| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 514263400 | Nitrogen bonded directly to ring carbon of the purine ring system (e.g., adenine, etc.) | 47 |
| 20080200483 | Purine Derivatives for Use as Adenosin A-2A Receptor Agonists - Compounds of formula I | 08-21-2008 |
| 20080269259 | Regulation of Autophagy and Cell Survival - Methods of treating an individual who has been identified as having glycolysis dependent cancer are disclosed. The methods comprise the step of: administering to such an individual a combination of an anti-cancer composition that renders the cancer incapable of glycolysis and an autophagy inhibitor. Pharmaceutical compositions and kits comprising that renders the cancer incapable of glycolysis and an autophagy inhibit are also disclosed. Methods of treating an individual who has a disease characterized b cell degeneration and cell death due to autophagy are disclosed. The methods comprise administering to the individual a permeable form of a metabolic substrate that can be oxidized in the tricarboxylic acid cycle to produce NADH. Methods for identifying an autophagy inhibitor comprising performing a test assay using an apopto sis-resistant cell are disclosed. | 10-30-2008 |
| 20090005400 | Biologically Active Aphrocallistin Compounds - The subject invention provides novel compositions of biologically active compounds which can advantageously be used in blocking cellular proliferation and/or treatment of cancer. | 01-01-2009 |
| 20090023754 | Modified release famciclovir pharmaceutical compositions - A modified release pharmaceutical composition of famciclovir contains at least 60% by weight famciclovir with at least 5% by weight of a release retardant. Particularly useful as a release retardant include polymers, especially a mixture of polyvinyl acetate and polyvinylpyrrolidone. A method of making such pharmaceutical compositions using a extruder and a granulation method is particularly useful. | 01-22-2009 |
| 20090149479 | DOSING REGIMEN - Methods and kits are provided enabling a twice daily dosing regimen that achieves daily patient blood levels of active pharmaceutical ingredient comparable to a dosing regimen requiring the same active ingredient to be administered three times a day. | 06-11-2009 |
| 20090170879 | 6,9-Disubstituted Purine Derivatives and Their Use as Cosmetics and Cosmetic Compositions - Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are provided. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like. | 07-02-2009 |
| 20090281127 | Organic Compounds - A compound of formula (I) and their preparation and use as pharmaceuticals | 11-12-2009 |
| 20090306098 | COMBINATION OF ROSCOVITINE AND A HDCA INHIBITOR TO TREAT PROLIFERATIVE DISEASES - A first aspect of the invention relates to a combination comprising roscovitine, or a pharmaceutically acceptable salt thereof, and a HDAC inhibitor selected from sodium butyrate, or a prodrug thereof, suberoylanilide hydroxamic acid (SAHA), sodium valproate and trichostatin A (TSA). A second aspect of the invention relates to a pharmaceutical product comprising roscovitine, or a pharmaceutically acceptable salt thereof, and a HDAC inhibitor selected from sodium butyrate, or a prodrug thereof, suberoylanilide hydroxamic acid (SAHA), sodium valproate and trichostatin A (TSA) as a combined preparation for simultaneous, sequential or separate use in therapy. A third aspect of the invention relates to a method for treating a proliferative disorder, said method comprising simultaneously, sequentially or separately administering roscovitine, or a pharmaceutically acceptable salt thereof, and a HDAC inhibitor selected from sodium butyrate, or a prodrug thereof, suberoylanilide hydroxamic acid (SAHA), sodium valproate and trichostatin A (TSA) to a subject. | 12-10-2009 |
| 20090306099 | Method of Screening for Drug Hypersensitivity Reaction - Methods of assessing the risk of clinical signs of hypersensitivity reaction to nucleoside antiviral compounds, including abacavir, are described. The methods include genotyping subjects for polymorphisms in the TNFα gene, the class 1 HLA genes, or a combination of both the TNFα and HLA genes. | 12-10-2009 |
| 20100010020 | PHOSPHODIESTERASE 4 INHIBITORS - PDE4 inhibition is achieved by novel compounds of the Formula I: | 01-14-2010 |
| 20100022562 | Use of Plant Growth Regulators to Reduce Abscisic Acid Related Plant Leaf Yellowing - The present invention describes methods for maintaining ABA-induced drought tolerance while reducing ABA-induced leaf yellowing through the combination of ABA with selected plant growth regulators. The present invention also describes a method of using selected ABA analogs to reduce water use with minimal leaf yellowing. | 01-28-2010 |
| 20100190806 | SUBSTITUTED 6-ANILINOPURINE DERIVATIVES AS INHIBITORS OF CYTOKININ OXIDASE/DEHYDROGENASE AND PREPARATIONS CONTAINING THESE DERIVATIVES - The invention relates to substituted 6-anilinopurine derivatives of the general formula I, wherein R denotes one to five substituents independently selected from the group consisting of hydrogen, halogen, hydroxyl, amino, alkyloxy and alkyl group, and R2 denotes amino, halogen, nitro, thio, alkylthio or alkyl group for use as inhibitors of cytokinin oxidase/dehydrogenase. The invention also relates to the compositions containing these derivatives. | 07-29-2010 |
| 20100216822 | Nucleotide Analogue Prodrug and the Preparation Thereof - (R)-9-[2-bis[pivaloyloxymeihoxy]phosphinoylmethoxypropyl]adenine (being abbreviated bis-POMPMPA, TD), the derivative and the use thereof. Also including the synthetic process of TD and the procedure for manufacturing solid TD, as well as the composition containing TD and the procedure for manufacturing the composition. | 08-26-2010 |
| 20100298352 | SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS - A method of inhibiting a carcinoma in a subject, comprising administering to the subject at least one therapeutic agent that selectively targets carcinoma stem cells. Illustrative carcinoma stem cell-selective therapeutic agents include CGP74514A, rottlerin, and A-77636. | 11-25-2010 |
| 20100298353 | Famciclovir for the treatment of recurrent herpes labialis using a one-day treatment - A method for the treatment of recurrent herpes labialis in mammals, including humans, which method comprises administering to the mammal in need of such treatment, an effective amount of penciclovir or famciclovir, or a pharmaceutically acceptable salt thereof for a period of one day. | 11-25-2010 |
| 20100298354 | Crystalline Form Of Abacavir That Is Essentially Free Of Solvent - Crystalline form of abacavir that is essentially free of solvent of formula (I), in particular crystalline Form I, and its preparation process which comprises the following steps: a) crystallizing abacavir from a solution of said compound in a (C | 11-25-2010 |
| 20100311767 | Method for the treatment of amyloidoses - The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an agonist of the P/Q type voltage-gated presynaptic calcium channel to said subject. | 12-09-2010 |
| 20110046164 | Purine Derivatives for Treatment of Cystic Diseases - Provided herein are methods of treatment of a cystic disease by administering a compound of Formula I. In certain embodiments, the compound for use in the methods provided herein is roscovitine or an analog thereof. | 02-24-2011 |
| 20110092521 | Methods of Treating Diseases Using Inhibitors of Nucleoside Phosphorylases and Nucleosidases - The invention relates to treating a disease or condition in which it is desirable to inhibit 5′-methylthioadenosine phosphorylase (MTAP) and/or 5′-methylthioadenosine nucleosidase (MTAN). The invention particularly relates to the co-administration of 5′-methylthioadenosine (MTA), or a prodrug of MTA, with one or more MTAP/MTAN inhibitors. Included among the diseases treatable are prostate cancer and head and neck cancer. | 04-21-2011 |
| 20110092522 | Wound and Skin Care Procuts - The invention provides compositions and methods that employ compounds that can stimulate proliferation of fibroblasts or keratinocytes and/or stimulate production of collagen by fibroblasts. These compositions and methods are useful for treating gum- and skin-related conditions. | 04-21-2011 |
| 20110092523 | AGENTS WHICH REGULATE, INHIBIT, OR MODULATE THE ACTIVITY AND/OR EXPRESSION OF CONNECTIVE TISSUE GROWTH FACTOR (CTGF) AS A UNIQUE MEANS TO BOTH LOWER INTRAOCULAR PRESSURE AND TREAT GLAUCOMATOUS RETINOPATHIES/OPTIC NEUROPATHIES - The present invention provides a method for lowering intraocular pressure and providing neuroprotection to a patient in need thereof by administering a therapeutically effective amount of at least one non-nucleotide or non-protein agent that inhibits expression and/or signaling of connective tissue growth factor (CTGF). | 04-21-2011 |
| 20110160228 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION - The present invention relates to compounds of formula (I) below in which: —R | 06-30-2011 |
| 20110160229 | AHCY HYDROLASE INHIBITORS FOR TREATMENT OF HYPER HOMOCYSTEINEMIA - The present invention is directed to AHCY inhibitors of formula (I): which are useful in the treatment of diseases characterized by high homocysteine levels, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases characterized by high homocysteine levels. | 06-30-2011 |
| 20110245277 | Famciclovir for the Treatment of Recurrent Herpes Labialis Using a One-Day Treatment - A method for the treatment of recurrent herpes labialis in mammals, including humans, which method comprises administering to the mammal in need of such treatment, an effective amount of penciclovir or famciclovir, or a pharmaceutically acceptable salt thereof for a period of one day. | 10-06-2011 |
| 20110263618 | METHOD OF PROMOTING HAIR GROWTH - The present invention is an invention belonging to the life style improving cosmetic in the field of hair maintenance and enrichment. More particularly, it relates to cosmetic compositions having an improved hair care actions such as to prevent hair loss and/or to promote hair growth on the scalp and skin of a mammal. | 10-27-2011 |
| 20110288106 | ADENINE RECEPTOR LIGANDS - The invention relates to adenine receptor ligands useful for treating, alleviating and/or preventing diseases and disorders related to adenine receptor function as well as pharmaceutical compositions comprising such compounds and methods for preparing such compounds. The invention is further directed to the use of these compounds, alone or in combination with other therapeutic agents, for the alleviating, preventing and/or treating diseases and disorders, especially the use as antinociceptive or neuroprotective drugs. | 11-24-2011 |
| 20120088781 | Famciclovir for the Treatment of Recurrent genital Herpes Labialis with a one day application - A method for the treatment of recurrent herpes labialis in mammals, including humans, which method comprises administering to the mammal in need of such treatment, an effective amount of penciclovir or famciclovir, or a pharmaceutically acceptable salt thereof for a period of one day. | 04-12-2012 |
| 20120252823 | ADENOSINE RECEPTOR AGONISTS, PARTIAL AGONISTS, AND ANTAGONISTS - Disclosed are A | 10-04-2012 |
| 20120329814 | Famciclovir for the treatment of recurrent herpes labialis using a one-day treatment - A method for the treatment of recurrent herpes labialis in mammals, including humans, which method comprises administering to the mammal in need of such treatment, an effective amount of penciclovir or famciclovir, or a pharmaceutically acceptable salt thereof for a period of one day. | 12-27-2012 |
| 20120329815 | Famciclovir for the Treatment of Recurrent Herpes Labialis using a One-Day Treatment - A method for the treatment of recurrent herpes labialis in mammals, including humans, which method comprises administering to the mammal in need of such treatment, and effective amount of penciclovir or famciclovir, or a pharmaceutically acceptable salt thereof for a period of one day. | 12-27-2012 |
| 20130005747 | METHOD FOR SELECTING A CANCER THERAPY - The present invention provides a method for determining whether or not a cancer subject is suitable for treatment with a purine-based roscovitine-like inhibitor, which method comprises the step of determining the ras status of the cancer, wherein a determination that the subject has mutant ras status is indicative that the subject is suitable for treatment with a purine-based roscovitine-like inhibitor. | 01-03-2013 |
| 20130203780 | FAMCICLOVIR AND DICLOFENAC COMBINATION THERAPY FOR FUNCTIONAL SOMATIC SYNDROMES - The present invention relates to pharmaceutical compositions comprising a combination of a therapeutically-effective amount of the antiviral compound famciclovir and a therapeutically-effective amount of the COX-2 inhibitor diclofenac. The invention is further related to methods of treating functional somatic syndromes by administering a therapeutically-effective combination of famciclovir and diclofenac. | 08-08-2013 |
| 20130231356 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA - Compounds that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3Kδ plays a role in leukocyte function, using the compounds also are disclosed. | 09-05-2013 |
| 20130296346 | DIPHENYL-AMINE DERIVATIVES: USES, PROCESS OF SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS - The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, a method of synthesis of said compounds, pharmaceutical compositions comprising them and their use as a medicament for treating inflammatory diseases. | 11-07-2013 |
| 20130338173 | Carbocycle-Substituted Purine And 7-Deazapurine Compounds - The present invention relates to carbocycle-substituted purine and 7-deazapurine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 12-19-2013 |
| 20140024663 | ATB(0,+) AMINO ACID TRANSPORTER AS A DRUG TARGET FOR TREATMENT OF ESTROGEN RECEPTOR-POSITIVE BREAST CANCER - The present invention includes inhibitors of the amino acid transporter ATB | 01-23-2014 |
| 20140094475 | SOLID FORMS OF ANTIRETROVIRAL COMPOUNDS, PROCESS FOR THE PREPARATION AND THEIR PHARMACEUTICAL COMPOSITION THEREOF - Disclosed are solid forms of antiretroviral compounds and anti-oxidative acids, and processes for their preparation. Pharmaceutical compositions using the solid forms are also disclosed. | 04-03-2014 |
| 20140163047 | COMPOSITION OF A CERAMIC MATRIX WITH A CONTROLLED RELEASE DRUG, A TABLET OBTAINED FROM THE COMPOSITION AND METHODS FOR OBTAINING THE COMPOSITION AND THE TABLET - The present invention refers to a composition of a ceramic matrix defined by pseudoboehmite nanoparticles and constructed for carrying and releasing medications in a controlled manner, in the treatment of human beings and animals presenting an organic deficiency which requires the application of said medications. The present invention further refers to the method for preparing said composition, in the form of a ceramic matrix, and also to the method of incorporating the drug acyclovir to said ceramic matrix, forming a tablet. | 06-12-2014 |
| 20140200229 | CARBOCYCLIC NUCLEOSIDES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS - Disclosed are compounds of the formula I | 07-17-2014 |
| 20140221399 | METHOD OF TREATING FUNCTIONAL SOMATIC SYNDROMES WITH COMBINATION OF FAMCICLOVIR AND CELECOXIB - The present invention relates to methods of treating fibromyalgia by administering a therapeutically-effective combination-dosage of famciclovir and celecoxib. The invention is also related to methods of treating functional somatic syndromes by administering a therapeutically-effective combination-dosage of famciclovir and celecoxib. | 08-07-2014 |
| 20140249165 | PURINE DERIVATIVES FOR TREATMENT OF CYSTIC DISEASES - Provided herein are methods of treatment of a cystic disease by administering a compound of Formula I. In certain embodiments, the compound for use in the methods provided herein is roscovitine or an analog thereof. | 09-04-2014 |
| 20140309242 | Method for activating AMPK and the use of Adenine - The present invention relates to adenine which is useful to activate AMP-activated protein kinase (AMPK) and the use of adenine in the prevention or treatment of conditions or disease and thereby prevent or treat conditions or diseases which can be ameliorated by AMPK in a mammal. | 10-16-2014 |
| 20150011568 | Famciclovir for the Treatment of Recurrent Herpes Labialis Using a One-Day Treatment - A method for the treatment of recurrent herpes labialis in mammals, including humans, which method comprises administering to the mammal in need of such treatment, and effective amount of penciclovir or famciclovir, or a pharmaceutically acceptable salt thereof for a period of one day. | 01-08-2015 |
| 20150111902 | Methods for Altering MRNA Splicing and Treating Familial Dysautonomia by Administering Kinetin, Benzyladenine, and Tocotrienols - This invention relates to methods for altering the splicing of mRNA in cells. In particular, this invention also relates to methods for increasing the ratio of wild type to misspliced forms of mRNA and corresponding encoded proteins in cells possessing a mutant gene encoding either the i) misspliced mRNA corresponding to the mutant protein or ii) a component in the splicing machinery responsible for processing the misspliced mRNA. In addition, this invention relates to treating individuals having a disorder associated with a misspliced mRNA, such as Familial Dysautonomia or Neurofibromatosis 1, by administering to such an individual a cytokinin such as kinetin. | 04-23-2015 |
| 20160000796 | PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTION OR TREATMENT OF CANCER - Abacavir, a nucleoside analogue reverse transcriptase inhibitor, has been found to exhibit an anti-cancer activity on ATL cells in vitro without inhibiting DNA replication of normal cells. Abacavir or a pharmaceutically acceptable derivative thereof is useful as an active ingredient of a pharmaceutical composition for use in the prevention or the treatment of cancer, in particular a cancer whose DNA repair system is impaired such as breast cancer or adult T-cell leukemia. | 01-07-2016 |
| 20160129005 | ADENINE DERIVATIVES HAVING IMMUNOMODULATING ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY - The compound 2-[1-(6-aminopurin-9-yl)-2-oxoethoxy]prop-2-enal of formula: | 05-12-2016 |
| 20160199377 | FAMCICLOVIR AND CELECOXIB COMBINATION THERAPY KIT FOR COGNITIVE DYSFUNCTION | 07-14-2016 |
