| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 540460000 | Plural nitrogens in the hetero ring | 33 |
| 20090105471 | MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION - The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. | 04-23-2009 |
| 20090111982 | MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION - The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. | 04-30-2009 |
| 20090156799 | Methods of making dyes - Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens. | 06-18-2009 |
| 20090156800 | PROCESS FOR MAKING MACROCYCLIC OXIMYL HEPATITIS C PROTEASE INHIBITORS - The present invention relates to a process for the preparation of macrocyclic compounds that are useful as hepatitis C virus (HCV) protease inhibitor compounds. | 06-18-2009 |
| 20090312541 | Process for preparing pharmaceutical compound and intermediates thereof - The present invention relates to novel intermediates of formula VII, | 12-17-2009 |
| 20100010215 | Introverted CB[N] Compounds - Inverted cucurbituril compounds having at least one pair of hydrogen atoms protruding into an internal molecular cavity thereof. | 01-14-2010 |
| 20100016578 | MACROCYCLIC SERINE PROTEASE INHIBITORS - Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof. | 01-21-2010 |
| 20100022767 | DEVELOPMENT OF A SYNTHESIS OF SYRINGOLIN A AND B AND DERIVATIVES THEREOF - The synthesis of syringolin A and B and derivatives thereof as well as to pharmaceutical compositions containing the syringolin A or B or derivatives thereof and the use of syringolin A and B and derivatives thereof for prophylaxis and treatment of cancer. | 01-28-2010 |
| 20100022768 | Reactive 1,3'-crosslinked carbocyanines and their bioconjugates - Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens. | 01-28-2010 |
| 20100036116 | Process for the preparation of a macrocycle - The present invention relates to a new process for the preparation of macrocyclic HCV protease inhibitor compounds of the formula | 02-11-2010 |
| 20100152438 | AMPHIPHILIC MOLECULAR MODULES AND CONSTRUCTS BASED THEREON - The present invention relates to the preparation of synthons that are used to form modules that, in turn, are used to form two-dimensional close-packed planar arrays, referred to as nanomembranes. In a presently preferred embodiment, a nanomembrane herein constitutes a filter. | 06-17-2010 |
| 20100168415 | Process for preparation of Caspofungin acetate - A process for making caspofungin acetate comprising the steps of:
| 07-01-2010 |
| 20100222574 | CYCLIC ANILINO - PYRIDINOTRIAZINES - The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m represents 1, n represents 1, Z represents N or C, in particular N; —X | 09-02-2010 |
| 20110040087 | PEPTIDE TURN MIMETICS - Peptide mimetics of structure X herein which (i) provide a wide range of sidechain functions at all sidechain positions, (ii) can be incorporated in a peptide sequence, (iii) can be readily synthesized and (iv) have a variety of conformations. There is also provided a novel process which can provide valuable intermediates in relation to production of peptide mimetics of structure X which intermediates have a high degree of chemo- and stereo-selectivity. Preferred mimetics include structures I, II, III, IV, V and VI. | 02-17-2011 |
| 20110263844 | METHOD FOR PREPARING MACROCYCLES - The present invention is directed to a method for the preparation of macrocyclic compounds of formula (I), | 10-27-2011 |
| 20120041191 | PHOSPHINATE RUTHENIUM COMPLEXES - Provided herein are ruthenium complexes of Formula (I), and processes of preparation thereof. Also provided are methods of their use as a metathesis catalyst. | 02-16-2012 |
| 20120041192 | MACROCYCLIC DERIVATIVES OF GLYCOLURILS, AND METHODS OF PREPARING AND USING THE SAME - The present invention relates to novel macrocyclic derivatives of glycolurils of general formula I, and methods of their preparation. These novel derivatives can be used for the selective removing of various compounds from solutions in polar and nonpolar solvents, and from water, e.g. for water purification and desalination, also for separation of liquid mixtures and mixtures of gases and organic solvent vapors, preparation of ion-exchange materials and materials which are used as stationary phase in chromatography, construction of sensors, transport and targeting of drugs in organisms, and also preparation of materials bearing aromatic or curative compounds. | 02-16-2012 |
| 20120095211 | SUBSTITUTED PROLINE INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IIIb, IV, IVa, IVb, V, Va, Vb, VI, VIa, VIb, and VIc, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. The embodiments also provide methods for the synthesis of subject compounds and intermediates in the synthetic methods. | 04-19-2012 |
| 20120142912 | POLYCYCLIC COMPOUNDS, TERMED CALIXURENES, AND USES THEREOF - Disclosed is a novel family of macrocyclic compounds, coined calixurenes, which comprises linear and cyclic oligomers composed of alternating moieties of an aromatic unit and a ureatic unit, linked to one another via a bridging moiety. | 06-07-2012 |
| 20120149895 | PROCESS FOR DIMETHYLATION OF ACTIVE METHYLENE GROUPS - The present invention discloses a process for dimethylation of active methylene groups. Specifically, the invention discloses a process for preparing 3-amino-2,2-dimethylpropanamide. Compounds produced by the present dimethylation process such as 3-amino-2,2-dimethylpropanamide can be used as intermediates in the route of synthesis of therapeutic, prophylactic or diagnostic agent, for example aliskiren or cryptophycin. Particularly, the invention relates to embodiments further extending to processes for preparing pharmaceutical dosage form comprising said therapeutic, prophylactic or diagnostic agents. More specifically, the invention relates to the use of compounds produced by the present dimethylation process for the manufacture of therapeutic, prophylactic or diagnostic agents or for the manufacture of pharmaceutical dosage forms comprising said therapeutic, prophylactic or diagnostic agents. The processes according to the present invention can be beneficially applied for the synthesis of various active pharmaceutical ingredients, such as aliskiren or crypthophycin. | 06-14-2012 |
| 20120238745 | Fluorescent dyes - Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens. | 09-20-2012 |
| 20120238746 | Processes and Intermediates for Preparing a Macrocyclic Protease Inhibitor of HCV - The present invention relates to synthesis procedures and intermediates of a compound of formula: | 09-20-2012 |
| 20120296085 | CHEMILUMINESCENT DYES AND DYE-STAINED PARTICLES - Chemiluminescent compounds that can be activated by reaction with chemical or photochemical sources of singlet oxygen are provided. At certain temperatures, such as from approximately 15 to 60° C., the compounds slowly return to their deactivated state by emitting visible and/or infrared light that is observable with various types of light detectors. Suitable conjugates of these compounds, or small particles containing these compounds, may be used for chemiluminescence imaging and sensing technologies. In particular, embodiments provide optical molecular imaging using novel squaraine rotaxane endoperoxides (SREPs) and squaraine catenane endoperoxides (SCEPs), interlocked fluorescent and chemiluminescent dye molecules that have a squaraine chromophore encapsulated inside a macrocycle endoperoxide. The dyes may be stored at low temperature, such as below 0° C., but, upon warming above 15° C., such as to body temperature, they undergo a unimolecular cycloreversion reaction that releases singlet oxygen and emits visible or near-infrared light that can pass through living tissue. The chemiluminescent signal is detectable with inherently high contrast because there is negligible background emission. | 11-22-2012 |
| 20120309961 | DIAZO BICYCLIC SMAC MIMETICS AND THE USES THEREOF - The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis. | 12-06-2012 |
| 20130102774 | THIONATION PROCESS AND A THIONATING AGENT - A process for transforming a group >C═O (I) in a compound into a group >C═S (II) or into a tautomeric form of group (II) in a reaction giving a thionated reaction product, by use of crystalline P | 04-25-2013 |
| 20130150572 | PHOSPHINATE RUTHENIUM COMPLEXES - Provided herein are ruthenium complexes of Formula I, and processes of preparation thereof. Also provided are methods of their use as a metathesis catalyst. | 06-13-2013 |
| 20130267698 | PHOSPHINATE RUTHENIUM COMPLEXES - Provided herein are ruthenium complexes of Formula I, and processes of preparation thereof. Also provided are methods of their use as a metathesis catalyst. | 10-10-2013 |
| 20140058082 | INTERMEDIATE FOR SYNTHESIZING CASPOFUNGIN AND PREPARATION METHOD THEREOF - The present invention relates to an intermediate, as represented by formula (I), for synthesizing caspofungin, and a preparation method thereof. The intermediate enables efficient preparation of caspofungin. | 02-27-2014 |
| 20140163219 | HCV Protease Inhibitors - A compound of general formula (I); | 06-12-2014 |
| 20140275520 | PROCESS FOR MAKING A 4-AMINO-4-OXOBUTANOYL PEPTIDE CYCLIC ANALOGUE, AN INHIBITOR OF VIRAL REPLICATION, AND INTERMEDIATES THEREOF - The invention provides a process of preparing 4-amino-4-oxobutanoyl peptides and cyclic analogues thereof of Compound I | 09-18-2014 |
| 20140323717 | Methods for Preparing Functional Tetraazacycloalkane Compounds using a Specific Cyclic Bisaminal Compound - Special C-functionalized cyclic bisaminal compounds having formula (I) or (II), their salts or solvates, methods for their preparation, their uses, and methods for preparing functional tetraazacycloalkane compounds implementing such cyclic bisaminal compounds. | 10-30-2014 |
| 20140350241 | PHOSPHINATE RUTHENIUM COMPLEXES - Provided herein are ruthenium complexes of Formula I, and processes of preparation thereof. Also provided are methods of their use as a metathesis catalyst. | 11-27-2014 |
| 20160108007 | SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS - The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs. | 04-21-2016 |
