Entries |
Document | Title | Date |
20080200432 | Fiber-Treating Agent - The present invention relates to a fiber-treating agent having a pH value of 2 to 5 at 20° C. and containing an alkoxysilane (a), an organic acid (b) and water (c), wherein 50% or more by weight of the component (a) is an alkoxysilane represented by the following formula (1): R | 08-21-2008 |
20080214500 | Injectable cement composition for orthopaedic and dental use - The present invention relates to ceramic precursor powder compositions and chemically bonded ceramic (CBC) materials, Ca-aluminate and/or calcium silicate, and a composite biomaterial with prolonged shelf time of the precursor, suitable for orthopaedic applications with improved injectability. The present invention also relates to a method of manufacturing said cured material, bioelements, implants, or drug delivery carrier materials made by said cured material, a kit comprising the ceramic precursor powder and hydration liquid, as well as the use of said ceramic precursor powder and hydration liquid, or said cured material, for orthopaedic and dental applications. | 09-04-2008 |
20080255068 | Chemical Compound and Its Use - The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis. | 10-16-2008 |
20080255069 | Medicament for Preventive and/or Therapeutic Treatment of Bowel Disease - A medicament for preventive and/or therapeutic treatment of a bowel diseases such as inflammatory bowel diseases including Crohn's disease, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid. | 10-16-2008 |
20080261917 | Isoindolin-1-One Derivatives - A compound of formula | 10-23-2008 |
20080261918 | Silicon Compounds and Their Use - A compound of any of formulas (I) to (V): wherein at least one of Y and Z includes a Si atom, is of utility in therapy. | 10-23-2008 |
20080261919 | Camptothecin-analog with a novel, "flipped" lactone-stable, E-ring and methods for making and using same - The present invention discloses: (i) a novel, lactone-stable, “flipped” E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof; (ii) methods of synthesis of said novel, lactone-stable, “flipped” E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof; (iii) pharmaceutically-acceptable formulations comprising said novel, lactone-stable, “flipped” E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more additional chemotherapeutic agents; (iv) methods of administration of said novel, lactone-stable, “flipped” E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more additional chemotherapeutic agents, to subjects in need thereof; and (v) devices for the administration of said novel, lactone-stable, “flipped” E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more chemotherapeutic agents, to subjects in need thereof. | 10-23-2008 |
20080261920 | 2-Aminooxazolines as TAAR1 ligands - The invention relates to compounds of formula I | 10-23-2008 |
20080269169 | Camptothecin analogs and methods of preparation thereof - A method of administering a topoisomerase inhibiting agent to a mammal includes administering a pharmaceutically effective amount of a compound having the following formula or a pharmaceutically acceptable salt thereof: | 10-30-2008 |
20080275002 | Method for Treatment of Hepatic Cancer - A method for therapeutic treatment of hepatic cancer, which comprises the step of administering 10 to 30 mg per day of 4-[3,5-bis(trimethylsilyl)benzamido]-benzoic acid or a physiologically acceptable salt thereof to a patient with hepatic cancer. | 11-06-2008 |
20080280855 | Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles - The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. | 11-13-2008 |
20080293674 | Azinyl Imidazoazine and Azinyl Carboxamide - The invention relates to azinylimidazoazines of structure (I) and their salts and N-oxides, | 11-27-2008 |
20080312183 | Dutpase Inhibitors - Deoxyuridine derivatives of the formula (I) where R | 12-18-2008 |
20080312184 | Composition for Preventing Plant Diseases and Method for Preventing the Diseases - The present invention is to provide a composition for preventing plant diseases which comprises at least Component I and Component II, is capable of obtaining a synergic effect that cannot be expected with each single component, is capable of markedly increasing a control effect in a much smaller amount of chemicals against various plant pathogens, and causes no phytotoxicity suffering. | 12-18-2008 |
20080312185 | SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES - Disclosed are methods of treating cancer by administration of compounds according to formula (I): | 12-18-2008 |
20080312186 | KETONES AND REDUCED KETONES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF BONE CONDITIONS - The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds of the formulae and pharmaceutically acceptable salts, amides, esters, and ethers thereof, wherein: Ar1, R | 12-18-2008 |
20080318899 | Pyridazine Compounds, Compositions and Methods - The invention relates to novel chemical compounds and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications. | 12-25-2008 |
20080318900 | Cosmetic Compositions Comprising At Least One Bis-Urea Derivative - Disclosed herein is a cosmetic composition comprising at least one continuous liquid fatty phase, comprising at least one compound of formula (I), or a salt and/or isomer thereof: | 12-25-2008 |
20090018103 | Diaminoalkane Aspartic Protease Inhibitors - Diaminoalkanes of Formula I have now been found which are orally active and bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with elevated levels of aspartic protease activity. The invention also relates to a method for the use of the compounds of Formula I in ameliorating or treating aspartic protease related disorders in a subject in need thereof comprising administering to said subject an effective amount of a compound of Formula I. | 01-15-2009 |
20090042835 | COMPOSITIONS AND METHODS FOR AMELIORATING HYPERLIPIDEMIA - The invention provides compositions comprising a pharmaceutical compound having one or more Microsomal Triglyceride Transfer Protein (MTP) inhibitors that are covalently linked to one or more Liver Fatty Acid-Binding Protein (L-FABP) inhibitors. Also disclosed are methods for using the inventive pharmaceutical compositions in the treatment of hepatic steatosis and hyperlipidemia while avoiding the harmful side effects of steatorrhea. | 02-12-2009 |
20090048212 | COSMETIC COMPOSITION COMPRISING AN OIL - Cosmetic composition comprising an oil The present invention relates to a composition for making up or caring for the skin in the form of a water-in-oil emulsion comprising an aqueous phase, at least 5% by weight, relative to the total weight of the composition, of a dispersed solid phase and a liquid fatty phase having at least one non-volatile fraction, the said liquid fatty phase comprising at least one first oil chosen from slow volatile oils with an evaporation rate of between 0.002 and 0.05 mg/cm | 02-19-2009 |
20090062234 | SUBSTITUTED ORGANOPOLYSILOXANES AND USE THEREOF - The invention relates to new compounds of Formula (1): wherein Q is selected from CXYR′ and RC(Z) wherein Z is selected from oxygen, hydrogen, OH, NR | 03-05-2009 |
20090069270 | Methods for Diluting Water-Stabilized Antimicrobial Organosilane Compositions - The present invention relates to methods for diluting water-stable organosilane compositions comprising an organosilane, optionally having a non-hydrolyzable organic group, but having one or more hydrolyzable groups, and an acidified stabilizing solution prepared from at least one acid, and at least one cationic surfactant, preferably at least one quaternary ammonium salt (QAS), in water. The organosilane composition is diluted with a glycol ether. The resultant diluted organosilane composition may be used to antimicrobially treat a substrate. | 03-12-2009 |
20090082308 | Benzothiophene derivatives - The present invention relates to a novel class of benzothiophene amide derivatives. The hydroxamic acid compounds can be used to treat cancer. The benzothiophene amide compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo. | 03-26-2009 |
20090088406 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS - The present invention provides a pyrrolidine compound of General Formula (1) | 04-02-2009 |
20090118232 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF - The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof. | 05-07-2009 |
20090124576 | Triazine Derivatives - Disclosed are triazine derivatives of formula | 05-14-2009 |
20090131365 | NOVEL HETEROCYCLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) - The present invention is directed to novel heterocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. | 05-21-2009 |
20090137527 | Compositions and methods for modulating immune function - The invention relates to methods of modulating immune function, suppressing immune response, treating autoimmune diseases or autoimmune disorders, and treating diseases, sequelae or pathological conditions mediated by an activation of the immune system comprising administering a compound of formula A, a compound of any one of formulae 1-49, a lipoxin compound, or an oxylipin compound. | 05-28-2009 |
20090143333 | SILICONE GEL-BASED COMPOSITIONS FOR WOUND HEALING AND SCAR REDUCTION - This invention is a composition comprising a cyclic siloxane, a silicone occlusive fluid, a silicone occlusive gel, and a silicone resin powder. The composition is useful for wound healing. | 06-04-2009 |
20090149425 | Malononitrile compound as pesticides - The present invention provides a malononitrile compound represented by the formula (I): wherein any one of X | 06-11-2009 |
20090149426 | PROCESS FOR SYNTHESIZING SILVER-SILICA PARTICLES AND APPLICATIONS - Size-controlled immobilization of metal nano-clusters onto particles or nanoparticles is achieved using a polyol process. Polyol processing makes it possible to use thiol groups as a chemical protocol to functionalize the surface of particles, such as silica and polystyrene nanoparticles. Metal nano-clusters, such as silver, gold, platinum and palladium, nucleate and grow on the surface of the particles. The metal nano-clusters may be synthesized in a one-pot process from metal salts, nitrates, nitrites, sulfates, sulfites and the like. Any source of metal ions compatible with the polyol suspension and selected particles may be used. The size of immobilized metal nano-clusters may be controlled by additions of a poly(vinylpyrrolidone) or other polymer capable of regulating the metal ion reduction and nucleation process and by controlling concentration of metal ions, the nucleation and/or growth temperatures, and processing time. | 06-11-2009 |
20090156552 | TOPICAL DELIVERY OF PHTHALOCYANINES - The invention relates to topical pharmaceutical compositions comprising a phthalocyanine, wherein a diamagnetic metal ion moiety is either coordinated or covalently bound to the phthalocyanine core. The invention also relates to methods for destroying cancer tissue, precancerous cells, photo-aged cells, damaged cells, or otherwise pathologic cells, or activated cells, such as lymphocytes or other cells of the immune system, or activated or inflamed tissue cells comprising topically administering to the cancer tissue or surrounding tissue an effective amount of a phthalocyanine composition. | 06-18-2009 |
20090156553 | PIPERAZINE COMPOUNDS WITH A HERBICIDAL ACTION - The invention relates to the use of piperazine compounds of formula (I) or the agriculturally useful salts of piperazine compounds of formula (I) as herbicides, the variables in formula (I) being defined as cited in the claims and the description. | 06-18-2009 |
20090156554 | P13-KINASES - New compounds of formula 1 are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. | 06-18-2009 |
20090170811 | Composition for treatment of a detached retina and method of prodution thereof - The present invention relates to a composition for use in the treatment of a detached retina, comprising an oil and an additive capable of increasing the extensional viscosity of the oil. The present invention also relates to a method and kit of parts for producing the composition. | 07-02-2009 |
20090176738 | Dermal medicament delivery system - There is provided a means of applying a heated medicament to the skin and concurrently hydrating the skin thus raising the efficacy of administration. | 07-09-2009 |
20090181928 | ORGANIC COMPOUNDS - Compounds of the formula | 07-16-2009 |
20090181929 | ORGANIC COMPOUNDS - The present invention provides a compound of formula (I): | 07-16-2009 |
20090197833 | Silicon Containing Compounds Having Selective Cox-2 Inhibitory Activity and Methods of Making and Using the Same - Silicon-containing compounds having selective COX-2 inhibitory activity, as well as compositions thereof are provided. The subject compounds find use in a variety of applications, including therapeutic applications. Also provided are kits containing the subject compounds and pharmaceutical preparations thereof. | 08-06-2009 |
20090203644 | Compositions for treating and/or preventing diseases characterized by the presence of metal ions - The present invention generally relates to the treatment and/or prevention of Alzheimer's disease, other neurodegenerative diseases, and/or diseases characterized by the presence of certain metal ions, by using certain compositions including silicon-amino compounds. In some cases, a silicon-amino compound of the invention may be bidentate, tridentate, or otherwise polydentate, and in certain instances, the silicon-amino compound, or a portion thereof, may sequester aluminum or other ions, for example, by electrostatically binding the ions. Further aspects of the invention relate to methods of making and using such compositions of the invention, as well as articles and kits associated with the compositions. | 08-13-2009 |
20090203645 | Broad Spectrum Disinfecting and Sterilizing Composition - The present invention relates to antimicrobial compositions including an aromatic dialdehyde and a quaternary ammonium compound wherein the aromatic dialdehyde is orthophthalaldehyde, isophthalaldehyde, terephthalaldehyde, or combinations thereof, and the ratio of aromatic dialdehyde to quaternary ammonium compound is from about 10:1 to about 1:5. The invention also relates to methods of treating surfaces using the antimicrobial compositions of the invention. | 08-13-2009 |
20090209490 | DISINFECTANT COMPOSITION - Disinfectant composition comprising slightly acidic electrolyzed water and 0.001-1.0 wt % of a polyether-modified silicone of formula (1) or formula (2) | 08-20-2009 |
20090215723 | Organic silicic acids complex for therapeutic and cosmetic applications - This invention describes materials containing organic silica, used in cosmetic for external uses (gel, cream or lotion) or for internal uses (microbeads/beads, tablets or solutions). These materials are vegetable extracts such as bamboo or algae which constitute richest sources in organic silica (more soluble and assimilable). After extraction in a basic medium, the organic silica extract can form a stable complex at acidic pH in presence of stabilizers such as gelatin, collagen, polyethylene glycol and/or chitosan, etc. These complexes can be used for cosmetic applications in gel, lotion and cream or as a matrix in order to immobilize various bioactive molecules. For internal uses, the soluble form of monomeric or oligomeric silicic acid is necessary to preserve its assimilability. In this context, the addition of stabilizers (gelatin and/or collagen) or the functionalization of silicic acid is possible to improve its solubility and biodisponibility. | 08-27-2009 |
20090215724 | Pyrrolopyrazine kinase inhibitors - The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, | 08-27-2009 |
20090215725 | Substituted 4-aminocyclohexane derivatives - Substituted 4-aminocyclohexane derivatives having the formula I: | 08-27-2009 |
20090270350 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives - This invention is directed generally to substituted pyridinone and pyrimidinone compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygeπase activity. Such substituted pyridinone and pyrimidinone compounds include compounds generally corresponding in structure to the following formula: wherein Z, n, R | 10-29-2009 |
20090275532 | COSMETIC COMPOSITION COMPRISING AN OIL - The present invention relates to a cosmetic composition for making up or caring for the skin in the form of a water-in-oil emulsion comprising an aqueous phase and at least 15% by weight, relative to the total weight of the composition, of a fatty phase comprising at least one liquid fatty phase having at least one non-volatile fraction, the said liquid fatty phase comprising at least one dry oil chosen from oils with a viscosity of less than or equal to 10 Cps, a surface tension of between 21 and 31 mN/m and an evaporation rate of less than 0.002 mg/cm2/minute, the said dry oil being present in the emulsion in a content ranging from 55% to 100% by weight relative to the total weight of the non-volatile fraction of the liquid fatty phase, the said liquid fatty phase being such that the calculated weight ratio of the liquid fatty phase remaining in the composition after 10 minutes of drying, to the initial liquid fatty phase, ranges from 0.75 to 1. The invention also relates to the use of the said composition for obtaining a uniform makeup and/or a makeup that does not transfer. | 11-05-2009 |
20090275533 | FUSED BICYCLIC PYRIMIDINE COMPOUNDS AS AURORA KINASE INHIBITORS - Fused bicyclic pyrimidine compounds of formula (I): | 11-05-2009 |
20090291915 | Silicon Compounds and Their Use - A compound of any of formulae (I) to (III) wherein at least one of Y and Z includes a Si atom, is of utility in therapy. | 11-26-2009 |
20090291916 | Trihydroxy Polyunsaturated Eicosanoid - The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives and analogs of trihydroxy polyunsaturated eicosanoids that can be prepared according to these methods. The invention also provides compositions and methods using trihydroxy polyunsaturated eicosanoid derivatives for the prevention, amelioration and treatment of a variety of diseases or conditions associated with inflammation or inflammatory response, autoimmune diseases, rheumatoid arthritis, cardiovascular diseases, or abnormal cell proliferation or cancer. | 11-26-2009 |
20090306014 | C-10 CARBAMATES OF TAXANES - Provided herein are C-10 taxane carbamates and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating cancer and taupathy. | 12-10-2009 |
20090306015 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF HIGHLY LIPOPHILIC SULFHYDRYL COMPOUNDS - Novel compositions of silicon-containing sulfhydryl compounds, their preparation and use in methods for treating disease are described. Silicon confers lipophilicity that can enhance the penetration of the silicon derivative sulfhydryl compounds across the gut wall, cell membranes and blood brain barrier, thus improving therapeutic properties including bioavailability, metabolism, and/or pharmacokinetics. The organosilyl group provides compounds having improved pharmacokinetics. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for treatment of diseases and other maladies or conditions and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. | 12-10-2009 |
20090306016 | FATTY ACID AMIDE HYDROLASE INHIBITORS - Disclosed are compounds of formula R—X—Y that may be used to inhibit the action of fatty acid amide hydrolase (FAAH). Inhibition of fatty acid amide hydrolase (FAAH) will slow the normal degradation and inactivation of endogenous cannabinoid ligands by FAAH hydrolysis and allow higher levels of those endogenous cannabinergic ligands to remain present. These higher levels of endocannabinoid ligands provide increased stimulation of the cannabinoid CB1i and CB2 receptors and produce physiological effects related to the activation of the cannabinoid receptors. They will also enhance the effects of other exogenous cannabinergic ligands and allow them to produce their effects at lower concentrations as compared to systems in which fatty acid amide hydrolase (FAAH) action is hot inhibited. Thus, a compound that inhibits the inactivation of endogenous cannabinoid ligands by fatty acid amide hydrolase (FAAH) may increase the levels of endocannabinoids and, thus, enhance the activation of cannabinoid receptors. Thus, the compound may not directly modulate the cannabinoid receptors but has the effect of indirectly stimulating the cannabinoid receptors by increasing the levels of endocannabinoid ligands. It may also enhance the effects and duration of action of other exogenous cannabinergic ligands that are administered in order to elicit a cannabinergic response. | 12-10-2009 |
20090318385 | Pyrazolopyride derivative and phosphodiesterase ( pde) inhibitors containing the same as active ingredient - A novel pyrazolopyridine derivative is provided which is useful as a pharmaceutical drug having phosphodiesterase inhibitory activity. | 12-24-2009 |
20090325900 | FUSED HETEROCYCLIC DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL USE THEREOF - The present invention provides a compound useful as an agent for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides a fused heterocyclic derivative represented by the following general formula (I), a pharmaceutical composition containing the same, a medicinal use thereof and the like. In the formula (I), ring A represents 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl; R | 12-31-2009 |
20090325901 | IMPROVEMENTS IN PHARMACEUTICAL COMPOSITIONS - The present invention relates to compounds of formula I or II: —wherein R is an alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, or aralkynyl group, that may be substituted or unsubstituted, and that optionally includes at least one heteroatom in its carbon skeleton; R | 12-31-2009 |
20090325902 | HETEROCYCLIC UREA DERIVATIVES AND METHODS OF USE THEREOF - Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described. | 12-31-2009 |
20100004201 | Cosmetic - The present invention provides a cosmetic that contains glycerin modified on both ends with silicone represented by the following general formula (a). | 01-07-2010 |
20100004202 | Quaternary ammonium-functionalized-POSS compounds - A silsesquioxane cage structure has a general formula [R | 01-07-2010 |
20100004203 | MEDICAMENT FOR PREVENTIVE AND/OR THERAPEUTIC TREATMENT OF BOWEL DISEASE - A medicament for preventive and/or therapeutic treatment of a bowel diseases such as inflammatory bowel diseases including Crohn's disease, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid. | 01-07-2010 |
20100009933 | HYDROXYLATED AMIDE SKIN MOISTURIZER - The invention relates to the cosmetic use, as a skin moisturizer, of a compound of formula (I): with (i) R | 01-14-2010 |
20100022475 | NOVEL TRIAZOLOPYRIMIDINE DERIVATIVES - The present invention relates to novel triazolopyrimidine derivatives of formula I as active ingredients which have microbiocidal activity, in particular fungicidal activity(I): wherein the substituents are as defined in claim | 01-28-2010 |
20100029586 | Packaging for a Fabric softening Composition - A packaged product comprising packaging in combination with a fabric softening composition incorporating a skin benefit agent as an ingredient to enable the fabric softening composition to render textile fabrics treated with the composition capable of delivering the skin benefit agent to the skin with which the fabrics come into contact, characterised in that the packaging incorporates tactile cues ( | 02-04-2010 |
20100029587 | CYCLIC SILOXANES AND THEIR USE - The invention relates to cyclic siloxanes in which organically modifying groups are bonded to the silicon atom via an oxygen atom (SiOC linkage), and to their use in the production of polyesterpolyurethane and as additive for enhancing the activity of biocides and pesticides. | 02-04-2010 |
20100029588 | SUBSTITUTED PHENYLAMIDINES AND THE USE THEREOF AS FUNGICIDES - The present invention relates to oxime ether-, hydrazone- or azomethine-substituted phenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the amidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat. | 02-04-2010 |
20100029589 | 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES - The invention relates to compounds of formula I | 02-04-2010 |
20100035839 | MEROCYANINE DERIVATIVES - Disclosed are merocyanine derivatives which correspond to the formula (I), wherein L | 02-11-2010 |
20100041627 | COMPOSITIONS COMPRISING POLYMERIC EMULSIFIERS AND METHODS OF USING SAME - Provided are compositions comprising a polymeric emulsifier, a hydrophobic agent, a wetting agent having at least one sulfonate group and at least one base-neutralizable carboxylic acid group, and a hydrophilic particulate material. Also provided are methods of mitigating diaper dermatitis using the composition, and methods of promoting the benefits associated with the compositions. | 02-18-2010 |
20100056477 | FUNGICIDAL MIXTURES OF AMIDINYLPHENYL COMPOUNDS - This invention relates to fungicidal mixtures of certain phenylamidines, their N-oxides, and/or agriculturally suitable salts thereof, and to compositions comprising such mixtures and methods for using such mixtures as fungicides. | 03-04-2010 |
20100069328 | NOVEL ORTHO-AMINOANILIDES FOR THE TREATMENT OF CANCER - The present invention is directed to a compound of formula I, | 03-18-2010 |
20100069329 | COSMETIC COMPOSITIONS COMPRISING HYDROLYSIS RESISTANT ORGANOMODIFIED DISILOXANE SURFACTANTS - Compositions comprising disiloxane surfactant compositions comprising a silicone composition comprising a silicone having the formula: | 03-18-2010 |
20100069330 | Pharmaceutical Compositions and Methods for Preparing and Using Lipophilic Organosulfur Cell Proliferation Inhibitors - Novel compositions of lipophilic organosulfur compounds, their preparation and use in methods for treating disease are described. Silicon confers lipophilicity that can enhance the penetration of the silicon derivative compounds across the gut wall, cell membranes and blood brain barrier, thus improving therapeutic properties including bioavailability, metabolism, and/or pharmacokinetics. The organosilyl group provides compounds having improved pharmacokinetics. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, polymorphic forms, crystalline forms or an amorphous form, pharmaceutical compositions and methods for treatment of diseases, maladies or conditions. Also disclosed are processes for making such compounds as well as intermediates useful in such processes. | 03-18-2010 |
20100075924 | DUTPASE INHIBITORS - Deoxyuridine derivatives of the formula | 03-25-2010 |
20100087394 | Compositions Containing Betaine and Hydrophobic Silica - A free-flowing, substantially dry-to-the-touch, particulate composition comprises (A) finely particulate hydrophobic silicone-treated silica having a surface area of from 80 to 300 m | 04-08-2010 |
20100087395 | COSMETIC PREPARATION - A cosmetic, wherein the cosmetic comprises tetraquistrimethylsiloxysilane represented by the formula (1) | 04-08-2010 |
20100093665 | SILYLATED PIPERIDINE DERIVATIVES - Compounds of formula I: I wherein at least one of R4 and R5 comprises Si(R6)3 as a substituent selectively attenuate production of Aβ(1-42) and hence find use in treatment of Alzheimer's disease and related conditions. | 04-15-2010 |
20100093666 | WATER-STABILIZED ANTIMICROBIAL ORGANOSILANE PRODUCTS, COMPOSITIONS, AND METHODS FOR USING THE SAME - The present invention relates to water-stable compositions and compounds formed by mixing an organosilane, optionally having a non-hydrolyzable organic group, but having one or more hydrolyzable groups, and an acidified stabilizing solution prepared from at least one acid, at least one glycol ether, and at least one cationic surfactant, preferably at least one quaternary ammonium salt (QAS), in water. The present invention also relates to methods of treating a substrate by mixing or contacting the substrate with the product, compound, or composition of this invention for a period of time sufficient for treatment of the substrate, methods of antimicrobially treating a food article, methods of antimicrobially coating a fluid container, methods of dyeing and treating a substrate, and methods of antimicrobially coating a latex medical article. The invention also pertains to a treated substrate having adhered thereto the product, compound, or composition of this invention. | 04-15-2010 |
20100113391 | BICYCLIC HETEROCYCLIC COMPOUND | 05-06-2010 |
20100120714 | SUBSTITUTED BENZENE FUNGICIDES - Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, | 05-13-2010 |
20100130446 | NITROGEN-CONTAINING FIVE-MEMBERED HETEROCYCLIC COMPOUND - The present invention provides a compound represented by the formula (I): | 05-27-2010 |
20100137243 | Oxazolidinone And/Or Isoxazoline As Antibacterial Agents - Compounds of Formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, and compounds as shown in Formula (I) wherein C is for example (D), (E), (F); wherein A and B are independently selected from (i) and (ii); R | 06-03-2010 |
20100137244 | PREPARATION AND UTILITY OF HMG-COA REDUCTASE INHIBITORS - Chemical syntheses and medical uses of novel modulators of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and diastereomeric mixtures of isomers, individual diastereomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of hypercholesterolemia, dyslipidemia, coronary artery disease, atherosclerosis, metabolic syndrome, a hyperproliferative disease such as colorectal cancer, prostate cancer, and melanoma, a neurodegenerative disease such as cerebral ischemia, Alzheimer's disease, and Parkinson's disease are described. | 06-03-2010 |
20100137245 | Heteerocyclyl-substituted thiazoles as crop protection agents - Heterocyclyl-substituted thiazoles of the formula (I), | 06-03-2010 |
20100144671 | Compositions and Methods for Cancer Treatment - Bromoacetoxycalcidiol (B3CD), which is structurally related to calcidiol, exhibits cytotoxic and apoptotic activity toward cancer cells, including highly aggressive neuroblastoma cells. A series of small molecules designed around the structure of B3CD is expected to have growth inhibitory and apoptogenic activities toward a wide range of malignancies. B3CD shows no apparent toxicity in vivo, indicating potential value as a chemotherapeutic agent which will be particularly useful in treating highly aggressive tumors. | 06-10-2010 |
20100144672 | PYRIMIDINYL PYRAZOLES AS INSECTICIDES AND PARASITICIDE ACTIVE AGENTS - The present invention relates to pyrimidinylpyrazoles and their use as insecticides, and also to processes for their preparation and to compositions comprising such arylpyrazoles. | 06-10-2010 |
20100152135 | COSMETIC KIT COMPRISING REACTIVE SILICONE COMPOUNDS AND A GLOSSY OIL - The invention relates to a cosmetic kit comprising at least two separately-packaged cosmetic compositions, -the kit comprising at least one silicone compound X, at least one silicone compound Y and, optionally, at least one catalyst, -with the proviso that the compounds X and Y—and the catalyst when present—are not simultaneously in one of said compositions, -said compounds X and Y being able to react together by a hydrosilylation reaction when the catalyst is present or by condensation reaction, when they are brought into contact with one another, -one at least of the first and second compositions comprising at least one glossy oil, -said compounds X and Y and said glossy oil, and their respective amounts, being such that the average gloss of the deposit comprising the two compositions is greater than or equal to 60 out of 100. Lastly the invention relates to a method of making-up keratin materials that involves applying the compounds X and Y and the glossy oil. | 06-17-2010 |
20100160255 | SPIRO-CYCLIC COMPOUND - The present invention provides a compound represented by the formula (I): | 06-24-2010 |
20100160256 | INDAZOLE COMPOUNDS - Provided are compounds represented by the following formula (A-1) and formula (1), or salts thereof. The compounds of formula (A-1) and formula (1) or salts thereof have 133 adrenergic receptor agonist activity, and thus are useful as therapeutic and prophylactic agent for diabetes mellitus, obesity, hyperlipidemia, depression, diseases caused by gallstones or hypermotility of the biliary tract, diseases caused by hyperactivity of the digestive tract, interstitial cystitis, overactive bladder or urinary incontinence, or as therapeutic and prophylactic agents for diseases concomitant with decreased tears. | 06-24-2010 |
20100179105 | KERATIN MATERIALS MAKE-UP KIT COMPRISING REACTIVE SILICONE COMPOUNDS AND A COMPATIBLE OIL - The invention provides a make-up kit comprising at least two compositions which are packaged separately, —the kit comprising at least one compound X, at least one compound Y and at least one catalyst or one peroxide, at least one of the compounds, X or Y, being a silicone compound, —with the proviso that the compounds X and Y—and the catalyst are not simultaneously in one of said compositions, —said compounds X and Y being able to react together by a hydrosilylation reaction or by a condensation reaction, when they are brought into contact with one another, —one at least of the first and second compositions comprising at least one compatible oil, —said compounds X and Y and said compatible oil, and their respective amounts, being such that the transfer index of a deposit comprising the two compositions is less than or equal to 40 out of 100. Finally, the invention relates to a method of making-up keratin materials that involves applying the compounds X and Y and the compatible oil. | 07-15-2010 |
20100184724 | COMPOSITIONS FOR TREATING AND/OR PREVENTING DISEASES CHARACTERIZED BY THE PRESENCE OF METAL IONS - The present invention generally relates to the treatment and/or prevention of Alzheimer's disease, other neurodegenerative diseases, and/or diseases characterized by the presence of certain metal ions, by using certain compositions including organosilicon compounds. A composition of the invention may be administered to a mammal, such as a human. In some cases, the composition may include a silanol, a silandiol, a silantriol, or a cyclic organosilane, and/or be able to form a silanol, a silandiol, or a silantriol upon exposure to physiological conditions such as are found in the blood, in the stomach and/or gastrointestinal tract, or in the brain or other organ. In certain cases, the organosilicon compound may be bound to a moiety able to be transported across the blood-brain barrier into the brain, for example, an amino acid, a peptide, a protein, a virus, etc. The organosilicon compound may also be labeled (e.g., fluorescently or radioactively) in certain instances. In some embodiments, the composition, or a portion thereof, may sequester aluminum, copper, iron or other ions, for example, by electrostatically binding to the ions. The composition may also include other functionalities such as amines, certain alkyl and/or aryl moieties (including substituted alkyls and/or aryls), or hydrophobic moieties, for example, to facilitate transport of the organosilicon compound through the blood-brain barrier. | 07-22-2010 |
20100190745 | HETEROCYCLIC UREA DERIVATIVES AND METHODS OF USE THEREOF - Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described. | 07-29-2010 |
20100190746 | QUINAZOLINONES AS POTASSIUM CHANNEL MODULATORS - Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions. | 07-29-2010 |
20100190747 | Fused ring compound and use thereof - The present invention provides a compound represented by the formula: | 07-29-2010 |
20100197633 | N-Alkyl-Heterocyclyl Carboxamide Derivatives - A compound of general formula (I): | 08-05-2010 |
20100210590 | COMPOSITIONS AND TREATMENTS FOR SEIZURE-RELATED DISORDERS - The present invention relates to therapeutic and/or prophylactic uses of pyridazine compounds and to pharmaceutical compositions containing one or more of these compounds as an active component for treating a disorder characterized by conduction disturbances, electroconvulsions and/or seizures, in particular epilepsy, more particularly pediatric epilepsy. In an aspect of the invention, the pyridnsine compound has the Formula (Ia) or (Ib) wherein R | 08-19-2010 |
20100210591 | BIS(TRIMETHYLSILYL)PHENYL COMPOUND OR SALT THEREOF, AND USE THEREOF - The present invention provides a compound that exhibits an excellent antitumor effect and reduces side effects, such as skin disorders, of the existing retinoid by selectively activating on the nuclear receptor RARα, thereby possibly producing significant improvement of clinical profits. Specifically, the present invention provides a bis(trimethylsilyl)phenyl compound represented by Formula (I): | 08-19-2010 |
20100210592 | AMINES OR AMINO ALCOHOLS AS GLYT1 INHIBITORS - The invention relates to the use of compounds of formula I | 08-19-2010 |
20100216744 | THICKENER/GELLANT FOR OILY SUBSTANCE - The purpose of the invention is to provide a thickening and gelling agent that is easily dispersed into an oily substance such as a silicone oil in a small addition amount, is free of liquid separation, stably forms a thickened material or a gel state, and can prepare a thickened product or a gel having spreadability and free of sticky feeling and dry feeling. The invention provides a thickening and gelling agent for an oily substance containing the components (A) a modified product of alkoxytitanium or alkoxyzirconium with a carboxylic acid and a hydroxy compound, and (B) at least one silicone oil selected from a silicone oil having an amino group and a silicone oil having a carboxyl group; an oily composition and a cosmetic preparation, containing the thickening and gelling agent. | 08-26-2010 |
20100222299 | COMPOUND - The present invention involves tetrahydroisoquinoline compounds and their use in the inhibition and/or prevention of tumor growth. | 09-02-2010 |
20100222300 | A2B Adenosine Receptor Antagonists - Disclosed are novel compounds that are A | 09-02-2010 |
20100227837 | Mobile Self-Spreading Biocides - A compound having the formula: | 09-09-2010 |
20100234323 | Antimicrobial Acids and Salts - The invention relates to novel acidic siloxane derivatives, the use, methods of use or processes making use of siloxane derivatives of this type, especially to achieve an anti-microbial, preservative and/or antiadhesive effect, for the protection of articles and/or materials, and a process for the manufacture of the novel compounds. The siloxane acids (which may also be in salt form) have the formula (I), formula (II) and/or formula (III), wherein the symbols have the meanings given in the specification. | 09-16-2010 |
20100234324 | Quinazolinamide derivatives - Novel quinazolinamide derivatives of the formula (I), in which R | 09-16-2010 |
20100240609 | PHTHALOCYANINE SALT FORMULATIONS - Pharmaceutical compositions of phthalocyanine compounds with a structure according to Formula (I) are described. Phthalocyanines are photosensitizer compounds having a phthalocyanine ring system that can be used for photodynamic therapy. Different phthalocyanines and phthalocyanine salts are shown to have useful characteristics such as water solubility, oil solubility, or tunable photostability. Formulations of phthalocyanines and phthalocyanine salts that can be used for topical and systemic administration are described. | 09-23-2010 |
20100240610 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF - This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule. | 09-23-2010 |
20100261673 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME - Embodiments of the present invention provide novel antibacterials that target penicillin-binding proteins or other important cellular targets. Methods for inhibiting growth (reproduction, etc.) of bacteria using compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, such as certain strains of | 10-14-2010 |
20100267666 | Pyrrolopyrazine kinase inhibitors - The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, | 10-21-2010 |
20100267667 | TELOMERASE ACTIVATING COMPOUNDS AND METHODS OF USE THEREOF - The present invention is directed to use of a series of compounds and compositions comprising the same for activating telomerase and treating diseases, disorders and/or conditions related thereto. | 10-21-2010 |
20100267668 | 4-AZETIDINYL-1-HETEROATOM LINKED-CYCLOHEXANE ANTAGONISTS OF CCR2 - The present invention comprises compounds of Formula (I). | 10-21-2010 |
20100267669 | HETEROCYCLIC CETP INHIBITORS - Compounds of formula Ia and Ib | 10-21-2010 |
20100267670 | NOVEL HETEROCYCLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) - The present invention is directed to novel heterocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. | 10-21-2010 |
20100273739 | Aminotetraline Derivatives, Pharmaceutical Composition, Containing Them, and Their Use in Therapy - The present invention relates to aminotetraline derivatives of the formula (I) | 10-28-2010 |
20100286088 | 3-Substituted-4-Oxo-3,4-Dihydro-Imidazo[5,1-d][1,2,3,5-Tetrazine-8-Carboxy- lic Acid Amides and Their Use - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide (collectively referred to herein as 3TM compounds). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative disorders such as cancer, etc., and methods of preparing such compounds. | 11-11-2010 |
20100286089 | Process for the Preparation of Entecavir and Novel Intermediates Thereof Via Carbon-Silicon Oxidation - Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation. | 11-11-2010 |
20100292184 | 17BETA-CYANO-19-ANDROST-4-ENE DERIVATIVE, ITS USE AND MEDICAMENTS COMPRISING THE DERIVATIVE - The 17β-cyano-19-androst-4-ene derivatives of the present invention possess gestagenic activity. They have the general chemical formula 1, in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO | 11-18-2010 |
20100298267 | AMINOPYRIMIDINAMIDES AS PESTICIDES - The present application relates to novel aminopyrimidinamides, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects. | 11-25-2010 |
20100305066 | Fused Thiophene Derivatives as Kinase Inhibitors - A series of 5,6-dihydro-1-benzothiophen-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. | 12-02-2010 |
20100317619 | Selective Agents for Pain Suppression - In preferred embodiments, the present invention provides methods of treatment and pharmaceutical compositions for the suppression, alleviation and prevention of the often chronic, severe and debilitating pain that can accompany inflammatory diseases and neuropathic insults, pain that is often unresponsive to conventional analgesic treatment. The preferred embodiments of the present invention further relate to methods of treatment and pharmaceutical compositions using benzodiazepine derivatives that provide suppression, alleviation and prevention of neuropathic pain, migraine-related pain and inflammatory pain with reduced sedative and ataxic side effects. | 12-16-2010 |
20100317620 | N-PHENYLIMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE COMPOUNDS, PREPARATION AND THERAPEUTIC USE THEREOF - Compounds of formula (I): | 12-16-2010 |
20100323987 | COMBINATIONS OF RETIGABINE AND SODIUM CHANNEL INHIBITORS OR SODIUM CHANNEL-INFLUENCING ACTIVE COMPOUNDS FOR TREATING PAINS - The invention relates to pharmaceutical combinations of retigabine and sodium channel inhibitors for treating, pains which are accompanied by an increase in muscle tone. | 12-23-2010 |
20110009363 | SYNTHESIS AND BIOLOGICAL ACTIVITIES OF NEW TRICYCLIC-BIS-ENONES (TBES) - This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these compounds are also disclosed. The inventors demonstrate the ability of these new TBEs to inhibit proliferation of human myeloma cells, inhibit the induction of iNOS in cells stimulated with interferon-γ, induce heme oxygenase-1 (HO-1), induce CD11b expression—a leukemia differentiation marker, inhibit proliferation of leukemia cells, induce apoptosis in human lung cancer, and induce apoptosis in other cancerous cells. The TBEs of this invention are expected to be useful agents for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress. | 01-13-2011 |
20110009364 | AZABICYCLIC CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF - The disclosure relates to compounds of formula (I): | 01-13-2011 |
20110009365 | DERIVATIVES OF INDOLE-2-CARBOXAMIDES AND OF AZAINDOLE-2-CARBOXAMIDES SUBSTITUTED WITH A SILANYL GROUP, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF - This disclosure relates to compounds of formula (I): | 01-13-2011 |
20110015152 | DIARYLMETHYL AND RELATED COMPOUNDS - This invention provides compounds of formula I: | 01-20-2011 |
20110021459 | DUTPASE INHIBITORS - Deoxyuridine derivatives of the formula | 01-27-2011 |
20110021460 | SELECTIVE HYDROSILYLATION METHOD AND PRODUCT - An asymmetric siloxane is made by reacting a silicone having the formula M | 01-27-2011 |
20110028433 | QUINAZOLINONE DERIVATIVES AS TUBULIN POLYMERIZATION INHIBITORS - The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization as well as pharmaceutical compositions comprising said compounds of formula (I) | 02-03-2011 |
20110034414 | FLUOROALKYLOXY ALKANES, PROCESS FOR PRODUCTION AND USES THEREOF - The present invention relates to fluoroalkyloxy alkanes having formula (I): R | 02-10-2011 |
20110039802 | NPY Y5 ANTAGONIST - The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I): | 02-17-2011 |
20110046088 | IMINIPYRIDINE DERIVATIVES AND THEIR USES AS MICROBIOCIDES - Compounds of the formula (I) in which the substituents are as defined in claim | 02-24-2011 |
20110053891 | 5-FLUOROPYRIMIDINONE DERIVATIVES - This present disclosure is related to the field of 5-fluoropyrimidinones and their derivatives and to the use of these compounds as fungicides. | 03-03-2011 |
20110059920 | AGENT FOR REGENERATION AND/OR PROTECTION OF NERVES - An EP2 agonist which may have an EP3 agonistic effect has an effect of regenerating and/or protecting nerves, and is therefore useful as a therapeutic agent for a disease of the peripheral nervous system, such as a lower or upper motor neuron disease, a nerve root disease, plexopathy, thoracic outlet compression syndrome, peripheral neuropathy, neurofibromatosis and neuromuscular transmission disease. An EP2 agonist which has an EP3 agonistic effect is a safe and effective agent for the regeneration and/or protection of nerves which has little influence on the circulatory system. | 03-10-2011 |
20110065667 | PHENYLPYRAZOLE DERIVATIVES - The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases. | 03-17-2011 |
20110065668 | PHENYLPYRAZOLE DERIVATIVES - The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases. | 03-17-2011 |
20110065669 | OXAZOLOBENZIMIDAZOLE DERIVATIVES - The present invention is directed to oxazolobenzimidazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved. | 03-17-2011 |
20110077220 | 4-OXO,1-4-DIHYDROQUINOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS - The present invention is directed to compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor. | 03-31-2011 |
20110082107 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 - The present invention relates to compounds with the formula (I), (II), (III) or (IV): | 04-07-2011 |
20110086816 | Antimicrobial Compounds - The invention relates to cationic siloxane derivatives for use especially as fungicides and/or antiadhesives. The cationic siloxane derivatives have the formula (I), wherein R1, R2, R3, R4, R | 04-14-2011 |
20110086817 | ANTI-BACTERIAL AGENTS FROM BENZO[D]HETEROCYCLIC SCAFFOLDS FOR PREVENTION AND TREATMENT OF MULTIDRUG RESISTANT BACTERIA - Embodiments herein provide compounds and methods of making and using such compounds for prevention and treatment of multidrug resistant bacteria. In particular, embodiments are directed to anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria. | 04-14-2011 |
20110092455 | Method and Composition for the Control of Arthropods - The present invention relates to the use of certain siloxanes and mixtures thereof in the control of arthropods such as insects and arachnids, and in particular ectoparasites, such as head lice. | 04-21-2011 |
20110105427 | DEAZAPURINES AND USES THEREOF - The present invention provides compounds having formula (I): | 05-05-2011 |
20110105428 | HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED IONIC SURFACTANTS - The present invention provides for a composition comprising a silane having the formula: | 05-05-2011 |
20110105429 | Thiazole-4-Carboxylic Acid Esters and Thioesters as Plant Protection Agents - The use of thiazole-4-carboxylic esters and thioesters of the formula (I) | 05-05-2011 |
20110105430 | PYRROLO [2,3-C] PYRIDINE DERIVATIVES AS P38 KINEASE INHIBITING AGENTS - Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (A) are inhibitors N of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation. | 05-05-2011 |
20110130361 | SILICON DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS - The present invention relates to a novel class of Silicon derivatives. The Silicon compounds can be used to treat cancer. The Silicon compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the Silicon derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the Silicon derivatives in vivo. | 06-02-2011 |
20110130362 | A2B ADENOSINE RECEPTOR ANTAGONISTS - Disclosed are novel compounds that are A | 06-02-2011 |
20110136760 | Kinase Inhibitors Useful for the Treatment of Myleoproliferative Diseases and other Proliferative Diseases - The present invention is concerned with novel compounds useful in the treatment of hyperproliferative diseases and mammalian cancers, especially human cancers. The invention also pertains to methods of modulating kinase activities, pharmaceutical compositions, and methods of treating individuals, incorporating or using the compounds. The preferred compounds are active small molecules set forth in formulae Ia-Iww. | 06-09-2011 |
20110136761 | Vapour of a Citrus Essential Oil Blend and Its Antimicrobial Properties - A vapour of a blend comprising the oil of orange and the oil of bergamot, a process for its preparation and its use as an antimicrobial. The vapour has been found to be particularly useful on food contaminated with microorganisms without affecting the sensory properties of the food. | 06-09-2011 |
20110136762 | FUNGICIDAL PYRIDAZINES - Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, | 06-09-2011 |
20110144056 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH - The present invention is directed to certain imidazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer disease, and Parkinson's disease | 06-16-2011 |
20110144057 | ANTAGONISTS OF THE VANILLOID RECEPTOR SUBTYPE 1 (VR1) AND USE THEREOF - The present invention is directed to compounds of formula (I) | 06-16-2011 |
20110144058 | INSECTICIDAL COMPOSITIONS - The present invention relates to insecticidal mixtures of chloronicotinyl insecticides of the formula (I) | 06-16-2011 |
20110166102 | NOVEL 2-SUBSTITUTED BENZIMIDAZOLES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) - The present invention is directed to a novel 2-substituted benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. | 07-07-2011 |
20110172183 | METHOD OF FIXING ANTIBACTERIAL AGENT ARTICLE OBTAINED BY THE METHOD - An object of the present invention is to provide a method of fixing an antibacterial agent, by which method it is possible to impart articles of a wide range of materials with excellent antibacterial property and good persistence of antibacterial activity. Specifically, the method of fixing an antibacterial agent, comprises the steps of:
| 07-14-2011 |
20110172184 | ANTITUMOR AGENT CONTAINING 4 - [[3,5 - BIS (TRIMETHYLSILYL) BENZOYL] AMINO] BENZOIC ACID - Disclosed is a novel combination therapy of sorafenib having a remarkable antitumor effect. Specifically disclosed is an antitumor agent obtained by combining sorafenib or a salt thereof with 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]benzoic acid or a salt thereof. | 07-14-2011 |
20110172185 | THERAPEUTIC DRUG FOR ADULT T-CELL LEUKEMIA - An object is to provide a novel therapeutic drug for adult T-cell leukemia having an ATL cell specific antitumor effect. The therapeutic drug for adult T-cell leukemia according to the invention is characterized by containing a compound represented by the formula I or a prodrug thereof, | 07-14-2011 |
20110183937 | Agent for Combating Ectoparasites - Disclosed is a composition for killing ectoparasites and/or their eggs, comprising at least one volatile, at room temperature liquid, non-polar organic solvent, 1 to 10 wt.-%, based on the total composition, of at least one spreading agent; and 35 to 65 wt.-%, based on the total composition, of at least one polysiloxane having a viscosity of greater than 90 cSt. | 07-28-2011 |
20110183938 | 1,7-DIAZACARBAZOLES AND METHODS OF USE - The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. | 07-28-2011 |
20110183939 | NOVEL PYROLINONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME - The present invention provides a novel P2X | 07-28-2011 |
20110195929 | COMPOUNDS FOR THE TREATMENT OF FLAVIVIRAL INFECTIONS - Described are various compounds and methods for the treatment of flaviviral infections. In particular, alkaloids and imino sugars in arabinose and/or lyxose stereochemical configuration with antiflaviviral activity are described. | 08-11-2011 |
20110195930 | PYRIDINE DERIVATIVE OR ITS SALT, PESTICIDE CONTAINING IT AND PROCESS FOR ITS PRODUCTION - To provide a novel pesticide. The present invention provides a pesticide which contains, as an active ingredient, novel pyridine derivative represented by the formula (I) or its salt: wherein R | 08-11-2011 |
20110207698 | HETEROARYL-SUBSTITUTED DICYANOPYRIDINES AND THEIR USE - The present application relates to novel heteroaryl-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders. | 08-25-2011 |
20110207699 | Anti-Viral Compounds - Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. | 08-25-2011 |
20110207700 | TRICYCLIC COMPOUND AND USE THEREOF - The present invention relates to the compound represented by formula (I): | 08-25-2011 |
20110224170 | Pyranopyranone derivatives as antimicrobial agents - Disclosed is the use of pyranopyranone derivatives of formula | 09-15-2011 |
20110237545 | TRIHYDROXY POLYUNSATURATED EICOSANOID DERIVATIVES - The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives and analogs of trihydroxy polyunsaturated eicosanoids that can be prepared according to these methods. The invention also provides compositions and methods using trihydroxy polyunsaturated eicosanoid derivatives for the prevention, amelioration and treatment of a variety of diseases or conditions associated with inflammation or inflammatory response, autoimmune diseases, rheumatoid arthritis, cardiovascular diseases, or abnormal cell proliferation or cancer. | 09-29-2011 |
20110237546 | METHOD FOR TREATING A MAMMAL BY ADMINISTRATION OF A COMPOUND HAVING THE ABILITY TO RELEASE CO - Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin. | 09-29-2011 |
20110257127 | A2B ADENOSINE RECEPTOR ANTAGONISTS - Disclosed are novel compounds that are A | 10-20-2011 |
20110257128 | 2-Alkyl-Cycloalk(en)yl-Carboxamides - Novel 2-alkylcycloalk(en)ylcarboxamides of the formula (I) | 10-20-2011 |
20110263529 | GAMMA SECRETASE MODULATORS - In its many embodiments, the present invention provides a novel class of heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions. | 10-27-2011 |
20110269712 | Fungicidal Carboxamides - This invention is directed to compounds of Formula (1) including all geometric and stereoisomers, N oxides, and agriculturally suitable salts thereof, agricultural compositions containing them and their use as fungicides, (1) provided that the compound of Formula 1 is other than 2-[1-[(2-chlorophenyl)acetyl]-4-piperidinyl]-N-methyl-N-[(1R)-1-phenylethyl]-4-thiazolecarboxamide and R | 11-03-2011 |
20110269713 | BRYOSTATIN ANALOGUES AND METHODS OF MAKING AND USING THEREOF - Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity. | 11-03-2011 |
20110269714 | Polycyclic Tetracycline Compounds - The present invention is directed to a compound represented by Structural Formula (I): | 11-03-2011 |
20110275595 | Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use - The present invention relates to compounds defined by formula I wherein the groups R | 11-10-2011 |
20110288050 | PROTEIN PHOSPHATASE INHIBITOR - Provided is a novel protein phosphatase inhibitor. The protein phosphatase inhibitor contains, as an active ingredient, a silicon compound represented by the following general formula (1) or a salt thereof, wherein R | 11-24-2011 |
20110288051 | TRIAZOLOPYRIDINE 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS - Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds of formula I: | 11-24-2011 |
20110294756 | GAMMA SECRETASE MODULATORS - In its many embodiments, the present invention provides a novel class of heterocyclic compounds of Group A or Group, as defined herein, as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions. | 12-01-2011 |
20110301122 | HETEROAROMATIC COMPOUNDS FOR USE AS HIF INHIBITORS - The present application relates to novel substituted aryl compounds, processes for their preparation, their use for treatment and/or prevention of diseases and their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures. | 12-08-2011 |
20110301123 | Fungicidal Heterocyclic Amines - Disclosed are compounds of Formula 1, N-oxides, and salts thereof, | 12-08-2011 |
20110306576 | COMPOUNDS AND METHODS RELATING THERETO - A compound of formula (II) or a pharmaceutically acceptable derivative thereof for use in a method of combating and/or detecting a pathogen; wherein X is selected from O, S and Se; each of R | 12-15-2011 |
20110312915 | Novel cosmetic compositions - The present invention is concerned with novel cosmetic or pharmaceutical compositions. More particularly, the invention is concerned with novel cosmetic or pharmaceutical compositions for treating or preventing any symptoms caused by negative developments of the physiological homeostasis of healthy skin, as well as for the promotion of hair growth and protection from hair loss. | 12-22-2011 |
20110319359 | INDANYL COMPOUNDS - Compounds exhibiting calcium receptor antagonist activity that are safe and orally administrable having Formula (I) or pharmaceutically acceptable salts thereof: | 12-29-2011 |
20120004196 | Anti-Viral Compounds - Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. | 01-05-2012 |
20120010168 | Unique Dual-Action Therapeutics - A new family of therapeutics which provides a controlled-release delivery platform for non-steroidal anti-inflammatory agents on an ester or an ester-carbonate backbone is disclosed herein. These agents are reversible inhibitors of acetylcholinesterase and are thus useful for clinical conditions benefiting from inflammation suppression and cholinergic intervention. These compounds are of the general formula wherein n=0, 1; X═C, Si, and N+ and NSAID=ibuprofen, naproxen, indomethacin and diclofenac. Other embodiments are also disclosed. | 01-12-2012 |
20120010169 | Solubilized Composition - This invention provides a solubilized composition in which a carboxy-modified silicone is solubilized in a large amount and stably. The solubilized composition is characterized by consisting of (a) one or more nonionic surfactant(s), having a weighted average of the HLB value of 10 to 15, selected from polyoxyethylene alkyl ether type nonionic surfactant represented by the following formula (I) or (II): | 01-12-2012 |
20120015905 | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES - The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis. | 01-19-2012 |
20120022021 | Mixtures of strobilurins with 1-methylcyclopropene - The present invention relates to mixtures comprising
| 01-26-2012 |
20120028919 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS - The present invention provides a compound of formula I | 02-02-2012 |
20120028920 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZO[B]THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS - A heterocyclic compound or a salt thereof represented by the formula (1): | 02-02-2012 |
20120035131 | PYRAZOLINE COMPOUNDS - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: | 02-09-2012 |
20120040930 | TETRACYCLIC TERPENE SERIES COMPOUNDS, METHODS FOR PREPARING SAME, USES THEREOF AS MEDICINES AND PHARMACEUTICAL COMPOUNDS CONTAINING SAME - The invention concerns a triterpene alkaloid of general formula (I). The invention also concerns a method for making same and use thereof as medicine. | 02-16-2012 |
20120040931 | NOVEL ORGANOPOLYSILOXANE AND COSMETIC CONTAINING THE SAME - There is disclosed an organopolysiloxane represented by the following general formula (1). | 02-16-2012 |
20120046242 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY - The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant Wnt/β-catenin signaling and administering to the selected subject a compound selected from the group consisting of those set forth in Table 1, Table 2, and a pharmaceutically acceptable salt thereof. A method of similarly modulating the Wnt/β-catenin pathway in a subject is also discussed. | 02-23-2012 |
20120058973 | COMPOSITIONS COMPRISING A SILICONE WATER-IN-OIL EMULSIFIER AND A LOW NITROGEN CONTAINING AMINO-FUNCTIONAL SILICONE GUM - Provided are compositions comprising a silicone water-in-oil emulsifier, a low nitrogen containing amino-functional silicone gum, a hydrophobic agent, a non-silicone primary emulsifier, and water. | 03-08-2012 |
20120065162 | N-N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS - The present invention provides a pyrrolidine compound of General Formula (1) | 03-15-2012 |
20120065163 | SEBUM ABSORPTION COMPOSITIONS - Sebum absorption compositions are disclosed which include (a) 1% to 20% by weight of the composition of a sebum absorption ingredient; and (b) 20% to 99% by weight of the composition of a volatile solvent. | 03-15-2012 |
20120065164 | FUNGICIDE PYRAZOLE CARBOXAMIDES DERIVATES - The present invention relates to pyrazole carboxamides derivatives of formula (1) wherein Y represents CR | 03-15-2012 |
20120071444 | METHOD AND COMPOSITION FOR THE CONTROL OF ECTOPARASITES - An ectoparasiticidal composition is provided that comprises a mixture of a carrier and an active with an emulsifying agent. The carrier comprises non-volatile low viscosity siloxane and the active comprises a non-volatile high viscosity siloxane. The low viscosity siloxane and the high viscosity siloxane both have a closed cup flash point of at least 100° C. Preferably, both the low viscosity siloxane and the high viscosity siloxane comprise a dimeticone or a dimeticonol or a mixture of same, the the low viscosity siloxane having a viscosity in the range of 5 to 1000 centistokes inclusive and the high viscosity siloxane having a viscosity of at least 1000 centistokes. | 03-22-2012 |
20120077775 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 - Disclosed are macrocyclic compounds of formulae I-V, which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also disclosed are pharmaceutical compositions comprising an effective kinase-inhibiting amount or an effective HSP90-inhibiting amount of the compounds and methods for the treatment of disorders that are mediated by kinases and HSP90. | 03-29-2012 |
20120077776 | HYDROLYSIS RESISTANT ORGANOMODIFIED TRISILOXANE SURFACTANTS - Three types of trisiloxane surfactants having the basic formula: | 03-29-2012 |
20120077777 | NGCYCLOARTANONE DERIVATIVES WITH ANTICANCER ACTIVITY - The present invention relates to a compound of following formula (I): | 03-29-2012 |
20120094956 | Treatment of Cancer with Specific RXR Agonists - A method of treating cancer is disclosed comprising administering to a patient in need of such treatment a RXR agonist at a level below the RAR activating threshold and at or above the RXR effective dose. | 04-19-2012 |
20120101061 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATION - The invention relates to novel resolvin compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel resolvin compounds of the invention. | 04-26-2012 |
20120108545 | Trioxane Monomers and Dimers - Monomeric and dimeric trioxane fluoroaryl amides, 5-carbon-linked, C-10 non-acetal trioxane dimer esters; trioxane silylamides; and trioxane dimer orthoesters and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases including, but not limited to, toxoplasmic infection; subjects afflicted with psychiatric conditions associated with toxoplasmic infection; and subjects afflicted with cancer. | 05-03-2012 |
20120115812 | SURFACE COATINGS FOR SKIN - The present invention relates to skin coating compositions and methods and, in particular, to coatings containing an active agent. In some embodiments, the coating may be applied to a skin surface and may be essentially colorless and transparent. In some aspects, the coating comprises a polymer and an active agent, and the polymer may be configured for sustained release of the active agent. In some aspects, the coating forms a barrier essentially impermeable to microorganisms yet permeable to water vapor. The coating may also be flexible and conformable to the surface. The coating may be applied to the skin using any suitable method. In some embodiments, the polymer and/or active agent are dissolved and/or suspended in a volatile solvent. In some embodiments, the volatile solvent may function as an antiseptic on skin. | 05-10-2012 |
20120122816 | COMPOSITIONS AND METHODS FOR ORGAN PRESERVATION - The invention relates to reducing, preventing or reversing organ damage, reducing and/or preventing stem cell damage and/or death, enhancing organ preservation and/or survival, or enhancing stem cell preservation and/or survival comprising administering a compound of formula A, a compound of any one of formulae 1-49 or I-III, a lipoxin compound, an oxylipin compound, or a combination of aspirin and an omega-3 fatty acid. | 05-17-2012 |
20120135958 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF - The invention relates to compounds of formula (I), where: A is a bond, an oxygen, or an | 05-31-2012 |
20120142633 | METHYLPYRROLOPYRIDINECARBOXAMIDES - The compounds of Formula (I), | 06-07-2012 |
20120149660 | NOVEL N-SUBSTITUTED 5-HYDROXYPYROLLINDES AS INHIBITORS OF MDM2-P53 INTERACTIONS - There are provided compounds of formula I | 06-14-2012 |
20120149661 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS - The invention relates to tetra-substituted heteroarylic compounds of the formula (I) | 06-14-2012 |
20120149662 | Heterocyclic Compounds as Janus Kinase Inhibitors - The invention provides compounds of formula (I): | 06-14-2012 |
20120157410 | COMPOSITIONS AND TREATMENTS USING PYRIDAZINE COMPOUNDS AND CHOLINESTERASE INHIBITORS - The invention relates to compositions, conjugates and methods comprising pyridazine compounds and cholinesterase inhibitors for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications. | 06-21-2012 |
20120165293 | SYNTHESIS OF PROSTANOIDS - The presently disclosed subject matter provides a method of synthesizing prostaglandins and prostaglandin analogs comprising the ring closing metathesis of compounds of Formula (I). Also provided are novel compounds of Formula (I) and Formula (II). In addition to their use as synthetic intermediates in the presently disclosed methods, compounds of Formula (II) can be used as prostaglandin and/or prostaglandin analog prodrugs. | 06-28-2012 |
20120165294 | 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES - The invention relates to compounds of formula I | 06-28-2012 |
20120172333 | PYRROLO-PYRIDINE DERIVATIVES AS ACTIVATORS OF AMPK - The present invention relates to pyrrolopyridone compounds of the formula (I), | 07-05-2012 |
20120172334 | CONTROLLED RELEASE PARTICLES AND METHOD FOR PRODUCING THE SAME - Controlled release particles are obtained by dissolving a hydrophobic antibiotic compound in a hydrophobic polymerizable vinyl monomer without the presence of a solvent, thereby preparing a hydrophobic solution, the hydrophobic antibiotic compound having a melting point of 100° C. or less, a polar term δp,compound of 2 to 8 [(J/cm | 07-05-2012 |
20120178713 | PHENYL SULPHONAMIDES AS MODULATORS OF ION CHANNELS - The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain. | 07-12-2012 |
20120184508 | PYRAZOLO PYRIMIDINES - Compounds of formula | 07-19-2012 |
20120184509 | Compounds as TRVP1 Blockers, Pharmaceutical Compositions and Medical Uses Thereof - A kind of new compounds, and their pharmaceutically acceptable salts, and hydrates are disclosed. The pharmaceutical composition thereof is also provided. And also are the medical uses of the compounds, pharmaceutically acceptable salts, hydrates and the pharmaceutical composition for treating the TRPV1-mediate diseases. | 07-19-2012 |
20120196832 | SUBSTITUTED POLYALKOXYSILOXANE COMPOSITIONS AND METHODS OF USE - Linear polydialkoxysiloxanes with 2-8 polymeric units have been reacted with alcohols by a transetherification reaction to provide hydrophilic and water soluble silicone products. The glycerol substituted siloxanes in particular are effective in topically treating skin lesions such as radiation burns. Compositions including the substituted polydialkoxysiloxane products inhibit biofilm formation when used as coatings on hard surfaces. | 08-02-2012 |
20120202774 | ACYLOXY- AND PHOSPHORYLOXY-BUTADIENE-FE(CO)3 COMPLEXES AS ENZYME-TRIGGERED CO-RELEASING MOLECULES - The present invention provides acyloxy- and phosphoryloxy-butadiene-Fe(CO) | 08-09-2012 |
20120214762 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR - The invention relates to novel compounds of Formula I: | 08-23-2012 |
20120214763 | MEMORY FIXATION ACCELERATOR - A medicament for promoting memory consolidation, which comprises, as an active ingredient, a non-natural retinoid, preferably a retinoid having a basic skeleton comprising an aromatic ring bound with an aromatic carboxylic acid or tropolone by means of a bridging group, more preferably 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or 4-[(3,5-bis-trimethylsilylphenyl)-carboxamido]benzoic acid. | 08-23-2012 |
20120214764 | METHOD AND KIT FOR GASTRO-INTESTINAL CLEANSING - A method of cleansing a mammalian GI tract is described and includes ingestion of polyethylene glycol (PEG) and magnesium citrate in a split-dose regimen. The split-dose regimen provides effective cleansing of the GI tract while minimizing discomfort and side effects to the patient A kit packaged with a first and second portion of PEG, and a first and second portion of magnesium citrate, and optionally simethicone is also provided. | 08-23-2012 |
20120220549 | Pituitous Silicone Fluids - Fluid compositions are disclosed containing a branched organopolysiloxane and a carrier fluid. The branched organopolysiloxane is obtainable by reacting an organohydrogencyclosiloxane and an alkenyl terminated polydiorganosiloxane. The disclosed fluid compositions possess pituitous rheological properties. | 08-30-2012 |
20120220550 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME - The present invention provides pyrazole derivative compounds and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of preventing and treating osteoporosis. | 08-30-2012 |
20120225844 | BICYCLIC TRIAZOLE AND PYRAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to bicyclic triazole and pyrazole lactams, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 09-06-2012 |
20120225845 | COMPOUNDS FOR DISEASES AND DISORDERS - The invention provides novel compounds useful for the treatment of disorders associated with a defect in vesicular transport (e.g., axonal transport). The compounds have a substituents chosen from -L-C(═O)OH, -L-CH═CHC(═O)OH, -L-C(═O)NH | 09-06-2012 |
20120232033 | AMINES OR AMINO ALCOHOLS AS GLYT1 INHIBITORS - The invention relates to the use of compounds of formula I | 09-13-2012 |
20120238526 | ACONITINE COMPOUNDS, COMPOSITIONS, USES, AND PREPARATION THEREOF - Compound derivatives of aconitine are provided, in particular derivatives that modulate the activity of sodium channels. Also provided are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier. The subject compounds are useful in treatments, including treatments to modulate neuronal activity or to bring about muscular relaxation. The compounds also find use in the treatment of subjects suffering from a voltage-gated sodium channel-enhanced ailment or from pain. Further methods are provided for the preparation of the aconitine derivatives. | 09-20-2012 |
20120245124 | TRPV3 Modulators - Disclosed herein are modulators of TRPV3 of formula (I) | 09-27-2012 |
20120245125 | PYRIDAZINE COMPOUNDS, COMPOSITIONS AND METHODS - The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for, research, drug screening, and therapeutic applications. | 09-27-2012 |
20120252757 | ORGANOPOLYSILOXANE AND COSMETIC CONTAINING IT - The invention provides an organopolysiloxane shown by the following formula (1); | 10-04-2012 |
20120252758 | Novel Bicyclic Pyridinones - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I | 10-04-2012 |
20120252759 | THIAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER - Compounds of the formula Ia and Ib, in which R | 10-04-2012 |
20120252760 | NOVEL PYRIDOPYRAZINES AND THEIR USE AS MODULATORS OF KINASES - The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general formulae (I) and (II), and to their preparation and use as medicaments, especially for the treatment of malignant disorders and other disorders based on pathological cell proliferations. | 10-04-2012 |
20120264713 | USE OF DOCOSATRIENES, RESOLVINS, AND THEIR STABLE ANALOGS IN THE TREATMENT OF AIRWAY DISEASES AND ASTHMA - The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification. | 10-18-2012 |
20120270838 | SPIROIMIDAZOLONE DERIVATIVE - The present invention relates to a compound represented by the following formula (1): | 10-25-2012 |
20120270839 | COMPOSITIONS AND METHODS FOR CANCER TREATMENT - Bromoacetoxycalcidiol (B3CD), which is structurally related to calcidiol, exhibits cytotoxic and apoptotic activity toward cancer cells, including highly aggressive neuroblastoma cells. A series of small molecules designed around the structure of B3CD is expected to have growth inhibitory and apoptogenic activities toward a wide range of malignancies. B3CD shows no apparent toxicity in vivo, indicating potential value as a chemotherapeutic agent which will be particularly useful in treating highly aggressive tumors. | 10-25-2012 |
20120277185 | Pesticidal Carboxamides - To provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Carboxamides represented by the following Formula (I) and use thereof as pesticides and an animal parasite control agent: | 11-01-2012 |
20120277186 | Tricyclic Derivatives and Their Pharmaceutical Use and Compositions - This application relates to tricyclic compounds of Formula I: | 11-01-2012 |
20120283216 | FUNGICIDAL 2-(BICYCLIC ARYLOXY)CARBOXAMIDES - Disclosed are compounds of Formula 1, N-oxides, and salts thereof, | 11-08-2012 |
20120283217 | MODULATORS OF AMYLOID-BETA PRODUCTION - As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease. | 11-08-2012 |
20120302523 | ENDOPEROXIDES AND METHODS OF PHOTOCATALYTICALLY SYNTHESIZING ENDOPEROXIDES - A method of making an endoperoxide from a diene and oxygen in the presence of a photocatalyst having an excited state lifetime of at least 100 nanoseconds, the endoperoxide being represented by the formula: | 11-29-2012 |
20120302524 | 1,3,4-OXADIAZOLE-2-CARBOXAMIDE COMPOUND - Provided is a 1,3,4-oxadiazole-2-carboxamide compound which has STAT3 inhibitory activity and is useful as an anticancer agent. Provided is a 1,3,4-oxadiazole-2-carboxamide compound represented by formula (I) or a pharmacologically acceptable salt thereof (in the formula, Ar represents a furyl group or the like; R | 11-29-2012 |
20120309713 | N-Cyclopropyl-(20R)-2-Methylene-19,26,27-Trinor-25-Aza-Vitamin D Analogs and Their Uses - This invention discloses N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs, and specifically N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-1α-hydroxyvitamin D | 12-06-2012 |
20120309714 | Heteroaromatic Phenylimidazole derivatives as PDE10A enzyme inhibitors - This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. | 12-06-2012 |
20120309715 | Use of Simethicone in Constipated Patients - Methods of treatment and kits using simethicone and another medicament, in a combined form, or separately or separately and sequentially wherein the sequential administration is close in time, as a medication for the treatment of constipated persons suffering from bloated feeling and gas discomfort during the night. | 12-06-2012 |
20120322761 | HETEROCYCLIC CETP INHIBITORS - Compounds of formula Ia and Ib | 12-20-2012 |
20130005686 | 2-Methylene-(22E)-25-Hexanoyl-24-OXO-26,27-Cyclo-22-Dehydro-19-Nor-Vitamin D Analogs - This invention discloses 2-methylene-(22E)-25-hexanoyl-24-oxo-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-(22E)-25-hexanoyl-24-oxo-26,27-cyclo-22-dehydro-19-nor-1α-hydroxyvitamin D | 01-03-2013 |
20130005687 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 - Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease. | 01-03-2013 |
20130012476 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS - The invention relates to compounds of formula (I) | 01-10-2013 |
20130018016 | Agent for Combating Ectoparasites - Disclosed is a composition for killing ectoparasites and/or their eggs, comprising at least one volatile, at room temperature liquid, non-polar organic solvent, 1 to 10 wt.-%, based on the total composition, of at least one spreading agent; and 35 to 65 wt.-%, based on the total composition, of at least one polysiloxane having a viscosity of greater than 90 cSt. | 01-17-2013 |
20130018017 | QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS - The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) | 01-17-2013 |
20130035310 | Piperidine and Piperazine Phenyl Sulfonamides as Modulators of Ion Channels - The present invention relates to piperidine and piperazine phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain. | 02-07-2013 |
20130045948 | AZOCYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE - Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, | 02-21-2013 |
20130053341 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE - Methods of treating disorders using compounds that modulate striatal-enriched tyrosine phosphatase (STEP) are de-scribed herein. Exemplary disorders include schizophrenia and cognitive deficit. | 02-28-2013 |
20130053342 | HYDROXYLATED AMIDE SKIN MOISTURIZER - The invention relates to the cosmetic use, as a skin moisturizer, of a compound of formula (I): | 02-28-2013 |
20130059818 | CARBOSILANE DENDRIMERS AND THE USE THEREOF AS ANTIVIRAL AGENTS - Highly branched macromolecules synthesized from a polyfunctional core, preferably silicon, or polyphenolic, with a carbosilane structure at its periphery functionalized with groups, preferably anionic, giving to the macromolecule a net negative charge. Furthermore, the invention relates to the procedures for their synthesis and their uses as antiviral agents, antibacterial and antifungal agents. | 03-07-2013 |
20130065854 | PLANT DISEASE CONTROL COMPOSITION AND ITS USE - A composition comprising a carboxamide compound represented by following formula (I), wherein R | 03-14-2013 |
20130065855 | FUNGICIDE N-[(TRISUBSTITUTEDSILYL)METHYL]-CARBOXAMIDE DERIVATIVES - The present invention relates to fungicidal N-[(trisubstitutedsilyl)methyl]carboxamide or its thiocarboxamide derivative, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions. | 03-14-2013 |
20130072455 | Methods and Compositions for Treating Ectoparasite Infestation - Compositions and methods for killing ectoparasites on a subject. Compositions containing a fatty acid ester, e.g., isopropyl myristate, effective for killing ectoparasites is described. Also described are compositions containing a fatty acid ester and a siloxane (e.g., decacyclomethicone). The compositions can also contain a mectin and/or a mycin, and S-methoprene. The compositions are useful against a variety of ectoparasites that afflict humans, animals, and plants, e.g., head lice, fleas, body lice, crab lice, scabies, ticks, and plant parasites. | 03-21-2013 |
20130072456 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS - The present invention relates to substituted bicyclic tetrahydropyrrole compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals. | 03-21-2013 |
20130079302 | N-[(HET)ARYLALKYL)] PYRAZOLE(THIO)CARBOXAMIDES AND THEIR HETEROSUBSTITUTED ANALOGUES - The present invention relates to fungicidal N-[(het)arylalkyl)]pyrazolecarboxamide or thiocarboxamide and their heterosubstituted analogues, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions. | 03-28-2013 |
20130085119 | AGENT FOR THE TREATMENT OF SKIN CONDITIONS - Disclosed are methods of treatment and compositions containing at least one non-volatile silicone oil in combination with at least one spreading agent for use in the treatment of skin conditions in mammals typified by scales, plaques and scabs and associated with punctiform bleeding during the removal of scales, plaque or scabs. Preferred conditions are selected from the group consisting of seborrheic dermatitis, psoriasis, and cradle cap wherein the incidence of punctiform bleeding and formation of bloody tear points on the skin during removal of the scales is diminished or prevented. | 04-04-2013 |
20130096083 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME - The use of isoquinolones for preparing drugs, including novel isoquinolones as well as their synthesis method. In particular, isoquinolone derivatives used in the treatment of pathological angiogenesis, and more particularly of cancer. | 04-18-2013 |
20130096084 | NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHBITORS - The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same. | 04-18-2013 |
20130102567 | 3-Desoxy-2-Methylene-Vitamin D Analogs and Their Uses - This invention discloses 3-desoxy-2-methylene-vitamin D analogs, and specifically (20S)-3-desoxy-1α,25-dihydroxy-2-methylene-vitamin D | 04-25-2013 |
20130102568 | ALKOXYIMINO DERIVATIVE AND PEST CONTROL AGENT - [PROBLEMS] The present invention provides a novel alkoxyimino derivative or a salt thereof, as well as to a pest control agent containing the derivative or salt thereof as an active ingredient, which shows an excellent pest control effect on a wide range of pests in the agricultural and horticultural field and is also capable of controlling resistant pests. | 04-25-2013 |
20130109652 | NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | 05-02-2013 |
20130109653 | Substituted Pyridine Compound | 05-02-2013 |
20130131015 | SYNTHESIS AND REGIOSELECTIVE SUBSTITUTION OF 6-HALO- AND 6-ALKOXY NICOTINE DERIVATIVES - The present invention provides active compounds for modulating nicotinic acetylcholine receptors and methods of making the same. The methods of preparing the active compounds utilize different intermediate compounds. | 05-23-2013 |
20130137658 | PLANT DISEASE CONTROLLING COMPOSITION AND USE THEREOF - A plant disease controlling composition is provided containing a pyridazine compound represented by formula (I): | 05-30-2013 |
20130143841 | BENZOHETEROCYCLIC ANTI-BACTERIAL AGENTS - Embodiments herein provide compounds and methods of making and using such compounds for prevention and treatment of multidrug resistant bacteria. In particular, embodiments are directed to anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria. | 06-06-2013 |
20130150325 | 3-(Fluorovinyl)pyrazoles and their use - The present application relates to novel 3-(fluorovinyl)pyrazole derivatives, to processes for their preparation, to their use for treatment and/or prevention of diseases and to their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures. | 06-13-2013 |
20130157976 | NOVEL PYRIDOPYRAZINES AND THEIR USE AS MODULATORS OF KINASES - The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general formulae (I) and (II), and to their preparation and use as medicaments, especially for the treatment of malignant disorders and other disorders based on pathological cell proliferations. | 06-20-2013 |
20130165408 | PHENYL CARBAMATE COMPOUNDS FOR USE IN PREVENTING OR TREATING EPILESY - A method for treatment or prevention epilepsy comprising administering a phenyl carbamate compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of epilepsy is provided. | 06-27-2013 |
20130165409 | PHENYL CARBAMATE COMPOUNDS FOR USE IN ALLEVIATING OR TREATING PAIN - A phenyl carbamate compound; a composition for treating and/or alleviating pain containing the phenyl carbamate compound or a pharmaceutically acceptable salt thereof as an active ingredient; a method of treating and/or alleviating pain comprising administering the phenyl carbamate compound or a pharmaceutically acceptable salt thereof to a patient in need of pain treatment; and a use of the phenyl carbamate compound or a pharmaceutically acceptable salt thereof in treating and/or alleviating pain, are provided. | 06-27-2013 |
20130165410 | PHENYL CARBAMATE COMPOUNDS FOR USE IN PREVENTING OR TREATING STROKE - A phenyl carbamate compound; a composition for treating and/or preventing stroke containing the phenyl carbamate compound or a pharmaceutically acceptable salt thereof as an active ingredient; a method of treating and/or preventing stroke comprising administering the phenyl carbamate compound or a pharmaceutically acceptable salt thereof to a patient in need of stroke treatment; and a use of the phenyl carbamate compound or a pharmaceutically acceptable salt thereof in treating and/or preventing stroke, are provided. | 06-27-2013 |
20130172292 | FUSED HETEROCYCLIC COMPOUNDS - The present invention provides a compound which has the effect of PDE 10A inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound represented by the formula (1′): wherein, Ring A′ represents an optionally substituted pyridine ring, an optionally substituted pyridazine ring, a pyrimidine ring, or 10 a pyrazine ring, R1′ represents (1) wherein, R | 07-04-2013 |
20130184238 | AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY - The present invention relates to aminotetraline derivatives of the formula (I) | 07-18-2013 |
20130184239 | COMBINATION OF SILOXANE AND ACTIVE INGREDIENT FOR TREATING DENTAL DISORDER - The invention relates to a pharmaceutical composition comprising a siloxane according to general formula (I)< | 07-18-2013 |
20130190271 | FUSED HETEROCYCLIC COMPOUNDS AND USES THEREOF - Disclosed is a harmful arthropod control composition comprising, as an active ingredient, a fused heterocyclic compound represented by formula (1) [wherein A | 07-25-2013 |
20130190272 | PEST CONTROLLING COMPOSITION AND METHOD FOR CONTROLLING PEST - The present invention provides a composition having an excellent controlling activity on a pest. The composition comprising a compound represented by Formula (1) and one or more pyrethroid compound(s) selected from Group (A) shows an excellent controlling activity on a pest. Group (A): a group consisting of acrinathrin, bifenthrin, cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lamda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, deltamethrin, etofenprox, fenpropathrin, fenvalerate, esfenvalerate, flucythrinate, fluvalinate, tau-fluvalinate, halfenprox, permethrin, protrifenbute, silafluofen, tefluthrin and tralomethrin | 07-25-2013 |
20130196950 | RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF - Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided. | 08-01-2013 |
20130196951 | USE OF NITRIC OXIDE TO ENHANCE THE EFFICACY OF SILVER AND OTHER TOPICAL WOUND CARE AGENTS - The present invention is directed to compositions comprising at least one nitric oxide donor and at least one second therapeutically active agent with antimicrobial or wound healing capability. In one embodiment, the nitric oxide donor is a nanoparticle which is designed to control for the amount and duration of release of nitric oxide. The nanoparticle may further comprise the additional therapeutically active agent. The composition is useful for enhancing wound healing and for treating and preventing microbial infection. In one embodiment, the composition is directed toward reducing oral bacteria or dental plaque. The combination of one or more nitric oxide donors and one or more additional therapeutically active agent results in unexpected synergistic effects, wherein both the antimicrobial efficacy of the nitric oxide and the antimicrobial or wound healing efficacy of the second therapeutically active agent are enhanced. As a result, a patient may benefit from reduced dosage requirements and a reduced likelihood of antimicrobial resistance. The composition may be formulated for local or systemic administration, for topical applications as well as for use in coatings for medical supplies and devices. | 08-01-2013 |
20130210767 | BIOCIDAL COMPOSITION AND METHOD - An aqueous biocidal composition comprising: (a) a compound of formula (II): or a derivative salt thereof wherein L is a linking group; each of R | 08-15-2013 |
20130210768 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 - The present invention is directed to 5-substituted 1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-one derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia. | 08-15-2013 |
20130210769 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY - The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1). | 08-15-2013 |
20130217650 | SUBSTITUTED 3-(5-MEMBERED UNSATURATED HETEROCYCLYL-1, 3-DIHYDRO-INDOL-2-ONE'S AND DERIVATIVES THEREOF AS KINASE INHIBITORS - The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. | 08-22-2013 |
20130231303 | 5-HALOGENOPYRAZOLE(THIO)CARBOXAMIDES - The present invention relates to novel 5-halogenopyrazole(thio)carboxamides, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. | 09-05-2013 |
20130237499 | Inhibitors of Human Immunodeficiency Virus Replication - The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection. | 09-12-2013 |
20130237500 | N-ARYL PYRAZOLE(THIO)CARBOXAMIDES - The present invention relates to novel (thio)carboxamides, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. | 09-12-2013 |
20130252922 | SUBSTITUTED PHENOXYPYRIDINES - The present invention relates to substituted phenoxypyridine compounds of general formula (I) in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients. | 09-26-2013 |
20130261081 | HETEROCYCLIC COMPOUNDS FOR TREATING OR PREVENTING DISORDERS CAUSED BY REDUCED NEUROTRANSMISSION OF SEROTONIN, NOREPHNEPHRINE OR DOPAMINE - A heterocyclic compound represented by the general formula (1) or a salt thereof: | 10-03-2013 |
20130274226 | SILICA NANOPARTICLE AGENT CONJUGATES - The invention provide a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises, for example, an ester, urea, thiourea, or thio ether group, and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm. The invention also provides novel methods of making and using the silica nanoparticles described herein. | 10-17-2013 |
20130281402 | HDAC INHIBITING DERIVATIVES OF CAMPTOTHECIN - The disclosure includes hydroxamic compounds of Formula I: (Formula I) wherein Z, L, R | 10-24-2013 |
20130296269 | 5-Halogenopyrazolecarboxamides - The present invention relates to novel 5-halogenopyrazole(thio)carboxamides, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. | 11-07-2013 |
20130296270 | METHOD FOR INHIBITING MICROORGANISMS OR PLANT PESTS USING EXFOLIATED CLAY/SURFACTANT COMPLEX - The present invention provides a method for inhibiting microorganisms or plant pests using exfoliated clay/surfactant complex. The weight ratio of the exfoliated clay to the surfactant can range from 99/1 to 1/99. Preferably, the exfoliated clay is an inorganic layered clay on a nano scale and the surfactant is cationic, nonionic, anionic or amphoteric. | 11-07-2013 |
20130296271 | Agri-Horticultural Pest Control Compositions Comprising 4-(3-Butynyl)Aminopyrimidine Derivatives - Agri-horticultural pest control compositions having outstanding control effect on pests, in particular, agri-horticultural pests, which comprise as active ingredients one or more 4-(3-butynyl)aminopyrimidine derivatives represented by the general formula [I], namely, | 11-07-2013 |
20130296272 | HETEROARYLPIPERIDINE AND -PIPERAZINE DERIVATIVES AS FUNGICIDES - Heteroarylpiperidine and -piperazine derivatives of the formula (I) | 11-07-2013 |
20130303483 | COSMETIC - A cosmetic comprising the following components (A), (B), (C) and (D):
| 11-14-2013 |
20130338104 | 3-Substituted-4-Oxo-3,4-Dihydro-Imidazo[5,1-d]1,2,3,5-Tetrazine-8-Carboxyl- ic Acid Amides and Their Use - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide (collectively referred to herein as 3TM compounds). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative disorders such as cancer, etc., and methods of preparing such compounds. | 12-19-2013 |
20130338105 | IMINIPYRIDINE DERIVATIVES AND THEIR USES AS MICROBIOCIDES - Compounds of the formula I | 12-19-2013 |
20130338106 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY - Disclosed are compounds of Formula I: and the pharmaceutically acceptable salts thereof, wherein “A” is S—; —SO—, —SO | 12-19-2013 |
20130345170 | Ear Pieces Having an Antimicrobial Treatment - A hearing aid, ear bud, ear plug, and hands-free headset are provided that may include one or more surfaces coated with an antimicrobial treatment, which may include a silane quaternary ammonium salt and isopropyl alcohol. The silane quaternary ammonium salt may include an unreacted organofunctional silane to promote bonding to the surfaces of the ear piece, such as 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride. Methods are also provided for coating, or otherwise integrating the antimicrobial treatment on or within a hearing aid, ear bud, ear plug, and hands-free headset. | 12-26-2013 |
20130345171 | TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASE AND THROMBOSIS - Provided herein are compositions for the treatment and/or prevention of cardiovascular disease (CVD), and methods of application and use thereof. In particular, the present invention provides treatment and/or prevention of cardiovascular disease with compounds that inhibit the production of TMA in the gut, such as 3,3-dimethyl-1-butanol (DMB) or other compounds represented by Formula I or as shown in FIGS. | 12-26-2013 |
20140005143 | Substituted PyridineCompound | 01-02-2014 |
20140024616 | 5-FLUORO PYRIMIDINE DERIVATIVES - This present disclosure is related to the field of 5-fluoro pyrimidines and their derivatives and to the use of these compounds as fungicides. | 01-23-2014 |
20140024617 | TREATMENT OF CANCER WITH COMPLEX ORGANIC-INORGANIC PIGMENT COMPOSITIONS - The present invention includes compositions and methods for treating disorders of the skin or mucosa resulting from cancer therapies comprising: identifying a patient receiving cancer treatment; and administering to said patient an effective dose of a treated organic/inorganic complex material with an organic dye molecule or derivative thereof, in a pharmaceutically acceptable carrier. | 01-23-2014 |
20140031317 | NOVEL 2-SUBSTITUTED BENZIMIDAZOLES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) - The present invention is directed to a novel 2-substituted benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. | 01-30-2014 |
20140045789 | PROCESS FOR THE PREPARATION OF C-FMS KINASE INHIBITORS - The present invention is directed to a process for the preparation of heterocyclic derivatives of formula I | 02-13-2014 |
20140045790 | Novel Bicyclic Pyridinones - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I | 02-13-2014 |
20140051660 | CYCLOPENTYLPYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS - Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: | 02-20-2014 |
20140057870 | BICYCLIC TRIAZOLE AND PYRAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to bicyclic triazole and pyrazole lactams, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 02-27-2014 |
20140066404 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME - The present invention provides pyrazole derivative compounds and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of preventing and treating osteoporosis. | 03-06-2014 |
20140066405 | LIQUID INSECTICIDE COMPOSITION - A liquid insecticide composition is provided containing a neonicotinoid-based compound, a silicone-based surfactant, and a water-soluble organic solvent. Furthermore, a method is provided for enhancing an insecticidal effect which includes using a silicone-based surfactant in combination with a neonicotinoid-based compound as an insecticidal active ingredient. | 03-06-2014 |
20140107069 | PLANT TREATMENT METHOD - A plant treatment method comprising contacting the plant with: (a) a compound of formula (I): or a derivative salt thereof wherein L is a linking group; each of R | 04-17-2014 |
20140107070 | PARAFFINIC OIL-IN-WATER EMULSIONS FOR CONTROLLING INFECTION OF CROP PLANTS BY FUNGAL PATHOGENS - This disclosure features fungicidal combinations that include a paraffinic oil and an emulsifier. The combinations can further include one or more of the following: pigments, silicone surfactants, anti-settling agents, conventional fungicides such as demethylation inhibitors (DMI) and quinone outside inhibitors (Qol) and water. The fungicidal combinations are used for controlling infection of a crop plant by a fungal pathogen. | 04-17-2014 |
20140107071 | METHODS OF MANUFACTURING TOPICAL COMPOSITIONS AND APPARATUS FOR THE SAME - Provided according to some embodiments of the invention are methods of manufacturing a pharmaceutical composition. In some embodiments, such methods include homogenizing at a first excipient composition that includes a viscosity agent and at least one solvent to form a first premix composition; separately homogenizing at least one active pharmaceutical ingredient (API) and a second excipient composition to form a second premix composition; and combining the first premix composition and the second premix composition to form the composition. The pre-mixing of constituents may increase the stability of the API and provide uniformity of the dispersion of the constituents throughout the final topical composition. | 04-17-2014 |
20140121181 | HYDROPHOBIC POLYMER COMPOUND HAVING ANTICOAGULANT EFFECT - A hydrophobic polymer compound is capable of inhibiting the blood coagulation reactions in both the primary hemostasis stage involving platelets and the coagulation thrombus formation stage involving blood coagulation factors, which hydrophobic polymer compound can be firmly immobilized on the surface of a medical device or medical material in a state where the compound retains its anticoagulant activity. A hydrophobic polymer compound in which a polymer compound inhibiting platelet adhesion is bound with a compound inhibiting blood coagulation reaction. | 05-01-2014 |
20140135287 | HYPERFORIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF - The present invention provides a novel 11-step enantioselective approach to the natural product hyperforin, which enables access to a wide variety of hyperforin analogs. The present invention also provides pharmaceutical compositions comprising inventive hyperforin analogs. Hyperforin analogs synthesized using the present synthetic method are envisioned useful in the treatment of various conditions, including, but not limited to, depression and conditions characterized by depression, inflammatory skin conditions, diabetes, asthma, chronic obstructive pulmonary disease (COPD), kidney disorders, and ischemic brain damage. | 05-15-2014 |
20140148411 | FUNGICIDE PYRAZOLE CARBOXAMIDES DERIVATIVES - The present invention relates to pyrazole carboxamides derivatives of formula (1) wherein Y represents CR | 05-29-2014 |
20140148412 | NOVEL 17B-HETEROARYL-SUBSTITUTED STEROIDS AS MODULATORS OF GABAA RECEPTORS - The invention is directed to novel 17β-heteroaryl substituted steroids of Formula I, pharmaceutical compositions thereof, and their use as modulators of GABA | 05-29-2014 |
20140155350 | Prodrugs of Neuraminidase Inhibitors - A new class of neuramidase inhibitor prodrugs is provided characterized by a prodrug moiety of a carboxyl group modified to form a carbonyl ethoxy amino acid, a carbonyl ethoxy dipeptide or a carbonyl ethoxy tripeptide, a guanidine group modified to form a carbonyl ethoxy amino acid, a carbonyl ethoxy dipeptide, a carbonyl ethoxy tripeptide; a primary alcohol modified to form an esterified single amino acid, dipeptide or tripeptide of zanavimir of the unaltered therapeutic agent. Exemplary therapeutic agents so modified to form prodrugs include zanavimir, oseltamivir and peramivir. The prodrug has increased oral bioavailability relative to the unaltered neuraminidase inhibitor and is effective in the inhibition of viral infections involving neuraminidase in the viral reproductive cycle. | 06-05-2014 |
20140155351 | PROCESS FOR THE PREPARATION OF PRASUGREL AND SEVERAL NOVEL CRYSTALLINE FORMS OF PRASUGREL HYDROCHLORIDE - Disclosed herein are a process or method for the preparation of prasugrel and several novel crystalline forms of prasugrel hydrochloride. The process comprises preparation of prasugrel by acetylation in solvents which have low boiling point and/or low toxicity, and the process not only avoids using solvents which have high boiling point and/or high toxicity such as toluene, acetonitrile and so on, but also resolves the problem about thermal instability of prasugrel, and the loss of prasugrel is reduced, as well as the yield is raised. The yield of prasugrel is higher than 85% and the purity is higher than 99.5%. The process can prepare prasugrel and its pharmaceutically acceptable salts. The novel crystalline forms of prasugrel hydrochloride are crystalline form H1, H2 and H3, and their performance in oral absorbability, activating metabolism and inhibiting platelet aggregation is excellent. They have a low toxicity and good thermal stability, and are applicable to the preparation of a drug for preventing or treating diseases caused by thrombosis or embolism. | 06-05-2014 |
20140155352 | COSMETIC TREATMENT PROCESSES AND KIT - The present invention relates to a cosmetic process for treating keratin materials, which can give them, especially in a long-lasting and reversible manner, interesting cosmetic properties; this process comprising the application to said materials:
| 06-05-2014 |
20140155353 | COSMETIC COMPOSITION - Provided is a cosmetic composition which has a structure-recovering property, is transparent, is satisfactory in smoothness when applied to the skin or hair, and has a good feeling in use, which comprises components (A) to (D) as described. | 06-05-2014 |
20140162979 | CONCENTRATED LAMELLAR LIQUID PERSONAL CLEANSING COMPOSITION - The invention relates to concentrated liquid cleansing compositions in lamellar phase which possess a lotion-like appearance conveying signals of enhanced moisturization. The use of a specific ratio of synthetic anionic surfactant(s) and co-surfactant(s) to fatty acid(s) in a structured liquid product was found to improve lather production by moderating or eliminating the increase in viscosity upon dilution. In a further embodiment, specific small hydrophobic molecules were found to improve freeze/thaw stability and thereby cause the inventive composition to maintain noticeable moisturization signals. | 06-12-2014 |
20140162980 | NOVEL MICROBIOCIDAL DIOXIME ETHER DERIVATIVES - The present invention provides compounds of formula (I) wherein G | 06-12-2014 |
20140162981 | SUBSTITUTED ARYLOXAZOLES AND THEIR USE - The present application relates to novel substituted aryloxazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders. | 06-12-2014 |
20140162982 | TOPICAL COMPOSITIONS FOR USE IN THE PREVENTION AND/OR TREATMENT OF DERMATITIS - The present invention relates to the use of topical compositions containing bromociclen for the prevention and/or treatment of various types of dermatitis, in particular eczema and psoriasis. | 06-12-2014 |
20140179630 | USE OF DOCASATRIENES, RESOLVINS, AND THEIR STABLE ANALOGS IN THE TREATMENT OF AIRWAY DISEASES AND ASTHMA - The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification. | 06-26-2014 |
20140200197 | HIV PROTEASE INHIBITORS - The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. | 07-17-2014 |
20140206645 | DUAL ACTION INHIBITORS AGAINST HISTONE DEACETYLASES AND 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE - Disclosed herein are novel compounds of formula (I), and uses thereof. The compounds of Formula (I) are inhibitors of histone deacetylases (HDACs) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR). Also provided are methods of using the compounds of Formula (I) for inhibiting the activity of HDACs and HMGR, treating diseases associated with HDACs or HMGR (e.g., cancer, hypercholesterolemia, an acute or chronic inflammatory disease, autoimmune disease, allergic disease, pathogen infection, neurodegenerative disease, or a disease associated with oxidative stress, | 07-24-2014 |
20140206646 | Heteroarylpiperidine and -piperazine derivatives as fungicides - Heteroarylpiperidine and -piperazine derivatives of the formula (I) | 07-24-2014 |
20140213549 | Substituted Pyridine Compound - The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I), | 07-31-2014 |
20140213550 | SILICATE PRODRUGS AND NANOPARTICLES - The invention provides silicate prodrugs comprising a therapeutic agent linked to one or more groups of formula (I): —Si(OR) | 07-31-2014 |
20140221310 | FLAP MODULATORS - The present invention relates to compounds of Formula (I), | 08-07-2014 |
20140221311 | FLAP MODULATORS - The present invention relates to compounds of Formula (I), | 08-07-2014 |
20140235576 | PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS IGLUR ANTAGONISTS - The present invention relates to compounds of Formula (I), combinations and use thereof for disease therapy, or pharmaceutically acceptable salt or solvate thereof, including all tautomers, stereoismers and polymorphs thereof, which are iGluR receptor inhibitors, and hence are useful in the treatment of psychiatric diseases or neurological disorders or a disease or disorder associated with abnormal activities of iGluR receptors. | 08-21-2014 |
20140235577 | EXTERNAL SKIN AGENT COMPRISING MODIFIED CLAY FOR PREVENTING INFLAMMATION - To provide An external skin agent that prevents onset of atopic skin inflammations and is low irritant to skin, which is characterized by including: 1) clay modified by a compound having a quaternary amino group; and 2) a polymer or copolymer that has a side chain including a structure similar to a biological component. | 08-21-2014 |
20140243286 | BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME - Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins. | 08-28-2014 |
20140249104 | PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 09-04-2014 |
20140249105 | NOVEL CERAMIDE ANALOGUES, PROCESSES FOR PREPARING SAME AND USES THEREOF - Compounds, ceramide analogues, having a cyclic structure derived from cyclopropane, cyclobutane or cyclopentane, the ring bearing two chains consisting of an amide function. Each amide function is attached to the ring by the nitrogen atom of the function and carries a hydrocarbon chain derived from a fatty acid. The amide functions can be cis or trans relative to one another. Processes for the preparation of these novel compounds as well as pharmaceutical and/or cosmetic compositions containing them. | 09-04-2014 |
20140249106 | Pituitous Silicone Fluids - Fluid compositions are disclosed containing a branched organopolysiloxane and a carrier fluid. The branched organopolysiloxane is obtainable by reacting an organohydrogencyclosiloxane and an alkenyl terminated polydiorganosiloxane. The disclosed fluid compositions possess pituitous rheological properties. | 09-04-2014 |
20140256677 | HETEROCYCLYLPYRI (MI) DINYLPYRAZOLE AS FUNGICIDALS - Heterocyclylpyri(mi)dinylpyrazole of the formula (I) | 09-11-2014 |
20140274950 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS - Provided herein are compounds of the formula (I): | 09-18-2014 |
20140274951 | LIGAND-THERAPEUTIC AGENT CONJUGATES, SILICON-BASED LINKERS, AND METHODS FOR MAKING AND USING THEM - The present invention relates to ligand-therapeutic agent conjugate compounds, silicon linkers for the conjugate compounds, compositions, methods for making them, and methods for the treatment of cancer using the conjugate compounds. The silicon-based linkers described herein can be used to deliver desired therapeutic agents to particular cells or tissue types targeted by the ligand. | 09-18-2014 |
20140274952 | NOVEL HETEROCYCLIC ALKANOL-DERIVATIVES - The present invention relates to novel heterocyclic alkanol derivatives, to processes for these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators. | 09-18-2014 |
20140296181 | METHODS OF MODULATING ONCOGENIC FUSION PROTEINS - Described herein, at least in part, are methods of modulating oncogenic fusion proteins. | 10-02-2014 |
20140296182 | METHOD AND COMPOSITION FOR TREATING LICE INFESTATION - Methods and compositions for the treatment of pediculosis comprising: between 1 and 20% (w/w) isopropyl myristate; between 1 and 20% (w/w) silicone oil; and at least 20% (w/w) water. Methods and compositions for dissolving nit glue comprising at least three components selected from the group consisting of benzyl alcohol, diacetone alcohol, acetic acid, and triethyl citrate | 10-02-2014 |
20140296183 | AMINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES - A novel amine compound represented by the following formula (I), which is superior in immunosuppressive action, rejection suppressive action and the like, and shows reduced side effects such as bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or hydrates thereof, or solvate, as well as a pharmaceutical composition containing this compound and a pharmaceutically acceptable carrier. | 10-02-2014 |
20140296184 | SILYLATED AZULENYL NITRONE SPIN TRAPS AS CHROMOTROPIC SUPEROXIDE DETECTORS - Silylated nitrones and methods of detecting and/or superoxide using silylated nitrones are disclosed herein. | 10-02-2014 |
20140309190 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS - Compounds that have agonist activity at one or more of the S | 10-16-2014 |
20140315856 | AMINOPYRAZOLE DERIVATIVE - A method for treating cancer that includes administering a pharmaceutically effective amount of a composition containing a compound represented by formula (I) or a pharmacologically acceptable salt thereof. In the formula, A represents a 5- to 10-membered heteroaryl group, or a C | 10-23-2014 |
20140315857 | N- (4 -QUINOLINYLMETHYL) SULFONAMIDE DERIVATIVES AND THEIR USE AS ANTHELMINTICS - Disclosed are compounds of Formula 1, N-oxides, and salts thereof, | 10-23-2014 |
20140315858 | FUNGICIDE N-[(TRISUBSTITUTEDSILYL)METHYL]-CARBOXAMIDE DERIVATIVES - The present invention relates to fungicidal N-[(trisubstitutedsilyl)methyl]carboxamide or its thiocarboxamide derivative, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions. | 10-23-2014 |
20140323435 | Thienopyrimidine Inhibitors of Atypical Protein Kinase C - The present application provides a compound of formula (I) | 10-30-2014 |
20140323436 | SUBSTITUTED BENZENE FUNGICIDES - Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, | 10-30-2014 |
20140323437 | Use of Metallocene Compounds for Cancer Treatment - Metallocene compounds and pharmaceutical compositions containing these metallocene compounds are disclosed and described. Methods of treating cancer employing such metallocene compounds and pharmaceutical compositions also are provided. | 10-30-2014 |
20140323438 | COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS - The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R | 10-30-2014 |
20140336150 | Administration of Karenitecin for the Treatment of Platinum and/or Taxane Chemotherapy-Resistant or -Refractory Advanced Ovarian Cancer - The present invention discloses and claims methods and compositions for the treatment of subjects having advanced ovarian cancer, including platinum and/or taxane chemotherapy resistant or refractory sub-populations, with the administration to the subject having advanced ovarian cancer of the silicon-containing highly lipophilic camptothecin derivative (HLCD), Karenitecin (also known as BNP1350; cositecan; 7-[(2′-trimethylsilyl)ethyl]-20(S) camptothecin) in an amount sufficient to provide a therapeutic benefit. The administration of Karenitecin by intravenous (i.v.) and/or oral methodologies are also disclosed and claimed. Methods for the administration of Karenitecin to increase Progression Free Survival (PFS) are also disclosed and claimed herein. | 11-13-2014 |
20140336151 | Silicon-Containing Fumaric Acid Esters - The present invention is directed to silicon-containing fumaric acid esters of the Formulae I-IV. The silicon-containing fumaric acid esters of Formulae I-IV are useful in transplantation medicine and for the treatment of autoimmune diseases and autoimmune-related diseases. (I), (II), (III) & (IV) | 11-13-2014 |
20140336152 | COMPOSITION FOR WET WIPES THAT ENHANCES THE EFFICACY OF CLEANSING WHILE BEING GENTLE TO THE SKIN - The present invention describes an oil-in-water emulsion composition for wet-wipes delivering an improved body cleansing performance while providing a gentle and smooth feeling to the user. | 11-13-2014 |
20140343015 | MORPHINAN DERIVATIVE - A morphinan derivative represented by the following general formula (I) | 11-20-2014 |
20140343016 | COSMETIC COMPOSITION COMPRISING A MODIFIED ALPHA-ALKOXYSILANE - The invention relates to a cosmetic composition, in particular a composition for making up and/or caring for keratin materials, preferably a nail makeup, comprising the compound of chemical formula (I) below: (I) in which: a and b independently represent an integer between 0 and 20; R1, R2, R11 and R12 independently represent an ethoxy group, a group (C | 11-20-2014 |
20140343017 | PYRROLE COMPOUND - Provided is a highly safe and effective compound represented by the following general formula (1) or a salt thereof which acts on tubulin and has an anticancer effect, wherein Ar represents an aryl group or a heteroaryl group; Z | 11-20-2014 |
20140364393 | SUBSTITUTED PIPERIDINYL-CARBOXAMIDE DERIVATIVES USEFUL AS SCD 1 INHIBITORS - The present invention is directed to novel piperidinyl-carboxamide derivatives, pharmaceutical compositions containing them and their use as inhibitors of SCD1, useful in the treatment of obesity, type-II diabetes and other related metabolic disorders. | 12-11-2014 |
20140364394 | Novel Liquid Organopolysiloxane And Uses Thereof - A liquid organopolysiloxane having fluidity at least 100° C., a silicon-bonded glycerin derivative group, and a crosslinked structure comprising a carbon-silicon bond at the crosslinking portion. | 12-11-2014 |
20140364395 | Pyranyl Aryl Methyl Benzoquinolinone M1 Receptor Positive Allosteric Modulators - The present invention is directed to pyranyl aryl methyl benzoquinazolinone compounds of formula (I) | 12-11-2014 |
20140371174 | Effervescent Dosage Form - An effervescent chewable dosage form that comprises a pH neutralization agent, an acid, and an effervescent agent. The chewable dosage form can also further comprise simethicone, a sweetener, and a lubricant. The pH neutralization agent can be calcium carbonate, the acid can be citric acid and the effervescent agent can be sodium bicarbonate. | 12-18-2014 |
20140378416 | SILYL-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES - The present invention relates to novel Silyl-Containing Heterocyclic Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, D, E, F and L are as defined herein. The present invention also relates to compositions comprising at least one Silyl-Containing Heterocyclic Compound, and methods of using the Silyl-Containing Heterocyclic Compounds for treating or preventing HCV infection in a patient. | 12-25-2014 |
20150018308 | Preparation of Triple Responsive Nanogel System and its Application - A thermal triple-responsive polymer, along with methods of its formation and use, is generally provided. The thermal triple-responsive polymer can comprise poly[(2-(pyridin-2-yldisulfanyl)-co-[poly(ethylene glycol)]-co-[N-isopropyl methacrylamide], which contains both disulfide bonds and ester bonds that are labile to high redox potential and acidic pH, respectively, and temperature sensitive segments. The thermal triple-responsive polymer can be modified with 4-methoxybenzoic acid to endow tumor targeting effect. Nanoparticles and nanogels that include such a thermal triple-responsive polymer are also provided, along with their methods of formation and use. | 01-15-2015 |
20150018309 | SUBSTITUTED 5-AMINOTHIENO[2,3-C]PYRIDAZINE-6-CARBOXAMIDE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 - In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M | 01-15-2015 |
20150018310 | SUBSTITUTED 3-(5-MEMBERED UNSATURATED HETEROCYCLYL-1, 3-DIHYDRO-INDOL-2-ONE'S AND DERIVATIVES THEREOF AS KINASE INHIBITORS - The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. | 01-15-2015 |
20150038460 | 6,5-Heterocyclic Propargylic Alcohol Compounds and Uses Therefor - The invention relates to novel compounds of Formula I: | 02-05-2015 |
20150051170 | EXTERNAL SKIN AGENT COMPRISING MODIFIED CLAY FOR PREVENTING INFLAMMATION - To provide an external skin agent that prevents onset of atopic skin inflammations and is low irritant to skin, which is characterized by including: 1) clay modified by a compound having a quaternary amino group; and 2) a polymer or copolymer that has a side chain including a structure similar to a biological component. | 02-19-2015 |
20150051171 | TETRAZOLINONE COMPOUNDS AND ITS USE AS PESTICIDES - The present invention provides a compound having an excellent efficacy for controlling pests. A tetrazolinone compound of a formula (1): [wherein R1 represents an C6-C16 aryl group, an C1-C12 alkyl group, or a C3-C12 cycloalkyl group, etc., which each optionally be substituted; R2, R3, R4 and R5 represent independently of each other a hydrogen atom, a halogen atom or an C1-C3 alkyl group, etc.; R6 represents an C1-C6 alkyl group, a C3-C6 cycloalkyl group, a halogen atom, a C1-C6 haloalkyl group, an C2-C6 alkenyl group, an C1-C6 alkoxy group, or a C1-C6 haloalkoxy group, etc.; R7, R8 and R9 represent independently of each other a hydrogen atom, a halogen atom, or an C1-C4 alkyl group, etc.; X represents an oxygen atom or a sulfur atom; and R10 represents an C1-C6 alkyl group, etc.] shows an excellent controlling efficacy on pests. | 02-19-2015 |
20150057246 | SILYL-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES - The present invention relates to novel Silyl-Containing Heterocyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, B, C, D and R | 02-26-2015 |
20150057247 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS - Provided herein are compounds of the formula (I): | 02-26-2015 |
20150072955 | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES - The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis. | 03-12-2015 |
20150080337 | N-CYCLOALKYL-N-[(TRISUBSTITUTEDSILYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES - The present invention relates to fungicidal N-cycloalkyl-N-[(trisubstitutedsilylphenyl)methylene]carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions. | 03-19-2015 |
20150080338 | COSMETIC COMPOSITION COMPRISING A SILANE AND A LIPOPHILIC THICKENER - The present invention relates to a composition comprising at least one lipophilic thickener and at least one silane corresponding to formula (I) below and/or oligomers thereof: R | 03-19-2015 |
20150087617 | INDOLE, INDOLINE DERIVATIVES, COMPOSITIONS COMPRISING THEM AND USES THEREOF - The invention provides indole and indoline derivatives and slats thereof, compositions comprising them and uses thereof for the treatment of diseases and disorders. | 03-26-2015 |
20150087618 | Anti-Viral Compounds - Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. | 03-26-2015 |
20150094281 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES - The invention relates to macrocyclic picolinamides of Formula I and their use as fungicides. | 04-02-2015 |
20150099719 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS - This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis. | 04-09-2015 |
20150099720 | ANDROGEN RECEPTOR MODULATOR COMPOUNDS AND METHODS - Provided herein are compounds having a structure selected from among Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and Formula (VI) that are androgen receptor modulators and/or androgen receptor binding agents. Also disclosed are methods of making and using such compounds, including, but not limited to, using such compounds for treating various conditions. | 04-09-2015 |
20150105347 | Shape-Changing Droplet - Shape-changing droplets, compositions comprising shape-changing droplets, methods of depositing benefit agents onto substrates using shape-changing droplets, and methods of making shape-changing droplets. | 04-16-2015 |
20150111851 | 5-FLUOROPYRIMIDINONE DERIVATIVES - This present disclosure is related to the field of 5-fluoropyrimidinones and their derivatives and to the use of these compounds as fungicides. | 04-23-2015 |
20150119361 | Active Compound Combinations - The invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a compound of formula (I) and at least one farther respiratory chain complex in inhibitor (B). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed. | 04-30-2015 |
20150126474 | BROAD SPECTRUM PRO-QUORUM-SENSING MOLECULES AS INHIBITORS OF VIRULENCE IN VIBRIOS - Using a whole-cell high-throughput screen, eleven molecules were identified that activate | 05-07-2015 |
20150126475 | PESTICIDAL COMPOSITION AND METHOD FOR CONTROLLING PESTS - To provide a pesticidal composition having a broad pesticidal spectrum, having high activity and having a long lasting effect. | 05-07-2015 |
20150126476 | TOPICAL COMPOSITIONS FOR USE IN THE PREVENTION AND/OR TREATMENT OF DERMATITIS - The present invention relates to the use of topical compositions containing bromociclen for the prevention and/or treatment of various types of dermatitis, in particular eczema and psoriasis. | 05-07-2015 |
20150133400 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses. | 05-14-2015 |
20150141372 | SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF CANCER - Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death. | 05-21-2015 |
20150291632 | METALLOENZYME INHIBITOR COMPOUNDS AS FUNGICIDES - The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes. | 10-15-2015 |
20150306118 | EXTERNAL SKIN AGENT COMPRISING MODIFIED CLAY FOR PREVENTING INFLAMMATION - To provide an external skin agent that prevents onset of atopic skin inflammations and is low irritant to skin, which is characterized by including: 1) clay modified by a compound having a quaternary amino group; and 2) a polymer or copolymer that has a side chain including a structure similar to a biological component. | 10-29-2015 |
20150335023 | SUBSTITUTED BENZENE FUNGICIDES - Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, | 11-26-2015 |
20150342972 | ANTITUMORAL COMPOUNDS - A compound of general formula (I) wherein A, Y, R | 12-03-2015 |
20150344454 | ANTITUMORAL COMPOUNDS - A compound of general formula (I) wherein A, Y, R | 12-03-2015 |
20150353471 | XANTHINE OXIDASE INHIBITORS AND METHODS OF USE - Small molecule xanthine oxidase inhibitors are provided, as well as compositions, methods for their use for treating disorders, mediated at least in part, by xanthine oxidase. | 12-10-2015 |
20150359223 | COMPOSITION AND METHOD FOR CONTROLLING PESTS - The present invention provides a composition for controlling pests comprising a compound represented by the formula (1): | 12-17-2015 |
20150361029 | S1P MODULATING AGENTS - Compounds of formula (I) can modulate the activity of one or more S 1P receptors. Sphingosine 1-phosphate (S IP) is a lysophospholipid mediator that evokes a variety of cellular responses by stimulation of five members of the endothelial cell differentiation gene (EDG) receptor family, namely S1P1, S1P2, S1P3, S1P4, and S1P5 (formerly EDG1, EDG5, EDG3, EDG6 and EDG8). The EDG receptors are G-protein coupled receptors (GPCRs) and on stimulation propagate second messenger signals via activation of heterotrimeric G-protein alpha (Ga.) subunits and beta-gamma (G( )y) dimers. | 12-17-2015 |
20150366968 | PSMA LIGANDS AND USES THEREOF - Compounds that are PSMA ligands, pharmaceutical compositions comprising these compounds, methods for treating and detecting cancers in a subject, methods for identifying cancer cells in a sample are described herein. Prostate-specific membrane antigen (PSMA) is a 120 kDa protein expressed in prostate tissues and was originally identified by reactivity with a monoclonal antibody designated 7EII-C5 (Horoszewicz et al., 1987, Anticancer Res. 7:927-935; U.S. Pat. No. 5,162,504). PSMA is characterized as a type II transmembrane protein sharing sequence identity with the transferrin receptor (Israeli et al., 1994, Cancer Res. 54:1807-1811). | 12-24-2015 |
20150376212 | FLAP MODULATORS - The present invention relates to compounds of Formula (I), or a form thereof wherein ring A | 12-31-2015 |
20160002169 | HETEROCYCLIC COMPOUND - The present invention provides a heterocyclic compound having a RORγt inhibitory action. | 01-07-2016 |
20160009756 | Commands and method of treating cancer via RHO pathway | 01-14-2016 |
20160038390 | TOPICAL COMPOSITIONS - Provided herein are anhydrous compositions that include at least one viscosity increasing agent, at least one organic solvent and at least one humectant. Such compositions may also include at least one active pharmaceutical ingredient (API) and/or at least one water repellant. Related compositions, methods and kits are also provided. | 02-11-2016 |
20160038403 | Process For Preparing Aminofunctional Silicone Emulsions - A process for preparing an aminofunctional silicone emulsion is disclosed comprising: I) forming a mixture of 100 parts of a polydialkylsiloxane having a viscosity of at least 50,000 mm | 02-11-2016 |
20160039809 | P2X7 MODULATORS - The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb). The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, Ia, IIa and IIb). Methods of making and using the compounds of Formulas (I, Ia, IIa and IIb) are also within the scope of the invention. | 02-11-2016 |
20160045505 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES - The present invention provides compounds of formula (I): (Formula (I)) or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease. | 02-18-2016 |
20160050929 | METHODS OF CONTROLLING NEONICOTINOID RESISTANT PESTS - The invention relates to a method of controlling insects (in particular insects of the order Hemiptera, especially aphids and whitefly) that are resistant to neonicotinoid insecticides, to methods of controlling insects whereby undesired insects are affected but beneficial arthropods are not affected, using compounds of formula (I) (where A, R1 and R2 are as defined above), and, further, to novel compounds of formula I which are useful in the aforementioned methods and/or which possess enhanced insecticidal properties, and to compositions containing said compounds. | 02-25-2016 |
20160052888 | SUBSTITUTED BICYCLIC COMPOUNDS - Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): | 02-25-2016 |
20160052912 | DIAMINOHETEROARYL SUBSTITUTED INDAZOLES - Compounds of formula (I) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals. | 02-25-2016 |
20160058757 | HETEROCYCLIC COMPOUNDS FOR TREATING OR PREVENTING DISORERS CAUSED BY REDUCED NEUROTRANSMISSION OF SEROTONIN, NOREPHNEPHRINE OR DOPAMINE - A heterocyclic compound represented by the general formula (1) or a salt thereof: | 03-03-2016 |
20160068528 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses. | 03-10-2016 |
20160074301 | ANTI-AGING SKIN CARE COMPOSITIONS AND REGIMENS - Multi-step cosmetic regimens are provided to improve the appearance of aging skin. A target portion of skin that exhibits a sign of skin aging is identified. A first formulation is topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a genetic co-expression module for one or more biological themes associated with skin cleansing and/or skin detoxification, and/or skin hydration to the target portion of skin. A second formulation is also topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a co-expression module for one or more biological themes associated with skin repair and/or rebuilding to the target portion of skin. | 03-17-2016 |
20160108050 | IMIDAZOTRIAZINECARBONITRILES USEFUL AS KINASE INHIBITORS - The invention provides compounds of Formula (I) | 04-21-2016 |
20160115181 | NOVEL PYRROLE COMPOUNDS WITH SILICON INCORPORATION - The present invention discloses novel Silicon incorporated pyrrole compounds of Formula I having potential anti-bacterial properties. The invention further discloses a process for synthesis of pyrrole compounds with silicon incorporation of Formula I and to the pharmaceutical composition thereof. | 04-28-2016 |
20160129023 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS - Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors. | 05-12-2016 |
20160143860 | Thin Film With Non-Self-Aggregating Uniform Heterogeneity And Drug Delivery Systems Made Therefrom - The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. | 05-26-2016 |
20160143905 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS - Provided is a superior, novel heterocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment spectrum, causes less side effects, and is superior in tolerability and safety, and use thereof. A heterocyclic compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof. | 05-26-2016 |
20160150788 | PLANT DISEASE CONTROL COMPOSITION AND ITS USE | 06-02-2016 |
20160157492 | ANTIBACTERIAL AGENT COMPOSITION AND ANTIVIRAL AGENT COMPOSITION COMPRISING SILICON-CONTAINING COMPOUND; ANTIBACTERIALIZING METHOD, CLEANING/MOUTH RINSING METHOD; METHOD FOR FIXING ANTIBACTERIAL AGENT AND ANTIVIRAL AGENT - Disclosed is an antibacterial agent composition which is highly safe and has excellent antibacterial abilities, by using a silicon-containing compound that is obtained by a specific manufacturing method. The antibacterial agent composition has a more stable antibacterial component, and is capable of imparting antibacterial abilities to teeth, while being also capable of cleaning an article or the mouth. Also disclosed are: an antiviral agent composition which is highly safe and has excellent virus deactivation abilities; an antibacterializing method, a cleaning/mouth rinsing method, each using the antibacterial agent composition or the antiviral agent composition; and a method for fixing an antibacterial agent or an antiviral agent. The antibacterial agent composition may contain a silicon-containing compound which is represented by general formula (1) and obtained by reacting a specific triethoxysilyl compound in an ethanol solvent. | 06-09-2016 |
20160159829 | ORGANOSILOXANE COMPOSITION HAVING HIGH REFRACTIVE INDEX AND APPLICATIONS CONTAINING THE SAME - The invention is directed to a silicone compound of the general formula (I) and a personal care composition comprising the silicone compound (I) as described herein, and to personal care applications containing the same and processes of making the silicone compound. | 06-09-2016 |
20160159832 | SILYLALKYLOXYARYL COMPOUNDS AND METHODS FOR TREATING CANCER - Silylalkyloxyaryl compounds useful as anti-cancer agents. The compounds and pharmaceutical compositions containing them are particularly useful for the treatment of melanoma, colon, neuroblastoma, bladder, breast, lung, pancreatic, melanoma, sarcoma, lymphoma or gastric cancer. | 06-09-2016 |
20160192651 | PESTICIDE | 07-07-2016 |
20160249615 | Use of Strobilurin Type Compounds for Combating Phytopathogenic Fungi Resistant to QO Inhibitors | 09-01-2016 |
20160249621 | COMPOSITION CONTAINING AN ORGANOSILANE AND A PHOTOCATALYST, AND METHODS OF TREATING FLOWERING PLANTS INFECTED WITH A BACTERIAL DISEASE USING THE COMPOSITION | 09-01-2016 |
20160250196 | SMALL MOLECULE SECURININE AND NORSECURININE ANALOGS AND THEIR USE IN INHIBITING MYELOPEROXIDASE | 09-01-2016 |
20160375051 | AGENT FOR THE TREATMENT OF SKIN CONDITIONS - Disclosed are methods of treatment and compositions containing at least one non-volatile silicone oil in combination with at least one spreading agent for use in the treatment of skin conditions in mammals typified by scales, plaques and scabs and associated with punctiform bleeding during the removal of scales, plaque or scabs. Preferred conditions are selected from the group consisting of seborrheic dermatitis, psoriasis, and cradle cap wherein the incidence of punctiform bleeding and formation of bloody tear points on the skin during removal of the scales is diminished or prevented. | 12-29-2016 |
20160376244 | HETEROCYCLIC COMPOUND - The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, which may be useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof: | 12-29-2016 |
20160376271 | P2X7 MODULATORS - The present invention is directed to compounds of Formulas (I, IIa and IIb): | 12-29-2016 |
20170233340 | NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF | 08-17-2017 |
20170233379 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | 08-17-2017 |
20180022751 | N-SUBSTITUTED 8-[(2,6-DIFLUOROBENZYL)OXY]-2,6-DIMETHYLIMIDAZO[1,2-A]PYRAZIN-3-CARBOXAMI- DE DERIVATIVES AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE (SGC) FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | 01-25-2018 |
20190141997 | ANTI-MICROBIAL COMPOSITIONS COMPRISING QUATERNARY ORGANOSILANE COMPOUNDS | 05-16-2019 |
20190142852 | HETEROCYCLIC COMPOUNDS FOR TREATING OR PREVENTING DISORERS CAUSED BY REDUCED NEUROTRANSMISSION OF SEROTONIN, NOREPHNEPHRINE OR DOPAMINE | 05-16-2019 |