| Entries |
| Document | Title | Date |
|---|
| 20080207654 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF - A compound represented by the formula (I): | 08-28-2008 |
| 20080214587 | Processes For the Preparation of Azoxystrobin Using Dabco as a Catalyst and Novel Intermediates Used in the Processes - The present invention relates, inter alia, to a process for preparing a compound of formula (I): which comprises either (a) reacting a compound of formula (II): with 2-cyanophenyl, or a salt thereof, in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane, or (b) reacting a compound of the formula (III): with a compound of the formula (IV): in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane; where W is the methyl (E)-2-(3-methoxy)acrylate group C(CO | 09-04-2008 |
| 20080221139 | Novel Compounds - The invention provides compounds of formula (I): | 09-11-2008 |
| 20080234301 | Alpha-4 Integrin Mediated Cell Adhesion Inhibitors for the Treatment or Prevention of Inflammatory Diseases - The present invention relates to novel compounds of formula (I), processes for their preparation, compositions comprising them and their use in the treatment or prevention of diseases capable of being modulated by the inhibition of cell adhesion. | 09-25-2008 |
| 20080242687 | SUBSTITUTED PYRIMIDINES - Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 10-02-2008 |
| 20080255166 | Dithiocarbamate derivatives and their use as antibacterial agents - The invention relates to the use of dithiocarbamate derivatives for the therapeutic or prophylactic treatment of infectious diseases in mammals (humans and animals) caused by bacteria, especially diseases like tuberculosis (TB) and lepra caused by mycobacteria and infectious diseases caused by staphylococci. The invention further relates to novel dithiocarbamate derivatives of the formula (I), wherein X is a bivalent residue selected from the group consisting of formulae having excellent antibacterial activities, and to pharmaceutical preparations containing the same. | 10-16-2008 |
| 20080269264 | Crystalline Forms of 3-[5-Chloro-4-[(2,4-Difluorobenzyl) Oxy]-6-Oxopyrimidin-1(6H)-Yl]-N-(2-Hydroxyethyl)-4-Methylbenzamide - Crystalline forms of the p38 kinase inhibitor 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4-methylbenzamide is provided. Also provided are combinations and pharmaceutical compositions comprising the crystalline forms, and methods for the prophylaxis and/or treatment of a p38 kinase-mediated condition comprising administering to a subject a therapeutically effective amount of the crystalline forms. | 10-30-2008 |
| 20080269265 | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas - This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy. | 10-30-2008 |
| 20080275070 | Aryl Ether Compounds and Their Preparation and Use Thereof - The invention relates to aryl ether compounds and its preparation method and use thereof. The aryl ether compounds of the invention having general formula (I): | 11-06-2008 |
| 20080280929 | Antifungal Wallboards and Building Materials and Methods for the Production Thereof - The present invention relates to, inter alia, methods for the treatment of wallboards and the treated wallboards. In particular, the invention relates to the treatment of wallboards with a fungicidally effective amount of a strobilurin or strobilurin-type fungicide. In a particular embodiment the fungicide is azoxystrobin. The invention also provides for the treatment of wallboards and building materials with combinations of fungicides present in synergistic amounts. | 11-13-2008 |
| 20090005403 | Alkinyl-Oxypyrimidines Used in the Form of Pesticides - The invention relates to compounds of the formula (I), | 01-01-2009 |
| 20090005404 | Pyridylsulfonamido pyrimidines for treating diabetic nephropathy - The present invention relates to the use of a compound of formula (I) wherein R | 01-01-2009 |
| 20090023761 | Heterocyclic compounds and their uses - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 01-22-2009 |
| 20090069351 | DEUTERIUM-ENRICHED BOSENTAN - The present application describes deuterium-enriched bosentan, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. | 03-12-2009 |
| 20090069352 | DEUTERIUM-ENRICHED CLAZOSENTAN - The present application describes deuterium-enriched clazosentan, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. | 03-12-2009 |
| 20090082375 | SOLID FORMS COMPRISING 3-(2,5-DIMETHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF USING THE SAME - Provided herein are solid forms comprising 3-(2,5-dimethyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione. Pharmaceutical compositions comprising the solid forms and methods for treating, preventing and managing various disorders are also disclosed. | 03-26-2009 |
| 20090111838 | 6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES AS PDE9A INHIBITORS - The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I) | 04-30-2009 |
| 20090118314 | TUMOR SUPPRESSOR - A compound having a sructure of propanedioic acid represented by the following formula ( | 05-07-2009 |
| 20090137616 | METHOD FOR THE CONTROL OF PHYTOPATHOGENIC FUNGI - The present invention provides a method of controlling | 05-28-2009 |
| 20090143416 | Method of Inducing Tolerance of Plants Against Bacterioses - A method of inducing tolerance of plants against bacterioses which comprises treating the plants, the soil or seeds with an effective amount of a combination of a compound of the formula I | 06-04-2009 |
| 20090197902 | Use of Pyrimidine Compounds in the Preparation of Parasiticides - The invention relates to the use of compounds of the general formula (I), wherein R | 08-06-2009 |
| 20090286816 | MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO - The present invention relates to 4-[5-Methoxy-6-(2-methyl-6-[1,2,4]triazol-1-yl-pyridin-3-ylamino)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complications thereof, | 11-19-2009 |
| 20090291974 | BOSENTAN SALTS - Stable acid addition salts of bosentan useful for the purification of bosentan base; the salts are in solid state and the starting acid has a pKa lower than 3. | 11-26-2009 |
| 20090298859 | METHOD FOR TREATING PLANTS - The present invention relates to the use of a fungicide selected from the group consisting of (i) a strobilurin or strobilurin-type fungicide or (ii) a triazole or an insecticide selected from the group consisting of (i) an avermectin, (ii) an organophosphate, (iii) a benzoylurea or (iv) a neonicotinoid in the production of a crop plant having raised levels of anti-oxidants. | 12-03-2009 |
| 20090306108 | SUBSTITUTED PYRIMIDINONES - Disclosed are compounds Formula I | 12-10-2009 |
| 20090306109 | FUNGICIDE ACTIVE SUBSTANCE COMBINATIONS - The novel active compound combinations comprising 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4]-triazole-3-thione of the formula | 12-10-2009 |
| 20090306110 | N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR - The present invention provides compounds of formula (I), which are antagonists of the 5-HT | 12-10-2009 |
| 20100004272 | Modulators of metabolism and the treatment of disorders related thereto - The present invention relates to 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino)-5-methyl-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity. | 01-07-2010 |
| 20100016342 | SOLID FORMS COMPRISING 3-(2,5-DIMETHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF USING THE SAME - Provided herein are solid forms comprising 3-(2,5-dimethyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione. Pharmaceutical compositions comprising the solid forms and methods for treating, preventing and managing various disorders are also disclosed. | 01-21-2010 |
| 20100029698 | Pesticidal Mixtures - The present invention relates to mixtures comprising, as active components, 1) an insecticidal compound I selected from fipronil and ethiprole; and 2) a fungicidal compound IIA selected from azoles, strobilurins, carboxamides, heterocylic compounds, carbamates, and other active compounds, and optionally 3) one or two fungicidal compounds IIB selected from List B which is defined as List A plus triticonazole, orysastrobin, in synergistically effective amounts, all as further defined in the description. | 02-04-2010 |
| 20100041682 | Ternary Pesticidal Mixtures - Ternary pesticidal mixtures comprising, as active components, an anthranilamid compound of the formula (I) wherein the variables are defined according to the description, and two fungicidal compounds II and III selected from the following groups: azoles, strobilurins, carboxamides, heterocylic compounds, carbamates, guanidines, antibiotics, nitrophenyl derivates, sulfur-containing heterocyclyl compounds, organometal compounds and other active compounds according to the description, in a synergistically effective amount, methods for controlling pests, and harmful fungi, methods of protecting plants from attack or infestation by insects, acarids or nematodes, methods for treating, controlling, preventing or protecting an animal against infestation or infection by parasites, compositions containing these mixtures, and methods for their preparation. | 02-18-2010 |
| 20100041683 | NOVEL CHAIN-BREAKING ANTIOXIDANTS - Compounds, preferably 5-pyrimidinol and 3-pyridinol derivatives, that act as effective chain breaking antioxidants of both the lipid and water-soluble variety (analogous to the natural Vitamins E and C), many of which are more reactive toward peroxyl radicals than the most potent form of Vitamin E. These compounds may exhibit many chemopreventive effects associated with conditions in which free radical-mediated cellular damage or disruption is implicated and Vitamins E and C are shown to have protective effects. Additionally, these compounds should be excellent oxidation inhibitors as additives to fuels, lubricants, rubber, polymers, chemicals, solvents and foodstuffs. | 02-18-2010 |
| 20100063076 | Endothelin receptor antagonists - This invention relates to novel endothelin receptor antagonists, derivatives, acceptable acid addition salts thereof. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by compounds that block the endothelin signaling pathway that leads to vasoconstriction and in particular those diseases or conditions beneficially treated by endothelin receptor antagonists. | 03-11-2010 |
| 20100081677 | HETEROARYLAMIDE PYRIMIDONE DERIVATIVES - The present invention discloses a series of pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: | 04-01-2010 |
| 20100087460 | ARYLAMIDE PYRIMIDONE DERIVATIVES - The present invention discloses a series of pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: | 04-08-2010 |
| 20100087461 | ARYLAMIDE PYRIMIDONE COMPOUNDS - The present invention discloses a series of pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: | 04-08-2010 |
| 20100099692 | HARMFUL ORGANISM CONTROL COMPOSITION - This invention provides a harmful organism control composition having an excellent harmful organism control effect and comprising as an effective ingredient the following 4-(2-butynyloxy)-5-fluoro-6-(3,5-dimethylpiperidino)-pyrimidine (X): | 04-22-2010 |
| 20100105709 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF - A compound represented by the formula (I): | 04-29-2010 |
| 20100144768 | KINASE INHIBITOR COMPOUNDS - Pyrimidinone derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as inflammatory diseases and certain types of cancer. | 06-10-2010 |
| 20100160358 | Pyridylsulfonamidyl-Pyrimidines for the Prevention of Blood Vessel Graft Failure - The present invention relates to the use of a compound of formula (I), wherein R | 06-24-2010 |
| 20100160359 | Modulators of Metabolism and the Treatment of Disorders Related Thereto - The present invention relates to 4-[5-methyl-6-(2-methyl-pyridin-3-yloxy)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity. | 06-24-2010 |
| 20100173919 | PHARMACEUTICAL COMPOSITION USING ALISKIREN AND AVOSENTAN - The present invention relates to a pharmaceutical composition and method of achieving a therapeutic effect including, but not limited to, the treatment of hypertension, kidney or heart disease in an animal, preferably a mammal including a human subject, using (i) SPP100/aliskiren or a pharmaceutically acceptable salt thereof in combination with (ii) SPP301/avosentan or a pharmaceutically acceptable salt thereof and (iii) a pharmaceutically acceptable carrier. | 07-08-2010 |
| 20100173920 | POLYMORPHS OF 3-(E)-2--3-METHOXYACRYLATE - The present invention relates to novel crystalline polymorphic and amorphous forms of the compound (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxy-acrylate(azoxystrobin). Infrared Raman spectra, X-ray powder diffraction pattern and differential scanning calorimetry thermogram of two polymorphs “A” and “B” are provided. Further, the present invention also provides methods for preparing the novel polymorphic forms “A” and “B”, as well as processes for producing mixtures of the polymorphs, and a process for preparing amorphous azoxystrobin. Yet further, the present invention provides anti-fungal compositions comprising the novel crystalline polymorphs “A” and “B” or amorphous azoxystrobin, which are useful for controlling and combating fungi grown on agricultural and horticultural crops and up-land, and methods of using the same as pesticidal agents for combating fungi on agricultural and horticultural crops. | 07-08-2010 |
| 20100179177 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 07-15-2010 |
| 20100197708 | INDOLE COMPOUNDS - Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole. | 08-05-2010 |
| 20100216825 | FUNGICIDAL COMPOSITIONS - A composition for control of diseases on useful plants or on propagation material thereof caused by phytopathogens, comprising (A) a compound of formula (I) or a tautomer of such a compound; and component (B) and component (C) are pesticides as described in claim | 08-26-2010 |
| 20100249162 | PROCESS FOR THE INTRODUCTION OF HYDROXYETHOXY SIDE CHAIN IN BOSENTAN - The present invention relates to an improved process for the preparation of bosentan. In particular it relates to a process for preparing bosentan substantially free from the dimer impurity of formula (II) and the 6-hydroxy impurity of formula (III). The invention also relates to a pharmaceutical composition comprising bosentan and its use in the treatment of endothelin-receptor mediated disorders. | 09-30-2010 |
| 20100261742 | NOVEL POLYMORPHIC FORMS - Novel polymorphic forms of bosentan and processes for their preparation are disclosed. Further, pharmaceutical compositions comprising said polymorphic forms and the use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris are disclosed. | 10-14-2010 |
| 20100286176 | FLOWERS - The present invention relates to methods for reducing the incidence of | 11-11-2010 |
| 20100292258 | SUBSTITUTED AROMATIC HETEROCYCLIC COMPOUNDS AS FUNGICIDES - The present invention relates to compounds of formula (I) wherein R | 11-18-2010 |
| 20100292259 | PYRIMIDYL INDOLINE COMPOUND - It is intended to provide a pyrimidyl indoline compound which structurally differs from compounds used as active ingredients in conventional oral hypoglycemic agents and has excellent hypoglycemic effect. The present invention provides a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof: | 11-18-2010 |
| 20100298361 | Alkylthio Pyrimidines As CRTH2 Antagonists - Provided herein are alkylthio substituted pyrimidine compounds having CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity, useful for the treatment or prophylaxis of diseases associated with CRTH2 activity, including the treatment of allergic diseases, eosinophil-related diseases and basophil-related diseases. | 11-25-2010 |
| 20100298362 | PROCESS FOR THE PREPARATION OF 4-[6-(6-METHANESULFONYL-2-METHYL-PYRIDIN-3-YLAMINO)-5-METHOXY-PYRIMIDIN-4- -YLOXY]-PIPERIDINE-1-CARBOXYLIC ACID ISOPROPYL ESTER - The present invention is directed to a process for the preparation of 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester, useful as glucose dependent insulinotropic receptor agonist, for the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity. | 11-25-2010 |
| 20100331352 | NOVEL CRYSTALLINE FORMS OF BOSENTAN - The present invention relates to novel crystalline forms of bosentan and processes for their preparation. Further, the invention relates to pharmaceutical compositions comprising said crystalline forms and use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris. | 12-30-2010 |
| 20110009437 | CARBOXAMIDE-HETEROARYL DERIVATIVES FOR THE TREATMENT OF DIABETES - Novel heterocyclic compounds of the formula I | 01-13-2011 |
| 20110015215 | CRYSTALLINE FORMS OF 4-[6-(6-METHANESULFONYL-2-METHYL-PYRIDIN-3-YLAMINO)-5-METHOXY-PYRIMIDIN-4- -YLOXY]-PIPERIDINE-1-CARBOXYLIC ACID ISOPROPYL ESTER - The present invention is directed to a novel crystalline forms of 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester, pharmaceutical compositions containing said crystalline form and the use of said crystalline forms in the treatment of metabolic related disorders. The present invention is further directed to processes for the preparation of the crystalline forms of 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester. | 01-20-2011 |
| 20110021547 | Substantially Pure and a Stable Crystalline Form of Bosentan - Described is a highly stable crystalline form of bosentan having a water content in the range of about 3-4% by weight, based on the total weight of the bosentan, (bosentan crystalline form A5), a process for preparation thereof, and pharmaceutical compositions comprising the bosentan crystalline form A | 01-27-2011 |
| 20110028500 | PLANT PATHOGEN INHIBITOR COMBINATIONS AND METHODS OF USE - Combinations, compositions and methods of use for modulating plant pathogen infection using plant extracts containing anthraquinone derivatives which induce resistance to plant phytopathogens and an antimicrobial agent, a biological control agent and/or a surfactant having fungicidal activity | 02-03-2011 |
| 20110028501 | SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT - Substituted cyclopropyl compounds of formula (I) are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119. | 02-03-2011 |
| 20110039871 | PROCESS FOR PREPARING BOSENTAN - The present invention relates to a novel intermediate useful in the preparation of bosentan and to processes for the preparation of said intermediate and bosentan. The invention further relates to compositions comprising bosentan prepared according to the processes of the invention and their use in the treatment of endothelin-receptor mediated disorders. | 02-17-2011 |
| 20110071175 | Indoles and Their Therapeutic Use - Compound of formula (I) are ligands of the CRTH2 receptor, useful inter alia for treatment of inflammatory conditions. Wherein X is —SO | 03-24-2011 |
| 20110077258 | TREATMENT OF MALARIA - The invention contemplates compositions for the treatment of malaria comprising an anti-malaria drug and an adjuvant which promotes vasodilation and methods of using same. | 03-31-2011 |
| 20110082160 | SYNERGISTIC FUNGICIDAL MIXTURES FOR FUNGAL CONTROL IN CEREALS - A fungicidal composition containing a fungicidally effective amount of a compound of Formula I-V and at least one fungicide selected from the group consisting of epoxiconazole, prothioconazole, azoxystrobin, pyraclostrobin, penthiopyrad, isopyrazam, bixafen, boscalid, prochloraz, and chlorothalonil provides synergistic control of selected fungi. | 04-07-2011 |
| 20110112120 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF - A compound represented by the formula (I): | 05-12-2011 |
| 20110112121 | Pharmaceutical Compositions and Solid Forms - The present invention relates to pharmaceutical compositions of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide, to the use of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide and compositions of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide in therapeutic applications, especially indications with a dysregulation/overexpression of VEFG, (neo)-vascularisation and VEGF driven angiogenesis and to methods for manufacturing such compositions, the invention further relates to specific forms of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide and to the manufacturing and use of such forms. The present invention also relates to a new process to produce 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide. | 05-12-2011 |
| 20110112122 | EPIMINOCYCLOALKYL[b] INDOLE DERIVATIVES AS SEROTONIN SUB-TYPE 6 (5-HT6) MODULATORS AND USES THEREOF - The present invention relates to epiminocycloalkyl[b]indole derivatives as serotonin sub-type 6 (5-HT | 05-12-2011 |
| 20110118290 | Novel Amides and Thioamides as Pesticides - The present application relates to novel amides and thioamides, to processes for preparation thereof and to use thereof for controlling animal pests, in particular arthropods and especially insects. | 05-19-2011 |
| 20110144140 | PYRIDINYL-PYRIMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS - This invention relates to novel pyridinyl-pyrimidine derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels. | 06-16-2011 |
| 20110152299 | SUBSTITUTED BENZAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME - Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention | 06-23-2011 |
| 20110178108 | Group of amino substituted benzoyl derivatives and their preparation and their use - A group of amino substituted benzoyl derivatives, their preparation and their use. The screening and research on an antiviral drug with hA3G/Vif as a target point proves that the 3-amino benzoyl derivatives not only have the combined activity for the hA3G/Vif, but also have a function of inhibiting replication of viruses. The present invention provides the possible breakthrough progress for the problem of HIV drug resistance, thereby providing a novel clinical antiviral drug which has higher efficiency. | 07-21-2011 |
| 20110178109 | PEST CONTROL COMPOSITION AND PEST CONTROL METHOD - A pest controlling composition comprising, as active ingredients, a pyrimidine compound represented by Formula (1): | 07-21-2011 |
| 20110195984 | PEST CONTROL COMPOSITION AND PEST CONTROL METHOD - A pest controlling composition comprising, as active ingredients, a pyrimidine compound represented by Formula (1) and an anthranilamide compound represented by Formula (2). | 08-11-2011 |
| 20110224241 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES AS FUNGICIDES - The present invention relates to compounds of Formula (I) wherein R | 09-15-2011 |
| 20110224242 | STYRLYQUINOLINES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC USES - The present disclosure concerns new substituted styrylquinolines, the process of their preparation and their therapeutic uses as integrase inhibitors and/or for the treatment and/or prevention of HIV. | 09-15-2011 |
| 20110245281 | DISPERSIBLE BOSENTAN TABLET - The invention relates to dispersible tablets comprising the compound 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(pyrimidin-2-yl)-pyrimidin-4-yl]-benzenesulfonamide. | 10-06-2011 |
| 20110263622 | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS - The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization and their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) | 10-27-2011 |
| 20110263623 | PROCESS FOR PREPARATION OF BOSENTAN - The present invention provides improved processes for preparing Bosentan. The present invention provides novel intermediates like 4,6-dihydroxy-5-(2-methoxy phenoxy)[2,2′]bipyrimidine of formula (II) and N-(6-Chloro-5-(2-ethoxyphenoxy)[2,2′-bipyrimidinyl]-4-t-butyl benzenesulfonamide cesium salt and process for preparation thereof. The invention also disclosed novel polymorphic form of the intermediates. | 10-27-2011 |
| 20110263624 | BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF - The present invention relates to Bicyclic Heterocycle Derivatives, compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a GPCR in a patient. | 10-27-2011 |
| 20110269784 | USE OF TETRAHYDROPYRIMIDINES - Tetrahydropyrimidines of the formula | 11-03-2011 |
| 20110275653 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 11-10-2011 |
| 20110281897 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 11-17-2011 |
| 20110281898 | PHENOXIACETIC ACID DERIVATIVES - The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation. | 11-17-2011 |
| 20110294835 | Muscarinic Agonists as Cognitive Enhancers - A method of treating a mental condition in a subject in need thereof, comprising: administering to a subject in need thereof an effective amount of compound CDD-102A. | 12-01-2011 |
| 20110294836 | ARYL GPR119 AGONISTS AND USES THEREOF - Aryl GPR119 agonists are provided. These compounds are useful for the treatment of diabetic diseases, including Type II diabetes and other diseases associated with poor glycemic control. | 12-01-2011 |
| 20110306623 | NOVEL COMPOUNDS COMPRISING A 3-(5-ALKOXYPYRIMIDIN-2-YL) PYRIMIDIN-4(3H)-ONE STRUCTURE AND DRUGS THAT COMPRISE SAME - Provided are novel compounds that have both angiotensin II receptor-antagonist effects and PPAR-activating effects that are useful as agents for preventing and/or treating hypertension, heart disease, angina, cerebral vascular accident, cerebrovascular disorder, ischemic peripheral circulatory disorder, kidney disease, atherosclerosis, inflammatory disease, type 2 diabetes mellitus, diabetic complication, insulin resistance syndrome, Syndrome X, metabolic syndrome, and hyperinsulinemia. Disclosed are 3-(5-alkoxypyrimidin-2-yl)pyrimidin-4(3H)-one derivatives represented by the General formula (I): [wherein R represents a C | 12-15-2011 |
| 20120028996 | NOVEL OXIME DERIVATIVES - The present invention relates to novel oxime derivatives of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation. | 02-02-2012 |
| 20120046308 | NOVEL ALPHA-PHENOXYBENZENEACETIC ACID DERIVATIVE AND PHARMACEUTICAL PREPARATION COMPRISING SAME - An α-phenoxybenzeneacetic acid derivative represented by general formula (I), which has both an angiotensin II receptor antagonistic activity and a PPARγ activation activity and is useful as a prophylactic and/or therapeutic agent for hypertension, metabolic syndrome or the like, a salt of the derivative, or a solvate of the derivative or the salt; and a pharmaceutical composition containing the derivative, the salt or the solvate. [In the formula, Q represents a group represented by formula (II) or (III) [wherein R | 02-23-2012 |
| 20120059020 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR PULMONARY FIBROSIS - Disclosed is a compound which has an inhibitory activity on plasminogen activator inhibitor-1 (PAI-1) and has a propanedioic acid structure represented by formula (1) [wherein R | 03-08-2012 |
| 20120095031 | CYCLOPROPANE COMPOUND - A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: | 04-19-2012 |
| 20120136015 | PROCESS FOR PREPARATION OF ENDOTHELIAL RECEPTOR ANTAGONIST (BOSENTAN) - The present invention relates to processes for the preparation of an endothelial receptor antagonist. The present invention particularly relates to synthesis of 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide (bosentan). | 05-31-2012 |
| 20120136016 | 4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS - The present invention relates to novel heterocyclic compounds of Formulae (I): (Chemical formula should be inserted here as it appears on abstract in paper form) Formula (I) as disclosed herein, or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are pharmaceutical compositions comprising said compounds, and methods for using said compounds for treating or preventing a thromboembolic disorder. | 05-31-2012 |
| 20120142714 | BICYCLIC COMPOUND - The present invention provides a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes and the like, and having superior efficacy. | 06-07-2012 |
| 20120142715 | POLYMORPH OF [4,6-BIS(DIMETHYLAMINO)-2-(4-BENZYL)PYRIMIDIN-5-YL] - Provided is a crystalline form of the ethylenediamine salt of [4,6-bis(dimethylamino)-2-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)pyrimidin-5-yl]acetic acid, processes for its preparation, pharmaceutical compositions comprising it, and methods of its use for treating, preventing, or ameliorating one or more symptoms of a CRTH2-mediated disorder or disease. | 06-07-2012 |
| 20120157482 | COMPOUNDS AND METHODS - Disclosed are compounds having the formula: | 06-21-2012 |
| 20120172382 | PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES - Compounds useful in the treatment of mammalian cancers and especially human cancers according to Formula I are disclosed. | 07-05-2012 |
| 20120172383 | FUNGICIDAL COMPOSITIONS BASED ON PYRIDYLMETHYLBENZAMIDE DERIVATIVES AND AT LEAST ONE COMPLEX III INHIBITING COMPOUND - 1) Fungicidal compositions comprising: a) at least one pyridylmethylbenzamide derivative of Formula (I), in which the various radicals are as defined in the description; and b) at least one compound (II) capable of inhibiting the transport of electrons of the respiratory chain of mitochondrial ubiquinol:ferricytochrome-c oxidoreductase or complex III in phytopathogenic fungal organisms. 2) Process for curatively or preventively controlling the phytopathogenic fungi of crops, characterized in that an effective and nonphytotoxic quantity of one of these fungicidal compositions is applied to the aerial parts of plants. | 07-05-2012 |
| 20120196881 | Treatment Of Pulmonary Hypertension With Carbonic Anhydrase Inhibitors - This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating pulmonary hypertension comprising administering a therapeutically effective dose of a carbonic anhydrase inhibitor to a patient in need of treatment. The disclosure finds utility in the fields of medicine and pharmacology. | 08-02-2012 |
| 20120196882 | COMPOUNDS THAT TREAT MALARIA AND PREVENT MALARIA TRANSMISSION - The invention provides methods and compounds for the treatment and prevention of malaria infection and transmission in a mammal by administering compounds of the invention to a mammal having or suspected of having a malaria infection. The invention also provides pharmaceutical compositions that can kill or arrest the growth of | 08-02-2012 |
| 20120220609 | 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE DERIVATIVE - The present invention provides a compound which enhances the production of erythropoietin. The present invention provides a compound represented by formula (1): | 08-30-2012 |
| 20120225895 | 1-HETERODIENE DERIVATIVE AND PEST CONTROL AGENT - The present invention provides a pest control agent having a novel skeleton, which can be synthesized industrially, and also has excellent biological activity and residual effects. Specifically, the present invention provides a 1-heterodiene derivative represented by Formula (1) or a salt thereof, and a pest control agent including, as an active ingredient, a 1-heterodiene derivative or a salt thereof. | 09-06-2012 |
| 20120232101 | Novel Compounds - The invention provides compounds of formula (I): | 09-13-2012 |
| 20120264772 | ANTIHYPERTENSIVE PHARMACEUTICAL COMPOSITION - Provided is an antihypertensive pharmaceutical composition containing Fimasartan, a pharmaceutically acceptable salt thereof, a solvate thereof or a hydrate thereof as an angiotensin II receptor blocker, and Amlodipine, an isomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof or a hydrate thereof as a calcium channel blocker. | 10-18-2012 |
| 20120270888 | PHARMACEUTICAL COMPOSITIONS OF RALTEGRAVIR, METHODS OF PREPARATION AND USE THEREOF - Disclosed are pharmaceutical compositions comprising HIV integrase strand transfer inhibitor. More particularly, oral pharmaceutical compositions of raltegravir or its pharmaceutically acceptable salts and process for preparing and use of the same are disclosed. | 10-25-2012 |
| 20120322819 | COMPOUND CONTAINING A NOVEL 4-ALKOXYPYRIMIDINE STRUCTURE AND MEDICINE CONTAINING SAME - Disclosed is novel compound and medicinal formulation containing same, possessing both angiotensin II receptor blocking and PPARγ activation effect, of use as a medicine for prevention and/or treatment of hypertension, heart disease, angina pectoris, cerebrovascular disorder, cerebral circulatory disturbances, post-ischemic peripheral circulatory damage, renal disease, arteriosclerosis, inflammatory disorder, type 2 diabetes, diabetic complications, insulin resistance syndrome, syndrome X, metabolic syndrome and hyperinsulinaemia. Further disclosed is the general formula I (where one or both of R | 12-20-2012 |
| 20130005752 | METALLOENZYME INHIBITOR COMPOUNDS - The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes. | 01-03-2013 |
| 20130005753 | HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES - The invention relates to novel organic compounds of formula (I) | 01-03-2013 |
| 20130012529 | HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES - The invention relates to novel organic compounds of formula (I) | 01-10-2013 |
| 20130018064 | Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of UseAANM Paras; Nick A.AACI San FranciscoAAST CAAACO USAAGP Paras; Nick A. San Francisco CA USAANM Cheng; YuanAACI Newbury ParkAAST CAAACO USAAGP Cheng; Yuan Newbury Park CA USAANM Powers; TimothyAACI MalibuAAST CAAACO USAAGP Powers; Timothy Malibu CA USAANM Brown; JamesAACI MoorparkAAST CAAACO USAAGP Brown; James Moorpark CA USAANM Hitchcock; Stephen A.AACI JupiterAAST FLAACO USAAGP Hitchcock; Stephen A. Jupiter FL USAANM Judd; TedAACI Simi ValleyAAST CAAACO USAAGP Judd; Ted Simi Valley CA USAANM Lopez; PatriciaAACI West HillsAAST CAAACO USAAGP Lopez; Patricia West Hills CA USAANM Xue; QiufenAACI Newbury ParkAAST CAAACO USAAGP Xue; Qiufen Newbury Park CA USAANM Yang; BryantAACI Simi ValleyAAST CAAACO USAAGP Yang; Bryant Simi Valley CA US - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I, wherein ring A, B | 01-17-2013 |
| 20130023547 | DISPERSIBLE TABLET - The invention relates to dispersible tablets comprising the compound 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(pyrimidin-2-yl)-pyrimidin-4-yl]-benzenesulfonamide. | 01-24-2013 |
| 20130040975 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO - GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: | 02-14-2013 |
| 20130065915 | NOVEL FORMULATION - The present invention provides a liquid formulation comprising a strobilurin fungicide, such as azoxystrobin, at least one non-ionic surfactant, at least one anionic surfactant and a solvent/carrier. | 03-14-2013 |
| 20130079360 | RALTEGRAVIR SALTS AND CRYSTALLINE FORMS THEREOF - The present invention includes new salts of Raltegravir and crystalline forms thereof, pharmaceutical compositions containing the salts or crystalline forms, methods of using the salts or crystalline forms or the compositions to treat HIV infection or to prepare medicament for treating HIV infection, and a process for preparing Raltegravir potassium. | 03-28-2013 |
| 20130096147 | Raltegravir Salts and Crystalline Forms Thereof - The present invention includes new salts of Raltegravir and crystalline forms thereof, pharmaceutical compositions containing the salts or crystalline forms, methods of using the salts or crystalline forms or the compositions to treat HIV infection or to prepare medicament for treating HIV infection, and a process for preparing Raltegravir potassium. | 04-18-2013 |
| 20130123287 | CONTROL AGENT FOR SOFT ROT AND CONTROL METHOD FOR THE SAME - Providing a novel control agent for soft rot and a novel control method for the same. A compound having no antibacterial activity against | 05-16-2013 |
| 20130143905 | NOVEL ANTAGONISTS FOR CCR2 AND USES THEREOF - The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) of formula (I) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. | 06-06-2013 |
| 20130143906 | SUBSTITUTED PYRIMIDINONE-PHENYL-PYRIMIDINYL COMPOUNDS - The present disclosure provides pyrimidinone-phenyl-pyrimidinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and inflammatory disease, having the structure of Formula (I): | 06-06-2013 |
| 20130150388 | INHIBITORS OF NEDD8-ACTIVATING ENZYME - Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer. | 06-13-2013 |
| 20130158053 | CRYSTALLINE FORMS OF 3-[5-CHLORO-4-[(2,4-DIFLUOROBENZYL) OXY]-6-OXOPYRIMIDIN-1(6H)-YL]-N-(2-HYDROXYETHYL)-4-METHYLBENZAMIDE - Crystalline forms of the p38 kinase inhibitor 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4-methylbenzamide is provided. Also provided are combinations and pharmaceutical compositions comprising the crystalline forms, and methods for the prophylaxis and/or treatment of a p38 kinase-mediated condition comprising administering to a subject a therapeutically effective amount of the crystalline forms. | 06-20-2013 |
| 20130158054 | POLYMORPHS OF 3-(E)-2--3-METHOXYACRYLATE - The present invention relates to novel crystalline polymorphic and amorphous forms of the compound (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxy-acrylate (azoxystrobin). Infrared Raman spectra, X-ray powder diffraction pattern and differential scanning calorimetry thermogram of two polymorphs “A” and “B” are provided. Further, the present invention also provides methods for preparing the novel polymorphic forms “A” and “B”, as well as processes for producing mixtures of the polymorphs, and a process for preparing amorphous azoxystrobin. Yet further, the present invention provides anti-fungal compositions comprising the novel crystalline polymorphs “A” and “B” or amorphous azoxystrobin, which are useful for controlling and combating fungi grown on agricultural and horticultural crops and up-land, and methods of using the same as pesticidal agents for combating fungi on agricultural and horticultural crops. | 06-20-2013 |
| 20130172375 | PHARMACEUTICAL COMPOSITION - The present invention relates to a pharmaceutical composition comprising a solid dispersion of a drug. In the composition, the drug is in substantially amorphous form. | 07-04-2013 |
| 20130184299 | CCR2 ANTAGONISTS AND USES THEREOF - The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. | 07-18-2013 |
| 20130225617 | INDOLES AND THEIR THERAPEUTIC USE - Compounds of the invention are ligands of the CRTH2 receptor, useful inter alia for treatment of inflammatory conditions. | 08-29-2013 |
| 20130245050 | Use of N-Phenylethylpyraozole Carboxamide Derivatives or Salts Thereof for Extending Shelf Life of Fruits and Vegetables - The present invention relates to the use of N-phenylethylpyrazole carboxamide derivatives or salts thereof for extended shelf life and storage stability of fruits and vegetables, to a method for extending shelf life or fruits and vegetables by applying N-phenylethylpyrazole carboxamide derivatives or salts thereof to the crops prior to the harvest of the fruits or vegetables. | 09-19-2013 |
| 20130252980 | NOVEL GPR 119 AGONISTS - The present invention relates to novel GPR 119 agonists of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation. | 09-26-2013 |
| 20130252981 | PYRIMIDINE COMPOUND AND USE THEREOF FOR PEST CONTROL - A pyrimidine compound of the formula (1): wherein: R | 09-26-2013 |
| 20130252982 | Biocide Compositions Comprising Alkoxylation Products Of Isoamyl Alcohol Deriatives - Suggested are alkoxylation products of 2-isopropyl-5-methyl-hexan-1-ol in which AO stands for an ethylene oxide, propylene oxide or butylenes oxide unit or their mixtures and n denominates an integer of from 1 to 100. | 09-26-2013 |
| 20130267545 | METHOD OF IMPROVING PLANT GROWTH BY REDUCING FUNGAL INFECTIONS - A method of improving the growth of plants such as corn, soybean, wheat, or rice is provided by reducing the incidence of one or more fungal infections. The method comprises the step of applying a foliar treatment composition at least once to established plants, wherein the treatment composition comprises effective amounts of active ingredients prothioconazole, trifloxystrobin, and azoxystrobin. | 10-10-2013 |
| 20140018377 | Aminopropenoates as Fungicides - This application claims priority to European Patent Application No. 09173304.8, filed Oct. 16, 2009, and the benefit of U.S. Provisional Application No. 61/253,091, filed Oct. 20, 2009, the disclosure of each of which is incorporated by reference herein in its entirety. | 01-16-2014 |
| 20140018378 | POLYMORPHS OF METHYL (E)-2--3-METHOXYACRYLATE - The present invention relates to novel crystalline polymorphic and amorphous forms of the compound methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (azoxystrobin). Infrared Raman spectra, X-Ray powder diffraction pattern and differential scanning calorimetry thermogram of two polymorphs “A” and “B” are provided. Further, the present invention also provides methods for preparing the novel polymorphic forms “A” and “B”, as well as processes for producing mixtures of the polymorphs, and a process for preparing amorphous azoxystrobin. Yet further, the present invention provides anti-fungal compositions comprising the novel crystalline polymorphs “A” and “B” or amorphous azoxystrobin, which are useful for controlling and combating fungi grown on agricultural and horticultural crops and up-land, and methods of using the same as pesticidal agents for combating fungi on agricultural and horticultural crops. | 01-16-2014 |
| 20140038992 | METHODS OF ADMINISTERING RALTEGRAVIR AND RALTEGRAVIR COMPOSITIONS - The present disclosure is related to amorphous raltegravir and the solid oral dosage forms of amorphous raltegravir that are of lower dosage than the commercially available reference dosage form. | 02-06-2014 |
| 20140051714 | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto - The present invention relates to the GPR119 agonist, 4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)-5-fluoro-6-(2-methyl-6-(methylsulfonyl)pyridin-3-yloxy)pyrimidine (Compound 1): and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are useful as single pharmaceutical agents or in combination with one or more additional pharmaceutical agents, such as, a DPP-IV inhibitor, a biguanide, an alpha-glucosidase inhibitor, an insulin analogue, a sulfonylurea, an SGLT2 inhibitor, a meglitinide, a thiazolidinedione, or an anti-diabetic peptide analogue, in the treatment of for example, a disorder selected from: a GPR119-receptor-related disorder; a condition ameliorated by increasing the secretion of an incretin; a condition ameliorated by increasing a blood incretin level; a condition characterized by low bone mass; a neurological disorder; a metabolic-related disorder; type 2 diabetes; obesity; and complications related thereto. | 02-20-2014 |
| 20140088124 | IMIDAZOLE DERIVATIVES - Described herein are compounds of formula (I), The compounds of formula I act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity. | 03-27-2014 |
| 20140094478 | COMPOSITION AND TABLET COMPRISING RALTEGRAVIR - The present invention relates to a composition and tablet comprising raltegravir and to a process for the preparation of such tablet. | 04-03-2014 |
| 20140135353 | CRYSTALLINE SODIUM SALT OF AN HIV INTEGRASE INHIBITOR - A crystalline sodium salt of a compound of formula I (INN: Raltegravir) | 05-15-2014 |
| 20140155419 | COMPOUNDS AND METHODS - The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ. | 06-05-2014 |
| 20140163053 | Use of Tetrahydropyrimidines - A method of treatment of postoperative inflammatory stress and pain comprising administering a tetrahydropyrimidine selected from ectoine and/or hydroxyectoine to a patient in need of such treatment. | 06-12-2014 |
| 20140187567 | AGRICULTURAL OR HORTICULTURAL FUNGICIDE COMPOSITION AND METHOD FOR CONTROLLING PLANT PATHOGEN - A composition having a stable and high fungicidal effect against a cultivated crop infected by a plant pathogen is provided. An agricultural or horticultural fungicide composition containing, as active ingredients, (a) fluazinam or its salt and (b) a strobilurin compound or its salt is provided; in addition, a method for controlling a plant pathogen by applying the subject agricultural or horticultural fungicide composition to a plant or a soil is provided; and furthermore, a method for controlling a plant pathogen by applying (a) fluazinam or its salt and (b) a strobilurin compound or its salt to a plant or a soil is provided. | 07-03-2014 |
| 20140187568 | CRYSTALLINE FORMS OF BOSENTAN SALTS AND PROCESSES FOR THEIR PREPARATION - The present invention relates to crystalline forms of bosentan salts and processes for their preparation. | 07-03-2014 |
| 20140187569 | CRYSTALLINE FORMS OF BOSENTAN SALTS AND PROCESSES FOR THEIR PREPARATION - The present invention relates to crystalline forms of bosentan salts and processes for their preparation. | 07-03-2014 |
| 20140206707 | 6-ALKYL-N-(PYRIDIN-2-YL)-4-ARYLOXYPICOLINAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME - Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 07-24-2014 |
| 20140243362 | SULFONAMIDE COMPOUNDS AND THEIR USE IN THE MODULATION RETINOID-RELATED ORPHAN RECEPTOR - The present invention is directed to novel retinoid-related orphan receptor gamma (RORγ) modulators of formula (I), processes for their preparation, pharmaceutical compositions containing these modulators, and their use in the treatment of inflammatory, metabolic and autoimmune diseases mediated by RORγ | 08-28-2014 |
| 20140256755 | Raltegravir Salts And Crystalline Forms Thereof - The present invention includes new salts of Raltegravir and crystalline forms thereof, pharmaceutical compositions containing the salts or crystalline forms, methods of using the salts or crystalline forms or the compositions to treat HIV infection or to prepare medicament for treating HIV infection, and a process for preparing Raltegravir potassium. | 09-11-2014 |
| 20140275132 | PYRIDINYL AND PYRIMIDINYL SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS - The present invention relates to novel pyridine or pyrimidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors. The invention relates specifically to the use of these compounds and their pharmaceutical compositions to treat disorders associated with chemokine receptor modulation. | 09-18-2014 |
| 20140275133 | MINERALOCORTICOID RECEPTOR ANTAGONISTS - The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof that are possible useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula (I), to their possible use for the treatment of the above mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula (I). | 09-18-2014 |
| 20140288104 | COMPOSITION AND METHOD FOR CONTROLLING PLANT DISEASES - The present invention provides a composition for controlling plant diseases having an excellent control efficacy on plant diseases. A composition for controlling plant diseases comprising an amide compound represented by a formula (I): wherein each of symbols are the same as defined in the Description; or salts thereof and at least one kind of compounds selected from the group (A) consisting of kresoxim-methyl, azoxystrobin, pyraclostrobin, picoxystrobin, enestrobin, trifloxystrobin, dimoxystrobin, fluoxastrobin, orysastrobin, famoxadone, fenamidone, metominostrobin, a compound represented by a formula (II): and pyribencarb shows an excellent controlling efficacy on plant diseases. | 09-25-2014 |
| 20140296269 | COMPOSITION AND METHOD FOR CONTROLLING PLANT DISEASES - The present invention provides a composition for controlling plant diseases having an excellent control efficacy on plant diseases. A composition for controlling plant diseases comprising an amide compound represented by a formula (I); wherein each of symbols are the same as defined in the Description; or salts thereof and at least one kind of compounds selected from the group (A) consisting of kresoxim-methyl, azoxystrobin, pyraclostrobin, picoxystrobin, enestrobin, trifloxystrobin, dimoxystrobin, fluoxastrobin, orysastrobin, famoxadone, fenamidone, metominostrobin, a compound represented by a formula (II) and pyribencarb: shows an excellent controlling efficacy on plant diseases. | 10-02-2014 |
| 20140315933 | CHEMICAL COMPOUNDS - The present invention relates to new sulfonamide URAT-1 inhibitor compounds of formula (I) or pharmaceutically acceptable salts thereof: | 10-23-2014 |
| 20140315934 | SUBSTITUTED BENZYLPYRAZOLES - Compounds of formula (I) and their use as pharmaceutical. | 10-23-2014 |
| 20140343083 | Pyrrolidine derivatives, pharmaceutical compositions and uses thereof - Pyrrolidine derivatives which are inhibitors of acetyl-CoA carboxylase(s) and their use in the treatment of obesity and type-2 diabetes. An exemplary compound is 2-(4-(1-[5-Chloro-6-(2-hydroxy-2-methyl-propoxy)-pyrimidin-4-yl]-(R)-pyrrolidin-3-yloxy)-phenyl)-N-cyclopropyl-propionamide. | 11-20-2014 |
| 20150011572 | INHIBITORS OF NEDD8-ACTIVATING ENZYME - Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer. | 01-08-2015 |
| 20150011573 | ADJUVANT COMPOSITIONS - Adjuvant compositions are provided which comprise at least one terpenic alkoxylate and at least one agrochemical active ingredient. | 01-08-2015 |
| 20150018376 | PYRIMIDIN-4-YL)OXY)-1H-INDOLE-1-CARBOXAMIDE DERIVATIVES AND USE THEREOF - This invention relates to certain metabolites of N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide In particular, the present invention relates to pharmaceutical compositions comprising these metabolites, as well as processes for their preparation and their use in the treatment of diseases. | 01-15-2015 |
| 20150038521 | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS - The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization and their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) | 02-05-2015 |
| 20150051231 | SYNERGISTIC COMBINATIONS OF TRIAZOLES, STROBILURINS AND BENZIMIDAZOLES, USES, FORMULATIONS, PRODUCTION PROCESSES AND APPLICATIONS USING THE SAME - The present invention relates to an agrochemically synergistic formulation of triazoles, strobilurins and benzimidazoles, in specific proportions for controlling and/or combating plagues and diseases caused therefrom in vegetable cultures. Also described are their process of preparation, use and method of use as well as the use of triazoles, strobilurins and benzimidazoles in the preparation of the agrochemically synergistic formulation of the invention. | 02-19-2015 |
| 20150057298 | NOVEL COMPOUNDS - The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, | 02-26-2015 |
| 20150065529 | SYNERGISTIC FUNGICIDAL MEXURES FOR FUNGAL CONTROL IN CEREALS - A fungicidal composition containing a fungicidally effective amount of a compound of Formula I-V and at least one fungicide selected from the group consisting of epoxiconazole, prothioconazole, azoxystrobin, pyraclostrobin, penthiopyrad, isopyrazam, bixafen, boscalid, prochloraz, and chlorothalonil provides synergistic control of selected fungi. | 03-05-2015 |
| 20150087665 | Pyrimidine carboxamide derivatives - The invention relates to a compound of the formula | 03-26-2015 |
| 20150119412 | HETEROCYCLIC COMPOUND - A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: | 04-30-2015 |
| 20150297549 | COMPOSITION COMPRISING A COMBINATION OF DHA AND EPA FOR ADMINISTRATION PRIOR TO COMMENCEMENT OF CHEMOTHERAPY - The invention relates to a composition comprising a combination of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The composition can be used for enhancing the activity of chemotherapy or radiotherapy and/or in the prevention or reduction of side effects caused by the chemotherapy or radiotherapy in a patient ill with cancer, the composition being intended for administration to the patient prior to the commencement of a cycle of chemotherapy or radiotherapy. | 10-22-2015 |
| 20150313218 | METHOD FOR INCREASING YIELD OF CROP SEEDS OR FRUITS IN NUMBER OR WEIGHT - A method is provided for increasing the number or weight of seeds or fruits of a crop, including a step of treating the crop with effective amounts of a compound represented by Formula (1) and at least one compound selected from the group (A): | 11-05-2015 |
| 20150322023 | Biaryl- or Heterocyclic Biaryl-Substituted Cyclohexene Derivative Compounds as CETP Inhibitors - The present invention provides biaryl- or heterocyclic biaryl-substituted cyclohexene derivative compounds, isomers thereof, or pharmaceutically acceptable salts. The compounds of the invention show a CETP inhibitory effect that increases HDL-cholesterol levels and reduces LDL-cholesterol levels. Pharmaceutical compositions comprising the compounds are useful for the prevention or treatment of dyslipidemia or dyslipidemia-related diseases. | 11-12-2015 |
| 20160000067 | FORMULATIONS - This invention relates to a formulation comprising a compound of formula (I) where R1 is hydrogen, methyl, ethyl, propyl or butyl; R2 is methyl or ethyl; R3 is hydrogen, methyl or ethyl; and n is 1, 2 or 3; to the use of a compound of formula (I) as a solvent; and to certain novel compounds of formula (I). | 01-07-2016 |
| 20160088841 | SYNERGISTIC SEED TREATMENT COMPOSITIONS - An agrochemical composition for the treatment of plant propagation material, comprising at least two active ingredient components together with a suitable carrier, wherein component I is fludioxonil (=4-(2,2-difluoro-1,3-benzodioxo1-4-yl)pyrrole-3-carbonitrile) and wherein component II is azoxystrobin (=methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate) or picoxystrobin (=methyl (E)-3-methoxy-2-[2-(6-trifluoromethyl-2-pyridyloxymethyl)phenyl]acrylate) or kresoxim-methyl (=methyl (E)-methoxyimino[2-(o-tolyloxymethyl)phenyl]acetate. | 03-31-2016 |
| 20160106747 | TREATING POSTOPERATIVE MECHANICAL STRESS WITH AN ECTOINE - A method of treatment of a patient suffering from postoperative inflammatory stress and pain caused by mechanical impact exerted on portions of the body of the patient that causes damaged tissue wherein the inflammatory stress and pain of the operation outlast the healing of damaged tissue and which is not related to, or caused by, uncontrolled proteolysis. The treatment comprises administering a tetrahydropyrimidine selected from ectoine and/or hydroxyectoine to the patient. | 04-21-2016 |
| 20160108031 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION - The invention relates to inhibitors of the NHR2 tetramerization and their use as tumor therapeutics (e.g. against acute myeloid leukemia (AML)), cytostatics, and diagnostic agents. | 04-21-2016 |
| 20160151370 | Substituted Benzylpyrazoles | 06-02-2016 |
| 20160158251 | COMPOSITION FOR PREVENTING OR TREATING MUSCULAR ATROPHY OR PROMOTING MUSCULAR REGENERATION IN SUBJECT COMPRISING SULFONAMIDE COMPOUND AND USE THEREOF - A composition for preventing or treating muscular atrophy or promoting muscular regeneration in a subject including a sulfonamide compound, a pharmaceutically acceptable salt, solvate, or polymorph thereof, or a combination of at least two of the foregoing, and a method of preventing or treating muscular atrophy or promoting muscular regeneration by using the composition. | 06-09-2016 |
| 20160249616 | METHOD OF INCREASING YIELD BY TREATING WITH FUNGICIDAL COMPOSITIONS | 09-01-2016 |
| 20180020665 | METHOD FOR CONTROLLING RUST | 01-25-2018 |
| 20220135588 | Five-Membered Heteroaryl-Fused Imidazole Compound And Application Thereof - A novel five-membered heteroaromatic imidazole compound and use thereof is disclosed herein. Specifically, disclosed is a compound as shown in formula (III) or a pharmaceutically acceptable salt thereof. Also disclosed is a method for treating a disease related to GLP-1 receptor such as type II diabetes. | 05-05-2022 |
