Entries |
Document | Title | Date |
20080249103 | Sirtuin polymorphisms and methods of use thereof - Provided herein are methods for diagnosis and prognosis using polymorphic variants of sirtuins. Such polymorphic may be used, for example, to identify subjects that would be responsive to treatment with a sirtuin modulating compound and/or subjects that are suffering from or susceptible to a disease mediated by a sirtuin. Also provided are methods for determining the predictive value of a sirtuin polymorphic variant, methods for evaluating sirtuin modulating compounds, and methods for determining appropriate dosage and/or treatment regimens for subjects having one or more sirtuin polymorphic variants. Screening methods for identifying sirtuin modulating compounds using polymorphic variants of a sirtuin are also provided. | 10-09-2008 |
20080287453 | Piperazine Compounds Useful as Antagonists of C-C Chemokines (Ccr2b and Ccr5) for the Treatment of Inflammatory Diseases - A compound of formula (I) | 11-20-2008 |
20080293732 | Substituted pyrazoles - Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S. | 11-27-2008 |
20080300255 | Substituted pyrazoles - Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S. | 12-04-2008 |
20080312246 | Substituted Piperazines as Metabotropic Glutamate Receptor Antagonists - The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: | 12-18-2008 |
20080318968 | Chemical Compounds - The invention relates to a novel group of compounds of Formula (I) or a salt thereof: | 12-25-2008 |
20090048264 | PIPERAZINE AMIDE DERIVATIVES - The invention is concerned with novel piperazine amide derivatives of formula (I) | 02-19-2009 |
20090054447 | 2,3 Substituted Pyrazine Sulfonamides as Inhibitors of CRTH2 - The present invention is related to the use of 2,3 substituted pyrazine sulfonamides of formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is related to the use of 2,3 substituted pyrazine sulfonamides for the modulation, notably the inhibition, of CRTH2 activity. | 02-26-2009 |
20090131449 | USE OF TRPV1 RECEPTOR ANTAGONISTS FOR TREATING DRY EYE AND OCULAR PAIN - Methods of treating symptoms of dry eye by administering inhibitors of transient receptor potential cation channel, subfamily V, member 1 (TRPV1) are disclosed. Methods of preventing or alleviating ocular pain by administering TRPV1 inhibitors are also disclosed. | 05-21-2009 |
20090143394 | COMPOUNDS FOR ACTIVATING TGF-BETA SIGNALING - Compositions and methods for treatment and prevention of disorders and conditions characterized by reduced TGF-β signaling are described. | 06-04-2009 |
20090149464 | Use of 1,4-bis (3-aminoalkyl) piperazine derivatives in the treatment of neurodegenerative diseases - Use of 1,4-bis(3-aminoalkyl)piperazine derivatives as defined in formula I or II for the manufacture of a pharmaceutical composition intended for the treatment of neurodegenerative diseases, related neurodegenerative diseases, developmental diseases or cancer. The instant invention is also directed to some specific 1,4-bis(3-aminoalkyl)piperazine derivatives and pharmaceutical composition including them. | 06-11-2009 |
20090203706 | LYSINE-BASED POLYMERIC LINKERS - The present invention provides polymeric linkers containing branching moieties. Methods of making the polymeric linkers and methods of making conjugates using the same are also disclosed. | 08-13-2009 |
20090215790 | Substituted Oxindole Derivatives, Medicaments Containing the Latter and Use Thereof - The invention relates to novel oxindole derivatives of general formula (I), in which the substituents R | 08-27-2009 |
20090253709 | SYNTHESIS, TELOMERASE INHIBITION AND CYTOTOXIC STUDIES ON 2,7-DISUBSTITUTED ANTHRAQUINONE DERIVATIVES - An series of 2,7-disubstituted anthraquinone derivatives including a formula I are provided. | 10-08-2009 |
20090270409 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY - The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119. | 10-29-2009 |
20090281109 | CYSTEINE AND CYSTINE PRODRUGS TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS - The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction. | 11-12-2009 |
20090306091 | ANTIMALARIAL THERAPY USING A COMBINATION OF SYNTHETIC ARTEMISININ DERIVATIVE AND BISQUINOLINE DERIVATIVE - The technical field of the present invention relates to antimalarial therapy using a synthetic artemisinin derivative and bisquinoline derivative. | 12-10-2009 |
20100075976 | SUBSTITUTED PIPERAZINYL PYRAZINES AND PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS - The present invention provides selective 5-HT | 03-25-2010 |
20100081665 | Anti-Malarial Compounds - The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal. | 04-01-2010 |
20100105694 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE - The present invention concerns substituted pyrazinone derivatives according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in claim | 04-29-2010 |
20100120785 | 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS - The present invention provides selective 5-HT | 05-13-2010 |
20100130506 | Organic Compounds - A compound of Formula I | 05-27-2010 |
20100137330 | Use - The present invention relates to a new use of a compound of the formula (I) | 06-03-2010 |
20100152197 | (4-TERT-BUTYLPIPERAZIN-2-YL)(PIPERAZIN-1-YL)METHANONE-N-CARBOXAMIDE DERIVATIVES - The present invention relates to compounds of formula (I) | 06-17-2010 |
20100184776 | PIPERIDINE/PIPERAZINE DERIVATIVES - The invention relates to a DGAT inhibitor of formula (I) including any stereochemically isomeric form thereof, wherein A represents CH or N; X represents O or NR | 07-22-2010 |
20100184777 | Substituted Pyrazinone Amides - The present invention provides compounds of Formula (I) | 07-22-2010 |
20100197700 | 5-HT7 RECEPTOR ANTAGONISTS - The present invention provides selective 5-HT | 08-05-2010 |
20100210661 | STAT3/5 ACTIVATION INHIBITOR - An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: | 08-19-2010 |
20100234390 | NOVEL COMPOUND AND THEIR USE - The present invention provides novel compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The novel compounds are useful as antibacterial agents in the treatment of conditions such as nosocomial pneumonia, community acquired pneumonia, infections caused by vancomycin resistant enterococci (VRE), methicillin resistant | 09-16-2010 |
20100234391 | N-SUBSTITUTED PIPERAZINES - Novel N-alkyl substituted piperazines have been discovered, which are useful as insecticides or fungicides. Such compounds are of Formula (I) | 09-16-2010 |
20100240670 | 4-[(ARYLMETHYL)AMINOMETHYL]PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION - The invention relates to 4-[(arylmethyl)aminomethyl]piperidine derivatives of general formula (I) | 09-23-2010 |
20100240671 | SUBSTITUTED HETEROCYCLIC COMPOUNDS - The present invention relates to substituted heterocyclic compounds of Formula I or XI: | 09-23-2010 |
20100286160 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS - Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions. | 11-11-2010 |
20100286161 | PYRAZINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS - This invention relates to novel pyrazine derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels. | 11-11-2010 |
20100324061 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS - Enantiomerically pure compound of formula 1 | 12-23-2010 |
20110021533 | CYSTEINE PRODRUGS TO TREAT SCHIZOPHRENIA AND DRUG ADDICTION - The present invention provides cysteine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction. | 01-27-2011 |
20110028487 | IMIDAZOPYRIMIDINES AND USES THEREOF - The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided. | 02-03-2011 |
20110112110 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF - Inhibitors of the oncogenic tyrosine kinase ALK and of the Bcr-Abl mutant T315I Bcr-Abl, pharmaceutical compositions containing the same and their use for the treatment of hyper-proliferative diseases. | 05-12-2011 |
20110112111 | DRUG COMBINATIONS COMPRISING A DGAT INHIBITOR AND A PPAR-AGONIST - The present invention relates to combinations of a DGAT inhibitor and a peroxisome proliferator-activator receptor (PPAR) agonist or a prodrug thereof. The invention further relates to methods for preparing such combinations, pharmaceutical compositions comprising said combinations as well as the use as a medicament of said combinations. | 05-12-2011 |
20110118275 | OXAZOLO[4,5-c]PYRIDINE SUBSTITUTED PYRAZINE - The present invention relates to a compound of formula (I) | 05-19-2011 |
20110124653 | ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS - The invention relates to dimeric aryl-sulphonamido compounds endowed with inhibitory activity against metalloproteases MMP, having formula (I) below (M)-L-(M′) (I), wherein M and M′, the same or different from each other, represent the residues of the metalloproteases inhibitors of formula (II), wherein R, R | 05-26-2011 |
20110136820 | Heterocyclic Compounds as CCR2 Antagonists - Compounds of formula (I) | 06-09-2011 |
20110172238 | BENZIMIDAZOLE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS - Compounds represented by formula I: | 07-14-2011 |
20110195973 | CYCLIC SUBSTITUTED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS POSSESSING BETA AGONIST ACTIVITY - The present invention relates to sodium channel blockers. The present Invention also includes a variety of methods of treatment using these inventive sodium channel blockers. | 08-11-2011 |
20110251209 | COMPOUNDS FOR TREATING PARASITIC DISEASE - A compound, particularly an antimalarial compound, according to formula I: | 10-13-2011 |
20110269772 | AXL KINASE INHIBITORS - Axl kinase inhibitory compounds are disclosed, as well as compositions and methods of using the same in the treatment of cancer and other conditions mediated by and/or associated with Axl kinase. | 11-03-2011 |
20110294819 | Hepatitis C Virus Inhibitors - The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein. | 12-01-2011 |
20120004241 | SUCCINATE SALT OF (2R)-METHYL-1-PIPERAZINE - The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. | 01-05-2012 |
20120022075 | NOVEL PHENYLPYRROLE DERIVATIVE - The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: | 01-26-2012 |
20120040992 | OLIGOOXOPIPERAZINES AND METHODS OF MAKING AND USING THEM - The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed. | 02-16-2012 |
20120040993 | NEUROPROTECTIVE MULTIFUNCTIONAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM - Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective function; (iii) a moiety that imparts combined antiapoptotic, neuroprotective and/or neurorestorative functions; (iv) a moiety that imparts brain MAO inhibition, preferably with little or no MAO inhibition in liver and small intestine; (v) a moiety that imparts cholinesterase inhibitory function; and (vi) a moiety that imparts an N-methyl-D-aspartic acid receptor (NMDAR) inhibition, and pharmaceutically acceptable salts and optical isomers thereof. The multifunctional compounds are useful in the treatment or prevention of diseases, disorders or conditions that can be prevented and/or treated by iron chelation therapy, and/or neuroprotection and/or neurorestoration, and/or apoptosis inhibition and/or MAO inhibition and/or cholinesterase inhibition and/or NMADR inhibition. The present invention encompasses compounds of the formulas I to VI. | 02-16-2012 |
20120108602 | Carbamoyl Compounds as DGAT1 Inhibitors 190 - DGAT-1 inhibitor compounds of formula (1), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity | 05-03-2012 |
20120115877 | Facially Amphiphilic Compounds, Compositions, And Uses Thereof In Treating Cancer - The present invention discloses compositions of facially amphiphilic compounds and their use in methods for treating or reducing cancers in animals, such as humans. | 05-10-2012 |
20120136000 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS - The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. | 05-31-2012 |
20120136001 | SUBSTITUTED OXINDOLE DERIVATIVES, MEDICAMENTS CONTAINING THE LATTER AND USE THEREOF - The invention relates to novel oxindole derivatives of general formula (I), in which the substituents A, B, R | 05-31-2012 |
20120190686 | BICYCLO[3.2.1]OCTYL AMIDE DERIVATIVES AND USES OF SAME - The present invention provides bicyclo[3.2.1]octyl amide derivatives of formula (I): | 07-26-2012 |
20120190687 | Pyrazinylpyrazoles - Pyrazin-2-ylpyrazoles are described, as is the use thereof as insecticides and/or parasiticides. | 07-26-2012 |
20120202823 | Multi-API Loading Prodrugs - The present invention accomplishes this by having multiple molecules of parent drugs attached to carrier moieties and by extending the period during which the parent drug is released and absorbed after administration to the patient and providing a longer duration of action per dose than the parent drug itself. Prodrug conjugates are suitable for sustained delivery of heteroaryl, lactam- amide-, imide-, sulfonamide-, carbamate-, urea-, benzamide-, acylaniline-, cyclic amide- and tertiary amine-containing parent drugs that are substituted at the amide nitrogen or oxygen atom with labile aldehyde-linked prodrug moieties. The carrier groups of the prodrugs can be hydrophobic to reduce the polarity and solubility of the parent drug under physiological conditions. | 08-09-2012 |
20120232088 | PIPERAZINEDIONE COMPOUNDS - This invention relates to piperazinedione compounds shown in the specification. These compounds are tyrosine kinase inhibitors and can be used to treat cancer. | 09-13-2012 |
20120264762 | Heterocyclic Compounds as CCR2 Antagonists - Compounds of formula (I) | 10-18-2012 |
20120277244 | PYRAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS - The invention relates to novel heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them. | 11-01-2012 |
20120289513 | (4-TERT-BUTYLPIPERAZIN-2-YL)(PIPERAZIN-1-YL)METHANONE-N-CARBOXAMIDE DERIVATIVES - The present invention relates to compounds of formula (I) | 11-15-2012 |
20120316178 | PIPERAZINES AS ANTIMALARIAL AGENTS - The invention relates to novel piperazine derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, such as especially malaria. | 12-13-2012 |
20120322807 | STAT3/5 ACTIVATION INHIBITOR - The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: | 12-20-2012 |
20120329807 | Multimeric VLA-4 Antagonists Comprising Polymers Moieties - Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The conjugates can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis. | 12-27-2012 |
20130012517 | Quinoline and Quinoxaline Derivatives as Kinase Inhibitors - A series of quinoline and quinoxaline derivatives, substituted by an optionally substituted bicyclic heteroaryl moiety consisting of two fused six-membered aromatic rings attached via an alkylene chain optionally linked to a heteroatom, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. | 01-10-2013 |
20130072497 | N- SUBSTITUTED PIPERAZINES - Novel N-alkyl substituted piperazines have been discovered, which are useful as insecticides or fungicides. Such compounds are of Formula (I) | 03-21-2013 |
20130079349 | 5-AMINO-3,6-DIHYDRO-1H-PYRAZIN-2-ONE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) - The present invention relates to novel 5-amino-3,6-dihydro-1H-pyrazin-2-one derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid. | 03-28-2013 |
20130109697 | HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF | 05-02-2013 |
20130143893 | PIPERAZINE DERIVATIVES AND METHODS OF USE - The invention provides 2-carboxamide piperazine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for the treatment of mammalian infertility. | 06-06-2013 |
20130158042 | NOVEL COMPOUNDS - This invention relates to compounds of formula I | 06-20-2013 |
20130252964 | Compounds And Methods For Treating Candidiasis And Aspergillus Infections - The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for killing or inhibiting the growth of a | 09-26-2013 |
20130289043 | (4-TERT-BUTYLPIPERAZIN-2-YL)(PIPERAZIN-1-YL)METHANONE-N-CARBOXAMIDE DERIVATIVES - The present invention relates to compounds of formula (I) | 10-31-2013 |
20130303542 | SUBSTITUTED PYRAZINAMIDE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders. | 11-14-2013 |
20130338163 | VINYL-ARYL DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to compounds that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders. | 12-19-2013 |
20130338164 | Multimeric VLA-4 Antagonists Comprising Polymers Moieties - Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The conjugates can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis. | 12-19-2013 |
20130338165 | Use of Compounds Elevating Glutathione Levels for the Treatment of Parkinson's Disease - Methods of treating Parkinson's Disease comprising administering compounds that up-regulate cystine-glutamate exchange (system X | 12-19-2013 |
20140031360 | BICYCLIC COMPOUNDS AS PIM INHIBITORS - The invention relates to bicyclic compounds of formula (1′), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer. | 01-30-2014 |
20140038978 | HETEROCYCLIC COMPOUNDS AS CCR2B ANTAGONISTS - Compounds of formula (I) | 02-06-2014 |
20140038979 | SULFONYL-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE - This invention comprises the novel compounds of formula (I) | 02-06-2014 |
20140121213 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS - In general, the present invention relates to uses of voltage-gated sodium channel blocker compounds, which include corresponding precursors, intermediates, monomers and dimers, corresponding pharmaceutical compositions, compound preparation and treatment methods for respiratory and respiratory tract diseases. | 05-01-2014 |
20140128404 | 1, 2, 4-Thiadiazol-5-Ylpiperazine derivatives useful in the treatment of neurodegenerative diseases - The present invention relates to a compound of formula (IA) The present invention also relates to the use of the compound of formula IA for treating certain neurodegenerative disorders characterized by cytotoxic TAU misfolding and/or aggregation. | 05-08-2014 |
20140155408 | PYRUVATE KINASE ACTIVATORS FOR USE IN THERAPY - Described herein are methods for using compounds that activate pyruvate kinase. | 06-05-2014 |
20140155409 | PIPERAZINE DERIVATIVES, METHODS FOR PREPARING SAME, AND USES THEREOF IN THE TREATMENT OF INSULIN RESISTANCE - The invention relates to a compound of formula (I), where R | 06-05-2014 |
20140171438 | Hybrid Compounds And Methods Of Making And Using The Same - The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a | 06-19-2014 |
20140206697 | HALOARYL SUBSTITUTED AMINOPURINES, COMPOSITIONS THEREOF,AND METHODS OF TREATMENT THEREWITH - Provided herein are Aminopurine Compounds having the following structure: | 07-24-2014 |
20140221384 | TETRA-O-SUBSTITUTED BUTANE-BRIDGE MODIFIED NDGA DERIVATIVES, THEIR SYNTHESIS AND PHARMAECUTICAL USE - The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers. | 08-07-2014 |
20140235649 | USE OF PHOSPHATASE INHIBITORS OR HISTONE DEACETYLASE INHIBITORS TO TREAT DISEASES CHARACTERIZED BY LOSS OF PROTEIN FUNCTION - A method of treating a mammalian subject afflicted with a disease characterized by a loss of protein function caused by a genetic abnormality associated with the disease comprising administering to the subject a therapeutically effective amount of a protein phosphatase 2A inhibitor or a histone deacetylase inhibitor. | 08-21-2014 |
20140235650 | PIPERAZINE DERIVATIVES, METHODS FOR PREPARING SAME, AND USES THEREOF IN THE TREATMENT OF INSULIN RESISTANCE - The invention relates to a compound of formula (I), where R | 08-21-2014 |
20140288086 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS - Enantiomerically pure compound of formula 1 | 09-25-2014 |
20140315914 | CARBAMATE-SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT DISEASES - The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders. | 10-23-2014 |
20140329826 | (2R)-1-(3-CHLORO-2-PYRAZINYL)-2-METHYLPIPERAZINE AND SALTS THEREOF - The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. | 11-06-2014 |
20150018364 | CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION WITH OLIGOOXOPIPERAZINE NONPEPTIDIC HELIX MIMETICS - The present invention relates to oligooxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF-1α. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation). | 01-15-2015 |
20150057289 | BICYCLO[3.2.1.]OCTYL AMIDE DERIVATIVES AND USES OF SAME - The present invention provides bicyclo[3.2.1]octyl amide derivatives of formula (I): | 02-26-2015 |
20150072991 | OLIGOOXOPIPERAZINES AND METHODS OF MAKING AND USING THEM - The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed. | 03-12-2015 |
20150094314 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE - A method of modulating ribonucleotide reductase activity in a neoplastic cell includes administering to the cell an amount of a ribonucleotide reductase allosteric modulator (RRAmod), the amount being effective to inhibit neoplastic cell growth. | 04-02-2015 |
20150322038 | PYRAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS - The invention relates to novel heterocyclic compounds of the formula | 11-12-2015 |
20150336933 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof - The present invention relates to compounds of general formula (I) | 11-26-2015 |
20160022673 | OXAZOLE AND ISOXAZOLE CRAC MODULATORS - The present invention relates to compounds of Formula (I) along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of CRAC. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of CRAC of Formula (I). | 01-28-2016 |
20160068546 | TREATING DISEASES MEDIATED BY BLOCKADE OF THE EPITHELIAL SODIUM CHANNEL WITH PYRAZINE-2-CARBOXAMIDE DERIVATIVES - A compound of Formula I | 03-10-2016 |
20160090366 | TREATMENT OF PULMONARY AND OTHER CONDITIONS - Disclosed is a compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: | 03-31-2016 |
20160120864 | Novel Pyrrole Derivatives - There is provided inter alia novel N-phenyl substituted pyrrole derivatives and their use in therapy, especially in the treatment of bacterial (e.g. pneumococcal) infections. | 05-05-2016 |
20160159754 | COMPOUNDS FOR TREATMENT OF CYSTIC FIBROSIS - Described herein are compounds, compositions, and methods of their use for the treatment of cystic fibrosis. | 06-09-2016 |
20160168124 | SUBSTITUTED PYRIDINE-PIPERAZINYL ANALOGUES AS RSV ANTIVIRAL COMPOUNDS | 06-16-2016 |