| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 536170500 | Sulfur containing (e.g., methylthiolincosaminide, etc.) | 15 |
| 20110201794 | Disaccharides for drug discovery - Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres. | 08-18-2011 |
| 20110288281 | METHOD FOR 2-SULFATION OF GLYCOSIDES - Method for selective 2-sulfation of glycosides. | 11-24-2011 |
| 20110306757 | PROCESS FOR THE SYNTHESIS OF UNPROTECTED PENTASACCHARIDES FROM A PROTECTED PENTASACCHARIDE PRECURSOR - Procedure for the synthesis of deprotected pentasaccharides from a protected precursor pentasaccharide through a reaction procedure having five stages whereamong is included an N-sulphation of amino groups and a hydrogenolysis of benzyl groups. Through this procedure a drastic reduction is achieved in the total synthesis time in comparison with the process traditionally employed, together with increased reproducibility thereof, permitting the standardisation thereof. | 12-15-2011 |
| 20120232258 | Process for the Preparation and Purification of Topiramate - A process for the preparation of topiramate in an one pot reaction comprises the following steps: A) reacting 2,3:4, 5-bis-O-{1-methylethylidene)-β-D-fructopyranose with sulfurylchloride in xylene in the presence of an organic or inorganic base to form 2,3:4, 5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfuryl chloride, B) adding a second organic solvent to the mixture obtained in step A) C) reacting the mixture obtained in step B) with ammonia to form topiramate. | 09-13-2012 |
| 20120309949 | METHOD FOR PREPARATION OF THE TETRASACCHARIDE LACTO-N-NEOTETRAOSE (LNNT) CONTAINING N-ACETYLLACTOSAMINE - The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions. | 12-06-2012 |
| 20150031865 | PROCESS FOR THE PRODUCTION OF FONDAPARINUX SODIUM - The present invention provides novel processes for the preparation of Fondaparinux sodium by using the compound of formula ABC5 | 01-29-2015 |
| 20150031866 | PROCESS FOR THE PRODUCTION OF FONDAPARINUX SODIUM - The present invention provides improved processes of preparing Fondaparinux sodium comprising converting a compound of formula ABCDE4 to Fondaparinux sodium at a reaction pH of no more than about 9.0. In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided. | 01-29-2015 |
| 20150126721 | METHODS AND INTERMEDIATES FOR THE PREPARATION OF FONDAPARINUX - The present invention relates to methods for the synthesis of fondaparinux and intermediates thereto. | 05-07-2015 |
| 20150344513 | METHODS AND INTERMEDIATES FOR THE PREPARATION OF FONDAPARINUX - The present invention relates to methods for the synthesis of fondaparinux and intermediates thereto. | 12-03-2015 |
| 536170600 | Nitrogen or sulfur in aglycone moiety | 6 |
| 20110028702 | COMPOSITIONS AND PROCESSES FOR PREPARING 13-DEOXY-ANTHRACYCLINES - 13-benzenesulfonylhydrazone anthracyclines useful in producing improved yields in the synthesis 13-deoxyanthrcyclines, and an improved method of reducing 13-benzene-sulfonylhydrazone anthracyclines to 13-deoxyanthrcyclines wherein the reduction reaction is maintained at temperatures of about 55° C. to 64° C. without stirring or agitation. The reaction is completed with the addition of aqueous bicarbonate which forms the 13-deoxyanthracycline and precipitates. The precipitates are filtered and the precipitate and filtrate are extracted separately with organic solvents. The crude 13-deoxy anthracycline can be converted to 5-imino-13-deoxy anthracycline by reaction with methanolic ammonia. The reaction can also be performed with an acidic pyridinium salt instead of a strong acid so that neutralization of the reaction or extraction of the product is not necessary, thereby facilitating purification. | 02-03-2011 |
| 20110130553 | NOVEL SYNTHESIS OF GALACTOSIDE INHIBITORS - Novel synthesis routes for preparation of thiodigalactosides and intermediates are presented. The method includes the use of a 3-azido-galactosyl thiouronium salt derivative, which is activated to the corresponding thiol in situ, which in turn is directly reacted with a 3-azido-galactosyl bromide resulting in the 3,3′-di-azido-thio-di-galactoside before the thiol has a chance to reduce the azido 10 group. Hence, in situ formation of the 3-azido-galactosyl thiol from the thiouronium salt is essential in the synthesis procedure, because any other method that generate the thiol separately results in extensive unwanted azide reduction. | 06-02-2011 |
| 20110130554 | PROCESS FOR THE GLYCOSIDATION OF COLCHICINE AND THIOCOLCHICINE - A process for the preparation of compounds having formula (I) is disclosed, wherein: —R | 06-02-2011 |
| 20130030162 | PROCESS FOR EXTRACTION OF GLUCOSINOLATES FROM BROCCOLI SEEDS - A new process for extracting and purifying glucosinolates from plant material, preferably broccoli sprouts or seeds is described. An alcoholic extract is adsorbed onto a basic resin and eluted with ammonia. Optionally, the alcoholic extract is passed through an ion-exchange column containing acidic resin prior to the adsorption/elution step. | 01-31-2013 |
| 20140171630 | NOVEL SYNTHESIS OF GALACTOSIDE INHIBITORS - Novel synthesis routes for preparation of thiodigalactosides and intermediates are presented. The method includes the use of a 3-azido-galactosyl thiouronium salt derivative, which is activated to the corresponding thiol in situ, which in turn is directly reacted with a 3-azido-galactosyl bromide resulting in the 3,3′-di-azido-thio-di-galactoside before the thiol has a chance to reduce the azido 10 group. Hence, in situ formation of the 3-azido-galactosyl thiol from the thiouronium salt is essential in the synthesis procedure, because any other method that generate the thiol separately results in extensive unwanted azide reduction. | 06-19-2014 |
| 20170233426 | METHOD FOR 2-SULFATION OF GLYCOSIDES | 08-17-2017 |
