| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 530389700 | Binds cancer cell or component or product thereof (e.g., cell-surface antigen, etc.) | 8 |
| 20100174053 | COVALENT DIABODIES AND USES THEREOF - The present invention is directed to diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers. The diabody molecules of the invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on the same or differing antigens. Additionally, the antigens may be from the same or different molecules. The individual polypeptide chains of the diabody molecule may be covalently bound through non-peptide bond covalent bonds, such as, but not limited to, disulfide bonding of cysteine residues located within each polypeptide chain. In particular embodiments, the diabody molecules of the present invention further comprise an Fc region, which allows antibody-like functionality to engineered into the molecule. | 07-08-2010 |
| 20110112281 | CYTOTOXIC COMPOSITION - The present invention relates to a cytotoxic composition that contains, as an active ingredient, an IgG antibody produced in eggs of a transgenic avian with a gene encoding the IgG antibody. The IgG antibody is expected to produce high anti-tumor effects with less side-effects because this antibody has higher CDC activity than that of the corresponding CHO cell-derived IgG antibody and its primary protein structure is not altered. The present invention also provides an agent for ameliorating or treating a cancer and an agent for treating an autoimmune disease, which contain the cytotoxic composition. | 05-12-2011 |
| 20120296070 | RECURRENT GENE FUSIONS IN PROSTATE CANCER - Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided. | 11-22-2012 |
| 20140024811 | CANCER DETECTION - Provided are methods of detecting cancer or pre-cancerous conditions in patients comprising assaying a patient sample for an elevated level of target molecules representative of expression of nucleosome assembly protein 1-like 1 (NAP1L1), wherein elevated levels of expression of NAP1L1 are indicative of a cancer of the colon, or a precancerous condition of the colon. Also provided are similar methods using panels of biomarkers such as HMGB1; PHB; RPL6; NAP1L1 and CK18. The invention also provides a method for assessing effectiveness of a therapy or putative therapy, methods of staging cancer and assessing progression of a cancer and methods of determining an appropriate cancer treatment regimen. | 01-23-2014 |
| 20140235833 | METHOD OF CLASSIFYING ANTIBODY, METHOD OF IDENTIFYING ANTIGEN, METHOD OF OBTAINING ANTIBODY OR ANTIBODY SET, METHOD OF CONSTRUCTING ANTIBODY PANEL AND ANTIBODY OR ANTIBODY SET AND USE OF THE SAME - The present invention relates to an isolated antibody against HER1, an isolated antibody against CD147, an isolated antibody against CD73, and an isolated antibody against EpCAM; reagents and compositions including said antibodies; and uses of said reagents, compositions, and antibodies. The present invention also relates to nucleic acids and vectors expressing said antibodies. The invention further relates to transformants comprising said nucleic acids or vectors. | 08-21-2014 |
| 20140364592 | CYTOTOXIC IMMUNOGLOBULIN - The invention relates to a cytotoxic modular antibody with a molecular weight of up to 6OkD, specifically binding to a cell surface target with a binding affinity of Kd<10 | 12-11-2014 |
| 20150119557 | IN VITRO CULTURE CONDITIONS FOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA/LYMPHOMA - We describe cell culture media for in vitro culture of a human cancer cell of the lymphocyte lineage (e.g., leukemia, lymphoma, or other blasts) or a precursor thereof, especially T-cell acute lymphoblastic leukemia lymphoma (T-ALL), as well as methods for at least maintenance, propagation, or both of the human cancer cell or its precursor. | 04-30-2015 |
| 20160145347 | Anti-Prostate Cancer Antibodies and Methods of Detection and Treatment of Prostate Cancer - Disclosed herein are antibodies that detect a lipid-like antigen on prostate cancer cells and methods of detecting and treating prostate cancer using the same. | 05-26-2016 |
