| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 530369000 | Separation, purification or synthesis | 10 |
| 20090099337 | S-NITROSO GROUP-CONTAINING ALBUMIN, METHOD FOR PRODUCTION, AND ANTICANCER AGENT - The present invention provides an S-nitroso group-containing albumin, comprising an S-nitroso group introduced to at least one lysine in the amino acid sequence for albumin. The S-nitro group has been introduced into a lysine in the S-nitroso group-containing albumin of the invention to allow more S-nitroso groups to be included in the albumin, thus ensuring more potent inhibition of cancer cells in NO groups. | 04-16-2009 |
| 20110152503 | Ultra-high Yield Of Alpha-1-Antitrypsin - The instant invention provides novel and effective methods of isolating alpha-1-antitrypsin from cryo-poor plasma and formulating it into therapeutic products. This invention achieves higher yields and a superior quality of alpha-1-antitrypsin. Alpha-1-antitrypsin is isolated from cryo-poor plasma, using one or more salts selected from a group comprising sodium citrate, sodium acetate, sodium gluconate, ammonium sulfate, sodium chloride, sodium sulfate and ammonium chloride in two fractionation steps, followed by diafiltration to remove those salts employed. | 06-23-2011 |
| 20110301329 | Process for the Purification of Recombinant Albumin - A process is provided for the preparation of a highly pure albumin solution the process comprising subjecting albumin (preferably expressed and secreted by transformed yeast) to a series of chromatographic steps. Preferably, the process comprises the steps of positive mode cation exchange chromatography, positive mode anion exchange chromatography, positive mode affinity chromatography, negative mode affinity chromatography (preferably using immobilised aminophenylboronic acid), negative mode cation exchange chromatography, and negative or positive mode anion exchange chromatography. A process for reducing the level of nickel in an albumin solution is also disclosed, as is a recombinant albumin coding sequence comprising two or more in-frame translation stop codons. Also disclosed is a process for producing recombinant albumin, the process comprising culturing a fungal cell expressing a is recombinant albumin coding sequence, wherein the cell has a reduced capacity of mannosylation of the recombinantly-expressed albumin. | 12-08-2011 |
| 20120202973 | METHOD FOR EXTRACTING RECOMBINANT HUMAN SERUM ALBUMIN FROM TRANSGENIC RICE GRAIN - A method for extracting recombinant human serum albumin (rHSA) from transgenic rice grain is provided, comprising the steps of: 1) grinding dehusked rice containing rHSA into milled rice grain with a fineness of 80˜120 mesh, which is mixed with a extraction buffer in a w/v ratio of 1:5, then extracting at 55˜60° C. for 1˜3 hours to obtain mixture I; said extraction buffer comprises 10˜30 mM phosphate buffer, 10˜20 mM sodium acetate, 15˜30 mM ammonium sulfate and 5˜20 mM sodium caprylate and has a pH of 6.5˜8; 2) adjusting the pH of mixture I to 4.0˜4.5, followed by precipitating at room temperature for 3˜12 hours to obtain mixture II; 3) filtering the mixture II and collecting the filtrate, to obtain a solution containing high concentration of rHSA. The concentration of rHSA in the resultant solution is 650˜660 μg/mL, which increases by 1.15 times comparing to the extraction amount before improvement, and the amount of non-target protein is reduced by 2.46 times. The method provides a basis for subsequent purification of rHSA. | 08-09-2012 |
| 20140031527 | METHOD FOR POLISHING ALBUMIN - The present invention provides a method of polishing albumin to remove contaminants comprising passing an albumin enriched solution through a hydrophobic charge-induction chromatographic resin and recovering the albumin solution which passes through the resin. Also provided is a polished albumin solution prepared by said method. | 01-30-2014 |
| 20140206844 | METHODS FOR ISOLATING BLOOD PRODUCTS FROM AN INTER-ALPHA INHIBITOR PROTEIN-DEPLETED BLOOD PRODUCT MATERIAL - Described is a method for isolating multiple blood products from a single starting material. Isolation of multiple blood products from a single starting material maximizes the efficiency of blood product isolation. In the present invention, one or more blood products are isolated from a blood product material previously depleted of inter-alpha inhibitor protein (IαIp). This method provides new paths for increasing the efficiency of isolating blood components and providing pharmaceutically acceptable forms of those components. | 07-24-2014 |
| 20150327572 | METHOD FOR OBTAINING VALUABLE PRODUCTS, IN PARTICULAR PROTEINS, FROM A NATIVE MIXTURE OF MATERIALS - A method for obtaining proteins from native mixtures of materials is disclosed. In an embodiment, the method includes: A): providing a native mixture of materials from seeds having hard fragmentable hulls; B): comminuting the mixture of materials; C): dispersing the comminuted mixture of materials with water; D): adjusting a pH of the pulp of step C) to an alkaline range pH>9.5; E): adding a water-soluble organic solvent alcohol to the pulp; F): separating off a solids phase from the pulp, which has a predominant fraction of the hulls, to form a hull-free pulp; G): shifting the pH of the hull-free pulp from step F) to a pH range of pH=4.5 to pH=7.2; and H): separating the hull-free pulp of step G) into a plurality of phases, wherein one of the plurality of phases is a protein concentrate phase. | 11-19-2015 |
| 20150361127 | METHODS FOR ISOLATING BLOOD PRODUCTS FROM AN INTER-ALPHA INHIBITOR PROTEIN-DEPLETED BLOOD PRODUCT MATERIAL - Described is a method for isolating multiple blood products from a single starting material. Isolation of multiple blood products from a single starting material maximizes the efficiency of blood product isolation. In the present invention, one or more blood products are isolated from a blood product material previously depleted of inter-alpha inhibitor protein (lαlp). This method provides new paths for increasing the efficiency of isolating blood components and providing pharmaceutically acceptable forms of those components. | 12-17-2015 |
| 20160009757 | PROCESS FOR ISOLATION OF PLASMA OR SERUM PROTEINS | 01-14-2016 |
| 20160122414 | METHOD FOR EXTRACTING RECOMBINANT HUMAN SERUM ALBUMIN FROM TRANSGENIC RICE GRAIN - A method for extracting recombinant human serum albumin (rHSA) from transgenic rice grain is provided, comprising the steps of: 1) grinding dehusked rice containing rHSA into milled rice grain with a fineness of 80˜120 mesh, which is mixed with a extraction buffer in a wily ratio of 1:5, then extracting at 5560° C. for 1˜3 hours to obtain mixture 1; said extraction buffer comprises 10˜30 mM phosphate buffer, 10˜20 mM sodium acetate, 1530 mM ammonium sulfate and 5˜20 mM sodium caprylate and has a pH of 6.5˜8; 2) adjusting the pH of mixture I to 4.0˜4.5, followed by precipitating at room temperature for 3˜12 hours to obtain mixture 3) filtering the mixture 11 and collecting the filtrate, to obtain a solution containing high concentration of rHSA. The concentration of rHSA in the resultant solution is 650˜660 μg/mL, which increases by 1.15 times comparing to the extraction amount before improvement, and the amount of non-target protein is reduced by 2.46 times. The method provides a basis for subsequent purification of rHSA. | 05-05-2016 |
