| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 540492000 | Plural nitrogens in the hetero ring | 52 |
| 20090264645 | Benzoimidazole compounds - Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H | 10-22-2009 |
| 20090270611 | Benzoimidazole compounds - Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H | 10-29-2009 |
| 20110092698 | NOVEL HETEROCYCLYL COMPOUNDS - The invention is concerned with novel bicyclic compounds of formula (I), | 04-21-2011 |
| 20110166342 | 7-MEMBERED RING COMPOUND AND METHOD OF PRODUCTION AND PHARMACEUTICAL APPLICATION THEREOF - A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: | 07-07-2011 |
| 20120259111 | SEVEN-MEMBERED RING COMPOUND AND PHARMACEUTICAL USE THEREFOR - A compound having a 7-membered nitrogen-containing ring skeleton represented by the formula (I), which is useful for the prevention or treatment of diseases, in which chymase is involved | 10-11-2012 |
| 20130012700 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES - The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices. | 01-10-2013 |
| 20130172549 | Heteroaryl amide derivatives - Heteroaryl amide derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies. | 07-04-2013 |
| 20130296551 | 7-MEMBERED RING COMPOUND AND METHOD OF PRODUCTION AND PHARMACEUTICAL APPLICATION THEREOF - A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: | 11-07-2013 |
| 20150322063 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF - A compound represented by Formula [1] (in the formula, Z | 11-12-2015 |
| 540493000 | Tetracyclo ring system having the hetero ring as one of the cyclos | 4 |
| 540494000 | Nitrogen of the hetero ring is shared by an additional cyclo of the tetracyclo ring system | 4 |
| 20130317211 | Pyrrolo[2,1-c][1,4]naphthodiazepine Linked Piperazine Compounds and a Process for the Preparation Thereof - The present invention provides a compound of general formula A, useful as potential antitumour agents against five human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]naphthodiazepine linked substituted piperazine conjugates attached through different alkane spacers of general formula A. (Formula I) General formula A. Where R=R′=(Formula II). n=1-9 and R″=methyl, ethyl, acetyl, benzyl, piperinoyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, pyridyl, pyrimidyl | 11-28-2013 |
| 20150099874 | CYTOTOXIC BENZODIAZEPINE DERIVATIVES - The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. | 04-09-2015 |
| 20170233392 | HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING | 08-17-2017 |
| 20170233436 | BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING | 08-17-2017 |
| 540495000 | Tricyclo ring system having the hetero ring as one of the cyclos | 25 |
| 20090203901 | Process for preparing pyrazole functionalized benzodiazepinones - The present invention provides innovative strategies for synthesizing pyrazole ring-functionalized benzodiazepinones. Alternative intermediates and high conversion strategies for forming alpha-aminobenzophenone intermediates involve a combination of aromatic acylation, displacement of electronegative leaving groups with amine, and then N-displacement strategies to produce the desired alpha-aminobenzophenone with primary amine functionality. Reaction strategies are then provided for converting alpha-aminobenzophenones to alpha-aminoamidobenzophenone intermediates with high yield and convenient reaction strategies. These alpha-aminoamidobenzophenone intermediates are then converted into benzodiazepinones. These benzodiazepinones are then converted to pyrazole ring functionalized benzodiazepinones through a series of innovative intermediates and/or reaction strategies. | 08-13-2009 |
| 20100125137 | Process for preparing Nevirapine - An improved process for preparing 11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one of Formula (I). | 05-20-2010 |
| 20100204468 | PROCESS FOR PRODUCING FARNESYLATED DIBENZODIAZEPINONE BY FERMENTATION - The present invention provides a scalable process for producing a concentrate containing a mass of a farnesylated dibenzodiazepinone by fermenting in an aqueous culture medium a strain of a microorganism that is capable of producing the farnesylated dibenzodiazepinone, upon completion of fermentation harvesting the fermentation broth and extracting the fermentation broth to provide an extract, and thereafter treating the extract to form the concentrate. The concentrate so produced may be utilized in downstream processes for producing pharmaceutical compounds. A strain of a | 08-12-2010 |
| 20100228023 | ONE STEP PROCESS FOR THE PREPARATION OF SUBSTITUTED 5, 10-DIHYDRODIBENZO [b,e][1, 4]DIAZEPINE-11-ONES - The present invention provides one step processes for the preparation of substituted dibenzo[b,e][1,4]-diazepine-11-ones by the reaction of substituted isatoic anhydrides with substituted 1,2-phenylenediamines in the presence of aqueous acetic acid. | 09-09-2010 |
| 20120116073 | P2X4 RECEPTOR ANTAGONIST - A compound having the following formula (II) or its pharmacologically acceptable salt is used as a P2X | 05-10-2012 |
| 20120271045 | METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS - A method of preparing a compound represented by Structural Formula (I): | 10-25-2012 |
| 20130172550 | P2X4 RECEPTOR ANTAGONIST - A diazepine derivative having the following formula (III) or a pharmacologically acceptable salt thereof is used as A P2X | 07-04-2013 |
| 20140357858 | P2X4 RECEPTOR ANTAGONIST - The present invention relates to a diazepine derivative represented by the following general formula (I) (in the formula, R | 12-04-2014 |
| 540496000 | Nitrogen of the hetero ring is shared by an additional cyclo of the tricyclo ring system | 17 |
| 20100113771 | NOVEL BENZOTHIAZOLE AND BENZOXAZOLE LINKED PYRROLO[2,1-C] [1, 4] BENZODIAZEPINE HYBRIDS AS NOVEL ANTITUMOUR AGENTS AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides a compound of general formula (9), useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4][benzodiazepine g hybrids of general formula (9). | 05-06-2010 |
| 20110196148 | UNSYMMETRICAL PYRROLOBENZODIAZEPINE-DIMERS FOR TREATMENT OF PROLIFERATIVE DISEASES - Claimed are unsymmetrical Pyrrolobenzodiazepine-dimers (PBD-dimers) of formula (I), that are unsymmetrical due at least to the values that the variables R | 08-11-2011 |
| 20110201803 | PYRROLOBENZODIAZEPINES - The invention relates to certain pyrrolobenzodiazepines (PBDs), and in particular pyrrolobenzodiazepine dimers bearing C2 substitutions, including compounds of formula (T): wherein: R | 08-18-2011 |
| 20110207924 | NEW PHENANTHRYLPHENOL LINKED PYRROLO [2, L-C] [L, 4] BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTITUMOUR AGENTS AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides a compounds of general formula (6), useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine hybrids of general formula (6). | 08-25-2011 |
| 20120095213 | CINNAMIDO-PYRROLO[2,1-C][1,4]BENZODIAZEPINES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides a compound of general formulae (8a-i), (11a-i), (14a-i), and (17a-i), useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of Cinnamido-pyrrolo[2,1-c][1,4]benzodiazepines of general formulae (8a-i), (11a-i), (14a-i), and (17a-i). | 04-19-2012 |
| 20120095214 | QUINAZOLINONE LINKED PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides a compound of general formulae 5a-r, 9a-i to 13a-i and 17a-i to 22a-i, useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine hybrids of general formulae 5a-r, 9a-i to 13a-i and 17a-i to 22a-i. | 04-19-2012 |
| 20120101270 | NOVEL PYRROLO[2,1-C][1,4] BENZODIAZEPINE DERIVATIVES WITH DITHIOCARBAMATE SIDE CHAINS AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides synthesis and in vitro anticancer activity of novel pyrrolo[2,1-c][1,4]benzodiazepine derivatives with dithiocarbamate side chains. The present invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine derivatives with dithiocarbamate side chains of general formula (A) and a process for the preparation thereof. | 04-26-2012 |
| 20120142913 | BENZYLIDINEANTHRACENONE LINKED PYRROLOBENZODIAZEPINE HYBRIDS USEFUL AS ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides a compound of formula 5, useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine hybrids of formula 5a-t. | 06-07-2012 |
| 20120253034 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE LINKED IMIDAZO[1,5-A]PYRIDINE CONJUGATES AS POTENTIAL ANTITUMOUR AGENTS AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides a compound of general formula 7, useful as potential antitumour agents against five human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine linked imidazo[1,5-a]pyridine conjugates attached through a piperazine moiety and different alkane spacers of general formula 7 | 10-04-2012 |
| 20120316335 | PYRROLO[2,L-C][L,4]BENZODIAZEPINE-BENZOTHIAZOLE OR BENZOXAZOLE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR THE PREPARATION THEREOF - A compound of general formula 9, useful as potential antitumour agents against human cancer cell line and a process for the preparation of Pyrrolo[2,1-c] [1,4]benzodiazepine-benzothiazole or benzoxazole conjugates linked through piperazine of general formula 9 wherein: R, R | 12-13-2012 |
| 20130035484 | INTERMEDIATES USEFUL FOR THE SYNTHESIS OF PYRROLOBENZODIAZEPINES - A compound of formula (I): which is substantially free of any of the corresponding compound of formula (IB): methods of making such compounds, and the further transformation of such compounds. | 02-07-2013 |
| 20130131336 | CARBAZOLE LINKED PYRROLO[2,1-C][1,4]BENZODIAZEFINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides a compound of general formulae A useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine hybrids of general formulae 6a-g, 10a-o, 14a-g and 18a-o. | 05-23-2013 |
| 20140155590 | Conjugates of Pyrrolo[1,4]Benzodiazepine Dimers As Anticancer Agents - The present invention relates to pyrrolo[1,4]benzodiazepine (PBD) dimer conjugates, to the compositions comprising them and to their therapeutic application, in particular as anticancer agents. The invention also relates to the process for the preparation of the conjugates, to their application as anticancer agents and to the dimers themselves. | 06-05-2014 |
| 540497000 | Additional hetero atom in the additional cyclo of the tricyclo ring system | 4 |
| 540498000 | The additional cyclo is five-membered consisting of nitrogen and carbon (e.g., imidazobenzodiazepinones, etc.) | 4 |
| 20110196149 | FLUORIDATION METHOD - A method for the fluoridation of an iodonium salt with a fluoride ion source which can be carried out in an aqueous reaction solvent. | 08-11-2011 |
| 20120190843 | AUTOMATED RADIOSYNTHESIS - The present invention provides a method to obtain radiofluorinated compounds useful for in vivo imaging GABA | 07-26-2012 |
| 20160016958 | Method of Labeling Flumazenil with F-18 and Separating and Purifying F-18-Flumazenil - Flumazenil (FMZ) is labeled with fluorine(F)-18 to obtain F-18-flumazenil. F-18-flumazenil can be strongly combined with type-A acceptor of gamma-aminobutyric acid (GABA | 01-21-2016 |
| 540499000 | The additional cyclo consists of three nitrogens and two carbons (e.g., triazolobenzodiazepinones, etc.) | 1 |
| 20120149898 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES - The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. | 06-14-2012 |
| 540500000 | Bicyclo ring system having the hetero ring as one of the cyclos | 14 |
| 20080227976 | PROCESS FOR SYNTHESIZING ASPARTIC AND GLUTAMIC ACID DERIVATIVES ESPECIALLY USEFUL AS INTERMEDIATES IN THE MANUFACTURE OF A CASPASE INHIBITOR - The invention relates to novel diazoketone derivatives. The invention also relates to processes for homologation of these diazoketone derivatives. The processes are useful for preparing compounds that are caspase inhibitors. | 09-18-2008 |
| 20100152439 | PRODUCTION METHOD - The present invention relates to a process for preparing compounds of general formula I | 06-17-2010 |
| 20110071286 | NOVEL PREPARATION PROCESS - A process for preparing compounds of the formula (I) | 03-24-2011 |
| 20110082294 | NOVEL BICYCLIC COMPOUNDS - The invention is concerned with novel bicyclic compounds of formula (I), | 04-07-2011 |
| 20110087021 | NOVEL PREPARATION PROCESS - A process for preparing compounds of the formula (I) | 04-14-2011 |
| 20120238749 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME - The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against interleukin-1 mediated diseases, including inflammatory diseases, autoimmune diseases and neurodegenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interleukin-1 mediated diseases using the compounds and compositions of this invention. | 09-20-2012 |
| 540504000 | The bicyclo ring system is 1,4-benzodiazepine (including hydrogenated) | 4 |
| 20120165519 | Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors - The present invention provides a compound of formula I or II | 06-28-2012 |
| 540509000 | Acyclic nitrogen bonded directly to the hetero ring | 2 |
| 20140100365 | BISFLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS - Disclosed are compounds of Formula (I) or prodrugs thereof; | 04-10-2014 |
| 20160060232 | BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS - Disclosed are compounds of Formula (I) or prodrugs thereof; | 03-03-2016 |
| 540514000 | Nitrogen in the 1-position substituent of the bicyclo ring system | 1 |
| 20110245492 | NOVEL ALLELIC VARIANT OF CYP2C19 ASSOCIATED WITH DRUG METABOLISM - The invention provides methods, PCR primers and sequence determination oligonucleotides for determining a human's capacity to metabolise a substrate of the CYP2C19 enzyme using genetic analysis. | 10-06-2011 |
| 540517000 | The bicyclo ring system is 1,5-benzodiazepine (including hydrogenated) | 4 |
| 20120010401 | METHOD FOR MANUFACTURING 1,5-BENZODIAZEPINE DERIVATIVE - An industrially advantageous method for producing a 1,5-benzodiazepine compound is provided. | 01-12-2012 |
| 540518000 | Additional chalcogen double bonded directly to ring carbon of the hetero ring | 3 |
| 20120149899 | PROCESS FOR PRODUCING BENZO[B][1,4]DIAZEPINE-2,4-DIONE COMPOUND - The present invention provides an industrially advantageous, simple, and efficient process for producing a key intermediate of a benzo[b][1,4]diazepine-2,4-dione compound, which is a therapeutic medicine for arrhythmia. | 06-14-2012 |
| 20140194621 | PROCESS FOR PRODUCING BENZO [B] [1,4] DIAZEPINE-2, 4-DIONE COMPOUND - A process for producing a compound represented by formula (1), | 07-10-2014 |
| 20140343278 | NITROGEN-CONTAINING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF ATRIAL FIBRILLATION - The present invention provides a novel diazepine compound that blocks the I | 11-20-2014 |
