 540567000 | Bicyclo ring system which contains the hetero ring as one of the cyclos | 9 |
| 20120010402 | CGRP Receptor Antagonists - The disclosure generally relates to the novel compounds of formula I, including their salts, which are CGRP receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP related disorders including migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD). | 01-12-2012 |
| 20120083603 | HIGH STABILITY POLYIONIC LIQUID SALTS - Polyionic liquid salts are provided comprising polycationic or polyanionic molecules. Further provided are solvents comprising one or more polyionic liquid salts, and the use of such polyionic liquid salts as stationary phases in gas chromatography, and as a reagent in electrospray ionization-mass spectrometry (ESI-MS). | 04-05-2012 |
| 540568000 | At least three ring hetero atoms in the bicyclo ring system | 7 |
| 20090012288 | Process for preparation of pentostatin (R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidaz[4,5-d][1,3] diazepin-8-ol - In a process for preparing pentostatin, the improvement wherein reduction is performed on ketone prior to deprotection, comprising:
| 01-08-2009 |
| 20090018329 | NOVEL HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS, IN PARTICULAR AS ANTIBACTERIALS AND BETA-LACTAMASE INHIBITORS - The invention relates to novel heterocyclic compounds of general formula (I), and their salts with a base or an acid: | 01-15-2009 |
| 20090062529 | MULTI-CYCLIC COMPOUNDS - A compound represented by the formula (I): | 03-05-2009 |
| 20100222575 | POLO-LIKE KINASE INHIBITORS - The present invention relates generally to processes of making 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide and Form A of 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide. | 09-02-2010 |
| 20110009619 | POLYCYCLIC COMPOUND - Disclosed is a compound represented by the formula (I): | 01-13-2011 |
| 20120259112 | METHODS FOR THE SYNTHESIS OF POLYCYCLIC GUANIDINE COMPOUNDS - The present invention provides methods for the synthesis of polycyclic guanidine compounds. In certain embodiments, provided methods include the step of contacting a described reagent with a triamine compound to provide a polycyclic guanidine compound. | 10-11-2012 |
| 20140194622 | METHODS FOR THE SYNTHESIS OF POLYCYCLIC GUANIDINE COMPOUNDS - The present invention provides methods for the synthesis of polycyclic guanidine compounds. In certain embodiments, provided methods include the step of contacting a described reagent with a triamine compound to provide a polycyclic guanidine compound. | 07-10-2014 |
