Entries |
Document | Title | Date |
20080207589 | CYCLIZED DERIVATIVES AS EG-5 INHIBITORS - The present invention relates to new substituted imidazole compounds have the following Formula (I) and to the pharmaceutically acceptable salts, esters, or prodrugs thereof, to compositions of the compounds together with pharmaceutically acceptable carriers, and to uses of the compounds: | 08-28-2008 |
20080261948 | Ligands for G-Protein Coupled Receptors - The invention provides compounds of general formulae I-IV or pharmaceutically acceptable salts thereof: | 10-23-2008 |
20080306041 | Cardiovascular Compounds Comprising Heterocyclic Nitric Oxide Donor Groups, Compositions and Methods of Use - The invention describes compositions and kits comprising at least one cardiovascular compound comprising at least one heterocyclic nitric oxide donor group, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (l) treating peripheral vascular diseases; (m) treating portal hypertension and (n) treating ophthalmic disorders. The cardiovascular compounds are preferably β-adrenergic antagonists, angiotensin-converting enzyme (ACE) inhibitors, anti-hyperlipidemic compounds, and antithrombotic and vasodilator compounds. The heterocyclic nitric oxide donor groups are preferably furoxans, sydnonimines, oxatriazole-5-ones and/or oxatriazole-5-imines. | 12-11-2008 |
20090054398 | CHEMICAL COMPOUNDS - The invention provides a new method for treating disorders associated with activation of the Notch signal transduction pathway comprising administering an effective amount of a compound of Formula (I), in free form or in a pharmaceutically acceptable salt form or in the form of a pharmaceutically acceptable solvate of the compound or the salt, to a human or animal patient in need thereof. | 02-26-2009 |
20090192139 | CGRP RECEPTOR ANTAGONISTS - The present invention is directed to compounds of Formula I: | 07-30-2009 |
20100041637 | 1,3-Oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11 -hydroxysteroid dehydrogenase 1 - This invention relates to novel compounds of the Formula (I), (I*), (I**), I, Ia, Ib, Ic, Id, Ie, If, Ig, Il | 02-18-2010 |
20100298293 | SUBSTITUTED OXAZOLIDINONES AND THEIR USE - The invention relates to novel substituted oxazolidinones, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for treatment and/or prophylaxis of diseases, especially of thromboembolic disorders. | 11-25-2010 |
20110003791 | Cyclized Derivatives as EG-5 Inhibitors - The present invention relates to new substituted imidazole compounds have the following Formula (I) and to the pharmaceutically acceptable salts, esters, or prodrugs thereof, to compositions of the compounds together with pharmaceutically acceptable carriers, and to uses of the compounds: | 01-06-2011 |
20110077236 | NEW CARBOXYLIC ACID AMIDES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS - The present invention relates to new substituted carboxylic acid amides of general formula | 03-31-2011 |
20110172205 | MONOCYCLIC AMIDE CGRP RECEPTOR ANTAGONISTS - Compounds of formula (I): wherein variables B, m, n, J, R | 07-14-2011 |
20130172318 | ANTI-INFLAMMATORY AGENTS - Disclosed herein are methods of preventing or treating inflammatory diseases using 3-aminolactam compounds, each with aromatic “tail groups”. Compounds as defined by formulae (I) and (I′), and the medical uses of the compounds, are described herein. | 07-04-2013 |
20130237522 | CARBOXYLIC ACID AMIDES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS - The present invention relates to new substituted carboxylic acid amides of general formula | 09-12-2013 |
20150025060 | Foamable Compositions and Kits Comprising One or More of a Channel Agent, a Cholinergic Agent, A nitric Oxide Donor and Related Agents and Their Uses - The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor; and (b) a foamable carrier comprising:
| 01-22-2015 |