Entries |
Document | Title | Date |
20080255136 | PYRROLIDONES WITH ANTI-HIV ACTIVITY - The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS. | 10-16-2008 |
20080269236 | Novel 1,2,4 Oxadiazole Compounds and Methods of Use Thereof - The invention relates to 1,2,4 oxadiazole compounds and analogs thereof, represented by formula (II), and compositions and methods of use thereof. | 10-30-2008 |
20090093491 | Diazine Azole Derivatives, Their Manufacture and Use as Pharmaceutical - Objects of the present invention are the compounds of formula I | 04-09-2009 |
20090099192 | Substituted 1H-pyrrole-2,5-diones - The invention relates to novel substituted 1H-pyrrole-2,5-diones of the formula (IA) | 04-16-2009 |
20090111819 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES - Pyridazin-3(2H)-one derivatives of formula (I) are found to inhibit PDE-4: | 04-30-2009 |
20090111820 | FUSED PYRROLIDINE 1,2,4-TRIAZOLE DERIVATIVES AS MODULATORS OF MGLUR5 - The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds. | 04-30-2009 |
20090111821 | AMINO 1,2,4-TRIAZOLE DERIVATIVES AS MODULATORS OF MGLUR5 - The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds. | 04-30-2009 |
20090111822 | 1,2,3-TRIAZOLE PYRROLIDINE DERIVATIVES AS MODULATORS OF MGLUR5 - The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds. | 04-30-2009 |
20090111823 | AMINOPYRIDINE DERIVATIVES AS MODULATORS OF MGLUR5 - The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds. | 04-30-2009 |
20090111824 | AMIDE LINKED HETEROAROMATIC DERIVATIVES AS MODULATORS OF MGLUR5 - The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds. | 04-30-2009 |
20090156607 | 2-OXO-1-PYRROLIDINE DERIVATIVES - The present invention concerns 2-oxo-1-pyrrolidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals. | 06-18-2009 |
20090156608 | Pyridazine Compound and Use Thereof - A pyridazine compound of the formula: | 06-18-2009 |
20090221599 | PHTHALAZINONE PYRAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS - Objects of the present invention are the compounds of formula I | 09-03-2009 |
20090270407 | FUNGICIDAL ISOXAZOLIDINES - Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, | 10-29-2009 |
20090275591 | 1-HETEROCYCLYLSULFONYL, 2-AMINOMETHYL, 5- (HETERO-) ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION INHIBITOR - The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R | 11-05-2009 |
20090275592 | Heterocyclic modulators of PKB - The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. | 11-05-2009 |
20090291960 | PYRROLINIDIUM DERIVATIVES AS M3 MUSCARINIC RECEPTORS | 11-26-2009 |
20090325974 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS - Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R | 12-31-2009 |
20100010001 | NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS - Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-4-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided. | 01-14-2010 |
20100048580 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES - The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases | 02-25-2010 |
20100120784 | NOVEL HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE - Heteroaromatic compounds of structural formula (I) or a pharmaceutically acceptable salt thereof, wherein W is a substituted heteroaryl, X and Y are each independently a bond, —O—, —S—, —S(O)—, —S(O) | 05-13-2010 |
20100152194 | ANTHRANILAMIDE ARTHROPODICIDE TREATMENT - This invention pertains to methods for protecting a propagule or a plant grown therefrom from invertebrate pests comprising contacting the propagule or the locus of the propagule with a biologically effective amount of a compound of Formula I, its N-oxide or an agriculturally suitable salt thereof | 06-17-2010 |
20100179161 | PYRAZOLINE DERIVATIVES FOR THE TREATMENT OF TURBERCULOSIS - Compounds of the formula (I) and pharmaceutically acceptable salts or in vivo hydrolysable esters thereof, useful in the treatment of | 07-15-2010 |
20100197699 | I-OXA-3-Azaspiro (4.5) Decan-2-One And 1-OXA-3, 8-Diazaspiro (4.5) Decan-2-One Derivatives For The Treatment of Eating Disorders - The present invention relates to novel compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, | 08-05-2010 |
20100204241 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES - Pyridazin-3(2H)-one derivatives of formula (I) are found to inhibit PDE-4: | 08-12-2010 |
20100210660 | Heterocyclic FXR Binding Compounds - The present invention relates to compounds which bind to the NRI H4 receptor (FXR) and act as agonists or partial agonists of the NR1 H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds. | 08-19-2010 |
20100216806 | ORTHO AMINOAMIDES FOR THE TREATMENT OF CANCER - Compounds of formula | 08-26-2010 |
20100240669 | NEW COMPOUNDS - The present invention relates to the compounds of general formula I | 09-23-2010 |
20100273805 | SULPHIDE BRIDGED DERIVATIVES AS MODULATORS OF MGLUR5 733 - The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds. | 10-28-2010 |
20100286159 | PYRIDAZINES - The present invention is concerned with isoxazole-pyridazines of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease. | 11-11-2010 |
20110003827 | HIV protease inhibiting compounds - A compound of the formula | 01-06-2011 |
20110028485 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS - Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R | 02-03-2011 |
20110053951 | METHODS FOR TREATING DISORDERS USING NMDA NR2B-SUBTYPE SELECTIVE ANTAGONIST - A method of treating, preventing or ameliorating a disease or condition by inhibiting NR2B subunit containing NMDA receptors using a compound according to formula (I) or a pharmaceutically acceptable salt thereof: | 03-03-2011 |
20110082153 | GAMMA SECRETASE MODULATORS - This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I). | 04-07-2011 |
20110092512 | NEW HSL INHIBITORS USEFUL IN THE TREATMENT OF DIABETES - The present invention relates to compounds of formula (I) | 04-21-2011 |
20110112109 | TRIAZOLONE DERIVATIVES - A compound represented by the following general formula (1) or salts thereof or hydrates of the foregoing: | 05-12-2011 |
20110118274 | PROTEASOME INHIBITORS AND THEIR USE IN TREATING PATHOGEN INFECTION AND CANCER - The present invention relates to proteasome inhibitors and their use in methods of treating a subject for a pathogen infection or cancer. The methods involve administering to the subject a compound of Formula (I). (I) where: Q is Formula or Formula, where the crossing dashed line illustrates the bond formed joining Q to the rest of the compound of Formula (I). The remainder of substituents of the compound of Formula (I) are defined in the present application. | 05-19-2011 |
20110201616 | SULFONAMIDE COMPOUNDS OR SALTS THEREOF - [Object] A compound which is useful as an EP1 receptor antagonist is provided. | 08-18-2011 |
20110301173 | 1-HETEROCYCLYLSULFONYL, 3-AMINOMETHYL, 5- (HETERO-) ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION INHIBITORS - The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R | 12-08-2011 |
20110301174 | 1-HETEROCYCLYLSULFONYL, 3-AMINOMETHYL, 5- (HETERO-) ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION INHIBITORS - The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R | 12-08-2011 |
20110312967 | BRIDGED AND FUSED ANTIDIABETIC COMPOUNDS - This invention provides for certain bridged and fused compounds of the formula G-L-A I or a pharmaceutically acceptable salt, ester of solvate thereof wherein: A is: (I) and the other variables are defined herein; the inventive compounds are agonists of the G-protein coupled receptor 40 (GPR40, also known as free fatty acid receptor FFAR). This invention further relates to pharmaceutical compositions containing these compounds, and the use of these compounds to regulate insulin levels in a mammal. The compounds may be used, for example in the prevention and treatment of Type 2 diabetes mellitus and in the prevention and treatment of conditions related to Type 2 diabetes mellitus, such as insulin resistance, obesity and lipid disorders. | 12-22-2011 |
20120059015 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS - The invention is directed to methods of using antagonists selective for the metabotropic mGlu5 receptor to treat conditions of neuromuscular dysfunction of the lower urinary tract in a mammal. Provided are methods of treating a mammal suffering from a condition of neuromuscular dysfunction of the lower urinary tract by administering a selective mGlu5 antagonist. The selective mGlu5 antagonist may be administered alone or in combination with one or more additional therapeutic agents for treating such a condition. Also provided are methods of identifying selective mGlu5 antagonists that are useful for treating neuromuscular dysfunction of the lower urinary tract in a mammal. Methods for treating migraine and gastroesophageal reflux disease (GERD) using selective mGlu5 antagonists are also disclosed. | 03-08-2012 |
20120065212 | HETEROARYLMETHYL AMIDES - The present invention relates to compounds of the formula | 03-15-2012 |
20120225886 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS - The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor. | 09-06-2012 |
20120277243 | PYRAZOLIDIN-3-ONE DERIVATIVES - The present invention relates to ethynyl derivatives of formula I | 11-01-2012 |
20130018055 | NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVESAANM Aebi; JohannesAACI BinningenAACO CHAAGP Aebi; Johannes Binningen CHAANM Binggeli; AlfredAACI BinningenAACO CHAAGP Binggeli; Alfred Binningen CHAANM Hertel; CorneliaAACI BrislachAACO CHAAGP Hertel; Cornelia Brislach CHAANM Konkar; Anish AshokAACI BinningenAACO CHAAGP Konkar; Anish Ashok Binningen CHAANM Kuehne; HolgerAACI LoerrachAACO DEAAGP Kuehne; Holger Loerrach DEAANM Kuhn; BerndAACI Reinach BLAACO CHAAGP Kuhn; Bernd Reinach BL CHAANM Maerki; Hans P.AACI BaselAACO CHAAGP Maerki; Hans P. Basel CHAANM Wang; HaiyanAACI AllschwilAACO CHAAGP Wang; Haiyan Allschwil CH - The invention provides novel compounds having the general formula (I) | 01-17-2013 |
20130023539 | PYRROLIDINE OR THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS AS AGONISTS OF G-PROTEIN COUPLED RECEPTOR 43 (GPR43) - The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases. | 01-24-2013 |
20130030002 | FUNGICIDAL OXIMES AND HYDRAZONES - Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, | 01-31-2013 |
20130109696 | Chemical Compounds | 05-02-2013 |
20130150374 | ARYLALKYLAMINE COMPOUND AND PROCESS FOR PREPARING THE SAME - The present invention relates to an arylalkylamine compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, a process for preparing the same, and use of the above-mentioned compound as an activating compound (CaSR agonist) of a Ca sensing receptor, a pharmaceutical composition containing the above-mentioned compound as an effective ingredient, etc. | 06-13-2013 |
20130225596 | NOVEL HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME (AS AMENDED) - The present invention provides novel compounds having a P2X | 08-29-2013 |
20140155407 | SELECTIVE CYP11B1 INHIBITORS FOR THE TREATMENT OF CORTISOL DEPENDENT DISEASES - The present invention relates to compounds which selectively inhibit CYP11B1. Preferably, the compounds of the present invention do not substantially inhibit CYP11B2. Moreover, the compounds of the present invention do not substantially inhibit CYP17 and/or CYP19, either. Amongst other applications of the compounds of the present invention, they can be used for the treatment of Cushing's syndrome or metabolic disease. | 06-05-2014 |
20140194436 | HETEROARYLMETHYL AMIDES - The present invention relates to compounds of the formula | 07-10-2014 |
20140200223 | INHIBITORS OF BETA-SECRETASE - The present invention is directed to a compound represented by the following structural formula | 07-17-2014 |
20140221383 | CETP INHIBITORS - Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis: | 08-07-2014 |
20140275102 | Solid State Forms of 6-[4-[3-((R)-2-Methylpyrrolidine-1-yl)-propoxy]phenyl] 2H-pyridazine-3-one Hydrochloride - Solid state forms of the compound 6-[4-[3-((R)-2-methylpyrrolidine-1-yl)-propoxy]phenyl]2H-pyridazine-3-one hydrochloride (Compound 1), processes for preparing the solid state forms, and pharmaceutical compositions thereof, are provided. Compound 1 is a histamine H3 receptor antagonist/inverse agonist. Thus the provided solid state forms are useful, for example, for the manufacture of a medicament for the treatment of disorders mediated by the H3 receptor. | 09-18-2014 |
20140329825 | NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE - The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical combinations thereof, and their use as medicaments, particularly for the treatment of neurodegeneration, muscle atrophy or diabetes/metabolic syndrome via inhibition of HDAC4. | 11-06-2014 |
20140343070 | PROTON PUMP INHIBITORS - A proton pump inhibitor containing a compound represented by the formula (I) | 11-20-2014 |
20140350026 | OXADIAZOLE COMPOUND AND PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF - The present invention provides an anti-Coxsackie virus oxadiazole compound as represented by formula (I), or the pharmaceutically acceptable salt thereof, a preparation method, a pharmaceutical composition, and use thereof, wherein R is CH3 or CF3; R′ and R″ are respectively H, alkyl or halogen; A is O or S; n is a number from 1 to 6; X is O, S or NH; Y is alkyl, unsubstituted cycloalkyl, mono-substituted cycloalkyl, disubstituted cycloalkyl, poly-substituted cycloalkyl, unsubstituted aryl, mono-substituted aryl, disubstituted aryl, poly-substituted aryl, unsubstituted 5-6 membered heterocyclyl, mono-substituted 5-6 membered heterocyclyl, disubstituted 5-6 membered heterocyclyl, or poly-substituted 5-6 membered heterocyclyl. Compared to prior art, the oxadiazole compound of the present invention has excellent anti-Coxsackie virus activity, lower toxicity and high safety. | 11-27-2014 |
20140371231 | Methods Of Treating Dyskinesia And Related Disorders - The present disclosure describes compounds and pharmaceutically acceptable salts thereof and compositions and formulations comprising the same that are useful in methods of treating dyskinesia or related disorders, and methods for treating dyskinesia or related disorders. | 12-18-2014 |
20150099757 | PYRIDAZINONE COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS AND METHODS OF TREATING DISORDERS - The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. | 04-09-2015 |
20150105398 | ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE - A substituted alkenylbenzene compound of formula (4): | 04-16-2015 |
20150141433 | N-ARYLMETHYL SULFONAMIDE NEGATIVE MODULATORS OF NR2A - Compounds that selectively negatively modulate NMDA receptors containing an NR2A subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the compounds are disclosed. | 05-21-2015 |
20160008357 | PYRIDAZINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING COGNITIVE IMPAIRMENT | 01-14-2016 |
20160058759 | GLUTAMINASE INHIBITOR THERAPY - Disclosed herein are methods of treating a subject having an altered NRF2/KEAP1 pathway, and compounds and compositions useful in such treatment. Also disclosed herein are methods of evaluating whether to administer a compound that inhibits glutathione production or a glutaminase inhibitor to a subject. | 03-03-2016 |
20160068521 | THIAZOLES AND USES THEREOF - This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions. | 03-10-2016 |
20160115155 | A PHENYL TRIAZOLE DERIVATIVE AND ITS USE FOR MODULATING THE GABAA RECEPTOR COMPLEX - This invention relates to a novel phenyl triazole derivative, pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound of the invention is in particular considered useful for the treatment of central nervous system diseases and disorders which are responsive to modulation of GABA | 04-28-2016 |
20160150787 | TETRAZOLINONE COMPOUNDS AND APPLICATIONS THEREOF | 06-02-2016 |
20160152596 | Nuclear Transport Modulators and Uses Thereof | 06-02-2016 |
20190144422 | HYDROXYALKYL-SUBSTITUTED HETEROARYLTRIAZOLE DERIVATIVES AND USES THEREOF | 05-16-2019 |