| Entries |
| Document | Title | Date |
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| 20080200430 | Methods of Use of Biomaterial and Injectable Implant Containing Biomaterial - This invention relates to the use of a biomaterial for the treatment, repair and/or enhancement of bodily tissue insufficiencies of the vocal chords, muscles, ligaments, cartilage, post-operative regions, sexual organs and/or weight supporting areas of the feet as well as other conditions of the bones and joints. The biomaterial for use in the invention may comprise an injectable bioresorbable polysaccharide composition wherein the polysaccharide may be succinochitosan glutamate. This invention also relates to the use of a biomaterial comprising an injectable bioresorbable polysaccharide composition in which resorbable particles may be in suspension, the said particles comprising or consisting essentially of chitin and/or chitosan, which may be free of any additional formulation modifying agents, and a process for manufacturing the same. The invention also includes the use of various medicaments in the biomaterial formulations to enhance the treatment of the affected area of the body. | 08-21-2008 |
| 20080207561 | NOVEL BIOMATERIALS AND A METHOD FOR MAKING AND USING SAME - A novel biomaterial is disclosed having unique properties that make it useful in ocular drug delivery applications, where the drugs selected from the group consisting of a prostaglandin, a prostamide, a non-steroidal anti-inflammatory drug (NSAID), and a corticosteroid, and mixtures, derivatives, salts and esters thereof. | 08-28-2008 |
| 20080214494 | METHOD OF DRUG DELIVERY BY CARBON NANOTUBE-CHITOSAN NANOCOMPLEXES - Functionalized Single Wall Carbon Nanotube (SWCNT) complexed with nanochitosan for use in the delivery of bioaffecting substances and diagnostic applications. fSWCNT complexed with the chitosan NG042 were used for delivery of DNA-encoding EGFP reporter protein and peptide. The results demonstrate that shown CNT-chitosan hybrid nanoparticles exhibit significantly higher transfection efficiency in vivo than chitosan alone. Furthermore, the functionalized nanotubes were tested for peptide transfer into HEK293 cells. The results showed that the hybrid nanoparticles efficiently transferred peptides. Together, these results show that hybrid SWCNT-chitosan particles increase DNA and peptide transfer into cells. | 09-04-2008 |
| 20080293671 | Combination of Polychitosamine and Fibrate for the Prevention and Treatment of Hyperlipidemia - The present invention relates to pharmaceutical compositions comprising a fibrate (e.g. ciprofibrate, gemfibrozil, benzafibrate, and fenofibrate) and a polychitosamine (e.g. chitosan) having molecular weights of less than 650 Kda and degrees of deacetylation of from 70% to 100%. Uses of said compositions for the treatment of hyperlipidemia and associated conditions (e.g. hypercholesterolemia, atherosclerosis, coronary heart disease and cardiovascular disease) or as functional foods are also disclosed. | 11-27-2008 |
| 20090054373 | CHITIN DERIVATIVES FOR HYPERLIPIDEMIA - The preferred embodiments relate to chitin derivatives for prevention or treatment of hyperlipidemia, such as hypercholesterolemia and the resultant atherosclerosis in a mammal. The preferred embodiments are useful for reducing serum cholesterol, and/or cholesteryl ester, triglycerides, phospholipids and fatty acids in a mammal. | 02-26-2009 |
| 20090093440 | Fragranced Therapeutic Delivery System - The present invention relates to multi-functional topical delivery systems for providing long-lasting delivery of fragrance as. well as skin-supporting and/or pharmaceutically active ingredients comprising (i) an oil phase; (ii) an aqueous phase; (iii) phenoxyethanol at a concentration of from about 2.0% to about 2.7% based on the total weight of the composition; (iv) an effective exfoliating amount of a hydrophobic hydroxycarboxylic acid selected from the group consisting of orthohydroxybenzoic acid, hydroxycarboxylic acids containing a C12-C24 fatty acid esterified to the alpha carbon hydroxyl group, hydroxycarboxylic acids containing a C12-C24 fatty alcohol esterified to a carboxyl group; (v) a non-ionic emulsifier having an HLB of from about 7 to about 10; (vi) a fragrance composition; and (vii) at least one skin-supporting or dermatopharmaceutically active agent. | 04-09-2009 |
| 20090137526 | Purification Method for Biomaterial - The present disclosure relates to methods for purifying chitin or chitosan, particularly for obtaining medical grade materials suitable for use in biocompatible devices,formulations, or other materials. Chitosan separation and purification methods are taught for obtaining high purity and fractionated bio-compatible medical grade materials. Chemistries and solvent systems are taught for the use in counter current chromatography, liquid/liquid or other microfluidic separation systems. | 05-28-2009 |
| 20090149421 | GEL FORMATION OF POLYELECTROLYTE AQUEOUS SOLUTIONS BY THERMALLY INDUCED CHANGES IN IONIZATION STATE - There is disclosed aqueous solutions of polyelectrolytes that can be neutralized by increasing temperature, under suitable polyelectrolyte charge state conditions, in order to obtain a homogeneous gel. This can be achieved by adding an appropriate weak electrolyte to the polyelectrolyte so that an increase of temperature will lead to a spatially homogeneous neutralization of the polyelectrolyte via proton transfer between the polyelectrolyte and the weak electrolyte. The ability of such a system to be thermally sensitive and to gel upon heating relies on the temperature dependence of the ionization equilibrium for the two components. This thermally induced neutralization reduces electrostatic repulsion between polyelectrolyte molecules allowing the manifestation of attractive polyelectrolyte-polyelectrolyte hydrophobic interactions and hydrogen bonding that result in gel formation. These new kinds of thermo sensitive gels can be used for biomedical applications. | 06-11-2009 |
| 20090149422 | HEMOSTATIC MATERIAL - A hemostatic powder comprises a chitosan salt together with at least one medical surfactant. At least one inert material may optionally be included. The hemostatic powder may be incorporated into wound dressings. | 06-11-2009 |
| 20090186851 | HEMOSTATIC MATERIAL - A hemostatic powder comprises a chitosan salt together with at least one inert material. The disclosure also relates to hemostatic powders into which fluid penetrability is 0.5 cm or more within 1 minute. At least one medical surfactant may optionally be included. The hemostatic powders may be incorporated into wound dressings. | 07-23-2009 |
| 20090197830 | Combination of polychitosamine and hmg-coa reductase inhibitor for hyperlipidemia - Combinations of therapeutic compounds for prophylaxis or treatment of hyperlipidemia and hyperlipidemia related disorders, such as hypercholesterolemia and the resultant atherosclerosis in a mammal. The combinations are useful for reducing serum cholesterol, and/or cholesteryl ester, triglycerides, phospholipids and fatty acids in a mammal. The methods of the preferred embodiments comprise administering to a mammal a first amount of polychitosamine and a second amount of an HMG-CoA reductase inhibitor (statin). | 08-06-2009 |
| 20090197831 | Composition for the Treatment of Obesity and Hyperlipidemia - Current invention is related to the pharmaceutical industry in general and to the industry of the manufacture of pharmaceutical products for weight reduction and hyperlipidemia treatment. The advantages of the current invention respect of the similar of the state of the art are that in the present invention side effects normally produced by the consumption of lipase inhibitors are eliminated; optimizing both the lipase inhibitor component and the fat-trapping; with the adequate composition of each one of the components and with very small amounts of each one. The invention consists of a composition for the treatment of the obesity and hyperlipidemia, characterized by comprising in combination a lipase inhibitor and a fat-trapping component. | 08-06-2009 |
| 20090197832 | POLYMER MIXTURES OF ANIONIC AND CATIONIC POLYSACCHARIDES AND USE THEREOF - Described in the present application are compositions comprising mixtures of polyanionic polysaccharides and polycationic polysaccharides consisting of oligosaccharide derivatives of chitosan. In the compositions of the invention said mixtures have proven to be soluble in aqueous environments, despite ionic complexes forming between the acid polysaccharides and chitosan derivatives. Said compositions have also demonstrated significant rheological behaviour with an unexpected increase in viscosity and viscoelasticity, although the polysaccharides used have relatively low average molecular weights. The said solubility and rheological behaviour renders the compositions of the invention particularly advantageous from the biomedical application viewpoint, in particular for viscosupplementation and particularly in the field of articular pathologies and of ophthalmic surgery. | 08-06-2009 |
| 20090203642 | SPRAY-DRIED CHITIN NANOFIBRILS, METHOD FOR PRODUCTION AND USES THEREOF - The invention relates to a novel method for production of nanofibrillar chitin, sustainable from an industrial manufacturing standpoint and suitable for producing chitin nanofibrils having improved properties and free from less crystalline components. The invention also relates to novel chitin nanofibrils obtained with said method and characterized by an increased dispersibility in aqueous media. The invention further relates to uses of nanofibrils in pastes and aqueous gels useful for topical on-skin application, to the manufacturing of materials of biomedical interest, as well as to the deposition of chitin nanofibrils on coating surfaces or the incorporation of the same inside of items like, e.g., fibers and fabrics of any Origin, natural as well as synthetic or mixed ones. | 08-13-2009 |
| 20090203643 | Method and composition for avoiding or mitigating the formation of preservative residues on the surface of wood treated with micronized copper-containing compositions - Disclosed is a wood preservative composition comprising micronized copper and copper-amine complex, wherein the copper component of the copper amine complex is from about 5% to about 50% by weight, based upon the total weight of copper in the composition. The copper amine complex serves to avoid wood surface “chalking” that is otherwise attributable to the presence of micronized copper in copper-based slurries used to treat wood products. In addition, the copper-amine complex enhances the antimicrobial efficacy of the composition when used in wood treatment applications by facilitating cell wall penetration of the treated wood. | 08-13-2009 |
| 20090253652 | PHOSPHATE-BINDING CHITOSAN AND USES THEREOF - The present invention provides compositions and methods for removing phosphate from a subject using chitosan. The present invention also provides compositions and methods for treating hyperphosphatemia based on phosphate-binding chitosan. | 10-08-2009 |
| 20090258839 | COMPOSITIONS COMPRISING CHITOSAN SUITABLE FOR COMPREHENSIVE THERAPEUTIC TREATMENT OR COMPREHENSIVE PREVENTION OF THE METABOLIC SYNDROME - The present invention relates to compositions comprising chitosan, in the form of drugs or food supplements, suitable for comprehensive therapeutic treatment or comprehensive prevention of the metabolic syndrome. Also described is their preparation. More generally, the invention concerns the use of chitosan for comprehensive therapeutic treatment or comprehensive prevention of the metabolic syndrome. | 10-15-2009 |
| 20090270346 | PROTECTIVE GEL BASED ON CHITOSAN AND OXIDIZED POLYSACCHARIDE - Bodily tissue and structures may be protected using a fluid layer containing a mixture of chitosan and oxidized polysaccharide. The mixture forms a protective gel layer via in situ crosslinking. Compared to crosslinking using a low molecular weight aldehyde such as glutaraldehyde or genipin, oxidized polysaccharides appear to provide faster gelation while avoiding the use of potentially less bioacceptable low molecular weight aldehydes. | 10-29-2009 |
| 20090270347 | METHODS OF PRODUCING MICROPARTICLES - Methods of producing microparticles, and especially chitin microparticles (CMP), are disclosed that involve reducing the size of (larger) particles using a (high shear) microfluidising instrument. | 10-29-2009 |
| 20090281058 | Compositions of partially deacetylated chitin derivatives - The present invention relates to compositions comprising biologically active chitinous oligomers and their endotoxin purified and partially deacetylated chitin polymer precursors, and their use in pharmaceutical compositions, biomaterial compositions, medical devices, and processes to produce the said oligomers. More specifically the present invention relates to novel compositions and processes to produce such compositions. The compositions include therapeutic hetero polymer and hetero oligomer compositions comprising specific sequences of N-acetyl glucosamine and glucosamine, developed to optimize chemical and structural features which are important for the therapeutic activity of these compositions. In addition, the present invention provides methods to use degree of deacetylation of a partially deacetylated chitin polymer in order to modulate physical and biological parameters in a calcium phosphate composite for bone implant applications. | 11-12-2009 |
| 20090291911 | REHYDRATABLE POLYSACCHARIDE PARTICLES AND SPONGE - Tissue and other body structures may be protected using a hydrated composition made from free-flowing substantially collagen-free rehydratable polysaccharide particles and rehydratable polysaccharide sponges. Rehydration of the particles without clumping may be carried out be dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated composition may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function. | 11-26-2009 |
| 20090291912 | CHITOSAN-CONTAINING PROTECTIVE COMPOSITION - Body tissue and structures may be protected using a fluid containing a mixture of partially crosslinked polysaccharide and a further crosslinker. The mixture desirably is sprayable, forms a fluid protective layer via in situ crosslinking, desirably does not drip or run from a treatment site, and may avoid the use of more rapidly curing but potentially less bioacceptable crosslinkers at the treatment site. | 11-26-2009 |
| 20090298792 | Anti-Inflammatory Polymer - The present invention provides the use of cellulose sulfate or chitosan for the manufacture of an anti-inflammatory pharmaceutical or cosmetic composition for the treatment of inflammation. | 12-03-2009 |
| 20090306013 | Drugs and Food Products for Hypophosphoric Normo-,Hyper-and Hypoproteic Diets, and Hypophosphoric Beverages - The present invention relates to an alimentary component comprising a physiologically acceptable phosphorus binding agent, in particular polyallylamine hydrochloride, polyallylamine carbonate, lanthanum carbonate, aluminium hydroxide, magnesium acetate, magnesium carbonate, calcium carbonate, calcium acetate, calcium citrate, calcium alginate, styrene divinyl-benzene ionic exchange resin, stabilized polynuclear iron hydroxide, calcium acetate plus magnesium carbonate and chitosan. Said component is useful in the nutrition of subjects in need of a low phosphorus level diet. | 12-10-2009 |
| 20100004198 | POLYSACCHARIDE GEL FORMULATION HAVING INCREASED LONGEVITY - Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide. In some embodiments, the incorporating step comprises 1) mixing the at least one inhibitor with the at least one polysaccharide at a highly hydrated state thereby encapsulating the at least one inhibitor in a polysaccharide network, and 2) dehydrating the polysaccharide network thereby controlling release kinetics or final swell ratio. In another embodiment, the incorporating step comprises 1) encapsulating at least one inhibitor into a biocompatible or biodegradable vessel and 2) combining the polysaccharide and the vessel into a gel formulation. The polysaccharide gel formulations described herein can be used for a variety of cosmetic applications. | 01-07-2010 |
| 20100041624 | Buprenorphine formulations for intranasal delivery - Aqueous formulations suitable for intranasal administration comprise buprenorphine or a physiologically acceptable salt or ester thereof and (a) a pectin having a degree of esterification of less than 50%, (b) chitosan and a polyoxyethylene-poly-oxypropylene copolymer (poloxamer) or (c) chitosan and hydroxypropylmethylcellulose. Such formulations can induce rapid and prolonged analgesia when delivered intranasally to a patient. The buprenorphine or buprenorphine salt or ester may be delivered to the bloodstream to produce within 30 minutes a therapeutic plasma concentration of buprenorphine, C | 02-18-2010 |
| 20100048508 | MIXTURE AND METHOD FOR REDUCING CHOLESTEROL USING HYDROPHOBIC MICROPARTICLES - The present invention relates to mixtures including hydrophobic microparticles comprising a positively charged polymer (e.g. a polysaccharide such as chitosan) chemically bound to an anionic or non-ionic surfactant such as lecithin. The mixtures are useful for reducing cholesterol of an animal, for example a bird such as a chicken or any type of mammal. Methods of manufacture and use of the mixtures are also disclosed herein. | 02-25-2010 |
| 20100056474 | Methods and Compositions for the Prevention of and Treatment of Infections Utilizing Chitosan-Derivative Compounds - The present invention is directed to the treatment and prevention of nosocomial infections or MRSA infections utilizing soluble chitosan or chitosan derivative compounds. These chitosan-derivative compounds, e.g., chitosan-arginine and chitosan-acid amines, exhibit bactericidal activity against bacterial pathogens, e.g., drug resistant bacteria such as Methicillin-resistant | 03-04-2010 |
| 20100093660 | ANTI-TUMOR COMPOSITION COMPRISING TISSUE-ACCUMULATING CHITOSAN GEL - The present invention is achieved based on a novel finding that chitosan gel having retentivity in tissue has an antitumor activity and provides an antitumor composition containing chitosan gel having retentivity in tissue. The chitosan gel having retentivity in tissue of the present invention is preferably chitosan gel formed of a chitosan derivative having a carbohydrate chain introduced thereto as a base, to which a photoreactive group is further introduced to form crosslink with photo-irradiation; or chitosan gel formed of a polyion complex, which is formed of a carbohydrate chain-containing chitosan derivative and another substance, for example, an acidic polysaccharide. The antitumor composition of the present invention can suppress growth of a tumor without bringing it into contact with the tumor but by simply arranging it near the tumor. | 04-15-2010 |
| 20100093661 | COMPOSITION COMPRISING CHITOSAN AND AN ACIDIC DRUG FOR ORAL CONTROLLED RELEASE - The present invention relates to a composition comprising an aqueous solvent and a conjugate of at least one hydrophilic polymer having a primary amine functional group, a derivative or monomer thereof and at least one acidic drug; a method for its preparation and use thereof. | 04-15-2010 |
| 20100105633 | PROCESS - The invention relates to a process for the preparation of water-soluble chitosan salts, to chitosan products produced by this process and to their uses, e.g. in pharmaceutical or veterinary compositions or as a food or cosmetic additive. More specifically, the invention relates to a process for preparing a water-soluble chitosan salt which comprises: (a) contacting a solid chitosan with at least one protic acid whereby to produce a water-soluble chitosan salt; and (b) optionally recovering said salt, wherein said chitosan is converted into said salt whilst remaining substantially in the solid state. Gaseous or liquid protic acids may be used, including hydrochloric, acetic and propionic acids. | 04-29-2010 |
| 20100120711 | AMPK POTENTIATOR CONTAINING CHITO-OLIGOSACCHARIDE - Disclosed herein is a composition for promoting AMPK activity, which comprises a chito-oligosaccharide as an active ingredient. The present composition affects the enzymes related to AMPK and lipid metabolism, and thus helps recovery from the condition lacking energy by various functions of controlling metabolism. Therefore, the present composition can enhance energy metabolism, thus making the composition effective for improving exercise capacity and reducing fatigue. The present composition can be used in the preparation of food or medicinal product as an endurance builder or for the prevention and improvement of fatigue. | 05-13-2010 |
| 20100130443 | CHITOSAN DERIVATIVES, COMPOSITIONS AND RELATED METHODS OF USE - Described herein are methods and compositions using chitosan derivatives to treat and/or inhibit acquisition of multiple drug resistance (MDR). Also described herein are methods and compositions using chitosan derivatives in combination with an antibacterial agent to treat a bacterial infection and/or inhibit growth of bacteria, for example, resulting in a synergistic or sensitizing effect. | 05-27-2010 |
| 20100152133 | USE OF CHITOSANS TO INCREASE NAIL GROWTH RATE - The present invention is directed to the use of chitosan, a chitosan derivative or a physiologically acceptable salt thereof, to increase nail growth rate. The invention is further directed to the use of chitosans to accelerate nail growth rate during treatment of nail illnesses, nail dystrophy or other nail conditions, in order to shorten considerably the specific treatments of said nail illnesses, nail dystrophy or other nail conditions. | 06-17-2010 |
| 20100160254 | Cellulose Sulfate for the Treatment of Rhinovirus Infection - The present invention provides the use of a polymer for the manufacture of an antiviral pharmaceutical composition for the treatment of a rhinovirus infection, wherein the polymer is cellulose sulfate. | 06-24-2010 |
| 20100190743 | Method and Composition for Treatment of a Mucosal Tissue Disorder - Methods of treating a subject suffering from a disorder in a mucosal tissue, such as interstitial cystitis; cancer in a mucous membrane such as bladder or vaginal cancer; Crohn's disease; inflammatory bowel disease or colitis, by administering a medicament containing a sulfated chitinous polymer administered topically are described. Pharmaceutical compositions containing the sulfate chitinous polymer are also disclosed. | 07-29-2010 |
| 20100204177 | PROCESS FOR PREPARING THERMOSENSITIVE (POLY(ETHYLENE OXIDE) POLY(PROPYLENE OXIDE)) DERIVATES THAT CAN BE USED TO FUNCTIONALIZE CHITOSAN - The invention relates to a thermosensitive (poly(ethylene oxide) poly(propylene oxide))-acetal derivative, which can be used to functionalize chitosan, and to the process for the preparation thereof. The invention therefore also relates to a process for functionalizing chitosan by grafting this thermosensitive copolymer and optionally another thermosensitive polymer, poly(ethylene oxide). A subject of the invention is also a chitosan-(poly(ethylene oxide) poly(propylene oxide))-poly(ethylene oxide) derivative which has the advantage of being water-soluble at physiological pH. The invention therefore also relates to the aqueous compositions comprising this derivative and to the use of this composition for the manufacture of gel by heating. | 08-12-2010 |
| 20100222297 | CELL WALL DERIVATIVES, THEIR PREPARATION PROCESS, AND USE THEREOF - In a first aspect, the present invention relates to a method for isolating cell wall derivatives from fungal or yeast biomass. According to this method, chitin polymers or chitin-glucan copolymers can be obtained. In another aspect, the invention relates to a method for preparing chitosan from chitin. The invention further relates to chitin polymers, chitin-glucan polymers and chitosan polymers obtainable by the methods according to the invention. Moreover, the invention relates to the use of chitin polymers, chitin-glucan copolymers or chitosan polymers obtainable by the method according to the present invention in medical, pharmaceutical, agricultural, nutraceutical, food, textile, cosmetic, industrial and/or environmental applications, and in particular of chitin-glucan copolymers used as a technological additive for treating a food-grade liquid or in orally administered compositions. | 09-02-2010 |
| 20100273737 | SUPPLEMENTARY FOOD COMPOSITION FOR REDUCING BODY ODOR - A food supplement for reducing body odor which includes a mixture of edible carriers with chitin aqueous solution lyophilized powder, chitosan aqueous solution lyophilized powder, chitin powder, chitosan powder, or a combination of these ingredients, in the form of tablets or pills. The food supplement has the outstanding effect of reducing various types of body odors, including Koreans' unique body odor, such as Kimchi smell or garlic smell; westerners' unique body odor, such as cheese smell or butter smell, Arabs' unique body odor, such as mutton smell, armpit odor and body odor that is unique to the aged. | 10-28-2010 |
| 20100311687 | POLYSACCHARIDES DERIVATISED WITH CITRIC ACID - Non-crosslinked derivatives of oligo/polysaccharides of formula I, wherein: X is OH, OM, NH—R | 12-09-2010 |
| 20110028429 | COMBINATION OF POLYCHITOSAMINE AND HMG-COA REDUCTASE INHIBITOR FOR HYPERLIPIDEMIA - Combinations of therapeutic compounds for prophylaxis or treatment of hyperlipidemia and hyperlipidemia related disorders, such as hypercholesterolemia and the resultant atherosclerosis in a mammal. The combinations are useful for reducing serum cholesterol, and/or cholesteryl ester, triglycerides, phospholipids and fatty acids in a mammal. The methods of the preferred embodiments comprise administering to a mammal a first amount of polychitosamine and a second amount of an HMG-CoA reductase inhibitor (statin). | 02-03-2011 |
| 20110034410 | Wound dressing and method for controlling severe, life-threatening bleeding - This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe 5 bleeding. The wound dressing for controlling severe bleeding is formed of a biomaterial comprising chitosan, a hydrophilic polymer, a polyacrylic polymer or a combination thereof, The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional 10 pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot formation at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of 15 blood out of the wound site. | 02-10-2011 |
| 20110207696 | Compositions for treating rosacea - The present invention is directed to compositions containing chitosan, a chitosan derivative or a physiologically acceptable salt thereof, and a short-medium chain dicarboxylic acid amide, or a physiologically acceptable salt thereof, forming a film after application onto the skin, useful for protecting skin of the face and of other affected areas in couperose, rosacea and telangiectasia of the legs. | 08-25-2011 |
| 20110224166 | COMPOSITION FOR ACTIVATING MITOCHONDRIA (As Amended) - The present invention relates to a composition for activating mitochondria which contains a chitooligosaccharide as an active constituent. The chitooligosaccharide can increase the activity of mitochondrial enzymes and increase the amount of mitochondrial DNA, and thus it can be suitably used as an active constituent in the composition for activating mitochondria. | 09-15-2011 |
| 20110237539 | Spinning Solution and Method for Manufacturing Biomaterial Fibers - Disclosed herein are spinning solutions and methods for manufacturing a biomaterial fiber. The spinning solution includes a biologically absorbable material having a haemostatic function, a polysaccharide selected from the group consisting of hyaluronic acid (HA) and gelatin, and a solvent, wherein the polysaccharide and the haemostatic material exist in a weight ratio between about 0.1 to about 3. The method includes steps of wet spinning the spinning solution into the biomaterial fiber. | 09-29-2011 |
| 20110301120 | USE OF A CHITOSAN POLYMER FOR HEPARIN NEUTRALIZATION - Use of a chitosan polymer for direct neutralization of heparin in blood and physiological fluids of mammals. The chitosan polymer may be applied as an intravenous solution or for neutralization of heparin in blood or other physiological fluid taken from a donor. | 12-08-2011 |
| 20120010167 | COUNTERMEASURE METHODS AND DEVICES - Embodiments of the present invention provide methods for protecting against toxic agents using chitosan formulations. | 01-12-2012 |
| 20120022019 | Medicinal Steroids Cream And A Process To Make It - The present invention relates to a composition for treating skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and a corticosteroid. It discloses a composition for treating skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) an active ingredient such as a corticosteroid used in treating skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The active ingredients, namely chitosan, and a corticosteroid, are incorporated in cream base for use in treating skin inflammation. | 01-26-2012 |
| 20120040927 | MEDICINAL ANTIFUNGAL AND STEROID CREAM INCORPORATING A BIOPOLYMER AND A PROCESS TO MAKE IT. - The present invention is directed to a composition for treating fungal skin infections & skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, a corticosteroid and an antifungal active ingredient. It discloses a composition for treating fungal skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) a combination of active pharmaceutical ingredients (APIs), clotrimazole and hydrocortisone acetate used in treating fungal skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, namely chitosan, corticosteroid in the form of hydrocortisone acetate, and an antifungal agent in the form of clotrimazole, are incorporated in cream base for use in treating fungal skin infections and skin inflammation due to allergy & itching, & wounds on human skin involving contacting human skin with the above identified composition. | 02-16-2012 |
| 20120058970 | METHOD AND SYSTEM FOR REVERSAL OF INTERACTIONS BETWEEN HYDROPHOBICALLY MODIFIED BIOPOLYMERS AND VESICLES OR CELL MEMBRANES - A method for reversing gelation of hydrophobically modified biopolymer attached to vesicle or cell membranes. The gelation of hydrophobically modified biopolymer attached to vesicles or cell membranes is reversed by application of a supramolecule, such as cyclodextrin, to the gelled composition. The supramolecule disrupts the interactions between the hydrophobically modified biopolymer and the vesicle or cell membrane, without affecting the structure of the membrane or the hydrophobically modified polymer to which the hydrophobic substituents are attached. A kit for treating wounds that includes a hydrophobically modified biopolymer and a supramolecule. The hydrophobically modified biopolymer is used to stop bleeding and the supramolecule is used to remove the hydrophobically modified biopolymer. | 03-08-2012 |
| 20120108539 | Medicinal Anti Acne Cream And A Process To Make It - The present invention relates to a composition for treating acne along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and an antiacne active ingredient. It discloses a composition for treating acne along with skin rejuvenation containing a) a biopolymer in the form of Chitosan, b) an active pharmaceutical ingredient (API) alone or in combination used in treating acne, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, d) water. The active ingredients, namely chitosan, and an antiacne agent, are incorporated in cream base for use in treating acne. | 05-03-2012 |
| 20120108540 | Preservatives from Chitin Derivatives - The invention comprises a process for producing a chitosan derivative, and a product prepared thereby, by activating chitosan or a chitosan precursor chitin in alcohol that contains water from 0% to maximum of about 30% and preparing derivatives by reacting with a reagent to get derivatives that have various uses including an antimicrobial, or a microbiostatic, or an antitranspirant, or an antifungal, or a fruit preservative properties or as carrier of active molecules or functional groups etc. or a combination thereof. Illustrated derivatives include acid, succinic, enzymatically deacetylated, enzymatically hydrolysed by chitinolysis, sugar, formaldehyde, phosphoric acid, hydrochloric acid and copper sulfate derivatives that are obtained by reaction individually or in a combination of consecutive reactions. A novel class of thermostable proteo-chitinase is also disclosed prepared from | 05-03-2012 |
| 20120129803 | COMPOSITION CONTAINING CHITOOLIGOSACCHARIDE FOR RECOVERING FROM FATIGUE - Disclosed is an anti-fatigue composition containing chitooligosaccharide as an active ingredient. The composition exhibits a fatigue recovery effect, and thus can be widely used in the health food or medical field. | 05-24-2012 |
| 20120142631 | MEDICINAL ANTIDIAPER RASH CREAM INCORPORATING A BIOPOLYMER AND A PROCESS TO MAKE IT - The present invention is directed to a composition for treating diaper rashes, along with skin rejuvenation containing a) a biopolymer in the form of Chitosan, b) a combination of active pharmaceutical ingredients (APIs), Benzalkonium Chloride & Cetrimide used in treating diaper rashes, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. | 06-07-2012 |
| 20120149659 | COMPOSITIONS AND METHODS FOR DELIVERING AN AGENT TO A WOUND - The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting). | 06-14-2012 |
| 20120232032 | ANTIMICROBIAL AND/OR EPITHELIAL CELL GROWTH STIMULATING SUBSTANCE AND COMPOSITION AND TISSUE DRESSING MATERIAL - A chitosan for use in an antimicrobial treatment of a patient's tissue and a pharmaceutical composition comprising a chitosan for use in an antimicrobial treatment of a patient's tissue. A method of treating a microbial infection, the method comprising the step of administering to a patient an effective amount of a chitosan and an aqueous solution comprising chitosan. A chitosan or a pharmaceutical composition comprising a chitosan for use in an epithelial cell growth stimulating treatment of a patient's tissue. A method of stimulating the growth of epithelial cells the method comprising the step of administering to a patient or to an epithelial cells containing cell culture an effective amount of a chitosan or a pharmaceutical composition comprising chitosan. A tissue dressing material characterized in that it consists of chitosan or a chitosan comprising composition. | 09-13-2012 |
| 20120252755 | COMPOSITIONS AND METHODS FOR DISINFECTING MATERIALS - The present invention relates to methods for disinfecting or decontaminating a material or for preventing an infection or contamination of a material. The invention further relates to compositions which are suitable for disinfecting a material or for preventing an infection or contamination of a material and to uses of such compositions. The invention further relates to a medical use of chitosan and to a pharmaceutical composition comprising the chitosan. The invention further relates to a method of treating a microbial infection and to an aqueous solution comprising chitosan. The invention moreover relates to a chitosan or a pharmaceutical composition comprising a chitosan for an epithelial cell growth stimulating treatment of a patient's tissue and to a method of stimulating the growth of epithelial cells. The invention also relates to a tissue dressing material. | 10-04-2012 |
| 20120258932 | COMBINATION OF POLYCHITOSAMINE AND HMG-COA REDUCTASE INHIBITOR FOR HYPERLIPIDEMIA - Combinations of therapeutic compounds for prophylaxis or treatment of hyperlipidemia and hyperlipidemia related disorders, such as hypercholesterolemia and the resultant atherosclerosis in a mammal. The combinations are useful for reducing serum cholesterol, and/or cholesteryl ester, triglycerides, phospholipids and fatty acids in a mammal. The methods of the preferred embodiments comprise administering to a mammal a first amount of polychitosamine and a second amount of an HMG-CoA reductase inhibitor (statin). | 10-11-2012 |
| 20120270835 | Medicinal Cream Made Using Hydrocortisone Acetate and A Process To Make The Same - The present invention relates to a composition for treating skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and a corticosteroid. It discloses a composition for treating skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) an active pharmaceutical ingredient (API) composition in the form of hydrocortisone acetate, used in treating skin inflammation c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, namely chitosan, and a corticosteroid in the form of hydrocortisone acetate, are incorporated in cream base for use in treating skin inflammation due to allergy & itching & wounds on human skin involving contacting human skin with the above identified composition. | 10-25-2012 |
| 20120277183 | PHOSPHATE-BINDING CHITOSAN AND USES THEREOF - The present invention provides compositions and methods for removing phosphate from a subject using chitosan. The present invention also provides compositions and methods for treating hyperphosphatemia based on phosphate-binding chitosan. | 11-01-2012 |
| 20120322758 | ANTI-WRINKLE COSMETIC COMPOSITION FOR COMPRISING 3-5 kDa CHITOOLIGOSACCHARIDES - The present invention relates to an anti-wrinkle cosmetic composition comprising chitooligosaccharide as an effective component, more specifically, the cosmetic composition to inhibit collagen degradation induced by UV-A irradiation. | 12-20-2012 |
| 20120329753 | CHITOSAN-DERIVATIVE COMPOUNDS AND METHODS OF CONTROLLING MICROBIAL POPULATIONS - The present invention is directed to chitosan-derivative compounds and structures, methods of making chitosan-derivative compounds and methods for controlling, inhibiting and enhancing microbial populations in a variety of environments. The present invention is also directed to the control, inhibition and enhancement of microbial populations in animals, particularly humans. The microbial populations include bacteria, viruses and other pathogens where control of microbial populations are a necessity. The chitosan-derivative compounds of the present invention include chitosan-arginine compounds, related chitosan-L/D unnatural amino acid compounds, chitosan-acid amine compounds, chitosan-L/D natural amino acid derivative compounds, co-derivatives of the chitosan-derivative compounds, salts of the chitosan derivative compounds, and chitosan-guanidine compounds. | 12-27-2012 |
| 20130029934 | SILYL-DERIVATIVES OF POLYSACCHARIDES - The present invention relates to novel silyl-derivatives of polysaccharides and their salts, the processes for their preparation and their use in cosmetic/pharmaceutical field. | 01-31-2013 |
| 20130029935 | MINERAL AMINO ACID POLYSACCHARIDE COMPLEX - This document provides complexes comprising a mineral-amino acid compound and a polysaccharide. For example, the document provides compositions containing such complexes and methods of making and using such complexes. | 01-31-2013 |
| 20130090306 | CHITOSAN BEADS AND FILLER COMPRISING SUCH BEADS - The present invention pertains to chitosan beads consisting of chitosan cross-linked with citrate ions. The present invention furthermore pertains to a filler comprising such chitosan-citrate beads. In one embodiment of the instant invention the filler is a dermal filler. In one further embodiment of the present invention the dermal filler is for the treatment of wrinkles and/or folds. In another embodiment of the instant invention the filler is for use in the treatment of a medical condition. The filler provided in the present invention may further comprise one or more active pharmaceutical ingredients. Further, the present invention pertains to a process for preparing the filler as claimed herein. | 04-11-2013 |
| 20130096082 | HEMOSTATIC COMPOSITIONS - The invention discloses a hemostatic composition composing chitin or a water insoluble chitin derivative, especially water insoluble chitosan, in particulate form, wherein the composition is present in paste form. | 04-18-2013 |
| 20130123213 | MODIFIED STARCH MATERIAL OF BIOCOMPATIBLE HEMOSTASIS - A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal. | 05-16-2013 |
| 20130237498 | METHODS OF USE OF BIOMATERIAL AND INJECTABLE IMPLANT CONTAINING BIOMATERIAL - This invention relates to the use of a biomaterial for the treatment, repair and/or enhancement of bodily tissue insufficiencies of the vocal chords, muscles, ligaments, cartilage, post-operative regions, sexual organs and/or weight supporting areas of the feet as well as other conditions of the bones and joints. The biomaterial for use in the invention may comprise an injectable bioresorbable polysaccharide composition wherein the polysaccharide may be succinochitosan glutamate. This invention also relates to the use of a biomaterial comprising an injectable bioresorbable polysaccharide composition in which resorbable particles may be in suspension, the said particles comprising or consisting essentially of chitin and/or chitosan, which may be free of any additional formulation modifying agents, and a process for manufacturing the same. The invention also includes the use of various medicaments in the biomaterial formulations to enhance the treatment of the affected area of the body. | 09-12-2013 |
| 20130244972 | INJECTABLE CHITOSAN MIXTURES FORMING HYDROGELS - A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., that includes at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions. | 09-19-2013 |
| 20130244973 | COMBINATION OF POLYCHITOSAMINE AND HMG-COA REDUCTASE INHIBITOR FOR HYPERLIPIDEMIA - Combinations of therapeutic compounds for prophylaxis or treatment of hyperlipidemia and hyperlipidemia related disorders, such as hypercholesterolemia and the resultant atherosclerosis in a mammal. The combinations are useful for reducing serum cholesterol, and/or cholesteryl ester, triglycerides, phospholipids and fatty acids in a mammal. The methods of the preferred embodiments comprise administering to a mammal a first amount of polychitosamine and a second amount of an HMG-CoA reductase inhibitor (statin). | 09-19-2013 |
| 20130244974 | SURGICAL HYDROGEL - A composition suitable for use in wound healing, particularly for reducing post-surgical adhesions, containing cross-linked derivatives of chitosan and dextran polymers. A hydrogel forms when solutions of the polymers are combined. | 09-19-2013 |
| 20130303480 | SOFT TISSUE AUGMENTATION THREADS AND METHODS OF USE THEREOF - This disclosure relates generally to soft tissue augmentation threads, methods of making such threads and uses thereof, for example, in aesthetic applications (e.g., facial contouring, soft tissue augmentation products), surgery (e.g., sutures), drug delivery, negative pressure wound therapy, moist wound dressing, and the like. | 11-14-2013 |
| 20130345168 | COSMETIC COMPOSITION FOR PREVENTING SKIN AGING CONTAINING CHITOOLIGOSACCHARIDES - The present invention relates to a composition for preventing skin aging containing chitooligosaccharides as an active ingredient. The invention provides a cosmetic composition for preventing skin aging caused by UV rays containing chitooligosaccharides of 1-3 kDa, 3-5 kDa or 5-10 kDa molecular weight as an active ingredient. | 12-26-2013 |
| 20140024615 | COMPOSITIONS AND METHODS FOR PREVENTING INFECTIOUS DISEASES IN FEMALES - A product that includes a bioadhesive treatment solution for prevention of infectious diseases in the urinary tract of a female is provided. The product includes a polysaccharide. The product is positioned over the urinary tract of a female to act as a barrier against infectious transfer. A method for applying the product and a method for making the product are also disclosed. | 01-23-2014 |
| 20140073601 | METHOD FOR TREATING THE EAR, NOSE OR THROAT - Bodily tissue and structures may be protected using a fluid layer containing a mixture of chitosan and oxidized polysaccharide. The mixture forms a protective gel layer via in situ crosslinking. Compared to crosslinking using a low molecular weight aldehyde such as glutaraldehyde or genipin, oxidized polysaccharides appear to provide faster gelation while avoiding the use of potentially less bioacceptable low molecular weight aldehydes. | 03-13-2014 |
| 20140107065 | Biopolymer System for Tissue Sealing - A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug. | 04-17-2014 |
| 20140113881 | ANTIINFECTIVE COMPOSITION - The present invention relates to the use of hydroxymethyl-group-containing glycosaminoglycans, such as in particular hydroxymethyl-hyaluronic acid, for the treatment and prevention of infectious diseases or malignant or premalignant diseases, in particular of the skin or mucosa. The invention additionally provides a preparation method for glycosaminoglycans modified with hydroxymethyl groups. | 04-24-2014 |
| 20140162977 | PROCESS AND DRESSING - An anti-microbial absorbent chitosan, optionally in the form or fibres, derivatised by treatment with high energy, in particular gamma, radiation, a non-woven fabric and an absorbent device comprising the derivatised chitosan, methods for the preparation of such a chitosan, non-woven fabric and an absorbent device, and the use of said absorbent device in wound care. | 06-12-2014 |
| 20140171385 | Materials for Short-Term Use in Mammals - Biodegradable materials are formed by mixing together two or more materials which have different resorption times and different mechanical characteristics. Devices formed of these materials can be used in mammals in numerous medical and surgical applications, including those for which the mechanical properties of the device, left in vivo, much change over time. | 06-19-2014 |
| 20140194379 | METHODS FOR THE PRODUCTION OF CHITIN NANOFIBERS AND USES THEREOF - Methods for the production chitin nanofibers and uses thereof. Furthermore, methods for the production of chitin nanofibers and the fabrication of chitin nanofiber structures and devices. | 07-10-2014 |
| 20140206642 | METHODS OF USE OF BIOMATERIAL AND INJECTABLE IMPLANT CONTAINING BIOMATERIAL - This invention relates to the use of a biomaterial for the treatment, repair and/or enhancement of bodily tissue insufficiencies of the vocal chords, muscles, ligaments, cartilage, post-operative regions, sexual organs and/or weight supporting areas of the feet as well as other conditions of the bones and joints. The biomaterial for use in the invention may comprise an injectable bioresorbable polysaccharide composition wherein the polysaccharide may be succinochitosan glutamate. This invention also relates to the use of a biomaterial comprising an injectable bioresorbable polysaccharide composition in which resorbable particles may be in suspension, the said particles comprising or consisting essentially of chitin and/or chitosan, which may be free of any additional formulation modifying agents, and a process for manufacturing the same. The invention also includes the use of various medicaments in the biomaterial formulations to enhance the treatment of the affected area of the body. | 07-24-2014 |
| 20140213548 | SYSTEM AND METHOD FOR HEMOSTATIC WOUND DRESSING - The present invention relates a novel hemostatic wound dressing, preferably comprising chitosan and an oxygen carrier such as a perfluorocarbon, and methods to treat hemorrhaging wounds and MRSA infections. The present invention helps with coagulation/clot formation as well as providing oxygen to the wound, all while being cost effective and competitive with current hemostatic dressings. | 07-31-2014 |
| 20140221308 | METHODS AND COMPOSITIONS OF REDUCING AND PREVENTING BACTERIAL GROWTH AND THE FORMATION OF BIOFILM ON A SURFACE UTILIZING CHITOSAN-DERIVATIVE COMPOUNDS - A method of treating a surface, the method comprising contacting (e.g., spraying) an effective amount of a composition comprising a chitosan (e.g., soluble or derivatized chitosan) with the surface, thereby treating the surface. Non-pharmaceutical compositions (e.g., liquid or dry powder compositions) include chitosan (e.g., a soluble or derivatized chitosan). The compounds and compositions described herein are biocompatible (e.g., non-toxic) and/or biodegradable (e.g., eco-friendly). Methods using the compositions described herein include methods of treating a surface (e.g., an inert and/or non-animal surface, e.g., a synthetic or semi-synthetic surface (e.g., cellulose, ceramic, plastic, metal, glass, wood, or stone); or a food or food product surface, the method comprising contacting (e.g., spraying) an effective amount of a composition comprising a chitosan (e.g., a soluble or derivatized chitosan described herein) with the inert and/or non-animal surface, or the food or food product surface, thereby treating the surface. | 08-07-2014 |
| 20140249102 | Topical Applicator Composition and Process for Treatment of Radiologically Contaminated Dermal Injuries - A topical applicator composition and process are described that decorporate radionuclides from radiologically-contaminated dermal surfaces and that further promote healing. The topical applicator includes a decorporation agent mixed with a plasticizing agent that forms a covering when applied to the dermal surface that decorporates radionuclides and minimizes their systemic migration. The topical applicator formulations can be delivered in conjunction with bandages and other application dressings. | 09-04-2014 |
| 20140274943 | MEDICINAL CREAM MADE USING SILVER SULPHADIAZINE AND CHITOSAN AND A PROCESS TO MAKE IT - The present invention is directed to a composition for treating bacterial skin infections, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and an antibacterial active ingredient. It discloses a composition for treating fungal skin infections along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) an active pharmaceutical ingredient (API) composition in the form of silver sulphadiazine used in treating bacterial skin infections, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, namely chitosan, and an anti bacterial agent in the form of silver sulphadiazine, are incorporated in cream base for use in treating bacterial skin infections with allergy & itching, & wounds on human skin involving contacting human skin with the above identified composition. | 09-18-2014 |
| 20140323433 | METHOD FOR REHYDRATING POLYSACCHARIDE PARTICLES - Tissue and other body structures may be protected using a hydrated composition made from free-flowing substantially collagen-free rehydratable polysaccharide particles and rehydratable polysaccharide sponges. Rehydration of the particles without clumping may be carried out be dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated composition may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function. | 10-30-2014 |
| 20140349960 | COMPOSITION FOR BODY FAT CONSUMPTION - The present invention related to a composition comprising an aqueous soluble-chitosan and a pharmaceutically acceptable carrier. Said composition can be used to increase lipase activity while having no harm in animal physiology. Together with the well known biocompatibility of chitosan, the present invention proves that the aqueous soluble-chitosan may be a potential candidate for body weight control. | 11-27-2014 |
| 20140349961 | COMPOSITION FOR ENHANCING INTESTINE METABOLISM - The present invention related to a composition comprising an aqueous soluble-chitosan and a pharmaceutically acceptable carrier. Said composition can be used to increase the defecation rate of an individual. Together with the well known biocompatibility of chitosan, the present invention proves that the aqueous soluble-chitosan may be a potential candidate for enhancing intestinal metabolism. | 11-27-2014 |
| 20140364391 | Immobilization Of An Active Agent On A Substrate Using Compounds Including Trihydroxyphenyl Groups - The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof. | 12-11-2014 |
| 20140378413 | HEMOSTATIC AGENTS AND METHODS OF USE - Modified chitosan hemostatic agents include reverse micelles ( | 12-25-2014 |
| 20150011503 | HEMOSTATIC DRESSING AND METHOD FOR MANUFACTURING THE SAME - A hemostatic dressing and method for manufacturing the same are disclosed. The hemostatic dressing comprises 25%-50% by weight of acidic chitosan fiber and 50%-75% by weight of crosslinked chitosan matrix. The hemostatic dressing of the present invention has better hemostasis effect and can maintain high stress intensity when be used. | 01-08-2015 |
| 20150011504 | Hydrogel compositions - Fragmented polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions. | 01-08-2015 |
| 20150018306 | CHITOSAN BASED HIGH PERFORMANCE FILTER WITH SELF-REGENERATING ABILITY - A self-regenerating chitosan based filter medium for disinfecting and purifying organic pollutants and other pollutants in a gas or liquid is disclosed herein. Porosity and surface charge of said filter medium is manipulative/tunable by varying one or more of the following parameter(s): concentration of chitosan, crosslinking density, amount of copolymers and additives, freezing temperature, freezing profile, and/or types of crosslinker used. The present filter medium is capable of self-regenerating under exposure to ultra-violet light for sufficient time and removing over 90% of the pollutants from each influent flowing through the filter medium. | 01-15-2015 |
| 20150065454 | Solution aqueuse homogene de chitosane injectable - The present invention relates to a homogeneous aqueous solution of injectable chitosan containing a chitosan having a degree of acetylation lower than 20%, said solution containing between 0.1 and 3.5% by weight of chitosan, said solution presenting a pH lower than 6.2, and said aqueous solution being capable of forming crystalline particles of chitosan after injection. The present invention also relates to compounds containing such a homogeneous aqueous solution of chitosan. The invention also relates to such compounds for their use as dermatological or cosmetic compounds, or for their use as a medical device, advantageously as a bioresorbable implant. | 03-05-2015 |
| 20150080335 | PROCESS FOR PRODUCING LOW ENDOTOXIN CHITOSAN - The present invention relates to a process for producing a low endotoxin alkali chitosan, and also to a process for producing low endotoxin neutral chitosan, chitosan salt and chitosan derivatives, and to the products of such processes. The process comprises contacting chitosan with an alkali solution to form a mixture and leaving the mixture for at least about 12 hours. The low endotoxin alkali chitosan may be used in the manufacture of other useful chitosan based products. | 03-19-2015 |
| 20150119357 | CHITOSAN STENTING PASTE - Nasal or sinus site may be treated with a ready-to-use paste having a high concentration of a water-soluble chitosan, an osmolality reducing agent in a phosphate-containing solution. The paste forms at room temperature, has a pH of at least 4 and the osmolality reducing agent does not crosslink with the water-soluble chitosan. The paste provides stenting and adheres to the nasal or sinus site and has a residence time of at least 1 day. | 04-30-2015 |
| 20150119358 | CHITOSAN PASTE WOUND DRESSING - A method for treating a wound with a ready-to-use composition having a high concentration of a water-soluble chitosan in a phosphate-containing solution. The composition is a paste at room temperature, has a pH of at least 4, adheres to the body tissue or surgical site and has a residence time of at least 1 day. | 04-30-2015 |
| 20150296777 | COMPOSITION COMPRISING CHITOSAN AND A FUNGICIDE - The present invention provides a composition comprising (i) chitosan or chitopoly- or chitooligo-saccharides thereof, wherein said chitosan or chitopoly- or chitooligo-saccharides thereof comprise β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine monomers and have a degree of acetylation between 0.05 and 0.20 and an average degree of polymerization ≦250 (molecular weight ≦42,000 Da), and (ii) a fungicide not containing chitopoly- or chitooligo-saccharides. | 10-22-2015 |
| 20150297633 | TREATMENT OF BONE MARROW EDEMA (OEDEMA) WITH POLYSULFATED POLYSACCHARIDES - A method for the treatment of bone marrow edema in a mammal comprising administering an effective amount of a polysulfated polysaccharide including salts thereof, to a mammal in need of such treatment. | 10-22-2015 |
| 20150306130 | CHITOSAN COVALENTLY LINKED WITH SMALL MOLECULE INTEGRIN ANTAGONIST FOR TARGETED DELIVERY - The invention relates to the chitosan polymer derivatives of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Y, X | 10-29-2015 |
| 20150335784 | FILLER COMPOSITION COMPRISING BETA-GLUCANS - The present invention pertains to a filler composition comprising β-glucan moieties and optionally a cosmetically and/or pharmaceutically acceptable carrier. It further relates to a filler composition, wherein said β-glucan moieties are cross-linked. In one embodiment of the instant invention the filler composition is a dermal filler. In one further embodiment of the present invention the filler composition is for the treatment of wrinkles and/or folds. In another embodiment of the instant invention the filler composition is for use in the treatment of a medical condition. The filler composition provided in the present invention may further comprise one or more active pharmaceutical ingredients. Further, the present invention pertains to a process for preparing the filler composition as claimed herein. | 11-26-2015 |
| 20150373984 | Antimicrobial Solution and Methods of Making and Using the Same - A chitosan solution is formed from chitin, which is a homopolymer of beta (1-4)- linked N-acetyl-D-glucosamine. Rinsed, dried and ground chitin undergoes a process of deacetylation to convert some N-acetyl glucosamine to glucosamine, a primary component of chitosan. The chitosan solution is prepared by mixing 5chitosan with a alpha-hydroxy acid such as glycolic acid. An aqueous chelated silver solution is prepared by mixing silver oxide with a carboxylic acid such as citric acid. The chitosan solution can then be mixed with the silver solution resulting in a cationic complex. The cationic complex of the present invention may then be electrostatically bonded with generally negatively charged surfaces. In use, citrate promotes uptake of the silver by microbes. The antimicrobial complex can be applied via several methods of application, including an impregnated wipe, a foam, a gel, a spray, a lotion and an ointment. | 12-31-2015 |
| 20160002360 | COMPOSITIONS OF PARTIALLY DEACETYLATED CHITIN DERIVATIVES - The present invention relates to compositions comprising biologically active chitinous oligomers and their endotoxin purified and partially deacetylated chitin polymer precursors, and their use in pharmaceutical compositions, biomaterial compositions, medical devices, and processes to produce the said oligomers. More specifically the present invention relates to novel compositions and processes to produce such compositions. The compositions include therapeutic hetero polymer and hetero oligomer compositions compricing specific sequences of N-acetyl glucosamine and glucosamine, developed to optimize chemical and structural features which are important for the therapeutic activity of these compositions. In addition, the present invention provides methods to use degree of deacetylation of a partially deacetylated chitin polymer in order to modulate physical and biological parameters in a calcium phosphate composite for bone implant applications. | 01-07-2016 |
| 20160015735 | ANTI-MICROBIAL COMPOSITION - A topical anti-microbial composition and use thereof comprising a quaternized chitosan derivative having a polymerizable organic moiety and an amphoteric surfactant. | 01-21-2016 |
| 20160022827 | HYBRID NANOMATERIAL OF GRAPHENE OXIDE NANOMATERIAL AND CATIONIC QUATERNIZED CHITOSAN - A hybrid nanomaterial consisting of graphene oxide (GO) nanomaterial covalently conjugated to cationic quaternized chitosan is provided. Method of preparing the hybrid nanomaterial, an antimicrobial composition containing the hybrid nanomaterial, and use of the antimicrobial composition in inhibiting growth of microorganisms in an environment are also provided. | 01-28-2016 |
| 20160082037 | COMPOSITION, PREPARATION, AND USE OF CHITOSAN POWDER FOR BIOMEDICAL APPLICATIONS - A powder chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using γ-irradiation, treated under a nitrogen plasma, or both. A powder chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using γ-irradiation, treating under a nitrogen plasma, or both. | 03-24-2016 |
| 20160108138 | PROCESS FOR PRODUCING LOW ENDOTOXIN CHITOSAN - The present invention relates to a process for producing a low endotoxin alkali chitosan, chitin, chitosan derivative or chitin derivative, and also to a process for producing low endotoxin neutral chitosan, chitosan salt and chitosan derivatives, and to the products of such processes. The process comprises contacting chitosan, chitin, chitosan derivative or chitin derivative with an alkali solution to form a mixture; leaving the mixture for a period of less than 1 hour and optionally drying the mixture. The low endotoxin alkali chitosan may be used in the manufacture of other useful chitosan based products. | 04-21-2016 |
| 20160121022 | PROCESS FOR PRODUCING LOW ENDOTOXIN CHITOSAN - The present invention relates to a process for producing a low endotoxin alkali chitosan, chitin, chitosan derivative or chitin derivative, and also to a process for producing low endotoxin neutral chitosan, chitosan salt and chitosan derivatives, and to the products of such processes. The process comprises contacting chitosan, chitin, chitosan derivative or chitin derivative with an alkali solution having a concentration of less than 0.25 M to form a mixture; leaving the mixture for a period of less than 12 hours and optionally drying the mixture. The low endotoxin alkali chitosan may be used in the manufacture of other useful chitosan based products. | 05-05-2016 |
| 20160151536 | METHODS OF USE OF BIOMATERIAL AND INJECTABLE IMPLANT CONTAINING BIOMATERIAL | 06-02-2016 |
| 20160158369 | PHARMACEUTICAL COMPOSITION FOR RESPIRATORY ADMINISTRATION - The present invention provides a pharmaceutical composition for respiratory administration containing a polysaccharide derivative having a group derived from a polysaccharide and a group derived from a physiologically active substance that is covalently bonded to the group derived from a polysaccharide. | 06-09-2016 |
| 20160175449 | NOVEL BIOMATERIALS AND A METHOD FOR MAKING AND USING SAME | 06-23-2016 |
| 20160193244 | DRUG CONTAINING CATIONIZED CHITOSAN | 07-07-2016 |
| 20180021369 | TREATMENT OF BONE MARROW EDEMA (OEDEMA) WITH POLYSULFATED POLYSACCHARIDES | 01-25-2018 |
