Class / Patent application number | Description | Number of patent applications / Date published |
530389500 | Binds bacterium or similar microorganism or component or product thereof (e.g., Pseudomonas, Chlamydia, Clostridium, bacterium-associated antigen, etc.) | 9 |
20110190479 | DIFFERENTIAL TARGETING OF TRIACYLGLYCEROL SYNTHASE AND WAX SYNTHASE ACTIVITY OF THE TRIACYLGLYCEROL SYNTHASE GENE FOR TUBERCULOSIS TREATMENT - The application reports the discovery that mycobacterial triacylglycerol synthase (MTTGS) enzymes also have a wax synthase function. This bifunctional enzymatic activity, or ‘dual function,’ implies that the enzymes contain separate binding sites for diacylglycerol and acyl alcohol and a common binding site for acyl-coenzyme A. Embodiments of the invention relate to methods of selection and/or design of therapeutic compounds that will reduce any potentially toxic side effects of candidate drugs designed to inhibit the mycobacterial enzyme. | 08-04-2011 |
20110230648 | METHOD OF BINDING BACTERIAL LIPOPOLYSACCHARIDES TO A SOLID PHASE - The subject the present invention is a method of producing affinity beds with bacterial lipopolysaccharide molecules bound to them in a non-covalent and stable fashion. The bed produced according to the present invention may be used in affinity chromatography for the purification of antibodies against lipopolysaccharides. It is particularly useful in the purification of antibodies against the labile epitopes of lipopolysaccharides, which degrade in heretofore used methods of covalent bonding of the lipopolysaccharide molecules to the solid phase. | 09-22-2011 |
20120149884 | SPECIFIC ANTIBODY SELECTION BY SELECTIVE ELUTION CONDITIONS - Methods for preparing high avidity anti-antigen polyclonal antibody preparations by antigen affinity column purification and high avidity anti-antigen polyclonal antibody preparations are described. | 06-14-2012 |
20120322988 | THERAPEUTIC AGENT FOR USE IN A METHOD OF TREATING PSORIASIS OR ATOPIC DERMATITIS - The present invention provides a therapeutic agent for psoriasis or atopic dermatitis, and comprises anti- | 12-20-2012 |
20130253175 | GRAM-POSITIVE BACTERIA SPECIFIC BINDING COMPOUNDS - The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals. | 09-26-2013 |
20130274451 | AFFINITY CHROMATOGRAPHY MATRIX - The present invention relates to a method of separating one or more immunoglobulin containing proteins from a liquid. The method includes first contacting the liquid with a separation matrix comprising ligands immobilised to a support; allowing the immunoglobulin containing proteins to adsorb to the matrix by interaction with the ligands; followed by an optional step of washing the matrix containing the immunoglobulin containing proteins adsorbed thereon; and recovering said immunoglobulin containing proteins by contacting the matrix with an eluent which releases the proteins. The method improves upon previous separation methods in that each of the ligands comprises one or more of a protein A domain (E, D, A, B, C), or protein Z, or a functional variant thereof, with at least one of the monomers having a substitution of the Asparagine at the position corresponding to N28 of B domain of Protein A or Protein Z, and wherein the ligand provides an increase in elution pH compared to non-substituted ligand. | 10-17-2013 |
20150080558 | CHROMATOGRAPHY MATRICES INCLUDING NOVEL STAPHYLOCOCCUS AUREUS PROTEIN A BASED LIGANDS - The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, | 03-19-2015 |
20150376266 | GRAM-POSITIVE BACTERIA SPECIFIC BINDING COMPOUNDS - The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals. | 12-31-2015 |
20160168232 | GRAM-POSITIVE BACTERIA SPECIFIC BINDING COMPOUNDS | 06-16-2016 |