Entries |
Document | Title | Date |
20080207725 | Phenyl-Pyrazole Derivatives as Non-Steroidal Glucocorticoid Receptor Ligands - A compound of formula (I): | 08-28-2008 |
20080214642 | Fungicidal N-Benzyl-5-Hydroxy-5-Phenylpryrazolines, Processes For Their Preparation and Compositions Comprising Them - N-benzoyl-5-hydroxy-5-phenylpyrazolines of the formula I | 09-04-2008 |
20080227840 | Bicyclic 5-Hydroxypyrazolines, Method For Producing the Same and Agents Comprising the Same - Bicyclic 5-hydroxypyrazolines of the formula I | 09-18-2008 |
20080234350 | Crystalline Modifications to Pyraclostrobin - The present invention relates to novel crystalline modifications of pyraclostrobin, to processes for their preparation and to the use of the novel modifications for preparing crop protection compositions. | 09-25-2008 |
20080293798 | Fungicidal Mixtures Comprising Substituted 1-Methylpyrazol-4-Ylcarboxanilides - Fungicidal mixtures, comprising as active components
| 11-27-2008 |
20090062365 | Pyrazoles for the Treatment of GERD and IBS - The present invention relates to novel pyrazole derivatives having a positive allosteric GABAB receptor (GBR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agonist, for the inhibition of transient lower esophageal sphincter relaxations, for the treatment of gastroesophageal reflux disease, as well as for the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS). The compounds are represented by the general formula (I) wherein R | 03-05-2009 |
20090093532 | POLYMORPHS AND AMORPHOUS FORMS OF 5-AMINO-1-[2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYL]-4-[(TRIFLUOROMETHYL)SU- LFINYL]-1H-PYRAZOLE-3-CARBONITRILE - The present invention relates to novel crystalline polymorphs, solvate pseudomorphs and amorphous form of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (fipronil). The present invention also provides methods for preparing the novel polymorphs, pseudomorphs and amorphous form, as well as insecticidal or pesticidal compositions comprising same, and methods of use thereof as pesticidal agents. | 04-09-2009 |
20090105326 | Crystalline Chemotherapeutic - N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea·¼ Ethanolate Crystalline Form 1, ways to make it, formulations comprising it and made with it and methods of treating patients having disease using it is disclosed. | 04-23-2009 |
20090186931 | Dinitropyrazole derivatives, their preparation, and energetic compositions comprising them - The present invention provides:
| 07-23-2009 |
20090186932 | Pesticidal N-Phenylpyrazole Derivatives - The invention relates to 5-(substituted dithio- or dioxy-alkylamino)pyrazole derivatives of formula (I) or salts thereof: wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests (including arthropods and helminths). | 07-23-2009 |
20090192208 | Pyrazole compounds and use thereof in noxious arthropod pests controlling composition - The present invention provides a pyrazole compound of formula (a): a noxious arthropod pests controlling composition containing the compound shown by the formula (a) as an active ingredient; and a method for controlling noxious arthropod pests comprising applying an effective amount of the compound shown by the formula (a). | 07-30-2009 |
20090221662 | Method for Controlling Arthropods - The present invention relates to a method for controlling arthropods by indirect contact action using the pesticides mentioned in the description. | 09-03-2009 |
20090221663 | PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS - A compound of Formula (I): | 09-03-2009 |
20090239924 | 1H-FURO[3,2-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS - Furo[3,2-c]pyrazole derivatives of formula (I) as defined in the description, and pharmaceutically acceptable salts thereof, wherein A is an aryl or heteroaryl ring, —NHZR | 09-24-2009 |
20090253767 | AMINOINDAZOLYLUREA DERIVATIVES - Novel aminoindazolylurea derivatives of the formula I (I), in which R | 10-08-2009 |
20090298902 | PESTICIDE COMPOSITIONS FOR COMBATING ARTHROPOD PESTS, SNAILS AND NEMATODES - The present invention relates to a pesticide composition in the form of a water absorbent granular material and to the use of such compositions for combating arthropod pests, in particular soil-living arthropod pests, and nematodes, with particular preference given to soil-living insect pests. The pesticide composition according to the invention as a water absorbent granular material, which contains: i) from 0.001 to 10% by weight of at least one pesticide compound, in particular a pesticide compound that is active against said soil-living arthropod pest, ii) from 80 to 99.999% by weight of at least one granular super absorbent polymer, and iii) water, wherein the % by weight are based on the total weight of the composition, except for water and wherein the components i) and ii) make up at least 90% by weight of the composition except for water, and wherein the water absorbent granular material is obtainable by a process which comprises the treatment of superabsorbent polymer granules with a liquid aqueous composition containing the at least one pesticide compound. | 12-03-2009 |
20090312387 | COMPOSITION FOR CONTROLLING PARASITES ON ANIMALS - The invention relates to novel compositions for controlling parasites on animals, comprising an N-phenylpyrazole in a formulation comprising aliphatic cyclic carbonates. | 12-17-2009 |
20100004307 | Process for the Sulfinylation of a Pyrazole Derivative - The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent S in the presence of at least one amine acid complex wherein the amine(s) are selected from secondary and/or tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent, wherein S is [CF | 01-07-2010 |
20100016398 | COMBINATION PRODUCT FOR CONTROLLING PARASITES ON ANIMALS - The invention relates to novel compositions for controlling parasites on animals, comprising an N-arylpyrazole and also a pyrethroid in a formulation comprising aliphatic cyclic carbonates and aliphatic cyclic or acyclic polyethers. | 01-21-2010 |
20100041727 | Crystalline Modification of Fipronil - The present invention relates to a crystalline modification of fipronil, to process for the preparation of the same, to pesticidal and parasiticidal mixtures and compositions comprising said crystalline modification and to their use for combating pests and parasites. | 02-18-2010 |
20100056596 | RESISTANCE-REPELLENT RETROVIRAL PROTEASE INHIBITORS - Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV infections in mammals, are also provided. | 03-04-2010 |
20100056597 | INDOLEDIONE DERIVATIVE - A compound represented by the general formula (I-a): | 03-04-2010 |
20100076045 | STABILIZED PHARMACEUTICAL SUB-MICRON SUSPENSIONS AND METHODS OF FORMING SAME - The present invention is directed to a pharmaceutical submicron suspension and a method of forming the submicron suspension. The submicron suspension is useful for delivery of relatively hydrophobic and/or low solubility therapeutic agent. The submicron suspension and method of forming the submicron suspension typically employ a polymeric material that aids in preventing aggregation of the therapeutic agent. | 03-25-2010 |
20100081698 | Crystalline Modification of Fipronil - The present invention relates to a crystalline modification of fipronil, to a process for the preparation of the same, to pesticidal and parasiticidal mixtures and compositions comprising said crystalline modification and to their use for combating pests and parasites. | 04-01-2010 |
20100093821 | 3-Amino-pyrazole-4-carboxamide derivatives useful as inhibitors of protein kinases - The invention relates to novel heterocyclic compounds of the formula | 04-15-2010 |
20100093822 | Process for the Sulfinylation of a Pyrazole Derivative - The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent S in the presence of at least one amine acid complex wherein the amine(s) are selected from cyclic secondary amines and the acid(s) are selected from sulfonic acid derivatives, and with the addition of a halogenating agent, wherein S is [CF | 04-15-2010 |
20100105752 | Crystalline Modification of Fipronil - The present invention relates to a crystalline modification of fipronil, to a process for the preparation of the same, to pesticidal and parasiticidal mixtures and compositions comprising said crystalline modification and to their use for combating pests and parasites. | 04-29-2010 |
20100125097 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND/OR A FORMAMIDINE, METHODS AND USES THEREOF - This invention relates to compositions for combating parasites in animals, comprising 1-arylpyrazole compounds alone or in combination with formamidine compounds. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infestation in an animal comprising administering the compositions of the invention to the animal in need thereof. | 05-20-2010 |
20100137395 | Process for the Sulfinylation of a Pyrazole Derivative - The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent selected from trifluoromethylsulfinic acid, trifluoromethylsulfinic acid anhydride, and a trifluoromethylsulfinate alkaline or alkaline earth metal salt and mixtures of the acid and/or the salt(s), in the presence of at least one amine acid complex wherein the amine(s) are selected from tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent. | 06-03-2010 |
20100144819 | Synergistic Methods for Control of Pests - The present invention provides a method for the synergistic control of insect pests, such as cockroaches and spiders, which comprises applying to a locus where insect pest control is needed or expected to be needed a synergistically effective amount of a combination of bifenthrin and fipronil. | 06-10-2010 |
20100210704 | 3-ALKOXY-1-PHENYLPYRAZOLE DERIVATIVES AND PESTICIDES - To provide pesticides such as insecticides, miticides and nematicides, which are excellent in the safety, pesticidal effects, residual effectiveness, etc., which further have infiltration, and which can be applied by soil treatment. | 08-19-2010 |
20100216860 | NOVEL COMPOUNDS - Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy. | 08-26-2010 |
20100227904 | Pharmaceutical Composition for Delivery of Receptor Tyrosine Kinase Inhibiting (RTKi) Compounds to the Eye - The present invention relates to development of efficacious pharmaceutical implant compositions comprising an active agent in a therapeutically effective amount and a polyethylene glycol having a molecular weight of at least 2000. | 09-09-2010 |
20100227905 | Pharmaceutical Composition for Delivery of Receptor Tyrosine Kinase Inhibiting (RTKi) Compounds to the Eye - The present invention relates to development of efficacious pharmaceutical compositions in the form of aqueous solutions comprising an active agent in a therapeutically effective amount and a polyethylene glycol having a molecular weight of at least 2000. | 09-09-2010 |
20100234441 | NOVEL COMPOUNDS - The present invention provides compounds of formula (I): | 09-16-2010 |
20100286223 | Condensed Heterocyclic Pyrazole Derivatives as Kinase Inhibitors - Bicyclo-pyrazole compound of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, processes for their preparation, combinatorial libraries comprising a plurality of them and pharmaceutical compositions thereof, are herewith disclosed: the compounds of the invention are useful, in therapy, as protein kinase inhibitors, for instance in the treatment of cancer. | 11-11-2010 |
20100331385 | PYRAZOLE UREA DERIVATIVES USED AS KINASE INHIBITORS - Compounds of Formula (I) where R | 12-30-2010 |
20110034530 | PROCESS FOR THE PREPARATION OF FIPRONIL AND ANALOGUES THEREOF - The present invention relates to a new and efficient process for preparing 5-amino-1-(2,6-dichloro-4-(trifluo-romethyl)phenyl)-4-(trifluoromethylthio)-IH-pyrazole-3-carbonitrile (hereinafter referred to as compound of formula I), which is useful as an intermediate for the antiparasitic agent fipronil, and a process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-tri-fluoromethylphenyl)-4-trifluoromethyl sulfinylpyrazole (hereinafter referred to as compound of formula II or fipronil). In one aspect, there is provided a process for preparing fipronil comprising: a) a step of reacting CF | 02-10-2011 |
20110039907 | ANT CONTROL - The present invention relates to a method of ant control using mixtures of fipronil and lambda-cyhalothrin. The invention also relates to a method of reducing the foraging activity of ants using said mixtures. | 02-17-2011 |
20110046195 | Non-Lactone Carbocyclic and Heterocyclic Antagonists and Agonists of Bacterial Quorum Sensing - Compounds which modulate quorum sensing in quorum sensing bacteria. Compounds of the invention inhibit quorum sensing and/or activate quorum sensing in various bacteria. Compounds that inhibit quorum sensing are particularly useful for inhibition of detrimental bacterial biofilm formation. Compounds that activate quorum sensing are particularly useful for promoting growth and biofilm formation of beneficial bacterial. | 02-24-2011 |
20110046196 | Insecticidal Fertilizer Mixtures - This invention relates to insecticidal fertilizer mixtures containing | 02-24-2011 |
20110054000 | Crystalline Modifications of Pyraclostrobin - The present invention relates to novel crystalline modifications of pyraclostrobin, to processes for their preparation and to the use of the novel modifications for preparing crop protection compositions. | 03-03-2011 |
20110060023 | PARASITICIDAL FORMULATION - The present invention provides a parasiticidal formulation comprising: Fipronil, or a veterinarily acceptable derivative thereof; at least one C | 03-10-2011 |
20110086898 | PYRAZOLOOXAZOLE COMPOUND - A compound represented by the formula (I) or pharmacologically acceptable salt thereof exhibits an excellent CRF receptor antagonism. | 04-14-2011 |
20110092559 | PYRROLE AND PYRAZOLE DAAO INHIBITORS - Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases involve administering to a subject in need of treatment a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof: | 04-21-2011 |
20110092560 | TOPICAL COMPOSITION FOR CONTROLLING ECTOPARASITES IN DOGS AND CATS - This invention describes a new topical formulation (spot-on) for controlling ectoparasites in cats and dogs, which comprises the active ingredient Fipronil and/or the derivates and salts thereof, as well as antioxidants and a suitable vehicle. The use of an organic solvent acting as the transdermal carrier provides this product with a longer residual period and, consequently, higher efficacy. | 04-21-2011 |
20110098332 | Insecticides for Increasing the Crop Yield - The present invention relates to the use of at least one insecticide selected from GABA antagonists for increasing the crop yield of at least one plant variety and to a method for increasing the crop yield of at least one plant variety by treating the propagules from which it is to grow with at least one GABA antagonist insecticide. | 04-28-2011 |
20110112161 | INDOLE AND INDAZOLE ANALOGS AS GLYCOGEN SYNTHASE ACTIVATORS - Provided herein are compounds of the formula (I): | 05-12-2011 |
20110178149 | Ether Compounds with Nitrogen-Containing 5-Member Heterocycle and Uses Thereof - The invention relates to ether compounds with nitrogen-containing 5-member heterocycle, represented by formula (I): | 07-21-2011 |
20110196010 | CRYSTALLINE CHEMOTHERAPEUTIC - N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea Hydrate Crystalline Form 1, ways to make it, formulations comprising it and made with it and methods of treating patients having disease using it are disclosed. | 08-11-2011 |
20110196011 | SUBSTITUTED ARYLPYRAZOLES - This invention relates to a combination product comprising a compound of formula I | 08-11-2011 |
20110201662 | METHOD FOR PRODUCING XPS MOULDED PIECES PROVIDED WITH INSECTICIDE - Process for the production of insecticide-modified extruded polystyrene foam (XPS) preforms, comprising the steps
| 08-18-2011 |
20110207792 | POLYMORPHS AND AMORPHOUS FORMS OF 5-AMINO-1-[2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYL]-4-[(TRIFLUOROMETHYL)SU- LFINYL]-1H-PYRAZOLE-3-CARBONITRILE - The present invention relates to novel crystalline polymorphs, solvate pseudomorphs and amorphous form of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (fipronil). The present invention also provides methods for preparing the novel polymorphs, pseudomorphs and amorphous form, as well as insecticidal or pesticidal compositions comprising same, and methods of use thereof as pesticidal agents. | 08-25-2011 |
20110224273 | Pyrazole Derivatives as 11-Beta-HSD1 Inhibitors - A compound of formula (I): | 09-15-2011 |
20110237641 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING THESE, METHOD OF PRODUCTION AND USE - The disclosure relates to a compound of formula (I): | 09-29-2011 |
20110281926 | METHOD FOR DRESSING SEEDS - The present invention relates to a method comprising treating plant propagation material with at least sticker selected from specific acrylate co-copolymers, to seed dressing formulations comprising such stickers and to plant propagation material coated with such stickers. | 11-17-2011 |
20120029043 | Pharmaceutical Composition Containing An N-Phenylpyrazole Derivative, And Use Thereof For Preparing A Topical Veterinary For Flea Control - The invention relates to a liquid pharmaceutical composition that contains an N-phenylpyrazole derivative as an active principle, benzyl alcohol, and an appropriately selected organic solvent, and to the use of such a composition for preparing a topically applied antiparasitic veterinary drug for preventing and/or treating flea infestation in pets, in particular in dogs and cats. | 02-02-2012 |
20120041043 | Sulfonamide Compounds for the Treatment of Respiratory Disorders - Compounds of formula (I) are agonists of PPARγ, useful for the treatment of respiratory disease; formula (I): wherein R | 02-16-2012 |
20120184589 | Pesticidal Mixtures - The present invention relates to synergistic mixtures comprising, as active components one insecticidal compound I selected from the group of acrinathrin, allethrin, alpha-cypermethrin, beta-cypermethrin, bifenthrin, cycloprothrin, cyfluthrin, cypermethrin, cyphenothrin, deltamethrin, dimefluthrin, esfenvalerate, etofenprox, fenpropathrin, fenvalerate, flucythrinate, imiprothrin, permethrin, prallethrin, profluthrin, pyrethrin I, pyrethrin II, resmethrin, silafluofen, tau-fluvalinate, tetramethrin, theta-cypermethrin, tralomethrin, transfluthrin and zeta-cypermethrin; and one fungicidal compound II selected from the group of azoxystrobin, coumethoxystrobin, coumoxystrobin, dimoxystrobin, enestroburin, fluoxastrobin, kresoxim-methyl, metominostrobin, orysastrobin, picoxystrobin, pyraclostrobin, pyrametostrobin, pyraoxystrobin, pyribencarb, trifloxysstrobin, 2-(ortho-((2,5-Dimethylphenyl-oxymethylen)phenyl)-3-methoxy-acrylic acid methyl ester, 2-(2-(3-(2,6-dichlorophenyl)-1-methyl-allylideneaminooxymethyl)-phenyl)-2-methoxyimino-N-methyl-acetamide in synergistic effective amounts. | 07-19-2012 |
20120196912 | PARASITICIDAL FORMULATION - The present invention provides a parasiticidal formulation comprising: Fipronil, or a veterinarily acceptable derivative thereof; at least one C | 08-02-2012 |
20120214857 | USE OF POLYMER PARTICLES CONTAINING INSECTICIDE IN ORDER TO IMPROVE THE SOIL MOBILITY OF INSECTICIDES, INSECTICIDE FORMULAS, POLYMER PARTICLES CONTAINING INSECTICIDE, AND METHOD FOR PEST CONTROL - Polymer particles, comprising
| 08-23-2012 |
20120264801 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS - Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38α, and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders. | 10-18-2012 |
20120270918 | Pyrazole Derivatives, Preparation Thereof, and Therapeutic Use Thereof - The invention relates to pyrazole derivatives of general formula (I): | 10-25-2012 |
20120277279 | Non-Steroidal Glucocorticoid Inhibitors and Their Use in Treating Inflammation, Allergy and Auto-Immune Conditions - The present invention provides compounds of formula (I): | 11-01-2012 |
20120302618 | USE OF BENZYDAMINE IN THE TREATMENT OF P40-DEPENDENT DISEASES - Use of benzydamine in the treatment of inflammatory diseases, in particular Crohn's disease, rheumatoid arthritis, psoriatic arthritis, and psoriasis, caused by an expression or overexpression of the cytokine subunit p40. | 11-29-2012 |
20130012562 | Composition for Controlling Parasites on Animals - The invention relates to novel compositions for controlling parasites on animals, comprising an N-phenylpyrazole in a formulation comprising aliphatic cyclic carbonates. | 01-10-2013 |
20130030031 | Novel Compounds - Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy. | 01-31-2013 |
20130065930 | TOPICAL COMPOSITION - A topical composition comprising: fipronil or a pharmaceutically acceptable salt thereof; at least one surfactant and at least one crystallization inhibitor for the treatment and protection of animals which are infested with parasites. | 03-14-2013 |
20130072536 | PYRAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. | 03-21-2013 |
20130116295 | ANTIPARASITIC FORMULATIONS - Fipronil formulations and fipronil/S-methoprene co-formulations are provided herein. These formulations optionally contain one or more additional active ingredient(s). The formulations comprise an organic solvent, an alcohol co-solvent, and one or more antioxidants and without any crystallization inhibitor. The formulations provided herein are antiparasitic, and can be used, for example, to combat dog and cat parasites, such as, fleas and ticks. | 05-09-2013 |
20130116296 | PYRAZOLE COMPOUND - The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT | 05-09-2013 |
20130137741 | Pharmaceutical Composition for Delivery of Receptor Tyrosine Kinase Inhibiting (RTKi) Compounds to the Eye - The present invention relates to development of efficacious pharmaceutical compositions in the form of aqueous solutions comprising an active agent in a therapeutically effective amount and a polyethylene glycol having a molecular weight of at least 2000. | 05-30-2013 |
20130143940 | FUNGICIDAL PYRAZOLES - Disclosed are compounds of Formula 1 and Formula 1A including all stereoisomers, N-oxides, and salts thereof, | 06-06-2013 |
20130210883 | LIPASE INHIBITORS - The invention provides a compound of formula (I) as defined herein | 08-15-2013 |
20130231380 | Rodenticide - The invention relates to the systemic insecticide fipronil in conjunction with a rodenticide used for manufacture of a bait composition to provide a lethal effect on fleas and/or ticks and a host rodent, following ingestion of the bait composition by the host rodent. Preferred rodenticides are brodifacoum, difethialone, flocoumafen, bromadiolone and mixtures thereof. The invention also relates to rodenticidal bait compositions and to a method of killing ticks and a host rodent by providing for ingestion to the rodent, a bait composition comprising an effective amount of a rodenticide and an acaricidally effective amount of fipronil. | 09-05-2013 |
20130237578 | PHARMACEUTICAL COMPOSITION - The present invention provides compounds of Formula I: | 09-12-2013 |
20130317074 | TOPICAL ANTIFUNGAL AGENT - An anti-fungal agent for tinea comprising as active ingredient a compound having the skeleton of 2-(1H-pyrazol-1-yl)phenol represented by the following formula (I) or (II) or a salt thereof is provided | 11-28-2013 |
20140005245 | INSECTICIDAL COMPOUNDS | 01-02-2014 |
20140024693 | TOPICAL COMPOSITION - A topical composition comprising: fipronil or a pharmaceutically acceptable salt thereof; at least one surfactant and at least one crystallization inhibitor for the treatment and protection of animals which are infested with parasites. | 01-23-2014 |
20140031406 | PYRAZOLE COMPOUND - The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT | 01-30-2014 |
20140051740 | AMINOTETRAHYDROPYRANS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES - The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved. | 02-20-2014 |
20140080883 | METHOD AND COMPOSITION FOR KILLING PARASITES ON AN ANIMAL - A spot-on pesticide composition for animals, specifically mammals, including dogs and cats, which composition comprises a combination of active components, including fipronil and a pyrethroid, and optionally an insect growth regulator, in doses and proportions which are parasiticidally effective against a variety of insects and pests, and in a formulation which is convenient for local application to the animal's skin, preferably localized over a small surface area. | 03-20-2014 |
20140080884 | NOVEL CRYSTALLINE FORMS OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR - Novel crystalline forms of (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine are potent inhibitors of dipeptidyl peptidase-IV and are useful for the treatment of non-insulin dependent (Type 2) diabetes mellitus. The invention also relates to pharmaceutical compositions containing these novel forms, processes to prepare these forms and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes. | 03-20-2014 |
20140100258 | METHODS FOR TREATING DEGENERATIVE DISEASES/INJURIES - Invented is a method of treating cardiovascular disease/injury, in a mammal, including a human, in need thereof which comprises the administration of a therapeutically effective amount of a non-peptide TPO receptor agonist to such mammal. | 04-10-2014 |
20140142156 | Non-Lactone Carbocyclic and Heterocyclic Antagonists and Agonists of Bacterial Quorum Sensing - Compounds which modulate quorum sensing in quorum sensing bacteria. Compounds of the invention inhibit quorum sensing and/or activate quorum sensing in various bacteria. Compounds that inhibit quorum sensing are particularly useful for inhibition of detrimental bacterial biofilm formation. Compounds that activate quorum sensing are particularly useful for promoting growth and biofilm formation of beneficial bacterial. | 05-22-2014 |
20140155452 | PHARMACEUTICAL COMPOSITION - The present invention provides compounds of Formula I: | 06-05-2014 |
20140206738 | LIPASE INHIBITORS - A compound of formula (I) as defined herein | 07-24-2014 |
20140213626 | POLYMORPHS AND AMORPHOUS FORMS OF 5-AMINO-1-[2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYL]-4-[(TRIFLUOROMETHYL)SU- LFINYL]-1H-PYRAZOLE-3-CARBONITRILE - The present invention relates to novel crystalline polymorphs, solvate pseudomorphs and amorphous form of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoroethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (fipronil). The present invention also provides methods for preparing the novel polymorphs, pseudomorphs and amorphous form, as well as insecticidal or pesticidal compositions comprising same, and methods of use thereof as pesticidal agents. | 07-31-2014 |
20140221448 | FUNGICIDAL PYRAZOLES - Disclosed are compounds of Formula 1 and Formula 1A including all stereoisomers, N-oxides, and salts thereof, | 08-07-2014 |
20140315969 | ECTOPARASITICIDAL METHODS - The invention provides an ectoparasiticidal formulation which comprises an ectoparasiticidal agent, preferably fipronil, as the pesticidally-active ingredient, together with a crystallization inhibitor selected from the group consisting of alkyl-substituted pyrrolidones, and optionally, one or more organic solvents and/or co-solvents. Preferably, the crystallization inhibitor is N-octyl pyrrolidone, and the organic solvent, if present, preferably comprises diethylene glycol monoethyl ether. The ectoparasiticidal formulation surprisingly yields a significantly enhanced speed of kill. Methods for manufacturing the formulation, as well as methods for treating animals infested with ectoparasites, are also disclosed. | 10-23-2014 |
20140315970 | ECTOPARASITICIDAL FORMULATIONS - The invention provides an ectoparasiticidal formulation which comprises an ectoparasiticidal agent, preferably fipronil, as the pesticidally-active ingredient, together with a crystallization inhibitor selected from the group consisting of alkyl-substituted pyrrolidones, and optionally, one or more organic solvents and/or co-solvents. Preferably, the crystallization inhibitor is N-octyl pyrrolidone, and the organic solvent, if present, preferably comprises diethylene glycol monoethyl ether. The ectoparasiticidal formulation surprisingly yields a significantly enhanced speed of kill. Methods for manufacturing the formulation, as well as methods for treating animals infested with ectoparasites, are also disclosed. | 10-23-2014 |
20140315971 | PYRAZOLE COMPOUND - The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT | 10-23-2014 |
20140329876 | PYRAZOLINE DERIVATIVES AND THEIR USE AS SELECTIVE ANDROGEN RECEPTOR MODULATORS - The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I), in which the substituents are as defined in the specification; to compounds of formula (I) for use as androgen receptor modulators. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition. | 11-06-2014 |
20150031736 | USE OF A PYRAZOLE DERIVATIVE IN THE TREATMENT OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE - Use of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide or a pharmaceutically acceptable derivative thereof in the manufacture of a medicament for the treatment of acute exacerbations of chronic obstructive pulmonary disease. Treatment may involve a single dose of the active ingredient by oral administration. | 01-29-2015 |
20150087684 | SPOT-ON PESTICIDE COMPOSITION - A spot-on pesticide composition for animals, specifically mammals, including dogs and cats, which composition comprises a combination of fipronil and etofenprox as the active components, in doses and proportions which are parasiticidally effective against a variety of insects and pests, and in a formulation which is convenient for local application to the mammal's skin, preferably localized over a small surface area. | 03-26-2015 |
20150111938 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS - The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds. | 04-23-2015 |
20150119439 | SATURATED ACYL GUANIDINE FOR INHIBITION OF F1F0-ATPASE - The invention provides saturated acyl guanidine compounds that inhibit F | 04-30-2015 |
20150297565 | PHENYLPYRAZOLE INJECTABLE COMPOSITIONS - This invention relates to a veterinary composition comprising a fluorinated cyclopropylphenylpyrazole. The veterinary composition also comprises a veterinary acceptable carrier including a triglyceride, a solvating agent and optionally an antioxidant. The compositions are injectable. The invention also relates to a method of treating an animal with a parasitic infestation by administering the veterinary composition to the animal in need thereof. | 10-22-2015 |
20150373974 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS - The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds. | 12-31-2015 |
20160007604 | NOVEL HALOGEN-SUBSTITUTED COMPOUNDS | 01-14-2016 |
20160007611 | Combination product for controlling parasites on animals | 01-14-2016 |
20160016911 | Treatment of Amyotrophic Lateral Sclerosis - The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds. | 01-21-2016 |
20160022640 | PYRAZOLE DERIVATIVES AND THEIR USES THEREOF - The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein U, R1, R2, R3 and Q are as defined herein. The disclosure also provides a method for treating or preventing a method for the prevention, treatment and/or alleviation of one or more autoimmune or alloimmune disease, pharmaceutical compositions and combination comprising a therapeutically effective amount of a compound, as defined herein. | 01-28-2016 |
20160051516 | METHOD OF TREATING DISEASE BY AURICULAR ANESTHESIA OF CRANIAL NERVES - Methods for treating a variety of diseases that comprises performing auricular anesthesia of various cranial nerves. A pharmaceutical composition is administered to an ear canal of a subject in need of such treatment, the composition including an analgesic and/or at least one anesthetic. Compositions useful in the taught methods are also provided. | 02-25-2016 |
20160068492 | POLYMORPHS AND AMORPHOUS FORMS OF 5-AMINO-1-[2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYL]-4-[(TRIFLUOROMETHYL)SU- LFINYL]-1H-PYRAZOLE-3-CARBONITRILE - The present invention relates to novel crystalline polymorphs, solvate pseudomorphs and amorphous form of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoro ethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (fipronil). The present invention also provides methods for preparing the novel polymorphs, pseudomorphs and amorphous form, as well as insecticidal or pesticidal compositions comprising same, and methods of use thereof as pesticidal agents. | 03-10-2016 |
20160075661 | SOLID FORMS OF FUNGICIDAL PYRAZOLES - Disclosed are solid forms of 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine (Compound 1). Methods for the preparation of solid forms of Compound 1 and for the conversion of one solid form of Compound 1 into another are disclosed. | 03-17-2016 |
20160115135 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS - The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds. | 04-28-2016 |
20160152594 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS | 06-02-2016 |
20160184268 | COMPOSITIONS OF ELTROMBOPAG - The present invention relates to compositions of eltrombopag olamine. The present invention also relates to process for preparing compositions comprising eltrombopag olamine. | 06-30-2016 |
20160200676 | METALLOPROTEASE INHIBITORS, METHODS FOR PRODUCING SAME, AND THERAPEUTIC USES THEREOF | 07-14-2016 |
20170233367 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS | 08-17-2017 |