| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 536122000 | Sulfur or halogen containing | 32 |
| 20080281090 | Microfluidic Chemical Reaction Circuits - New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents. | 11-13-2008 |
| 20090030191 | Process for Producing Carbon-Reduced Aldose Compounds - The present invention provides a process capable of industrially producing 5-deoxy-L-arabinose, important as a raw material for the production of sapropterin useful as a therapeutic agent for atypical hyperphenylalaninemia, satisfactorily efficiently even with a simple production apparatus. Provided is the process for producing 5-deoxy-L-arabinose characterized by including: reacting L-rhamnose with a C | 01-29-2009 |
| 20090030192 | Process for production of compound labeled with radioactive fluorine - A process for the production of [ | 01-29-2009 |
| 20090036668 | MICROFLUIDIC RADIOSYNTHESIS SYSTEM FOR POSITRON EMISSION TOMOGRAPHY BIOMARKERS - Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber. | 02-05-2009 |
| 20090118493 | PROCESS FOR PURIFICATION OF TRICHLOROGALACTOSUCROSE BASED ON DIRECT EXTRACTION IN ORGANIC SOLVENT FROM REACTION MIXTURE FOLLOWED BY EVAPORATIVE REMOVAL OF SOLVENT - A process of azeotropic removal of dimethylformamide, abbreviated as DMF, from a process stream containing DMF requiring its removal, is described wherein the said Process Stream being obtained in a process for preparation of 4,1′,6′ trichlorogalactosucrose, abbreviated as TGS, or TGS-6-ester including TGS-6-acetate or TGS-6-benzoate, comprising steps of (a) evaporation of the said process stream under reduced pressure to a concentrate to effect removal of a part of DMF azeotropically, (b) diluting the concentrate obtained at the end of step (a.) of this claim with water, preferably to about 5 to 10 times the volume of the said concentrate, and (c) repeating the cycles of evaporation under reduced pressure and dilution with water for more number of times until content of DMF in the concentrated mass is reduced to 0.5% or less of the concentrate. | 05-07-2009 |
| 20100029930 | Stabilisation of Radiopharmaceutical Precursors - The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed. | 02-04-2010 |
| 20100105889 | PROCESS FOR THE PREPARATION OF PENTOSAN POLYSULFATE OR SALTS THEREOF - A process for the preparation of Pentosan polysulfate sodium comprising a step of purifying depolymerized crude Pentosan polysulfate sodium by filtration through NF membrane system. | 04-29-2010 |
| 20100184969 | Process to Prepare Sucralose - The present invention relates to a process to prepare sucralose. More particularly the said process relates to the production of sucralose, chemically known as, 6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside of formula (1) | 07-22-2010 |
| 20100197906 | Method for purification of chlorinated sucrose derivatives from reaction mixture by chromatography - A chromatographic process of DMF removal from an aqueous composition is described comprising its loading on a column of hydrophobic fixed bed adsorbent and eluting out DMF with an aqueous alkaline buffer. This method is useful to remove DMF as a process of general application wherever simultaneous removal and isolation of DMF is desired from an organic molecule which is not an organic solvent, is soluble in DMF. This method can be used for simultaneous removal of DMF from reaction mixtures and isolation of Trichlorogalactose (TGS) or TGS-6-acetate in a process of production of TGS. | 08-05-2010 |
| 20110098465 | Nonflow -Through Apparatus And Method Using Enhanced Flow Mechanisms - Methods and apparatus for facilitating the synthesis of compounds in a nonflow-through device are presented. Application of the nonflow-through methods and microfluidic devices to the synthesis of radiolabeled compounds is described. These methods and apparatus enable the introduction of a pressurized gas through a tangential slit into a vortex reactor of the nonflow-through device, while one or more liquids are delivered to the reaction chamber through the same or different inlet ports. The introduction of the pressurized gas produces a cyclonic motion of the mixture within the reactor. Such a mechanism may be used to facilitate the evaporation of various liquids within the reactor at lower temperatures, thus reducing the production of unwanted byproducts that are associated with the use of high temperatures. In addition, thorough mixing of various liquids may be effected rapidly while allowing chemical reactions to take place efficiently within the vortex reactor. | 04-28-2011 |
| 20110207921 | SULFATED DERIVATIVE OF GASTRODIA ELATA POLYSACCHARIDE, PREPARATION METHOD AND ANTITUMOR USE THEREOF - The present invention discloses a sulfated derivative of polysaccharide extracted from | 08-25-2011 |
| 20110288287 | Halogen Substituted Saccharide, Method for Producing Same, Reaction Composition of Same and Device for Producing Same - The present invention provides: a method for synthesizing a halogen-substituted saccharide from a leaving group-substituted saccharide in a short-time and continuously; a reaction composition; and a device for synthesis of same, i.e., the method being for synthesizing a halogen-substituted saccharide from a leaving group-substituted saccharide by a halogen-substituted saccharide synthesis reaction using a subcritical fluid or a supercritical fluid as the reaction solvent; the reaction composition of the same being an aqueous solution of halogen-substituted saccharide; and the device for synthesis being a device for producing the same, the method being for producing a halogen-substituted saccharide with a subcritical fluid or a supercritical fluid at a temperature of 100 to 400° C. and a pressure of 0.1 to 40 MPa or a mixed solvent of aprotic organic solvent or inorganic solvent mixed therein as the reaction solvent, under catalyst-free condition, by introducing the leaving group-substituted saccharide and the reaction solvent into a circulating-type high-temperature and high-pressure device to produce selectively a halogen-substituted saccharide while reducing the amount of energy consumption and the amount of waste, at high yield, high selectivity, high speed and continuously. | 11-24-2011 |
| 20120029183 | SULFATED C-GLYCOSIDE, METHOD FOR ISOLATING SAME AND METHOD FOR SYNTHESIZING SAME - Provided are a sulfated C-glycoside which is a novel compound serving as a precursor of chafuroside and chafuroside analogs; a method for efficiently producing the sulfated C-glycoside; and a method for efficiently producing chafuroside and chafuroside analogs using said sulfated C-glycoside. A sulfated C-glycoside represented by general formula (A1) or (B1) [wherein R | 02-02-2012 |
| 20120071647 | Microfluidic reactor having an annular reaction chamber - A microfluidic reactor has a reaction chamber which is configured as an annular channel. It is provided that segments have been formed in the annular channel such that a sequence of inlets and outlets (allows an alternation between the process fluids (A and B) to take place. Furthermore, particles which circulate in the annular channel and can be used, for example, for the adsorption and desorption of ions may be provided in the annular channel. In this way, the ions concerned can, for example, be extracted from the process fluid (A) and transferred into the process fluid (B). In a method, the reactor can be used for example for the purpose of obtaining | 03-22-2012 |
| 20120157675 | PURIFICATION OF TERTIARY FORMAMIDE CONTAMINATED WITH TERTIARY ACETAMIDE - A chlorinating agent such as a chloroiminium species is used to remove or neutralize tertiary acetamide present as a contaminant in a tertiary formamide solvent. Tertiary formamide solvent purified or treated in this manner can be used as a reaction vehicle for the chlorination of sucrose-6-acylates, thereby improving the yields of the desired sucralose-6-acylate (an intermediate in the production of sucralose). | 06-21-2012 |
| 20120232263 | Mimetics of Sulfated Oligosaccharides - The present invention is directed to sulfated oligosaccharides having 4, 5 or 6 saccharidic units and wherein a glycosidic bond between two saccharide units is substituted by a C—C bond, and wherein the sulfation degree expressed as percentage of OH groups substituted by a OSO | 09-13-2012 |
| 20120264932 | DIGITAL MICROFLUIDIC PLATFORM FOR RADIOCHEMISTRY - Disclosed herein are methods of performing microchemical reactions and electro- wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing | 10-18-2012 |
| 20120289694 | L-PROLINE AND CITRIC ACID CO-CRYSTALS OF (2S,3R,4R,5S,6R)-2-(3-((5-(4-FLUOROPHENYL)THIOPHEN-2-YL)METHYL)-4-METHYLP- HENYL)-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL - The present invention is directed to L-proline and citric acid co-crystals of (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, pharmaceutical compositions containing said co-crystals and their use in the treatment glucose-related disorders such as Type 2 diabetes mellitus and Syndrome X. | 11-15-2012 |
| 20120302742 | PROCESS FOR ISOLATING FUCOIDAN AND LAMINARIN FROM LIVE, HARVESTED SEAWEED - The present invention is directed to a process for obtaining at least one of fucoidan and laminarin from live, harvested seaweed, wherein the process comprises the steps of: (i) harvesting seaweed comprising fucoidan and laminarin to obtain live, harvested seaweed, wherein the live, harvested seaweed exudes to form an exudate solution; (ii) collecting the exudate solution from the live, harvested seaweed, wherein the fucoidan and laminarin are dissolved in the exudate solution; and (iii) separating the at least one of fucoidan or laminarin from the exudate solution. | 11-29-2012 |
| 20130005958 | DEVICES AND METHODS FOR REDUCING RADIOLYSIS OF RADIOISOTOPES - Disclosed are devices and methods for reducing radiolysis of radiopharmaceuticals during filtration, concentration and purification. The devices comprises two or more confining geometry having a cross-section dimension below the beta(+) or beta(−) range of the radioisotope in use, when containing the radioisotope, and configured in such a way that neighboring geometries are isolated from its nearest neighbor such that no measurable kinetic positron energy transfer occurs between the confining geometries when containing the radioisotope. Methods of filtration of radioisotope containing mixtures are also disclosed. | 01-03-2013 |
| 20130060017 | METHODS FOR SYNTHESIZING LABELED COMPOUNDS - The invention relates to methods for synthesizing compounds on solid supports. The invention also relates to synthesizing labeled compounds, such as those used in the field of radiopharmaceuticals. The invention relates to methods for synthesizing halogenated radiopharmaceuticals such as fludeoxyglucose (also known as fluorodeoxyglucose or FDG). | 03-07-2013 |
| 20130144051 | Device And Method For The Preparation Of Radiochemical Compounds - The invention relates to a device for the preparation of radiochemical compounds. It is provided that the device comprises at least a reaction module, a dosing module, and a storage module, wherein; the reaction module has at least one reaction vessel having a closable opening through which substances needed for the preparation of a predetermined radiochemical compound can be introduced into the reaction vessel of the reaction module and through which the prepared radiochemical compound can be removed from the reaction vessel of the reaction module; the dosing module has at least one pipetting head which can be moved relative to the storage module and the reaction module and in x, y, and z directions and also has at least one dosing unit; and at least one reservoir for one of the substances needed for the preparation of the respective radiochemical compound is formed in the storage module. | 06-06-2013 |
| 20130144052 | DEVICE FOR THE SYNTHESIS OF RADIO-LABELED COMPOUNDS - The invention relates to a device for the synthesis of radio-labeled compounds, which comprises | 06-06-2013 |
| 20130197215 | Chlorination of Carbohydrates and Carbohydrate Derivatives - Disclosed is a method for chlorinating a carbohydrate or a derivative thereof to produce a polychlorinated carbohydrate or a derivative thereof, such as sucralose, the method involves (i) reacting the carbohydrate or derivative thereof with a chlorinating agent to obtain a reaction mixture comprising said polychlorinated carbohydrate or derivative thereof and at least one under-chlorinated carbohydrate or derivative thereof, (ii) returning the at least one under-chlorinated carbohydrate or derivative thereof to a chlorinating step and further chlorinating the at least one under-chlorinated carbohydrate or derivative thereof to obtain the desired polychlorinated carbohydrate or derivative thereof; and (iii) optionally repeating steps (i) and (ii) “n” times where n≧1. The polychlorinated carbohydrate or a derivative thereof is obtained in high yields. | 08-01-2013 |
| 20140128595 | Process for the Preparation of -C-Aryl Glucosides - The present invention provides processes for stereoselectively preparing C-arylglucosides that can be useful as synthetic building block or drugs, including SGLT2 inhibitors. | 05-08-2014 |
| 20140187768 | CHLORINATION OF CARBOHYDRATES AND CARBOHYDRATE DERIVATIVES - Disclosed is a method for chlorinating a carbohydrate or a derivative thereof to produce a polychlorinated carbohydrate or a derivative thereof, such as sucralose, the method involves (i) reacting the carbohydrate or derivative thereof with a chlorinating agent to obtain a reaction mixture comprising said polychlorinated carbohydrate or derivative thereof and at least one under-chlorinated carbohydrate or derivative thereof, (ii) returning the at least one under-chlorinated carbohydrate or derivative thereof to a chlorinating step and further chlorinating the at least one under-chlorinated carbohydrate or derivative thereof to obtain the desired polychlorinated carbohydrate or derivative thereof; and (iii) optionally repeating steps (i) and (ii) “n” times where n≧1. The polychlorinated carbohydrate or a derivative thereof is obtained in high yields. | 07-03-2014 |
| 20140316130 | USE OF MICROFABRICATED DEVICES - This invention relates to the miniaturisation of radiosyntheses onto microfabricated devices, and in particular to use of microfabricated devices for radiosynthesis, isolation, and analysis of radiotracers for use in Positron Emission Tomography (PET). | 10-23-2014 |
| 20150018541 | STABILISATION OF RADIOPHARMACEUTICAL PRECURSORS - The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed. | 01-15-2015 |
| 20150133650 | DEVICE AND METHOD FOR THE PRODUCTION OF RADIOCHEMICAL COMPOUNDS - The invention relates to a device for the preparation of radiochemical compounds. It is provided that the device comprises at least a reaction module, a dosing module, and a storage module, wherein
| 05-14-2015 |
| 20160176909 | REGIOSELECTIVE SILYL EXCHANGE OF PER-SILYLATED OLIGOSACCHARIDES | 06-23-2016 |
| 20170233424 | CHLORINATION OF SUCROSE-6-ESTERS | 08-17-2017 |
| 20180025801 | RADIOISOTOPE RECOVERY | 01-25-2018 |
