Class / Patent application number | Description | Number of patent applications / Date published |
514266230 | The additional hetero ring is five-membered consisting of carbon and plural nitrogens as the only ring members | 41 |
20080269263 | Synergistic Fungidical Active Substance Combinations - The present invention relates to novel active substance combinations which contain spiroxamine, which is known, a known azole and a known carboxamide and which are very suitable for controlling undesired phytopathogenic fungi. | 10-30-2008 |
20090036474 | Quinazoline derivatives for use against cancer - The invention concerns quinazoline derivatives of Formula (I) or a pharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each of p, R | 02-05-2009 |
20090156619 | Heterocycle Substituted Amide and Sulfur Amide Derivatives as Histone Deacetylase (HDAC) Inhibitors - The present invention related to compounds of formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. Compounds of the present invention are useful for treating or preventing neurodegenerative diseases, schizophrenia and stroke among other diseases. | 06-18-2009 |
20090264451 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS - The present invention is directed to novel 6-1H-imidazo-2-aryl and 2-heteroaryl quinazoline and quinoline of formula I, corresponding salts and solvates thereof, to a process for their preparation and to the use of this compounds and corresponding pharmaceutical composition for the treatment of pain and inflammatory related disorders. Compounds of the invention have been proven highly effective in the pharmacological treatment of both inflammatory and neuropathic pain, in addition to striking anti-inflammatory properties. Their effectiveness in interfering with COX-2 and inflammatory cytokines expressions and production, highlights them as interesting compounds also for the treatment of cancer in addition to several inflammatory diseases. | 10-22-2009 |
20100261740 | NOVEL 4-(TETRAZOL-5-YL)-QUINAZOLINE DERIVATIVES AS ANTI CANCER AGENT - The invention relates to substituted 4-(tetrazol-5-yl)-quinazoline derivatives of the formula-I, or pharmaceutically-acceptable salts thereof, which possess anti-proliferative activity such as anti-cancer activity and are accordingly useful in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of substituted 4-(tetrazol-5-yl)-quinazoline derivatives, to pharmaceutical compositions containing the compound and to its use in the manufacture of medicaments for the production of an anti-proliferative effect in a warm-blooded animal such as man. | 10-14-2010 |
20100298359 | GAMMA SECRETASE MODULATORS - This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R | 11-25-2010 |
20110118289 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW MAO INHIBITORS AND IMIDAZOLINE RECEPTOR LIGANDS - The present invention is directed to 6-(1H-imidazo-1-yl)-2-aryl and 2-heteroaryl quinazoline and quinolines derivatives, compounds of formula (I), their pharmaceutical acceptable salts and solvates and corresponding pharmaceutical compositions, that acts as Monoamine Oxidase (MAO) inhibitors and Imidazoline Receptor ligands: | 05-19-2011 |
20110166168 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments - The present invention relates to sulphone-substituted quinazoline derivatives of the formula (I), processes for their preparation and their use as a medicament for the treatment of various diseases. | 07-07-2011 |
20110212980 | COMBINATIONS FOR THE TREATMENT OF MIGRAINE - The present invention relates to novel combinations suitable for the treatment of migraine of various genesis or aetiology, which comprise, as active ingredients, at least one 5-HT | 09-01-2011 |
20110245280 | FRUGICIDAL MIXTURES BASED ON TRIAZOLES - A fungicidal mixture, comprising
| 10-06-2011 |
20110257209 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS - The present invention is directed to novel 6-1H-imidazo-2-aryl and 2-heteroaryl quinazoline and quinoline of formula I, corresponding salts and solvates thereof, to a process for their preparation and to the use of this compounds and corresponding pharmaceutical composition for the treatment of pain and inflammatory related disorders. Compounds of the invention have been proven highly effective in the pharmacological treatment of both inflammatory and neuropathic pain, in addition to striking anti-inflammatory properties. Their effectiveness in interfering with COX-2 and inflammatory cytokines expressions and production, highlights them as interesting compounds also for the treatment of cancer in addition to several inflammatory diseases. | 10-20-2011 |
20110263620 | QUINOLINE COMPOUNDS AND THEIR USE FOR TREATING VIRAL INFECTION - Quinoline compounds of formula (I): | 10-27-2011 |
20110281896 | OPTICALLY PURE QUINAZOLINE COMPOUNDS - Optical pure quinazoline compounds, especially compounds of the general formula (I), wherein R | 11-17-2011 |
20110319435 | FUNGICIDE MIXTURES - The invention relates to a method for combating fungi and spores and suitable means therefor, and to the use thereof. | 12-29-2011 |
20110319436 | Methods and Compositions for Modulating IRE1, SRC, and ABL Activity - Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl. | 12-29-2011 |
20120115893 | Substituted Bicyclic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands - Substituted bicyclic carboxamide and urea compounds corresponding to formula (I) | 05-10-2012 |
20120122903 | 1-H-QUINAZOLINE-2, 4-DIONES FOR USE IN THE TREATMENT OF NEURONAL CEROID LIPOFUSCINOSIS - The invention concerns the use of competitive AMPA receptor antagonists for the treatment, prevention or delay of progression of neuronal ceroid lipofuscinosis. | 05-17-2012 |
20120142713 | CRYSTALLINE FORMS OF 6-(1H-IMIDAZOL-1-YL)-2-PHENYLQUINAZOLINE - The present invention relates to the solid state of 6-(1H-imidazol-1-yl)-2-phenylquinazoline (I) and therefore to novel crystalline forms of the base and of pharmaceutically acceptable salts and solvates thereof, and also to methods for preparing them, to the respective pharmaceutical formulations and to their therapeutic use. Compound (I) may be obtained as the free base in five different crystalline forms, three polymorphic forms and two hydrates. Some pharmaceutically acceptable salts of (I) that have physicochemical characteristics acceptable for pharmaceutical development were obtained, and the respective polymorphic forms and/or hydrates were characterized. | 06-07-2012 |
20120172380 | NOVEL 4-(TETRAZOL-5-YL)-QUINAZOLINE DERIVATIVES AS ANTI CANCER AGENT - The invention relates to substituted 4-(tetrazol-5-yl)-quinazoline derivatives of the formula-I, | 07-05-2012 |
20120283280 | IMIDAZOTETRAZINONE-BASED COMBI-MOLECULES - A series of new chemical agents that demonstrate anti-tumor activity are described herein. The new chemical agents exhibit a dual mode of anti-tumor action: blocking epidermal growth factor receptor (EGFR) mediated signal transduction and damaging DNA by alkylation. | 11-08-2012 |
20130090346 | Use of 1H-quinazoline-2,4-diones - The invention concerns the use of competitive AMPA receptor antagonists for the treatment or prevention of photosensitive epilepsy. | 04-11-2013 |
20130109706 | QUINAZOLINE-BASED T CELL PROLIFERATION INHIBITORS | 05-02-2013 |
20130165458 | QUINAZOLINE COMPOUNDS AS KINASE INHIBITORS - A compound for treating protein kinase-related disease or disorder having a structure of formula (A): | 06-27-2013 |
20130172373 | QUINAZOLINE COMPOUNDS - Provided are certain quinazoline compounds, compositions thereof and methods of use thereof. These quinazoline compounds can effectively inhibit the overexpression and/or overactivity of epidermal growth factor receptor (EGFR). | 07-04-2013 |
20130225614 | 4-AZOLYLAMINOQUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF - Provided herein are 4-azolylaminoquinazoline compounds for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase-mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions. | 08-29-2013 |
20130225615 | 2-CYCLOQUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF - Provided herein are 2-cycloquinazoline compounds for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase-mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions. | 08-29-2013 |
20140018376 | Use of 1H-Quinazoline-2,4-Diones - The invention concerns the use of competitive AMPA receptor antagonists for the treatment, prevention or delay of progression of Rasmussen's encephalitis and/or certain forms of epilepsy. | 01-16-2014 |
20140107138 | FUNGICIDAL COMPOSITION AND METHOD FOR CONTROLLING PLANT DISEASES - A fungicidal composition containing, as active ingredients, (a) a benzoylpyridine derivative represented by the following formula or its salt: | 04-17-2014 |
20140163050 | Use of 1H-quinazoline-2,4-diones - The invention concerns the use of competitive AMPA receptor antagonists for the treatment or prevention of photosensitive epilepsy. | 06-12-2014 |
20140194449 | OPTICALLY ACTIVE PYRAZOLYLAMINOQUINAZOLINE, AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF - Provided herein is an optically active pyrozolylaminoquinazaline, and pharmaceutical compositions thereof. Also provided herein is a method for treating, preventing, or ameliorating one or more symptoms of a JAK-mediated condition, disorder, or disease. Further provided herein is a method for treating, preventing, or ameliorating one or more symptoms of a proliferative disease, inflammatory disease, or renal disease. | 07-10-2014 |
20140206706 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS - The present invention provides a method for treating a thrombotic or an inflammatory disorder administering to a patient in need thereof a therapeutically effective amount of at least one compound of Formula (I) or Formula (V): | 07-24-2014 |
20140296268 | THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING ALLOSTERIC KINASE INHIBITION - The present invention is directed to methods and compositions for suppressing lymphangiogenesis, angiogenesis and/or tumor growth. The methods comprise contacting the tumor with a compound that (i) stabilizes a protein kinase in the inactive state and (ii) is not an ATP competitive inhibitor of the protein kinase in the active state. | 10-02-2014 |
20140309246 | METHODS AND USE OF BIFUNCTIONAL ENZYME-BUILDING CLAMP-SHAPED MOLECULES - This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for inhibiting cell proliferative disorders, especially those disorders characterized by over activity and/or inappropriate activity of a EGFR, including EGFR-related cancers, and methods for treating these disorders. | 10-16-2014 |
20140378485 | QUINAZOLINONE DERIVATIVES AS HCV INHIBITORS - Inhibitors of HCV replication of formula (I) including stereochemically isomeric forms, salts, and solvates thereof, wherein R and R′ have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy. | 12-25-2014 |
20150025092 | SOLID FORMS COMPRISING OPTICALLY ACTIVE PYRAZOLYLAMINOQUINAZOLINE, COMPOSITIONS THEREOF, AND USES THEREWITH - Solid forms comprising pyrazolylaminoquinazoline, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders are disclosed. | 01-22-2015 |
20150087664 | QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS - Compounds having the formula (I) wherein R | 03-26-2015 |
20150141443 | OPTICALLY ACTIVE PYRAZOLYLAMINOQUINAZOLINE, AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF - Provided herein is an optically active pyrazolylaminoquinazoline, and pharmaceutical compositions thereof. Also provided herein is a method for treating, preventing, or ameliorating one or more symptoms of a JAK-mediated condition, disorder, or disease. Further provided herein is a method for treating, preventing, or ameliorating one or more symptoms of a proliferative disease, inflammatory disease, or renal disease. | 05-21-2015 |
20150307509 | FUSED RING COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF - Provided are fused tricyclic compounds effective to inhibit the function of the NS5A protein of formula (I), wherein X, X′, Y, Y′, A, A′, Q | 10-29-2015 |
20150342182 | Seed Treatment Compositions and Methods - The invention relates to seed treatment compositions comprising active ingredient, polyarylphenol polyalkoxy ether phosphate and/or polyarylphenol polyalkoxy ether sulphate, and copolymer having polyalkoxy ether side chains. | 12-03-2015 |
20150361069 | QUINAZOLINES AS KINASE INHIBITORS - Disclosed are compounds that are inhibitors of RIP2 kinase and methods of making and using the same. | 12-17-2015 |
20160074381 | MODULATORS OF CELLULAR ADHESION - The present invention provides compounds having formula (I): | 03-17-2016 |