| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 514599000 | Thiocarboxamides, (i.e., C(=S)-N) | 16 |
| 20080269340 | BIS (thio-hydrazide amide) salts for treatment of cancers - Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I): | 10-30-2008 |
| 20080319080 | Amide Compounds and Their Use - Since an amide compound represented by the formula (1) | 12-25-2008 |
| 20090042991 | Methods of increasing natural killer cell activity for therapy - Methods of employing bis(thio-hydrazide amides) to increase NK cell activity in a subject in need thereof, e.g., a subject with an infection or an immunodeficiency, are provided such that the disorder is not cancer, a proliferative cell disorder, a non-infective heat shock protein 70 (Hsp70) responsive disorder, or a proteasome-inhibitor responsive disorder. Typically, a subject, e.g., a human, can be in need of increased NK cell activity has an immunodeficiency or is treated for an infection (e.g., a bacterial, viral, fungal, or parasite infection, or a combination thereof). The method includes administering to the subject an effective amount of a compound represented by Structural Formula I: Y is a covalent bond or an optionally substituted straight chained hydrocarbyl group, or, Y, taken together with both >C=Z groups to which it is bonded, is an optionally substituted aromatic group. R | 02-12-2009 |
| 20100056635 | NOVEL PROTEIN KINASE MODULATORS AND THERAPEUTIC USES THEREOF - The present invention provides new tyrphostin derivatives acting as substrate competitive protein tyrosine kinase (PTK) inhibitors and receptor tyrosine kinase (RTK) inhibitors, methods of their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for preventions and treatments of PTK and RTK related disorders such as metabolic, fibrotic, and cell proliferative disorders, in particular psoriasis and cancer. | 03-04-2010 |
| 20100249239 | BIS(THIO-HYDRAZIDE AMIDE) FORMULATION - Disclosed herein are compositions comprising a compound represented by structural formula (I): | 09-30-2010 |
| 20100311840 | ORAL FORMULATIONS OF BIS(THIOHYDRAZIDE AMIDES) - Disclosed herein are oral formulations of bis(thio-hydrazide amides) compounds of the following structural formula (I): or a pharmaceutically acceptable salt thereof, wherein R | 12-09-2010 |
| 20100324143 | BIS(THIO-HYDRAZIDE AMIDE) SALTS FOR TREATMENT OF CANCERS - Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I): | 12-23-2010 |
| 20110105618 | NOVEL MODULATORS OF PROTEIN KINASE SIGNALING - The present invention provides new tyrphostin derivatives acting as protein kinase (PK) and receptor kinase (RK) signaling modulators. The invention further provides methods of their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for preventions and treatments of PK and RK related disorders such as metabolic, inflammatory, fibrotic, and cell proliferative disorders, in particular cancer. | 05-05-2011 |
| 20120004310 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS - Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule. | 01-05-2012 |
| 20120035266 | BIS(THIO-HYDRAZIDE AMIDE) SALTS FOR TREATMENT OF CANCERS - Disclosed are bis(thio-hydrazide amide) disalts and pharmaceutical compositions thereof. Also disclosed are methods of using bis(thio-hydrazide amide) disalts to treat cancer. | 02-09-2012 |
| 20130289122 | SUBSTITUTED 2-[2-(PHENYL) ETHYLAMINO] ALKANEAMIDE DERIVATIVES AND THEIR USE AS SODIUM AND/OR CALCIUM CHANNEL MODULATORS - Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them are useful as sodium and/or calcium channel modulators for preventing, alleviating and curing pathologies wherein the above mechanisms play a pathological role. The compounds may be particularly useful for the prevention, alleviation, and curing of, for example, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases. | 10-31-2013 |
| 20140113972 | PRESELECTION OF SUBJECTS FOR THERAPEUTIC TREATMENT WITH ELESCLOMOL BASED ON HYPOXIC STATUS - The present invention provides methods for the preselection of a subject for therapeutic treatment with elesclomol based on modulated levels of hypoxia in the subject. In one embodiment, the invention provides methods for the preselection of a subject for therapeutic treatment with elesclomol based on modulated levels of lactate dehydrogenase (LDH). The invention also provides methods for treating cancer in a subject by administering an effective amount of elesclomol to the subject, wherein the subject has a modulated level of hypoxia. The invention further provides kits to practice the methods of the invention. | 04-24-2014 |
| 20140296343 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS - Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule. | 10-02-2014 |
| 20140350115 | POLYMORPHS OF N-MALONYL-BIS(N`-METHYL-N`-THIOBENZOYLHYDRAZIDE) - At least 70% by weight of Compound 1 is the single crystalline form, Form A, Form C, or Form D, of the compound. A pharmaceutical composition comprises a pharmaceutically acceptable carrier or diluent, and compound 1, wherein at least 70% by weight of the compound is the single crystalline form, Form A, Form C, or Form D, of the compound. A method of treating a subject with cancer comprises administering to the subject an effective amount of compound 1 or the pharmaceutical composition. | 11-27-2014 |
| 20150057357 | BIS (THIOHYDRAZIDE AMIDE) COMPOUNDS FOR TREATING CANCERS - Methods of treating a subject with cancer characterized by an impaired ability to repair oxidative DNA damage, comprising administering to the subject an effective amount of a bis(thiohydrazide amide) compound are provided. | 02-26-2015 |
| 20160029634 | MICROBIOCIDES AND USES THEREOF - The compositions and methods for control of microbial growth, for example, in oil and gas field fluids. The present invention also relates to microbicides, and more particularly, to the use of biocides in gas and oil field fluids. | 02-04-2016 |
