| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 540002000 | Cyclopentanohydrophenanthrene ring system containing | 86 |
| 540003000 | Heavy metal or aluminum containing | 1 |
| 20110201802 | Novel Compound and Functional Luminescent Probe Comprising the Same - Disclosed is a compound characterized by comprising a linker, an oxygen-concentration-responsive phosphorophore which is linked to a first end of the linker, and a fluorophore which is lined to a second end of the linker. In the compound, it is preferred that the triplet level of the phosphorophore be lower than that of the fluorophore. The compound can be used as an oxygen-responsive luminescent probe. | 08-18-2011 |
| 540005000 | Phosphorus attached directly or indirectly to the cyclopentanohydrophenanthrene ring system by nonionic bonding | 1 |
| 20090286973 | LIGAND-CONJUGATED MONOMERS - This invention relates composition and methods for making and using chemically modified oligonucleotides agents for inhibiting gene expression. | 11-19-2009 |
| 540006000 | Spiro | 23 |
| 540007000 | Plural spiro atoms | 3 |
| 20140364600 | IMIDAZOLYL PROGESTERONE ANTAGONISTS - Described herein are imidazolyl compounds which either act as pure antiprogestins and methods of using such pure antagonists for gynecological indications and breast cancer. | 12-11-2014 |
| 20150031875 | COMBINED SYNTHESIS ROUTE FOR DESOGESTREL AND ETONOGESTREL - The present invention relates to a synthesis route and to steroid derivatives of general formula VI and VII useful in the synthesis of desogestrel and etonogestrel. | 01-29-2015 |
| 540008000 | The cyclopentanohydrophenanthrene ring system is part of a polycyclo ring system having at least five cyclos | 1 |
| 20100048887 | COMPOUNDS INCLUDING AN ANTI-INFLAMMATORY PHARMACORE AND METHODS OF USE - This invention provides novel compounds comprising the following anti-inflammatory pharmacore: | 02-25-2010 |
| 540015000 | The cyclopentanohydrophenanthrene ring system is part of a polycyclo ring system having at least five cyclos | 15 |
| 20100261896 | METHODS FOR THE PREPARATION OF DROSPIRENONE - Described herein are methods of making drospirenone. Also described are intermediate compounds that may be used to synthesis drospirenone. | 10-14-2010 |
| 20110275796 | Process for the Production of 3-Oxo-pregn-4-ene-21,17-carbolactones by the Metal-Free Oxidation of 17-(3-Hydroxypropyl)-3,17-dihydroxyandrostanes - This invention relates to processes for the production of 3-oxo-pregnane-21,17-carbolactones of formula II | 11-10-2011 |
| 20120316333 | PREPARATION METHOD OF DROSPIRENONE - The present invention discloses the preparation method of drospirenone. 3β,5-dyhydroxy-6β,7β,15β,16β-dimethylene-5β-androstane-17,20-epoxy is taken as the raw material. It is subject to oxidization of the hydroxyl at the 3 | 12-13-2012 |
| 20130030169 | Process for the Preparation of Drospirenone - A process is described, comprising the oxidation of 17α-(3-hydroxypropyl)-6β,7β,15β,16β-dimethylen-5β-androstan-3β,5,17β-triol, for the preparation of drospirenone, a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for preparing pharmaceutical compositions with contraceptive action. | 01-31-2013 |
| 20130131335 | METHODS FOR THE PREPARATION OF DROSPIRENONE AND INTERMEDIATES THEREOF - The invention relates to a process for the preparation of Drospirenone in high yields and purity starting from a compound of formula 2 | 05-23-2013 |
| 20140343275 | PROCESS FOR THE PREPARATION OF DROSPIRENONE - It is described of a process for the preparation of drospirenone, the compound of formula 1 shown below, a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for preparing pharmaceutical compositions having contraceptive action, starting from 17α-(3-hydroxypropyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-trioI. | 11-20-2014 |
| 20160002284 | Process for the Preparation of Drospirenone - A process is described wherein, by employing 17α-(3-hydroxypropyl) -63,7β3;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol (II) as starting product, in a single stage reaction there is obtained drospirenone, (I), whereby the reaction is achieved using gaseous oxygen as the stoichiometric oxidant in the presence of a catalytic system containing (i) TEMPO or a derivative thereof (ii) a ferric salt (Fe3+) and (iii) NaCl. The product drospirenone is a known synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic action, that is useful for preparing pharmaceutical compositions with contraceptive action. | 01-07-2016 |
| 20160052960 | PROCESS FOR THE PREPARATION OF DROSPIRENONE - A process is disclosed wherein, using either 17a-(3-hydroxypropyl)-6p,7p;15p,16p-dimethylene-5p-androstane-3p,5,17p-triol (II) or 3β,5̂iÎκ̂-6β,7β;15β,16β-dimethylene-5β,17α-pregnane-21,17-carbolactone (III) as starting material, through a single-step reaction it is obtained drospirenone (I), a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for preparing pharmaceutical compositions with contraceptive action. | 02-25-2016 |
| 540016000 | Hetero ring is one of the cyclos of the polycyclo ring system | 7 |
| 540017000 | The hetero ring is five-membered, consisting of one oxygen and four carbons, and shares the spiro atom with a six-membered oxygen containing hetero ring (e.g., sapogenins, etc.) | 2 |
| 20110144323 | AMORPHOUS AND CRYSTALLINE FORMS OF SMILAGENIN AND ITS HYDRATES - The invention provides smilagenin in novel amorphous, crystalline, hydrated and solvated forms, and the use thereof in manufacturing pharmaceutical or edible grade smilagenin and its derivatives. | 06-16-2011 |
| 540022000 | Halogen, cyano, nitrogen or sulfur bonded directly to the cyclopentanohydrophenanthrene ring system | 1 |
| 20100069627 | NOVEL METHOD FOR THE DIASTEREOSELECTIVE PRODUCTION OF A CHIRAL PRIMARY AMINE ON A STEROID - The invention relates to a diastereoselective method for obtaining a primary amine on a steroid, comprising the reduction of an oxime by lithium in ammonia at a low temperature in an ether/alcohol mixture. | 03-18-2010 |
| 540023000 | The spiro atom is the 17-position carbon of the cyclopentanohydrophenanthrene ring system | 5 |
| 20080200668 | Industrial Process for the Preparation of 17-Hydroxy-6Beta, 7Beta; 15Beta, 16Beta-Bismethylene-3-Oxo-17Alpha-Pregn-4-Ene-21-Carboxylic Acid Y-Lactone and Key Intermediates for this Process - The invention relates to an industrial process for the preparation of 17-hydroxy-6β,7β;15β,16β-bismethylene-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone of formula (I), and to the key-intermediates for this process. | 08-21-2008 |
| 20090012286 | PROCESS FOR THE PREPARATION OF 17-(3-HYDROXYPROPYL)-17-HYDROXYSTEROIDS - The present invention relates to a process for the preparation of 17α-(3-hydroxypropyl)-17β-hydroxysteroids of the formula I | 01-08-2009 |
| 20090023914 | Process for preparing drospirenone and intermediate thereof - The present invention encompasses processes for preparing drospirenone and intermediates thereof. | 01-22-2009 |
| 20110060140 | SYNTHESIS OF (+) CORTISTATIN A AND RELATED COMPOUNDS - An in vitro synthesis of (+) cortistatin A from readily available precursors is disclosed, as are the syntheses of related 17-aryl substituted compounds, the 17-aryl substituted compounds themselves and novel compounds useful in their preparation. | 03-10-2011 |
| 20120214987 | METHODS AND COMPOUNDS FOR PREPARING 3ALPHA-OXYGEN SUBSTITUTED STEROIDS - The invention relates to processes for preparing 3α-O-linked steroids including 3α-O-linked-androst-5-ene steroids and 3α-O-linked-5a-androstane steroids. In one process a 3α,4α-epoxy androst-5-en-17-one is predominately reduced at the epoxy moiety wherein reduction of the 3α,4α epoxy functional group occurs preferentially at position C4 with retention of configuration at position C3 to provide a 3α-O-linked-androst-5-ene steroid. In another process, conditions are provided for inversion of configuration of a 3β-hydroxy-androst-5-ene steroid by the Mitsunobu reaction to provide a 3α-O-linked-androst-5-ene steroid with reduced amounts of 3α,5α-cycloandrostane side-product impurities. | 08-23-2012 |
| 540028000 | The spiro includes the cyclopentanohydrophenanthrene ring system and a hetero ring | 5 |
| 540031000 | Plural oxygens in the spiro hetero ring | 2 |
| 20110028711 | Unsaturated Steroid Compounds - The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome. | 02-03-2011 |
| 540034000 | The spiro hetero ring shares the 3-position carbon of the cyclopentanohydrophenanthrene ring system | 1 |
| 540036000 | Nitrogen attached directly or indirectly to the cyclopentanohydrophenanthrene ring system by nonionic bonding | 1 |
| 20140296510 | Method for preparing ulipristal acetate and key intermediate thereof - A method as well as new intermediates for preparing Ulipristal acetate (a compound I) and a method for preparing the new intermediates are provided. The intermediate in a constitutional formula IV is conductive to reacting with methyl lithium or methyl Grignard reagent, a protective group is easy to be removed after a reaction, side reactions are few, a mid-term treatment is simple, the reagents used are cheap, costs are low and a yield is high, if a compound in a constitutional formula V is obtained by the reaction of a compound in a constitutional formula III and the intermediate in the constitutional formula IV, the yield of a two-step reaction is 75%, a purity is above 98%. | 10-02-2014 |
| 540041000 | The spiro hetero ring contains -C(=X)-O-, wherein X is chalcogen, as part of the ring (e.g., spiro-lactones, etc.) | 3 |
| 20080234478 | Process for the preparation and purification of eplerenone - A process for the preparation and purification of Eplerenone is described wherein hydroxylated impurities are removed using a novel derivatization procedure. | 09-25-2008 |
| 20100222571 | PROCESS FOR THE PREPARATION OF DROSPIRENONE - A process for the preparation of Drospirenone (I) according to the scheme (A) wherein the substituent R is defined in the description. The process improves the product yield and purity by reducing the formation of undesired side-products and is particularly convenient for industrial-scale manufacturing. | 09-02-2010 |
| 540044000 | Chalcogen, halogen, or nitrogen attached indirectly to the cyclopentanohydrophenanthrene ring system by acyclic nonionic bonding | 1 |
| 20160108083 | PROCESS FOR THE PREPARATION OF 7 alpha -(METHOXYCARBONYL)-3-OXO-17alpha-PREGN-4,9(11)-DIEN-21,17-CARBOLACTONE, A USEFUL INTERMEDIATE FOR THE SYNTHESIS OF MOLECULES WITH PHARMACOLOGICAL ACTIVITY - An improved process for the preparation of intermediate (V) through the elimination of a molecule of water from intermediate (IV) is described. | 04-21-2016 |
| 540047000 | The cyclopentanohydrophenanthrene ring system is part of a polycyclo ring system having at least five cyclos | 22 |
| 20150368291 | N-acetyl amino acid ESTER derivatives of Betulin and preparation method thereof - The present invention disclosed N-acetyl amino acid ester derivatives of betulin and the preparation method thereof, the method comprising the steps that in the presence of an alkaline substance, a catalyst and a racemization-inhibitor, the carboxyl group of N-acetyl amino acid is activated by a coupling agent; and then the activated N-acetyl amino acid is reacted with betulin via esterification reaction to obtain the N-acetyl amino acid ester derivative of betulin. The present invention provided a simple synthesis method to synthesize the N-acetyl amino acid ester derivatives of betulin by using betulin as a precursor compound and modifying the molecular structure of betulin. Such structural modification of betulin significantly enhances the anti-tumor activity of the betulin derivatives and therefore has important values. | 12-24-2015 |
| 540048000 | Hetero ring is one of the cyclos of the polycyclo ring system | 21 |
| 20130060019 | Compounds for Use in Treating Neurodegenerative Disorders, Synthesis Thereof, and Intermediates Thereto - The present invention provides methods of making a compound of formula II: | 03-07-2013 |
| 20130060020 | Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I: | 03-07-2013 |
| 20130060021 | Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I: | 03-07-2013 |
| 20130060022 | Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I: | 03-07-2013 |
| 20130060023 | Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I: | 03-07-2013 |
| 20130060024 | Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I: | 03-07-2013 |
| 540049000 | The hetero ring contains nitrogen | 1 |
| 540058000 | The hetero ring is five-membered | 1 |
| 20160152659 | NOVEL SOLANIDINE-DERIVED COMPOUNDS | 06-02-2016 |
| 540061000 | The hetero ring contains plural oxygens | 8 |
| 20100222572 | PROCESSES FOR THE PREPARATION OF CICLESONIDE AND ITS CRYSTAL MODIFICATION - Improved processes for the synthesis of ciclesonide, chemically termed as [11β,16α(R)]-16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione and its crystal modification. | 09-02-2010 |
| 540062000 | Two of the cyclos share at least three ring members or a ring carbon is shared by three of the cyclos (e.g., bridged, peri-fused, etc.) | 1 |
| 20120130067 | Sterol Derivatives and Their Synthesis and Use - Sterol derivatives with structural formula I or II are disclosed, wherein R is defined as the description of the invention. Their synthesizing methods and anti-tumor use are also disclosed. Especially, the compound of formula I, in which R is O (i.e. the compound CL 168-6), has the anti-tumor therapeutic index of 49.3. The compound can be used to prepare a medicine for prevention or treatment of immunological diseases and cancers such as liver cancer and lung cancer. | 05-24-2012 |
| 540063000 | The hetero ring is ortho-fused to the D ring | 6 |
| 20120309959 | Controlled Release and Taste Masking Oral Pharmaceutical Composition - Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract. | 12-06-2012 |
| 540065000 | Nitrogen or acyclic chalcogen bonded directly to the hetero ring (e.g., cyclic carbonates, etc.) | 2 |
| 20090259037 | PROCESS FOR PREPARING BUDESONIDE - A process is described for preparing budesonide which comprises the steps of: a) preparing an aqueous hydrochloric acid solution; b) reacting 16α-hydroxyprednisolone and butyraldehyde within the solution prepared in step a), in an inert atmosphere; c) quenching the reaction of step b) with water. The process of the invention enables the ratio between the A and B epimers of budesonide to be controlled. | 10-15-2009 |
| 20100331539 | PROCESS FOR THE PREPARATION OF PREGNANE DERIVATIVES - A stereoselective and enrichment process for the preparation of ciclesonide is described. | 12-30-2010 |
| 540066000 | The A ring is a benzene ring | 1 |
| 20090240049 | Purification of air sensitive steroids - The present invention provides a purification method for air sensitive steroids, by reacting an amino acid or an analogue thereof with the 21-aldehyde oxidation product of such air sensitive steroids to form an adduct that is separated from the purified air sensitive steroids. | 09-24-2009 |
| 540067000 | Sulfur or nitrogen attached directly or indirectly to the cyclopentanohydrophenanthrene ring system by acyclic nonionic bonding | 1 |
| 20150105547 | NITRIC OXIDE RELEASING STEROIDS - The invention relates to nitrooxyderivative of corticosteroids of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof | 04-16-2015 |
| 540068000 | Halogen attached indirectly to the cyclopentanohydrophenanthrene ring system by acyclic nonionic bonding | 1 |
| 20130225804 | NOVEL METHOD FOR MANUFACTURING OF CICLESONIDE - The invention relates to a process for preparing the corticosteroid ciclesonide, used for the treatment of respiratory complaints, in epimerically pure form of formula 1: | 08-29-2013 |
| 540076000 | The hetero ring is three-membered consisting of one oxygen and two carbons (e.g., oxirane, etc.) | 5 |
| 540078000 | The hetero ring shares the 1,2-positions of the cyclopentanohydrophenanthrene ring system | 1 |
| 20090137794 | Processes for the synthesis of rocuronium bromide - The invention encompasses processes for synthesizing 1-[17β-acetyloxy-3α-hydroxy-2β-(4-morpholinyl)-5α-androstan-16β-yl]-1-(2-propenyl)pyrrolidinium bromide (rocuronium bromide) and intermediates thereof. | 05-28-2009 |
| 540081000 | The hetero ring shares the 6,7-positions of the cyclopentanohydrophenanthrene ring system | 2 |
| 20100063272 | METHOD FOR PRODUCING STEROID COMPOUND - It is an object of the present invention to provide a novel method for producing a steroid compound. The present invention provides a method for producing 5β-3,7-dioxocholanic acid or an ester derivative thereof, using, as a raw material, a sterol having double bonds at position 5 and at position 24, such as cholesta-5,7,24-trien-3β-ol, ergosta-5,7,24(28)-trien-3β-ol, desmosterol, fucosterol, or ergosta-5,24(28)-dien-3β-ol, via the following 4 steps: | 03-11-2010 |
| 20110009615 | METHOD FOR PRODUCING A STEROID COMPOUND - An object of the present invention is to provide a novel method for producing a steroid compound. The present invention provides a method for producing 3,7-dioxo-5β-cholanic acid or ester derivatives thereof, which uses, as raw materials, sterols having double bonds at positions 5 and 24, such as cholesta-5,7,24-trien-3β-ol, ergosta-5,7,24(28)-trien-3β-ol, desmosterol, fucosterol, or ergosta-5,24(28)-dien-3β-ol, and which comprises the following 4 steps: (I) a step of performing oxidation of a hydroxyl group at position 3 and isomerization of a double bond at position 5 to position 4; (II) a step of converting position 24 to a carboxyl group or an ester derivative thereof by the oxidative cleavage of a side chain; (III) a step of introducing an oxygen functional group into position 7; and (IV) a step of constructing a 5β-configuration by reduction of a double bond at position 4. | 01-13-2011 |
| 540087000 | The hetero ring shares the 9,11-positions of the cyclopentanohydrophenanthrene ring system | 2 |
| 540088000 | Halogen bonded directly to the cyclopentanohydrophenanthrene ring system | 1 |
| 20140179914 | PROCESS FOR THE PREPARATION OF 6-ALPHA-FLUORO PREGNANES - Disclosed is a process for the preparation of 6-α-fluoro pregnanes of formula I | 06-26-2014 |
| 540089000 | Having -C(=X)-, wherein X is chalcogen, bonded directly to the cyclopentanohydrophenanthrene ring system | 1 |
| 20130211069 | PROCESS FOR THE PREPARATION OF 17-DESOXY-CORTICOSTEROIDS - The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the 17-hydroxy starting material with an excess of Trimethylsilyl Iodide. The present invention is specifically advantageous in preparing 17-desoxy corticosteroid derivatives having one or more halogen groups at positions 2, 6, 7 or 9 of the corticosteroid such as Clocortolone of Desoximetasone. | 08-15-2013 |
| 540090000 | The hetero ring shares at least three ring members with one other cyclo of the polycyclo ring system (i.e., bridged) | 1 |
| 540091000 | Bridge consisting of oxygen and carbon between the 6- and 10-positions of the cyclopentanohydrophenanthrene ring system (e.g., 6,19-oxido steroids, etc.) | 1 |
| 20090216008 | METHOD FOR THE PREPARATION OF 21-HYDROXY-6,19-OXIDOPROGESTERONE (21OH-6OP) - A method of preparing 21-hydroxy-6,19-oxidoprogesterone, or an acylated or phosphorlated version thereof. | 08-27-2009 |
| 540094000 | Hetero ring attached directly to the cyclopentanohydrophenanthrene ring system by nonionic bonding | 19 |
| 20120116069 | GLUCOSE METABOLISM-IMPROVING AGENT AND GLUCOSE METABOLISM-IMPROVING COMPOSITION - A sugar metabolism-improving agent including at least one of a compound having a structure expressed by the following Structural Formula (1) and a compound having a structure expressed by the following Structural Formula (2). | 05-10-2012 |
| 20160251392 | 5-Beta, 14-Beta-Androstane Derivatives Useful For The Treatment Of Proteinuria, Glomerulosclerosis And Renal Failure | 09-01-2016 |
| 540095000 | The hetero ring contains nitrogen | 15 |
| 20100036115 | Novel Compositions for the Delivery of Negatively Charged Molecules - This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAs, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules. | 02-11-2010 |
| 20100152437 | Methanesulfonate salts of abiraterone-3-esters and recovery of salts of abirater one-3-esters from solution in methyl tert-butyl ether - A salt of a compound of formula (I) may be made with methanesulfonic acid. The salt and salts with other acids may be prepared by recovering from methyl tert-butyl ether (MTBE). | 06-17-2010 |
| 20110288288 | Process for the preparation of 17-0-vinyl- triflates as intermediates - A compound of formula (I) or a pharmaceutically-acceptable salt thereof, may be made by a process including a triflating step by which a ketone of formula (II) is converted into a triflate of formula (III) in the presence of a base comprising a tertiary or heterocyclic amine such that the pK | 11-24-2011 |
| 20130090468 | METHANESULFONATE SALTS OF ABIRATERONE-3-ESTERS AND RECOVERY OF SALTS OF ABIRATER ONE-3-ESTERS FROM SOLUTION IN METHYL TERT-BUTYL ETHER - A salt of a compound of formula (I) may be made with methanesulfonic acid. The salt and salts with other acids may be prepared by recovering from methyl tert-butyl ether (MTBE). | 04-11-2013 |
| 20140011992 | SYNTHESIS OF ABIRATERONE AND RELATED COMPOUNDS - The present invention relates to processes for obtaining abiraterone and derivatives thereof, such as abiraterone acetate, by means of a Suzuki coupling through a steroid borate of general formula (IV) or a C—C coupling through a steroid hydrazone of general formula (II), as well as to intermediates useful in said processes. | 01-09-2014 |
| 20140256932 | PROCESS FOR PREPARING 17-SUBSTITUTED STEROIDS - The present invention relates to a process for the preparation of 17-substituted steroids and, more particularly, to an improved method of synthesizing abiraterone or derivatives thereof in high yield and purity by means of a key 3-formate intermediate. | 09-11-2014 |
| 20150133652 | ACETATIC ABIRATERONE TRIFLUOROACETATE AND PREPARATION METHOD AND APPLICATION OF SAME - Provided are acetaic abiraterone trifluoroacetate, a preparation method and an application of same. The acetaic abiraterone trifluoroacetate is obtained through a salt-forming reaction between acetaic Abiraterone and trifluoroacetic acid. The acetaic abiraterone trifluoroacetate undergoes self-purification through recrystallization, and dissociation and recrystallization are performed on the purified abiraterone acetate trifluoroacetate, so that the obtained acetaic abiraterone has a high purity, a high yield and stable quality, and is capable of meeting the requirement for mass production of acetaic abiraterone. | 05-14-2015 |
| 20150329585 | METHANESULFONATE SALTS OF ABIRATERONE-3-ESTERS AND RECOVERY OF SALTS OF ABIRATER ONE-3-ESTERS FROM SOLUTION IN METHYL TERT-BUTYL ETHER - A salt of a compound of formula (I) may be made with methanesulfonic acid. The salt and salts with other acids may be prepared by recovering from methyl tert-butyl ether (MTBE). | 11-19-2015 |
| 20160002283 | NOVEL COMPOSITIONS AND METHODS FOR TREATING PROSTATE CANCER - Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat androgen receptor mediated diseases or conditions. In some embodiments, the solid matrix comprises a polymer. In some embodiments, the polymer is soluble in an aqueous solution. In particular embodiments, the aqueous solution is water. In other embodiments, the aqueous solution has a pH of 5.0 or greater. | 01-07-2016 |
| 20160052958 | PROCESS FOR THE PURIFICATION OF ABIRATERONE ACETATE - The invention relates to a process for the purification of crude abiraterone acetate by treatment with polymer resins in aqueous solvent. The purified product is recovered by simple concentration and filtration. | 02-25-2016 |
| 20160168191 | PROCESS FOR THE PREPARATION OF ABIRATERONE OR ABIRATERONE ACETATE | 06-16-2016 |
| 20160168192 | PROCESS FOR THE PREPARATION OF ABIRATERONE AND ABIRATERONE ACETATE | 06-16-2016 |
| 540096000 | Plural nitrogen containing hetero rings bonded directly to the cyclopentanohydrophenanthrene ring system | 3 |
| 20100105892 | PURIFICATION PROCESS COMPRISING DISSOLVING AN ORGANIC COMPOUND IN CARBONATED WATER AND FREEZE-DRYING - A process for the purification of a crude organic compound comprising dissolving said compound in carbonated water to form a solution and freeze drying said solution. | 04-29-2010 |
| 20130303753 | PREPARATION METHOD OF ROCURONIUM - A method for preparing rocuronium is disclosed. 2β-(4-Morpholinyl)-16β-(1-pyrrolidinyl)-5α-androstan-3α-ol-17β-acetate is used as a starting material and is directly reacted with 3-bromopropene at ambient temperature to produce rocuronium. | 11-14-2013 |
| 20140200340 | METHOD FOR PURIFYING ROCURONIUM BROMIDE - Provided is a method for purifying rocuronium bromide, which comprises: formulating crude rocuronium bromide to be purified into an aqueous solution, distilling off excess residue solvents at reduced pressure, absorbing by adding active carbon or silica gel, then filtrating, quick freezing the filtrate into ice, and then lyophilizing to obtain rocuronium bromide. | 07-17-2014 |
| 540100000 | The hetero ring contains plural chalcogens | 2 |
| 20090259038 | PROCESS FOR PRODUCING (5ALPHA7ALPHA)-3-SPIRO-2'-(1',3'-DIOXOLAN)-24-OXOCHOLEST-22-EN-7-YL BENZOATE - The present invention provides a method of producing (5α,7α)-3-spiro-2′-(1′,3′-dioxolan)-24-oxocholest-22-en-7-yl benzoate represented by the formula (I) | 10-15-2009 |
| 20140058079 | DERIVATIVES OF ALLOPREGNANOLONE AND OF EPIALLOPREGNANOLONE AND USES THEREOF FOR TREATING A NEUROPATHOLOGICAL CONDITION - The présent invention relates to novel neurosteroids, especially derivatives of allopregnanolone and of epiallopregnanolone of formula (I) and the uses thereof as médicament for the treatment of neuropathologies, in particular neuropathies induced by the chemotherapy of a cancer. Thèse molécules according to the invention have both preventative and curative effects. The neurosteroids according to the invention may also be of use in the treatment of neurodegenerative disorders, in particular for preventing neuronal cell death. They may thus be used as neuroprotectants and/or as an agent that stimulâtes neuronal prolifération. | 02-27-2014 |
| 540106000 | Nitrogen attached directly to the cyclopentanohydrophenanthrene ring system by nonionic bonding | 1 |
| 20140309417 | PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES - The present invention relates to a process for the preparation of sterol derivatives comprising the reaction of an α-epoxy compound with an amine in an alcohol comprising 3 to 5 carbon atoms as a solvent. | 10-16-2014 |
| 540107000 | Nitrogen containing hetero ring attached indirectly to the cyclopentanohydrophenanthrene ring system by nonionic bonding | 9 |
| 540108000 | The hetero ring is five-membered and has plural hetero atoms | 3 |
| 20100048888 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules - The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.), cholesterol, hormones, antivirals, peptides, proteins, chemotherapeutics, small molecules, vitamins, co-factors, nucleosides, nucleotides, oligonucleotides, enzymatic nucleic acids, antisense nucleic acids, triplex forming oligonucleotides, 2,5-A chimeras, dsRNA, allozymes, aptamers, decoys and analogs thereof, and small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), short hairpin RNA (shRNA), and RNAi inhibitor molecules, to relevant cells and/or tissues, such as in a subject or organism. Such novel cationic lipids, microparticles, nanoparticles and transfection agents are useful, for example, in providing compositions to prevent, inhibit, or treat diseases, conditions, or traits in a cell, subject or organism. The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP). | 02-25-2010 |
| 20120046461 | STEROIDAL ANTI-HORMONE HYBRIDS - Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods for inhibiting the interaction between a co-regulatory protein and an androgen or estrogen receptor, and methods for treating cancer. | 02-23-2012 |
| 20140194620 | 18F-LABELED PRECURSOR OF PET RADIOACTIVE MEDICAL SUPPLIES, AND PREPARATION METHOD THEREOF - The present invention relates to a precursor of positron emission tomography (PET) radioactive medical supplies, a preparation method thereof, and an application thereof, and more specifically, to a precursor having a tetravalent organic salt leaving group, a preparation method, and a method for preparing desired PET radioactive medical supplies in a high radiochemical yield within a short preparation time by introducing | 07-10-2014 |
| 540109000 | The hetero ring is in the 17-position substituent of the cyclopentanohydrophenanthrene ring system | 2 |
| 540110000 | The hetero ring is bonded directly to a -C(=X)- group, wherein X is chalcogen | 1 |
| 20090163705 | CATIONIC LIPIDS - Cyclic lipid moieties are described herein. | 06-25-2009 |
| 540112000 | Chalcogen or nitrogen in chain between the hetero ring and the cyclopentanohydrophenanthrene ring system | 1 |
| 20160009754 | BERBERINE-URSODEOXYCHOLIC ACID CONJUGATE FOR TREATING THE LIVER | 01-14-2016 |
| 540113000 | Chalcogen in chain between the hetero ring and the cyclopentanohydrophenanthrene ring system | 4 |
| 20120149894 | NOVEL CATIONIC LIPIDS WITH VARIOUS HEAD GROUPS FOR OLIGONUCLEOTIDE DELIVERY - The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with siRNA, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo. | 06-14-2012 |
| 20120253032 | NOVEL CATIONIC LIPIDS WITH SHORT LIPID CHAINS FOR OLIGONUCLEOTIDE DELIVERY - The instant invention provides for novel cationic lipids with short lipid chains that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo while decreasing inflammatory toxicities. | 10-04-2012 |
| 20130245253 | Conjugated Neuroactive Steroid Compositions And Methods Of Use - The present disclosure provides modified neuroactive steroids. The modified neuroactive steroids may comprise, consist of, or consist essentially of a therapeutic agent and/or a modifying moiety. The modified neuroactive steroid can have modified characteristics as compared to native neuroactive steroids that do not include a modifying moiety and/or therapeutic agent. The modified neuroactive steroid may be, for example, modified pregnenolone, pregnenolone metabolites, allopregnanolone, and/or allopregnanolone metabolites. The modified neuroactive steroids can be used to treat, prevent and/or ameliorating a phenotypic state of interest in a subject. | 09-19-2013 |
| 20140121367 | SUBSTITUTED METHYLFORMYL REAGENTS AND METHOD OF USING SAME TO MODIFY PHYSICOCHEMICAL AND/OR PHARMACOKINETIC PROPERTIES OF COMPOUNDS - The present invention relates to the synthesis and application of novel chiral/achiral substituted methyl formyl reagents to modify pharmaceutical agents and/or biologically active substances to modify the physicochemical, biological and/or pharmacokinetic properties of the resulting compounds from the unmodified original agent. | 05-01-2014 |
| 540114000 | Oxygen containing hetero ring attached indirectly to the cyclopentanohydrophenanthrene ring system by nonionic bonding | 10 |
| 20130274460 | Electrophilic Reagents for Monohalomethylation, Their Preparation and Their Uses - The invention provides electrophilic monohalomethylating reagents, methods for their preparation and methods for preparation of monohalomethylated biologically active compounds using such reagents. Typical monohalomethyl groups transferred are FH2C—, CIH2C— and others. The reagents used for transferal of the groups are described by Formulae A-D: wherein: X═F, CI, Br, I, sulfonate esters, phosphate esters or another leaving group; R11=tetrafluoroborates, inflates, halogen, perchlorate, sulfates, phosphates or carbonates The other variables are as defined in the claims. | 10-17-2013 |
| 20130274461 | METHOD FOR PREPARING FLUTICASONE FUROATE - Method for preparing fluticasone furoate (6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-[(2-furoyl)oxy]-3-oxo-androsta-1,4-diene-17β-carbothioic acid S-fluoromethyl ester) by directly subjecting a compound of Formula III and a complex of a fluoromethylating reagent in presence of an organic base to a replacement reaction to obtain the target compound. Generation of impurities in a process via Compound IV is avoided; the method is simple with mild reaction conditions, suitable for industrial production, and yields products with purity of 98% by HPLC. | 10-17-2013 |
| 20140148593 | PROCESS FOR PREPARING FLUTICASONE PROPIONATE/FUROATE - The present invention relates to an improved process for the preparation of substituted Fluticasone derivatives. The invention also reveals the processes for the purification of Fluticasones and related intermediates to provide the highly pure product. | 05-29-2014 |
| 20140200341 | Method for the Production of Fluoromethyl Esters of Androstan-17 beta Carboxylic Acids - Described herein are processes for the preparation of monofluoromethylated organic biologically active compounds, starting from protected intermediates and/or reagents to obtain compounds such as fluticasone propionate and fluticasone furoate, in presence of decarboxylating reagents XeF | 07-17-2014 |
| 20160130223 | Electrophilic Reagents for Monohalomethylation, Their Preparation and Their Uses - The invention provides a compound of formula A, B, C or D, methods for making them, intermediates therefor, and their use in making organic biologically active compounds: | 05-12-2016 |
| 540115000 | The hetero ring contains -C(=X)-O-, wherein X is chalcogen, as part of the ring (e.g., lactones, etc.) | 2 |
| 20120190841 | COMPOUND HAVING NEURITE-OUTGROWING ACTIVITY - There is provided a novel compound having neurite-outgrowing activity that is useful for the prevention or the treatment of a neurodegenerative disease. A compound of Formula (I) | 07-26-2012 |
| 20130116428 | NOVEL POLY(ETHYLENE OXIDE)-BLOCK-POLY(ESTER) BLOCK COPOLYMERS - The present invention relates to micelle-forming poly(ethylene oxide)-block-poly(ester) block copolymers having reactive groups on the polyester block therein. The biodegradability of these copolymers and their biocompatibilities with a large number of bioactive agents make them suitable as carriers for various bioactive agents. The bioactive agents, such as DNA, RNA, oligonucleotide, protein, peptide, drug and the like, can be coupled to the reactive groups on the polyester block of the copolymer. | 05-09-2013 |
| 540116000 | Additional hetero atom in the oxygen containing hetero ring | 1 |
| 20130046090 | CYCLISATION PROCESS OF FORMING A MULTIPLE RING COMPOUND - The present invention relates to a cyclisation process of forming a multiple ring compound from an isoprenoid compound. The cyclisation process involves reacting the isoprenoid compound with an acetal initiator under conditions sufficient to form the multiple ring compound. The isoprenoid compound is contacted with an initiator and optionally with a catalyst. Cyclisation occurs by reaction of the initiator with the isoprenoid compound. Cyclic aceta compounds wherein the acetal forms part of 6-membered unsaturated ring are also defined. | 02-21-2013 |
| 540117000 | The A ring is a benzene ring | 1 |
| 20090118495 | Process for the Preparation of 6-alpha,9-alpha-difluoro-17-alpha-((2-furanylcarbonyl)oxy)-11-beta-hydrox- y-16-alpha-methyl-3-oxo-androsta-1,4-diene-17-beta- -carbothioic acid S-fluoromethyl - A novel process for preparing a compound of formula (I) | 05-07-2009 |
| 540118000 | The hetero ring is bonded directly to chalcogen which is bonded directly to the cyclopentanohydrophenanthrene ring system | 1 |
| 20090062526 | NOVEL METHOD OF SYNTHESIZING ALKYLATED BILE ACID DERIVATIVES - A novel, improved method of synthesizing alkylated bile acid derivatives is provided. Such derivatives include, but are not limited to the active, potent, and selective FXR receptor agonist such as 6-ECDCA and other CA, DCA and CDCA derivatives. The first step of the synthesis selectively oxidates CDCA, CD, or DCA related starting material. An efficient combined deprotonation, trapping, ethylation, deprotection and reduction system is used to produce the desired alkylated bile acid derivatives. This practical synthesis offers a simple and economical pathway suitable for a large-scale manufacturing of alkylated bile acid derivatives including, but not limited to, 6-ECDCA. | 03-05-2009 |
