| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 514211100 | Three ring hetero atoms in the polycyclo ring system | 50 |
| 20080293689 | Compounds with Atypical Antipsychotic Activity - Formula (I) compounds with atypical antipsychotic activity | 11-27-2008 |
| 20090062253 | HETEROCYCLODIAZEPINE CANNABINOID RECEPTOR MODULATORS FOR TREATMENT OF DISEASE - The present invention relates to compounds and methods useful as modulators of CB2 for the treatment or prevention of disease states including, but not limited to pain, autoimmune disease, malabsorption syndrome, pulmonary disease, osteoporosis, muscle spasm in cancer, neuromuscular disorder, and atherosclerosis progression. | 03-05-2009 |
| 20090131401 | Transcription factor modulating compounds and methods of use thereof - Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms. | 05-21-2009 |
| 20090131402 | Fused heterocyclic compound and use thereof - The present invention relates to a serotonin 5-HT | 05-21-2009 |
| 20090215742 | AMIDE RESORCINOL COMPOUNDS - The present invention is directed to compounds of formula (I), | 08-27-2009 |
| 20100004221 | THIAZEPINE DERIVATIVE - Thiazepine derivative or a pharmacologically acceptable salt thereof having an effect of inhibiting 11β-hydroxysteroid dehydrogenase type 1 and having a formula (1): | 01-07-2010 |
| 20100016281 | PYRIMIDINE COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS - Certain pyrimidine-containing compounds are serotonin receptor modulators useful in the treatment of serotonin-mediated diseases. | 01-21-2010 |
| 20100022508 | ANTIVIRAL COMPOUNDS - The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 01-28-2010 |
| 20100173890 | Compounds, Process for their Preparation, Intermediates, Pharmaceutical Compositions and their use in the Treatment of 5-HT6 Mediated Disorders such as Alzheimer's Disease, Cognitive Disorders, Cognitive Impairment Associated with Schizophrenia, Obesity and Parkinson's Disease - The present invention relates to new compounds of formula I, or salts, solvates or solvated salts thereof, process for their preparation and to new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in the treatment of 5-HT6 mediated disorders such as Alzheimer's disease, cognitive disorders, cognitive impairment associated with schizophrenia, obesity and Parkinson's disease. | 07-08-2010 |
| 20100216769 | SUBSTITUTED GLYCINAMIDES, PROCESS FOR THEIR MANUFACTURE AND USE THEREOF AS MEDICAMENTS - The present invention relates to new substituted glycinamides of general formula (I) | 08-26-2010 |
| 20100227848 | OXO BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS - The present invention is directed to oxo bridged diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved. | 09-09-2010 |
| 20100273767 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF - The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2 -a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7 -octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2 -a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I) | 10-28-2010 |
| 20100286120 | PYRIDOOXAZEPINE DERIVATIVE AND USE THEREOF - The present invention provides a compound having a superior serotonin 5-HT | 11-11-2010 |
| 20100298292 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF - The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) | 11-25-2010 |
| 20110015176 | SUBSTITUTED HETEROARYLAMIDE OXAZEPINOPYRIMIDONE DERIVATIVES - The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: | 01-20-2011 |
| 20110015177 | SUBSTITUTED ARYLAMIDE OXAZEPINOPYRIMIDONE DERIVATIVES - The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: | 01-20-2011 |
| 20110118231 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF - The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) | 05-19-2011 |
| 20110136782 | NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE AND FUNGICIDE FOR AGRICULTURAL AND HORTICULTURAL USE - The present invention provides a nitrogen-containing heterocyclic compound represented by formula (I) and salt thereof (wherein, R | 06-09-2011 |
| 20110263567 | COMPOUNDS FOR INHIBITING SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) / VASCULAR ADHESION PROTEIN-1 (VAP-1) AND USES THEREOF FOR TREATMENT AND PREVENTION OF DISEASES - The present invention relates to compounds of general formula (i) having an oxime moiety or a pharmaceutically acceptable salt, hydrate or solvate thereof and its use for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1), a pharmaceutical composition comprising the compound or a salt, hydrate or solvate thereof as an active ingredient, a method for the prevention or the treatment of a SSAO/VAP-1 related disease, said diseases including acute or chronic inflammatory diseases, diseases related to carbohydrate metabolism, diabetes-associated complications, diabetic retinopathy and macular oedema, diseases related to adipocyte or smooth muscle dysfunctions, neurodegenerative diseases and vascular diseases. | 10-27-2011 |
| 20110288070 | METHODS FOR TREATING COGNITIVE DISORDERS USING INHIBITORS OF HISTONE DEACETYLASE - This disclosure relates to compounds for the inhibition of histone deacetylase and treatment of a cognitive disorder or deficit. More particularly, the disclosure provides for compounds of formula (I) wherein (I), Q, J, L and Z are as defined in the specification. | 11-24-2011 |
| 20120058989 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS - Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): | 03-08-2012 |
| 20120071462 | Dihydrobenzoxathiazepine compounds, a process for their preparation and pharmaceutical compositions containing them - Compounds of formula (I): | 03-22-2012 |
| 20120122843 | Compounds and Their Use for Treatment of Amyloid Beta-Related Diseases - The present invention relates to novel compounds of formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said compounds, processes for making said compounds, and their use as medicaments for treatment and/or prevention of Aβ-related diseases. | 05-17-2012 |
| 20120135979 | PYRAZINOOXAZEPINE DERIVATIVES - Provided is a compound having a serotonin 5-HT | 05-31-2012 |
| 20120157440 | NOVEL FUSED PYRIDINE COMPOUNDS AS CASEIN KINASE INHIBITORS - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: | 06-21-2012 |
| 20120165312 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF - The present invention relates to a serotonin 5-HT | 06-28-2012 |
| 20120196848 | THIENOOXAZEPINE DERIVATIVE - Provision of a compound having a serotonin 5-HT | 08-02-2012 |
| 20130035326 | BIARYL COMPOUNDS AND METHODS OF USE THEREOF - Provided herein are compounds for treatment of KIT, CSF-1R and/or FLT3 kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions. | 02-07-2013 |
| 20130079331 | BENZOXAZEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE - Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z | 03-28-2013 |
| 20130210803 | FUSED TETRACYCLIC PYRIDO [4,3-B] INDOLE AND PYRIDO [3,4-B] INDOLE DERIVATIVES AND METHODS OF USE - This disclosure is directed to fused tetracyclic pyrido[4,3-b]indoles and pyrido[3,4-b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder. | 08-15-2013 |
| 20130217672 | (+)-3-HYDROXYMORPHINAN-BASED POLYCYCLE DERIVATIVES - A (+)-3-hydroxymorphinan-based polycycle derivative of formula (I) is effective as a neuroprotective agent for neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and ischemic stroke. | 08-22-2013 |
| 20130225558 | FUSED TETRACYCLIC PYRIDO [4,3-B] INDOLE AND PYRIDO [3,4-B] INDOLE DERIVATIVES AND METHODS OF USE - This disclosure is directed to fused tetracyclic pyrido[4,3-b>]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder. | 08-29-2013 |
| 20130261105 | NOVEL PYRAZOLOPYRIMIDINES - This invention relates to novel pyrazolopyrimidines and their use as metabotropic glutamate 5 receptor antagonists (mGlu5 receptor antagonists), pharmaceutical compositions containing the same, and methods of using the same as agents for treatment or amelioration of mGlu5 receptor mediated disorders. | 10-03-2013 |
| 20130338141 | HIV INTEGRASE INHIBITORS - Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: | 12-19-2013 |
| 20140080808 | TETRAHYDROTHIAZEPINE DERIVATIVE - The present invention relates to a compound represented by the following general formula (I) | 03-20-2014 |
| 20140121199 | (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS - A dual H1/5-HT | 05-01-2014 |
| 20140171410 | Batrachotoxin Analogues, Compositions, Uses, and Preparation Thereof - Compounds relating to batrachotoxin are provided, in particular analogues that modulate the activity of sodium channels. Also provided are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier, including vehicles that modulate transdermal permeation of the compound. The subject compounds are useful in treatments, including treatments to reduce neuronal activity or to bring about muscular relaxation. The compounds also find use in the treatment of subjects suffering from a voltage-gated sodium channel-enhanced ailment or from pain. Further methods are provided for the preparation of the batrachotoxin-related compounds. | 06-19-2014 |
| 20140171411 | (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS - A dual H1 inverse agonist/5-HT | 06-19-2014 |
| 20140243316 | Tetrahydroimidazo(1,5-D)[1,4]Oxazepine Derivative - A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof works as an mGluR2 antagonist, and is applicable as a therapeutic agent for neurological disorders related to glutamate dysfunction and diseases involving the mGluR2, such as Alzheimer's disease: | 08-28-2014 |
| 20140303144 | COMPOUNDS AND METHODS OF TREATING HYPERTENSION - Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor α | 10-09-2014 |
| 20140323468 | ALDOSTERONE SYNTHASE INHIBITORS - The present invention relates to compounds of formula (I): | 10-30-2014 |
| 20140336177 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL - The present invention provides compounds of Formula I | 11-13-2014 |
| 20150111877 | TETRAHYDRONAPHTHYRIDINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE - The invention provides tetrahydronaphthyridine and related compounds, pharmaceutical compositions, methods of inhibiting RORγ activity, reducing the amount of IL-17 in a subject, and treating immune disorders and inflammatory disorders using such tetrahydronaphthyridine and related compounds. | 04-23-2015 |
| 20150291626 | HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF - Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes. | 10-15-2015 |
| 20150315210 | NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS - This invention relates to novel fused quinazoline derivatives of Formula I as c-Met inhibitors, their synthesis and uses for treating c-Met mediated disorders. | 11-05-2015 |
| 20150322083 | (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS SELECTIVE 5-HT2A INVERSE AGONISTS | 11-12-2015 |
| 20150353576 | (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS - A dual H1 inverse agonist/5-HT2A receptor antagonist of the formula: [Formula I], its uses, and methods for its preparation are described. | 12-10-2015 |
| 20160039820 | PYRIDOINDOLOBENZ[B,E]AZEPINE DERIVATIVES AND USES THEREOF - The present invention discloses pridoinolobenz[b,c]azepine derivatives of Formula 1, wherein X is —O—, —S—, —SO—, or —SO | 02-11-2016 |
| 20160052937 | Tetrahydroimidazo[1,5-d][1,4]oxazepine compound - A compound represented by formula (I): | 02-25-2016 |
| 20160096851 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF - The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) | 04-07-2016 |
