| Entries |
| Document | Title | Date |
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| 20080227857 | N-Alkylcarbonyl-Amino Acid Ester and N-Alkylcarbonyl-Amino Lactone Compounds and Their Use - The present invention generally relates to refreshing, soothing, and cooling compounds that affect sensory processes. More particularly, the present invention pertains to certain N-alkylcarbonyl-amino acid ester and N-alkylcarbonyl-amino lactone compounds as described herein; compositions and articles comprising such compounds; and methods of treatment, for example, methods of alleviating the discomforts of irritation, itch, and pain in the skin and in the linings of the oral cavity and upper respiratory tract, for example, in methods of treatment of cough and/or asthma. | 09-18-2008 |
| 20080242722 | Combination Therapy for Treating Cyclooxygenase-2 Mediated Diseases or Conditions in Patients at Risk of Thrombotic Cardiovascular Events - The invention is directed to a method for treating a cyclooxygenase-2 mediated disease or condition in a mammalian patient at risk of a thrombotic cardiovascular event, wherein the patient is on aspirin therapy to reduce the risk of the thrombotic cardiovascular event, | 10-02-2008 |
| 20080262082 | COMPOSITION CONTAINING S-(-)-TULIPALIN B OR ACETYLATED-S-(-)-TULIPALIN B - The present invention provides S-(−)-tulipalin B, acetylated-S-(−)-tulipalin B and an antibacterial composition comprising the same. The active compound tulipalin B and composition of the present invention exhibit superior and stable antibacterial activity over a broad range of temperature and pH, as compared to conventional natural antibacterial agents used in related industries. Therefore, the composition and active compound of the present invention can be widely used as a natural food preservative and/or an antibacterial agent in a variety of fields such as foods, pharmaceuticals, cosmetics, fibers, livingwares, and the like. | 10-23-2008 |
| 20080287532 | OXACYCLOPENTENE-2 DERIVATIVES - The present invention relates to oxacyclopentene-2 derivatives as compounds possessing antiinflammatory, neuroprotective, immunomodulatory and cardiovascular activities in mammals. | 11-20-2008 |
| 20090005440 | PHARMACEUTICAL COMPOSITION AND HEALTH FOOD COMPRISING EXTRACT OF PHELLINUS SP.PL 3 OR PHELLINSIN A ISOLATED FROM THE SAME AS AN EFFECTIVE COMPONENT FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE - The present invention relates to a pharmaceutical composition and health food comprising | 01-01-2009 |
| 20090118364 | Novel diterpenes from the fruiting body of antrodia camphorata and pharmaceutical compositions thereof - The present invention relates to novel diterpene compounds isolated from the fruiting body of | 05-07-2009 |
| 20090137665 | NOVEL METHOD OF NEUROPROTECTION BY PHARMACOLOGICAL INHIBITION OF AMP-ACTIVATED PROTEIN KINASE - A method of neuroprotection which comprises administration of an AMPK inhibitor to a patient who is experiencing or has experienced a stroke, the compound being an AMPK inhibitor. Treatments with these agents significantly reduce the size of infarcts, and therefore minimize the loss of brain tissue and neurons. Thus, function can be preserved after stroke or ischemic injury in the brain. Similarly, neuronal loss can be minimized in degenerative diseases that cause neuronal compromise by perturbing energy utilization and availability in neurons. | 05-28-2009 |
| 20090247626 | Method of Treating Dyslipidemia Using Naturally Occurring Diterpene - A method for treatment and or/prevention of dyslipidemia is provided. The invention relates to reducing low density lipoprotein cholesterol concentration by using naturally occurring diterpene (16α-hydroxycleroda-3,13(14)Z-dien-15,16-olide, a compound having formula (1)) isolated from leaves of | 10-01-2009 |
| 20090286873 | AI-2 compounds and analogs based on Salmonella typhimurium LsrB structure - This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in | 11-19-2009 |
| 20100022639 | Methods of Inducing Weight Loss - This invention provides a method for inducing weight loss in an animal by administering to the animal a compound which reduces the expression and/or secretion of neuropeptide Y (NPY). The effect may be accomplished directly, indirectly, or humorally. Preferably, administration of this compound has the effect of increasing malonyl CoA levels in the animal. Compounds administered according to this invention may be inhibitors of fatty acid synthase (FAS), including substituted α-methylene-β-carboxyl-γ-butyrolactones, or inhibitors of malonyl Coenzyme A decarboxylase (MCD). Preferably, the compound is administered in an amount sufficient to reduce the amount and/or duration of expression and/or secretion of NPY to levels at or below those observed for lean animals. In another preferred embodiment, the administration will reduce expression and/or secretion to levels observed for fed or satiated animals; more preferably, administration will reduce the level of NPY below that of fed animals. In a particular embodiment, this invention provides a method for inducing weight loss in an animal by administering a compound which inhibits feeding behavior in the animal. The method is particularly useful for inducing weight loss in animals deficient in expression of the hormone leptin or animals resistant to the action of leptin. | 01-28-2010 |
| 20100029761 | NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME - A pharmaceutical diluent and a compound of formula VI: wherein: R10=H, or C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing halogen atoms; R11=H3 or C]-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing halogen atoms; R12=H, or C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing halogen atoms, —C(O)R13, where R13 is H, Ci-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing halogen atoms, or —OH, —OR14 or —NR14, where R14 is H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing halogen atoms. | 02-04-2010 |
| 20100035981 | PARTICULATE AQUEOUS SYSTEM FOR THE PREPARATION OF A FORMULATION FOR THE TREATMENT OF ADIPOSE DISEASES - Aqueous particulate system comprising at least one water dispersible biopolymer, at least one surfactant, and water for the preparation of a formulation for the treatment of adipose diseases and/or conditions with improved bioavailability and good retardation of the release of active substances. | 02-11-2010 |
| 20100048696 | AGRICULTURAL DISEASE CONTROL AGENT - The present invention provides a disinfectant comprising as an active ingredient maleic acid and/or maleic anhydride. | 02-25-2010 |
| 20100093846 | HYDROXAMATE COMPOSITIONS - The present disclosure provides compositions including a first component including at least one phospholipid possessing at least one vinyl group, a second component including a furanone possessing vinyl and/or acrylate groups, and a third component including a hydroxamate. Compositions, medical devices, and coatings including copolymers and blends of the foregoing components are also provided. | 04-15-2010 |
| 20100120905 | SYSTEM AND METHOD FOR CONTROLLING GROWTH OF MICROORGANISMS WITH BROMINATED FURANONES - A method for inhibiting the growth of a microorganism using an effective amount of one or more of the following synthetic brominated furanones: (i) 4-bromo-5Z-(bromomethylene)-3-methylfuran-2-one; (ii) 3-(dibromomethyl)-5-(dibromomethylene)furan-2-one; (iii) 3-(bromomethyl)-5-(dibromomethylene)furan-2-one; (iv) 4-bromo-3-(bromomethyl)-5Z-(bromomethylene)furan-2-one; or (v) 4-bromo-5-(dibromomethyl)-3-methylfuran-2(5H)-one. The brominated furanones inhibit the growth of both fungi and bacteria, including the fungal species | 05-13-2010 |
| 20100144866 | ANTI-FATIGUE AGENTS AND ORAL COMPOSITIONS CONTAINING ANDROGRAPHOLIDE AS ACTIVE INGREDIENT - Disclosed is a composition which is safe for a human body and an animal, can be ingested continuously on a daily basis, has an anti-fatigue activity, and is effective for the prevention or treatment of a disease or condition associated with fatigue. Specifically disclosed is an anti-fatigue agent comprising andrographolide optionally together with an α-lipoic acid as an active ingredient(s). Also disclosed is a novel oral composition comprising andrographolide and an α-lipoic acid. The anti-fatigue agent and the oral composition are useful for the prevention or treatment of chronic fatigue syndrome, overfatigue, physical fatigue, mental fatigue and organ fatigue. | 06-10-2010 |
| 20100197781 | Anti-Malarial Compound Isolated from Gomphostema Niveum - The present invention provides an antimalarial compound 3-[2-(2-Hydroxymethyl-1, 4a, 5-trimethyl-7-oxo-1,2,3,4,4a, 7 8, 8a-octahydronaphthalen-1-yl)-ethyl]-5H-furan-2-one of the formula 1 given below | 08-05-2010 |
| 20100204317 | METHODS OF TREATING DERMATOLOGICAL DISORDERS OR CONDITIONS - This invention is directed to the use of TOFA in the treatment of acne and other dermatological disorders. This invention is also directed to pharmaceutical compositions comprising TOFA and a pharmaceutically acceptable excipient for dermatological or oral administration. | 08-12-2010 |
| 20100286262 | PTGS2 HAPLOTYPES - It has been demonstrated that a group of single nucleotide polymorphisms can be used to determine the presence or absence of certain extended PTGS2 haplotypes in the genome of a subject or individual, in order to determine the susceptibility to disease of the subject, the disease prognosis of the subject, or predict the response to therapy of the subject, thereby allowing personalised therapy of said subject. | 11-11-2010 |
| 20110054018 | Inotilone derivatives as coherent biological response modifier (cBMR) - Optimal compositions of derivatives of 5-methyl-3(2H)-furanone compounds and phenylpropanoid polyketides related to inotilone, that exert biological response modification in health and disease, and their method of preparation, are disclosed. Methods of treating degenerative conditions stemming from over-expression of inducible nitric oxide synthase (iNOS) using these compositions are also disclosed. | 03-03-2011 |
| 20110077295 | ANDROGRAPHOLIDE DERIVATIVES AND USE THEREOF IN MANUFACTURE OF MEDICAMENTS - The present invention relates to an andrographolide derivative of the formula (I), wherein R | 03-31-2011 |
| 20110092587 | Branched-chain amino acid composition for improving skeletal muscle protein metabolism - The present invention relates to compositions and methods for improving skeletal muscle protein metabolism through encouraging skeletal muscle protein synthesis, reducing skeletal muscle protein degradation, and attenuating inflammatory signaling in exercising muscle. | 04-21-2011 |
| 20110092588 | LACTONE FORMULATIONS AND METHOD OF USE - Compounds of Formulae Ia and Ic having a lactone structure and an methylene group at the alpha-position of the lactone structure and methods for using and making the compounds have been disclosed. The lactone compounds can be reacted with an neucleaphilic agent to open the lactone ring to a compound of Formula Ib. The lactone of Formula Ia and its functional derivatives have been isolated from | 04-21-2011 |
| 20110184059 | METHYLENE FURANONE DERIVATIVES AND USE OF SAID DERIVATIVES AS A PHOTOPROTECTING OR ANTIOXIDANT OR DEPIGMENTATION AGENT IN COSMETIC OR DERMATOLOGICAL COMPOSITIONS - The present invention relates to novel methylene furanone derivatives as well as the use thereof as a protective, antioxidant, or depigmentation agent in cosmetic or dermatological compositions. | 07-28-2011 |
| 20110281942 | Tautomycetin and Tautomycetin Analog Biosynthesis - The present invention relates to tautomycetin (TTN) and analogs thereof. Also provided are methods of using TTN and analogs thereof in the treatment of various diseases relating to SHP2 function. | 11-17-2011 |
| 20120010282 | Tautomycetin and Tautomycetin Analog Biosynthesis - The present invention relates to the biosynthetic gene cluster for tautomycetin (TTN) produces tautomycetin. Also provided are engineered micro-organisms for the production of TTN and analogs thereof, as well as methods of screening for compounds for activity. | 01-12-2012 |
| 20120029070 | BURDOCK FRUIT EXTRACT CONTAINING ARCTIGENIN AT HIGH CONTENT AND PROCESS FOR PRODUCING SAME - PROBLEM TO BE SOLVED | 02-02-2012 |
| 20120157522 | B. Anthracis Prevention and Treatment: Mutant B. Anthracis Lacking Luxs Activity and Furanone Inhibition of Growth, AI-2 Quorum Sensing, and Toxin Production - The present invention pertains to the discovery that | 06-21-2012 |
| 20120178803 | METHOD FOR TREATING BRAIN CANCER OR REDUCING TEMOZOLOMIDE-RESISTANCE OF BRAIN CANCER CELLS - Provided is a method for treating brain cancer or reducing temozolomide-resistance of brain cancer cells in a subject, comprising administrating to the subject an effective amount of an active ingredient selected from the group consisting of (Z)-butylidenephthalide of formula (I), a pharmaceutically acceptable salt of (Z)-butylidenephthalide, a pharmaceutically acceptable ester of (Z)-butylidenephthalide, and combinations thereof: | 07-12-2012 |
| 20120316232 | COMBINATION OF A CENTRALLY-ACTING ANALGESIC AND A SELECTIVE CYCLOOXYGENASE-2 INHIBITOR ANTI-INFLAMMATORY AGENT FOR THE TREATMENT OF INFLAMMATION AND PAIN IN THE VETERINARY FIELD - The present invention relates to veterinary pharmaceutical compositions for the treatment of pain and inflammation, containing a combination of Tramadol and Firocoxib, for oral administration. | 12-13-2012 |
| 20120329868 | PARACONIC ACIDS AS PIGMENTATION ACTIVATORS - The invention relates to a mixture comprising protolichesterinic acid or a salt thereof or a diastereoisomer thereof or a derivative thereof, and lichesterinic acid or a salt thereof or an enantiomer thereof or a derivative thereof, for use for stimulating pigmentation of the skin and/or of its appendages. | 12-27-2012 |
| 20130030049 | METHODS OF TREATING DERMATOLOGICAL DISORDERS OR CONDITIONS - This disclosure is directed to the use of TOFA in the treatment of inflammatory disorders, including dermatological disorders. | 01-31-2013 |
| 20130190394 | Applications Of Arctigenin In Formulating Drugs For Preventing Or Treating Diseases Related To Red Blood Cell Reduction - Provided are applications of arctigenin in formulating medicines for preventing or treating diseases related to blood cell reduction, and preparations that contain arctigenin, particularly micro-emulsions that contain arctigenin. Experiments show that arctigenin can significantly increase the white cell counts after chemotherapy, especially the neutrophil granulocyte counts. | 07-25-2013 |
| 20130225675 | BACTERIAL CONTROL OF WATER BASED FLUIDS DURING SUBSURFACE INJECTION AND SUBSEQUENT RESIDENCE TIME IN THE SUBTERRANEAN FORMATION - Apparatus and methods to prevent the proliferation of undesired life forms in a subterranean formation, comprising forming a fluid comprising an inhibitor; and introducing the inhibitor to a surface in the formation. Apparatus and methods to prevent the proliferation of undesired life forms along a surface of tubular or equipment for use in the oil field services industry, comprising forming a coating comprising an inhibitor; and introducing the coating to a surface of the tubular or equipment. Apparatus and methods to prevent the proliferation of undesired life forms along a surface of tubular or equipment for use in the oil field services industry, comprising forming a material comprising an inhibitor; and embedding the material into a surface of the tubular or equipment. | 08-29-2013 |
| 20130237596 | Uses of 15-benzylidene-14-deoxy-11,12-didehydroandrographolide Derivatives in the Preparation of Antineoplastic Drugs - The present invention relates to the preparation of anti-tumor drugs with andrographolide derivatives, which belongs to the field of pharmaceutical technology, and involves 15-benzylidene substituted derivatives of 14-deoxy-11,12-didehydro-andrographolide and their 3,19-ester derivatives. Proved by the experiments, these compounds significantly inhibited the colony formation and migration ability of various cancer cells, and also inhibited the migration ability of vascular endothelial cells in vitro. The compounds of this invention significantly inhibited the tumor growth, invasion, metastasis and angiogenesis on mouse xenograft models, and inhibited the experimental lung metastasis of B16-F10 malignant melanoma cells. Therefore, this class of compounds could be used as the active ingredients for the preparation of antineoplastic drugs, which are of efficiency and low-toxicity. Thereby it has potential to expand the selectable range of clinical drug and is of high significance to make full use of the plant resources of | 09-12-2013 |
| 20140045933 | METHODS AND COMPOSITIONS FOR TREATING METABOLIC SYNDROME - Provided are methods, compositions, systems, and kits for treating metabolic syndrome or a disorder associated with metabolic syndrome, e.g., obesity, dyslipidemia, and/or a diabetic condition, comprising administering systemically to a subject one or more compounds of the Formula (I) and/or (II): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, polymorph, tautomer, isotopically enriched derivative, or prodrug thereof, wherein, L, R | 02-13-2014 |
| 20140073690 | COVALENT INHIBITION OF BACTERIAL QUORUM SENSING - Inhibitors of bacterial communication, such as quorum sensing, and method of use and manufacture thereof. | 03-13-2014 |
| 20140113963 | ANTIBIOTIC COMPOSITION CONTAINING ERYTHORBYL LAURATE AND ITS USAGE - An antibiotic composition including erythorbyl laurate as an active ingredient and a use thereof are disclosed. Erythorbyl laurate is confirmed to have antibiotic effects on Gram-positive bacteria and thus is used as an antibiotic agent in foods, cosmetics, feeds, and the like and utilized in the form of a hand cleaner and other medicines for external application. | 04-24-2014 |
| 20140187627 | USES OF C15-SUBSTITUTED ANDROGRAPHOLIDE DERIVATIVES IN THE PREPARATION OF ANTI-HEPATITIS B VIRUS MEDICAMENT - Disclosed is a use of C15-substituted andrographolide derivatives in preparation of anti-hepatitis B virus medicaments. In the present invention, the HepG2.2.15 cells are used to measure the amount of the hepatitis B virus surface antigen (HBsAg) secretion in the supernatant of the culture; the duck hepatitis B virus (DHBV) is used to infect the model and the DHBV-DNA level in serum is measured, and the pathological change in hepatic tissue is observed. A number of andrographolide derivative compounds are screened, compounds having a good anti-HBV effect are preferred, which has a structure represented by general formula 1 set forth herein. Due to high anti-HBV activity and low toxicity, as well as good protection against hepatic injury, the compounds can be used as the active ingredient for preparing anti-HBV medicaments, thereby providing a new pharmaceutical way for treatment of hepatitis, and broadening the range of clinical medicines. | 07-03-2014 |
| 20150025135 | Methods and Compositions for Treating Leukemia - The present invention provides methods and compositions for treating leukemia by cyclohexenone compounds. | 01-22-2015 |
| 20150051278 | METHOD OF EXTERMINATING HARMFUL INSECT - The invention is a method of exterminating a harmful insect with an agricultural and horticultural insecticide containing one or more kinds of compound (A) selected from a specific polyoxyethylene fatty acid ester, a specific polyoxyethylene sorbitan fatty acid ester, a specific (poly)glycerol fatty acid ester, and a specific alkyl saccharide, and a compound (B) of an alcohol having a linear or branched alkyl group having 8 to 14 carbon atoms or a linear or branched alkyl ether having 6 to 12 carbon atoms, provided that an agricultural chemical ingredient of an agricultural chemical is not substantially contained. | 02-19-2015 |
| 20150105459 | LICHESTERINIC ACID AND THE DERIVATIVES OF SAME AS PIGMENTATION INHIBITORS - The invention relates to the cosmetic use of a compound chosen from the compounds of formula (A) and the salts of same as an agent for depigmenting the skin and/or keratinous appendages. | 04-16-2015 |
| 20150105460 | LABDANE DITERPENOID COMPOUNDS, SEMEN BIOTAE EXTRACT, AND PREPARATION METHOD AND USE THEREOF - Provided in the present invention are various labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases. Also provided in the present invention is a semen biotae extract comprising one or more labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases. | 04-16-2015 |
| 20150119458 | 4-((SUBSTITUTED PHENYL) DIFLUOROMETHYL) PHENOXY CARBOXYLIC ACID DERIVATIVE, AND PREPARATION METHOD AND USES THEREOF - The present invention discloses a 4-((substituted phenyl)difluoromethyl)phenoxycarboxylic acid derivative and preparation process and use thereof. More specifically, the present invention relates to a compound of the following formula I, which is defined in the specification. The compounds according to the present invention can be used as PPAR agonists, and demonstrates a strong effect on reducing the levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) in blood plasma, and thus the compound according to the present invention can be used in the preparation of a medicament for treating or preventing hyperlipoidemia or cardio-cerebrovascular diseases caused by hyperlipoidemia, such as diabetes, atherosclerosis, stroke, coronary heart disease, etc. The present invention also relates to a novel intermediate compound for the preparation of the compound of formula I and preparation method thereof. | 04-30-2015 |
| 20150352075 | Treatment of Alzheimer's and Cognitive Impairment With Andrographolides - We found that Andrographolide binds to GSK-3β: | 12-10-2015 |
| 20150376152 | Process for Ultra Pure Chemical Production from Biobased Raw Starting Materials - Processes and methods for making ultra-pure (>99.50% by weight), biobased crotonic acid, gamma-butyro lactone, acrylic acid and delta-valerolactone from renewable carbon resources are described herein. | 12-31-2015 |
| 20160022614 | COMPOSITIONS AND METHODS FOR TREATING CANCER - Compositions containing one or more COX inhibitors in combination with one or more antagonists of 20-HETE (20-hydroxyeicosatetraeonic acid), and optionally a pharmaceutically acceptable excipient are provided. Preferred compositions include rofecoxib in combination with HET | 01-28-2016 |
| 20160082059 | METHOD FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASES - Provided herein is a method for preventing or treating neurodegenerative disease in a subject, comprising administrating to the subject an effective amount of a composition which comprises a semen biotae extract. The neurodegenerative disease is associated with α-synuclein, such as Alzheimer's disease, Parkinson's disease, Huntington disease, or Amyotrophic lateral sclerosis. | 03-24-2016 |
| 20160115141 | CARBOXYLIC ACID DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISORDERS - Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, wherein the compounds are quinone or naphthoquinone compounds with carboxylic acid or carboxylic acid derivative substituents. | 04-28-2016 |
