| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 540519000 | Polycyclo ring system which contains the hetero ring as one of the cyclos | 34 |
| 540520000 | Two of the cyclos share at least three ring members or a ring member is shared by three of the cyclos (e.g., bridged, peri-fused, etc.) | 5 |
| 20100056777 | ANTIOXIDANT INFLAMMATION MODULATORS: OLEANOLIC ACID DERIVATIVES WITH SATURATION IN THE C-RING - This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: | 03-04-2010 |
| 20100093997 | FLUORINATED CATHARANTHINE DERIVATIVES, THEIR PREPARATION AND THEIR UTILISATION AS VINCA DIMERIC ALKALOID PRECURSORS - The fluorinated derivatives of catharanthine according to the invention respond to the general formula I: | 04-15-2010 |
| 20120271046 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING THE SAME - The present invention relates to 7-membered nitrogen-containing heterocyclic compounds and methods of making the same. Using a novel aza-[4+3] cycloaddition reaction, the 7-membered heterocyclic compounds are synthesized by reacting a first reactant and a second reactant. Exemplary first reactants and second reactants include α-halohydroxamates and dienes, respectively. | 10-25-2012 |
| 20130144053 | Process for the Production of Seven-Membered Lactam Morphinans - The present invention relates to improved processes for preparing lactam morphinans. The processes generally transform keto-morphinans to seven-membered lactam morphinans using a hydroxyamine sulfonic acid reagent and proceed in high yield and with good selectivity. | 06-06-2013 |
| 20150065703 | 7-MEMBERED FUSED HETEROCYCLES AND METHODS OF THEIR SYNTHESIS - Disclosed are a new method for synthesizing 7-membered fused heterocycles and compounds synthesized by the new method. The method involves a dual activation strategy using an N-heterocyclic carbene catalyst as a first Lewis base and another second Lewis base. Compounds synthesized by the disclosed method may include new benzoxopinone compounds, as well as benzoxepane compounds and benzoazepinone compounds that optionally may be derived from the disclosed benzoxopinone compounds. | 03-05-2015 |
| 540521000 | Plural hetero atoms in the polycyclo ring system | 2 |
| 20080306257 | Syntheses and Preparations of Narwedine and Related Novel Compounds - The present invention relates to a process for preparing racemic narwedine (which can be can be kinetically resolved) to yield (−)-narwedine and which is the biogenic precursor of (−)-galanthamine) and the use thereof as a starting material for producing (−)-galanthamine. The invention further includes processes for preparing (−)-galanthamine and (−)-galanthamine hydrobromide, as well as related novel compounds. | 12-11-2008 |
| 20100234588 | SYNTHETIC METHOD FOR CERATAMINE A AND B AND ANALOGS THEREOF - Methods are provided for preparing compounds of the general formula (I) | 09-16-2010 |
| 540522000 | Tricyclo ring system which contains the hetero ring as one of the cyclos | 2 |
| 20080293933 | PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE COMPOUNDS - The invention relates to a process for the optical resolution of a dibenzo[b,d]azepinone derivative of formula II, | 11-27-2008 |
| 20090247744 | HYDROFORMYLATION PROCESS FOR PHARMACEUTICAL INTERMEDIATE - The invention relates to an improved process for the preparation of an advanced synthetic intermediate of ACE inhibitors. In one aspect, the present invention is based on a novel process for the preparation of an aldehyde of formula (I), wherein (N) | 10-01-2009 |
| 540523000 | Bicyclo ring system which contains the hetero ring as one of the cyclos | 25 |
| 20090082559 | Process for Crystallization of Benazepril Hydrochloride - An improved process for the crystallization of benazepril hydrochloride to obtain in at least 99.8% diastereomeric purity. The process comprises making a concentrated solution of benazepril hydrochloride in ethanol and adding the resulting solution to a non-solvent diisopropyl ether. | 03-26-2009 |
| 20090306369 | PROCESS FOR PREPARING BENZAZEPINE COMPOUNDS OR SALTS THEREOF - This invention provides a process for preparing benzazepine compounds of the formula (1): wherein X | 12-10-2009 |
| 20090318682 | Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid - Process for the synthesis of the compound of formula (I): | 12-24-2009 |
| 20100056778 | Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl) nitrile and application in the synthesis of ivabradine - Process for the optical resolution of the compound of formula (I): | 03-04-2010 |
| 20100160628 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid - Process for the synthesis of ivabradine of formula (I): | 06-24-2010 |
| 20100179316 | PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND POLYMORPH THEREOF - The present invention encompasses a process for the preparation of highly pure ivabradine hydrochloride by treating ivabradine with alcoholic hydrogen chloride. The invention further encompasses amorphous ivabradine hydrochloride and process for its preparation using suitable acid addition salts of ivabradine. | 07-15-2010 |
| 20100249396 | BENZAZEPINONE COMPOUND - The present invention relates to a benzazepinone compound represented by the following formula (I): | 09-30-2010 |
| 20100249397 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid - Process for the synthesis of ivabradine of formula (I): | 09-30-2010 |
| 20100249398 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid - Process for the synthesis of ivabradine of formula (I): | 09-30-2010 |
| 20110015390 | PROCESS - The present invention generally relates to a novel process for preparing vitronectin receptor antagonist compounds having a benzodiazepinyl core structure. This invention relates to the preparation of pharmaceutically active compounds which inhibit the vitronectin receptor and are useful for treatment of inflammation, cancer and cardiovascular disorders, such as atherosclerosis and restenosis, and diseases wherein bone resorption is a factor, such as osteoporosis. In particular, the present invention relates to a novel process for preparing (±)-3-oxo-8-{[3-(pyridin-2-ylamino)propyl]oxy}-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid, (R)-3-oxo-8-{[3-(pyridin-2-ylamino)propyl]oxy}-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid and (S)-3-oxo-8-{[3-(pyridin-2-ylamino)propyl]oxy}-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid or a pharmaceutically acceptable salt thereof. | 01-20-2011 |
| 20110294999 | PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID - Process for the synthesis of ivabradine of formula (I): | 12-01-2011 |
| 20120095215 | MEDICAL COMPOSITION FOR TREATMENT OR PROPHYLAXIS OF EYE DISEASES - The present invention is to provide a medical composition for the treatment or prophylaxis of diseases caused by angiogenesis of eyes which comprises a compound represented by the following formula (I): | 04-19-2012 |
| 20120172589 | PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID - Process for the synthesis of ivabradine of formula (I): | 07-05-2012 |
| 20120208996 | PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID - Process for the synthesis of ivabradine of formula (I): | 08-16-2012 |
| 20130158256 | PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID - Process for the synthesis of ivabradine of formula (I): | 06-20-2013 |
| 20130158257 | PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID - Process for the synthesis of ivabradine of formula (I): | 06-20-2013 |
| 20130211070 | NEW PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF (3,4 DIMETHOXY-BICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL)NITRILE AND APPLICATION IN THE SYNTHESIS OF IVABRADINE - Process for the optical resolution of the compound of formula (I): | 08-15-2013 |
| 20130261298 | PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID - Process for the synthesis of ivabradine of formula (I): | 10-03-2013 |
| 20140107334 | PROCESS FOR THE SYNTHESIS OF 3-(2-BROMO-4,5-DIMETHOXYPHENYL)PROPANENITRILE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID - Process for the synthesis of the compound of formula (I): | 04-17-2014 |
| 20140128598 | PROCESS FOR THE SYNTHESIS OF (2E)-3-(3,4-DIMETHOXYPHENYL)PROP-2-ENENITRILE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID - Process for the synthesis of the compound of formula (I): | 05-08-2014 |
| 20140163220 | PROCESS FOR THE SYNTHESIS OF 3-(2-BROMO-4,5-DIMETHOXYPHENYL)PROPANENITRILE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID - Process for the synthesis of the compound of formula (I): | 06-12-2014 |
| 20140296512 | PROCESS FOR THE SYNTHESIS OF 7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE COMPOUNDS, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE - Process for the synthesis of the compound of formula (I): | 10-02-2014 |
| 20140357859 | PROCESS FOR THE MANUFACTURE OF IVABRADINE AND OF INTERMEDIATES OF SYNTHESIS THEREOF - The invention concerns a new process for the resolution of ivabradine and of intermediates of synthesis thereof. | 12-04-2014 |
| 20140357860 | SALT OF IVABRADINE WITH ADIPIC ACID - The present invention relates to pharmaceutical compositions with delayed release which contain ivabradine adipate as active substance. The present invention furthermore relates to processes for the preparation of this composition and certain salts of ivabradine. | 12-04-2014 |
| 20160107998 | A PROCESS FOR PREPARING IVABRADINE - The invention refers to a process for preparing ivabradine, in particular a process for preparing an ivabradine salt. | 04-21-2016 |
