| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 506040000 | For creating a library | 59 |
| 20080200349 | MICRODEVICES HAVING A PREFERENTIAL AXIS OF MAGNETIZATION AND USES THEREOF - This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided. | 08-21-2008 |
| 20080207468 | Micro-fabricated stamp array for depositing biologic diagnostic testing samples on bio-bindable surface - The present invention discloses micro-stamp array supported on a substrate comprising a plurality of micro-stamp sticks. Each of the micro-stamp sticks includes a micro-stamp-stick head having a channel opened through a central portion in each of the micro-stamp sticks. Each of the micro-stamp-stick heads is attached to a tapered guide tube surrounded by tapered guide-tube walls wherein the tapered guide tube is in hydraulic communication with the micro-stamp-head channel. The micro-stamp array further includes a filler chip that includes a filler reservoirs disposing on top of the tapered guide tubes, each of the filler reservoirs having a refill channel opened to the tapered guide tube for refilling the tapered guide tube and the channels. | 08-28-2008 |
| 20080220990 | Methods, systems, and software for identifying functional bio-molecules - The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods. | 09-11-2008 |
| 20080280785 | FLUIDIC NANO/MICRO ARRAY CHIP AND CHIPSET THEREOF - A fluidic nano/micro array chipset comprises a microarray filling chip and a nano/micro array stamping chip. There are a plurality of sample containers and a plurality of nano/micro channels on the top of the microarray filling chip, and a plurality of nano/micro-scaled micro filling holes on the bottom of the microarray filling chip. Each nano/micro channel is connected to one of the sample containers and leads the sample solution in that sample container to the corresponding micro filling hole. The nano/micro array stamp chip comprises a plurality of stamping heads arranged in an array pattern, with a body part of the stamp chip and a plurality of space channels forming hydrophobic areas. Each sample solution is stored in the body of the stamp chip, and is transported by the corresponding stamping head to the stamping part of this stamping head. | 11-13-2008 |
| 20080287322 | Method and Coating Apparatus for the Manufacture of a Microarray - In a method for the manufacture of a microarray, surface areas of a chip are brought into contact with different aqueous solutions that contain at least one coating substance. For each of the individual surface areas, an absorbent substrate is provided and is filled with the solution that is to be brought into contact with the surface area in question. Then, for the printing of the surface area with the at least one coating substance contained in the solution, each substrate is brought into contact with the surface area in question. | 11-20-2008 |
| 20080318809 | CORRECTION FOR ILLUMINATION NON-UNIFORMITY DURING THE SYNTHESIS OF ARRAYS OF OLIGOMERS - The present invention provides an apparatus and a method for the synthesis of arrays of oligomers that have tight illumination intensity requirement. The apparatus and the method contain a mechanism to correct for illumination non-uniformity during the oligomer array synthesis process. To correct for illumination non-uniformity, the illumination intensity of different oligomer synthesis positions across an area in which oligomers are synthesized are determined first. Then, the differences in illumination intensity among the positions are evaluated mathematically. Next, any non-uniformity in illumination intensity is corrected by either reducing the intensity of the light for the brighter positions before the light reaches the illumination area or reducing the illumination time of the brighter positions during one protection group deprotection period. | 12-25-2008 |
| 20090069200 | System for Preparing Arrays of Biomolecules - Provided are systems for arrays for assaying various biomolecules and other compounds in a microtiter plate format. The wells are designed so as to contain subwells to facilitate fluid communication between subwells and to allow for efficient human or robotic manipulation of samples and assay of binding or other interactions of components within the wells. | 03-12-2009 |
| 20090143251 | APPARATUS FOR PRODUCING PROBE CARRIER - An apparatus for producing a probe carrier in which ambient humidity for a plurality of nozzles of a liquid ejection device for ejecting droplets of solutions containing probes to the surface of a carrier is controlled to 50% or more, preferably 60% or more. A part of solution supply passages to the plurality of nozzles is constructed from gas permeable membranes permitting gas-liquid separation under reduced pressure. These gas permeable membrane portions are gathered and altogether placed under reduced pressure to remove air bubbles from the respective solutions supplied to the plural nozzles and decrease the amount of a dissolved gas, which causes air bubbles to be generated. | 06-04-2009 |
| 20090258797 | SYSTEMS FOR FILLING A SAMPLE ARRAY BY DROPLET DRAGGING - Systems for filling sample array by droplet dragging are provided. One aspect of the invention provides an array filling system for filling a platen having a platen surface and an array of receptacles, the receptacles having an internal surface and the receptacles separated by the platen surface, the system comprising: a liquid transfer device capable of holding liquid; and a controller configured to position the liquid transfer device in proximity to the platen surface and to move the liquid transfer device across the surface and over the receptacles to be filled so as to cause sequential communication of liquid in the liquid transfer device with the interior surface of each receptacle. | 10-15-2009 |
| 20100160185 | Synthesis of Oligomers in Arrays - Systems, including apparatus and methods, for synthesis of oligomers in arrays. | 06-24-2010 |
| 20100216669 | Capillary-Channel Probes For Liquid Pickup, Transportation And Dispense Using Stressy Metal - Fluidic conduits, which can be used in microarraying systems, dip pen nanolithography systems, fluidic circuits, and microfluidic systems, are disclosed that use channel spring probes that include at least one capillary channel. Formed from spring beams (e.g., stressy metal beams) that curve away from the substrate when released, channels can either be integrated into the spring beams or formed on the spring beams. Capillary forces produced by the narrow channels allow liquid to be gathered, held, and dispensed by the channel spring probes. Because the channel spring beams can be produced using conventional semiconductor processes, significant design flexibility and cost efficiencies can be achieved. | 08-26-2010 |
| 20100317548 | High-throughput cell transfection device and methods of using thereof - Transfecting biology cells with nucleic acid molecules (DNA, siRNA) is an essential prerequisite in elucidating how genes function in complex cellular context and how their activities could be modulated for therapeutic intervention. Traditionally studies are carried out on a low throughput gene-by-gene scale, which has created a huge bottleneck in functional genomic study and drug discovery. Development of high-throughput cell transfection technology will permit functional analysis of massive number of genes and how their activities could be modulated by chemical or biological entities inside cells. This invention describes design, construction of device and apparatus for high throughput effective cell transfection. Procedures and protocols for using the device and apparatus are also described in the application. Novel methods of using the device in cell-based assays are also disclosed. | 12-16-2010 |
| 20100331220 | ACOUSTIC DEVICE - There is disclosed an acoustic device for manipulation of fluid samples including fluid samples comprising particles characterised in that it comprises a flexible member, a sound wave generator for generating a sound wave and a sound wave coupler for coupling the sound wave from the generator into the flexible member, in which the device, flexible member and the coupler are adapted to excite a predetermined acoustic mode of pure resonant vibration in the flexible member at a predetermined frequency of the sound wave. | 12-30-2010 |
| 20110152128 | ENHANCED MICROPLATE CONFIGURATIONS - An enhanced microplate and retention device for selectively retaining tube inserts within the microplate. A dynamic microplate having a selectable number of interchangeable microwells. | 06-23-2011 |
| 20110152129 | SAMPLE WELL STRIP - A multiple cuvette strip comprises a plurality of wells and a reversible interlocking device. The well strips can be reversibly interlocked to other well strips to form a sample holder system. One embodiment of a well strip comprises a flange and a slot to form a reversible interlocking device. | 06-23-2011 |
| 20110195874 | SYSTEMS AND METHODS FOR BIOMARKER ANALYSIS - Systems and methods of biomarker analysis. In at least one embodiment of a system for determining the therapeutic potential of a therapeutic compound the present disclosure, the system comprises a detection platform, a computer database capable of receiving a plurality of binding characteristics, a processor operably coupled to the computer database and the detection platform. In at least one embodiment, the processor has and executes a software program operational to determine a binding characteristic of the detection agent and a stabilized diagnostic agent in each of the plurality of detection sites, compare the binding characteristic among each of the plurality of detection sites, wherein the comparison of binding characteristics is capable of determining the stabilizing agent with the greatest effect on the binding characteristic between the detection agent and the diagnostic agent, generate a binding record using the compared binding characteristics, and deliver the binding record to a recipient. | 08-11-2011 |
| 20110257049 | Sample Block Apparatus and Method for Maintaining a Microcard on a Sample Block - A thermal cycling device for thermally cycling samples of biological material contained in a microcard having a top and bottom surface. The thermal cycling device can include a sample block having an upper surface configured for engaging the bottom surface of a microcard, a vacuum device, and a temperature control system operatively connected with the sample block. The upper surface of the sample block may include a plurality of channels, the channels defining spaces between the sample block and the bottom surface of a microcard that may be positioned thereon. The vacuum device may be in fluid communication with the sample block for drawing gas out of the spaces defined by the channels in the sample block. The vacuum device may be configured for substantially maintaining a vacuum between the sample block and microcard so that a retention force is imparted on the microcard to urge the microcard toward the sample block. Methods of maintaining a microcard on a sample block of a thermal cycling device are also provided. | 10-20-2011 |
| 20110263464 | ENHANCED DROP MIXING USING MAGNETIC ACTUATION - A method and device for merging and mixing at least two separate and distinct fluid drops on a substrate, includes a drop merging area on the surface, where a first magnetic material is placed at a first location. A first drop of fluid is then placed at the first location on the surface, resulting in the first magnetic material being at least partially positioned within the first drop of fluid. A second drop of fluid is then placed at a second location on the surface of the drop merging area. A magnetic field is applied by a varying magnetic field generator to at least a portion of the drop merge area of the substrate, which includes at least the first location on the substrate. The varying magnetic field will act on the first magnetic material to move the first magnetic material within the first drop of fluid, causing a stirring of the fluid. A drop merging force from a drop merging mechanism is applied to at least one of the first drop of fluid and the second drop of fluid within the drop merge area. This causes at least one of the first drop of fluid and the second drop of fluid to move toward the other and make contact. The internal stirring of the fluid in the first drop of fluid by the movement of the magnetic material enhances the mixing of the constituents of the first drop of fluid and the constituents of the second drop of fluid. | 10-27-2011 |
| 20110281776 | INTEGRATED SAMPLE PREPARATION SYSTEMS AND STABILIZED ENZYME MIXTURES - The present invention provides integrated sample preparation systems and stabilized enzyme mixtures. In particular, the present invention provides microfluidic cards configured for processing a sample and generating DNA libraries that are suitable for use in sequencing methods (e.g., next generation sequencing methods) or other suitable nucleic acid analysis methods. The present invention also provides stabilized enzyme mixtures containing an enzyme (e.g., an enzyme used in whole genome amplification), BSA, and a sugar. Such enzyme mixtures may be lyophilized and stored at room temperature without significant loss of enzyme activity for months. | 11-17-2011 |
| 20110287982 | CELL CULTURE DEVICE - The invention relates to the field of cell and tissue culture. In particular, the invention relates to devices for cell culture. A device for cell culture, according to the invention comprises (i) a medium conduit having one open end and one end closed by a porous membrane fused across it; and (ii) a frame holding the medium conduit in a substantially vertical orientation; wherein the medium conduit is adapted to permit retention by capillarity of a sufficient volume of liquid culture medium in the medium conduit to contact the surface of the porous membrane and thus supply nutrients to cells that may be grown on the porous membrane, characterised in that the surface of the membrane contralateral to the surface of said porous membrane sealed to said medium conduit comprises a hydrophobic barrier adapted to contain the culture. | 11-24-2011 |
| 20110312841 | FABRICATION SYSTEM FOR LAB-ON-A-CHIP (LOC) DEVICES WITH DIFFERING APPLICATION SPECIFIC FUNCTIONALITY - A fabrication system for lab-on-a-chip (LOC) devices with differing application specific functionality, the fabrication system having a database of different functional categories, each of the functional categories having a plurality of functional section designs, means for selecting a compilation of the functional section designs to generate a LOC design in accordance with a specific functionality intended for LOC devices fabricated in accordance with the LOC design, and, a MST (microsystems technology) fabrication facility for fabricating LOC devices in accordance with the LOC design, wherein, the functional section designs in any one of the functional categories are functionally compatible with at least one of the functional section designs in the other functional categories. | 12-22-2011 |
| 20110312842 | OLIGONUCLEOTIDE SPOTTING DEVICE - An oligonucleotide spotting device for contactless spotting of oligonucleotide probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having a supporting substrate, an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, and, an array of ejectors, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, wherein, the ejectors are configured to eject droplets containing the oligonucleotide probes from the corresponding reservoir onto the surface. | 12-22-2011 |
| 20110312843 | SPOTTING DEVICE FOR COMPLETE ASSAY SPOTTING OF LOCS - A spotting device for contactless spotting of a lab-on-a-chip (LOC) device with oligonucleotide probes, the LOC device having an array of hybridization chambers for receiving the oligonucleotide probes, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample and the array of hybridization chambers being configured to hold a complete assay of oligonucleotide probes necessary for a predetermined analysis of the biological sample, the spotting device having an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, and, an array of ejectors, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively such that the ejectors eject droplets containing the oligonucleotide probes from the corresponding reservoir into one of the hybridization chambers, wherein, the array of reservoirs is configured to contain the complete assay of oligonucleotide probes necessary for the predetermined analysis to be performed by the LOC device. | 12-22-2011 |
| 20110312844 | BIOCHEMICAL DEPOSITION DEVICE - A biochemical deposition device for contactless deposition of biochemicals on a surface, the biochemical deposition device having an array of reservoirs for containing a plurality of biochemicals, and, an array of ejectors, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, wherein, the ejectors are configured to eject droplets containing the biochemical from the corresponding reservoir onto the surface. | 12-22-2011 |
| 20110312845 | OLIGONUCLEOTIDE SPOTTING DEVICE WITH LAMINAR STRUCTURE - An oligonucleotide spotting device for contactless spotting of oligonucleotide probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, an array of ejectors overlaying the array of reservoirs, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, wherein, the ejectors are configured to eject droplets containing the oligonucleotide probes from the corresponding reservoir onto the surface. | 12-22-2011 |
| 20110312846 | OLIGONUCLEOTIDE SPOTTING DEVICE WITH FLUIDICS ON BOTH SIDES OF SUPPORTING SUBSTRATE - An oligonucleotide spotting device for contactless spotting of oligonucleotide probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having a supporting substrate, an array of reservoirs on one side of the supporting substrate, the reservoirs configured for containing the oligonucleotide probes suspended in a liquid, an array of ejectors on the other side of the supporting substrate, and, a plurality of inlet channels for fluid communication between the reservoirs and the ejectors, wherein, the ejectors are configured to eject droplets containing the oligonucleotide probes from the corresponding reservoir onto the surface. | 12-22-2011 |
| 20110312847 | SPOTTING DEVICE WITH STORED OLIGONUCLEOTIDE SPECIFICATION DATA - A spotting device for contactless spotting of oligonucleotide probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the spotting device having an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, an array of ejectors in fluid communication with the reservoirs, each having an actuator for ejecting droplets of liquid containing the oligonucleotide probes, and, CMOS circuitry for providing each of the drop ejection actuators with a drive pulse for droplet ejection, wherein, the CMOS circuitry has a digital memory. | 12-22-2011 |
| 20110312848 | OLIGONUCLEOTIDE SPOTTING DEVICE FOR WAFER-SCALE SPOTTING OF LOCS - An oligonucleotide spotting device for contactless spotting of a silicon wafer on which an array of lab-on-a-chip (LOC) devices are fabricated, the LOC devices being configured to use the oligonucleotide probes to detect target nucleic acid sequences in a biological sample and each having an array of hybridization chambers for receiving the oligonucleotide probes, the oligonucleotide spotting device having an array of reservoirs on one side of the supporting substrate, the reservoirs containing sufficient amount of the oligonucleotide probes suspended in a liquid to spot all the LOC devices on the wafer, and, an array of ejectors overlaying the array of reservoirs for fixed movement therewith, such that the ejectors eject droplets containing the oligonucleotide probes from the corresponding reservoir into one of the hybridization chambers. | 12-22-2011 |
| 20110312849 | OLIGONUCLEOTIDE SPOTTING DEVICE FOR EJECTING LOW VOLUME DROPLETS - An oligonucleotide spotting device for contactless spotting of probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having a monolithic supporting substrate, an array of ejectors formed on one side of the supporting substrate such that the ejectors eject droplets containing the oligonucleotide probes onto the surface, wherein during use, each of the ejectors in the array is configured to eject droplets having a volume less than 100 picoliters. | 12-22-2011 |
| 20110312850 | BIOCHEMICAL DEPOSITION DEVICE WITH HIGH DEPOSITION RATE - A biochemical deposition device for contactless deposition of biochemicals on a surface, the biochemical deposition device having a supporting substrate, an array of reservoirs on one side of the substrate, the reservoirs being configured for containing a plurality of biochemicals, and, an array of ejectors on the other side of the supporting substrate, each of the ejectors being configured for fluid communication with the reservoirs, wherein during use, the array of ejectors eject droplets containing the biochemicals onto the surface at a rate greater than 100 droplets per second. | 12-22-2011 |
| 20110312851 | DEVICE FOR HIGH DENSITY SPOTTING OF OLIGONUCLEOTIDES - An oligonucleotide spotting device for contactless spotting of probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having an array of ejectors, each having an actuator for ejecting droplets of liquid containing the probes, CMOS circuitry for providing each of the actuators with a drive pulse for droplet ejection, wherein, the array of ejectors is configured to spot the probes onto the surface at a density more than 1 probe spot per square millimeter. | 12-22-2011 |
| 20110312852 | ROBOTIC SYSTEM FOR LOADING OLIGONUCLEOTIDES INTO SPOTTING DEVICES - A robotic system for spotting oligonucleotides having an oligonucleotide spotting device for contactless spotting of oligonucleotides onto a surface, the oligonucleotide spotting device having an array of ejectors, each having a drop ejection actuator for ejecting droplets of liquid containing the oligonucleotides onto a surface, at least one reservoir in fluid communication with one or more of the ejectors and CMOS drive circuitry for providing each of the drop ejection actuators with a drive pulse for droplet ejection, and, an apparatus for loading oligonucleotides into the oligonucleotide spotting device, the apparatus having a stage for detachably mounting a plurality of the oligonucleotide spotting devices, and a plurality of oligonucleotide containers mounted for movement relative to the stage, each of the oligonucleotide containers having a droplet dispenser for ejecting droplets of fluid containing oligonucleotides into the reservoirs of the oligonucleotide spotting devices. | 12-22-2011 |
| 20110312853 | OLIGONUCLEOTIDE SPOTTING ROBOT - An oligonucleotide spotting robot for spotting oligonucleotide probes into a microfluidic device having a digital memory for data related to the oligonucleotide probes loaded into the microfluidic device, the oligonucleotide dispensing robot having an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, an array of ejectors, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, a mounting surface for detachably mounting the microfluidic device for movement relative to the ejectors, and, a control processor for operative control of the ejectors and the mounting surface, wherein, the control processor is configured to activate the ejectors, move the ejectors selected for activation into registration with the microfluidic device and download the data to the digital memory. | 12-22-2011 |
| 20110312854 | OLIGONUCLEOTIDE SPOTTING ROBOT FOR SPOTTING ARRAYS OF LOCS - An oligonucleotide spotting robot for spotting oligonucleotide probes into an array of lab-on-a-chip (LOC) devices, each having a digital memory for data related to the oligonucleotide probes loaded into that LOC device, the oligonucleotide dispensing robot having an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, an array of ejectors, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, a mounting surface for detachably mounting the array of LOC devices for movement relative to the ejectors, and, a control processor for operative control of the ejectors and the mounting surface, wherein, the control processor is configured to activate the ejectors, move the ejectors selected for activation into registration with one or more of the LOC devices and download the data specifically relevant to each of the LOC devices into the digital memory of that LOC device. | 12-22-2011 |
| 20110312855 | OLIGONUCLEOTIDE SPOTTING ROBOT FOR HIGH DENSITY SPOTTING OF OLIGONUCLEOTIDES - An oligonucleotide spotting robot for spotting oligonucleotide probes onto a substrate, the oligonucleotide dispensing robot having an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, an array of ejectors, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, a mounting surface for detachably mounting the substrate for movement relative to the ejectors, and, a control processor for operative control of the ejectors and the mounting surface, wherein, the array of ejectors is configured to spot the probes onto the surface at a density more than 1 probe spot per square millimeter. | 12-22-2011 |
| 20110312856 | APPARATUS FOR DISPENSING REAGENTS, LOADING OLIGONUCLEOTIDE SPOTTING DEVICES AND SPOTTING OLIGONUCLEOTIDE PROBES - An apparatus for dispensing reagents, loading oligonucleotide spotting devices and spotting oligonucleotide probes, the apparatus having a plurality of reagent vials, each with a droplet dispenser, a plurality of oligonucleotide vials, each with a droplet dispenser, a mounting surface for detachably mounting a microfluidic device for movement relative to the reagent vials, and detachably mounting an oligonucleotide spotting device, a chuck for detachably mounting the oligonucleotide spotting device adjacent the mounting surface, and, a control processor for operative control of the reagent and oligonucleotide vials, the oligonucleotide spotting device when mounted in the chuck and movement of the mounting surface relative to the reagent and oligonucleotide vials, and the oligonucleotide spotting device, wherein, the control processor is configured to activate any of the droplet dispensers, move the microfluidic device into registration with the reagent vials and move the oligonucleotide spotting device into registration with the oligonucleotide vials. | 12-22-2011 |
| 20120004145 | OLIGONUCLEOTIDE SPOTTING ROBOT FOR WAFER-SCALE SPOTTING OF LOCS - An oligonucleotide spotting robot for spotting oligonucleotide probes into a silicon wafer on which an array of lab-on-a-chip (LOC) devices are fabricated, each LOC device having a digital memory for data related to the reagents loaded into the LOC device, the oligonucleotide dispensing robot having an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, an array of ejectors, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, a mounting surface for detachably mounting the array of LOC devices for movement relative to the ejectors, and, a control processor for operative control of the ejectors and the mounting surface, wherein, the control processor is configured to activate the ejectors, move the ejectors selected for activation into registration with one or more of the LOC devices and download the data specifically relevant to each of the LOC devices into the digital memory of that LOC device. | 01-05-2012 |
| 20120231976 | Microfluidic Chip for High-Throughput Perfusion-Based Three-Dimensional Cell Culture - A microfluidic chip for three-dimensional cell culture with high-throughput perfusion includes an array of cell culture units, each unit including a cell culture medium inlet hole connecting to one cell culture medium tank, at least one micro-bioreactor, at least one microchannel and at least one medium collection and analysis tank. Each medium collection and analysis tank is connected to an air chamber with an air channel and the air chamber has negative pressure source holes to generate negative pressure to drive the culture medium. The microfluidic chip also includes an intermediate plate connected to the bottom surface of the roof, and two bottom plates detachably assembled at the bottom of the intermediate plate. The first and second bottom surfaces have micro-bioreactors and cylindrical recessed slots and the intermediate plate has corresponding holes to achieve the goal of three-dimensional cell culture using minimum experimental resources with high-throughput perfusion. | 09-13-2012 |
| 20130005614 | SILICON STRUCTURE, ARRAY SUBSTRATE USING THE SAME AND METHOD FOR PRODUCING SILICON STRUCTURE - A silicon structure has a substrate, a first layer formed on a surface of the substrate, and a fibrous film formed on a surface of the first layer. The first layer and the fibrous film are silicon compounds made of the same elements, and the first layer and the fibrous film are directly bonded together. | 01-03-2013 |
| 20130059763 | System for photolithographic synthesis of polymer arrays - The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays. | 03-07-2013 |
| 20130102502 | BIO-CHIP - There is provided a bio-chip including a first substrate including a first recess formed in a first end surface thereof; and a second substrate including a first coupling pillar inserted into the first recess and a second coupling pillar in contact with a second end surface opposed to the first end surface. | 04-25-2013 |
| 20130261029 | VARIABLE PITCH ARRAY SPOTTER - A spotter that includes a plurality of spotting heads, each of the plurality of spotting heads having a discharging portion at a tip portion, the plurality of spotting heads form an m×n array (m, n>1) with m spotting heads arranged lengthwise and n spotting heads arranged crosswise; and a pitch varying mechanism configured to vary an array pitch of the plurality of spotting heads arrayed in a lengthwise direction and an array pitch of the plurality of spotting heads arrayed in a crosswise direction. | 10-03-2013 |
| 20140011711 | MICROARRAY CELL CHIP - Disclosed herein is a microarray cell chip. The microarray cell chip includes an upper substrate that has biomatrices encapsulating biomaterials formed on one surface thereof and through holes penetrating from one surface to the other surface thereof and a lower substrate that is coupled with the upper substrate and is provided with wells storing reagents supplied to the biomatrices. The microarray cell chip according to the present invention can smoothly transfer the culture media and the reagents to the biomaterials embedded in the biomatrices through the diffusion and simply separate the upper substrate from the lower substrate, thereby improving the easiness of washing. Therefore, the present invention provides an environment similar to the bio environment, thereby making it possible to increase accuracy of an experiment. | 01-09-2014 |
| 20140249057 | Fluid Processing Device for Oligonucleotide Synthesis and Analysis - The present teachings provide a fluid processing device adapted to produce different oligomers in a plurality of respective reaction sites. The fluid processing device can comprise a first manifold for delivering reactants to the plurality of reaction sites, and a second manifold for removing waste from, and optionally delivering wash fluid to, the plurality of reaction sites. Surface tension control valves can be disposed in fluid communication with the first manifold and can selectively allow reactants and/or fluids into the reaction sites. A method of making oligonucleotides is also provided. | 09-04-2014 |
| 20140336084 | COATED SUBSTRATES FOR HIGH ENERGY CAPTURE PHASE BINDING AND METHODS OF PRODUCTION AND USE THEREOF - A substrate, which is useful for performing biological, chemical and diagnostic assays, and a method for preparing the substrate are provided. The substrate has an upper surface with a coating disposed thereon. The coating comprises a charged polymer, a non-ionic polyether, and a silicate compound. The substrate can increase capture phase binding and reduce non-specific binding of biomolecules for a biological microarray. | 11-13-2014 |
| 20150038379 | METHODS AND DEVICES FOR MICRO-ISOLATION, EXTRACTION, AND/OR ANALYSIS OF MICROSCALE COMPONENTS - Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation apparatus described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation apparatus can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The micro-isolation apparatus can further comprise a chambered microfluidic device comprising channels providing access to wells defined in photosensitive material. The micro-isolation apparatus can comprise a chambered microfluidic device without access wells defined in photosensitive material where valves control the flow of gases or liquids through the channels of the microfluidic device. Also included are methods for selectively isolating cellular material using the apparatuses described herein, as are methods for biochemical analysis of individual regions of interest of cellular material using the devices described herein. Further included are methods of making masking arrays useful for the methods described herein. | 02-05-2015 |
| 20150051118 | Coated Substrate for Biological Reaction Systems - An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site. | 02-19-2015 |
| 20150072900 | SAMPLE PROCESSING DROPLET ACTUATOR, SYSTEM AND METHOD - Sample processing droplet actuators, systems and methods are provided. According to one embodiment, a stamping device including a droplet microactuator is provided and includes: (a) a first plate including a path or network of control electrodes for transporting droplets on a surface thereof; (b) a second plate mounted in a substantially parallel orientation with respect to the first plate providing an interior volume between the plates, the second plate including one or more stamping ports for transporting some portion or all of a droplet from the interior volume to an exterior location; (c) a port for introducing fluid into the interior volume between the plates; and (d) a path or network of reference electrodes corresponding to the path or network of control electrodes. Associated systems and methods including the stamping device are also provided. | 03-12-2015 |
| 20150126412 | SYSTEMS FOR FILLING A SAMPLE ARRAY BY DROPLET DRAGGING - A method and an array filling system for loading a plurality of disparate sample containers, the sample containers comprising an integral structure. Each receptacle is characterized by a hydrophilic surface, and the receptacles are separated by a hydrophobic surface. The system has a liquid transfer device capable of holding liquid and adapted for motion to cause sequential communication of liquid held in the liquid transfer device with successive receptacles of the array by dragging the liquid across the hydrophobic surface. | 05-07-2015 |
| 20150298088 | DEVICES AND SYSTEMS FOR CREATION OF DNA CLUSTER ARRAYS - The present invention comprises systems and devices for isothermal amplification of polynucleotide sequences to produce DNA cluster arrays. | 10-22-2015 |
| 20150314292 | DROPLET CREATION TECHNIQUES - The present invention is generally related to systems and methods for producing droplets. The droplets may contain varying species, e.g., for use as a library. In some cases, at least one droplet is used to create a plurality of droplets, using techniques such as flow-focusing techniques. In one set of embodiments, a plurality of droplets, containing varying species, can be divided to form a collection of droplets containing the various species therein. A collection of droplets, according to certain embodiments, may contain various subpopulations of droplets that all contain the same species therein. Such a collection of droplets may be used as a library in some cases, or may be used for other purposes. | 11-05-2015 |
| 20150321195 | TEMPERATURE CONTROL DEVICES AND METHODS - Temperature control devices and methods are described. The described temperature control devices and methods comprise optical emission and detection assemblies and can be used in PCR and qPCR applications. | 11-12-2015 |
| 20150352513 | Microfluidic Droplet Queuing Network - A multi-port liquid bridge ( | 12-10-2015 |
| 20160040111 | HIGH-THROUGHPUT CULTURE AND TRANSFER DEVICE AND METHOD - A method and device for creating hanging drop cell aggregates. The method and device includes a plurality of pegs that allow for high throughput culture of aggregates. Also disclosed are means of transferring formed aggregates to various destinations, such as well plates, scaffolding, tissues, or wounds. Use of the device permits aggregates to be prepared or created in larger quantities than current methods, and allows for them to be transferred more efficiently. | 02-11-2016 |
| 20160045885 | SCREENING ASSAYS AND METHODS - Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody. | 02-18-2016 |
| 20160089651 | DE NOVO SYNTHESIZED GENE LIBRARIES - De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein. | 03-31-2016 |
| 20160096160 | DE NOVO SYNTHESIZED GENE LIBRARIES - De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein. | 04-07-2016 |
| 20160114323 | MICROFLUIDIC DEVICE AND ARRAY DISK - The invention relates to microfluidic devices and array disks for “one-pot” isolated chemical reactions. The array disks comprise a plurality of sectors in which each sector comprises one microfluidic device. The microfluidic devices comprise a fluid delivery channel and an array of wells wherein the fluid delivery channel delivery fluid into the wells in a serpentine arrangement. In some embodiments, the fluid delivery channel is directly above the array of wells. In other embodiments, the fluid delivery channel is offset from the array of wells so that side channels branching from the fluid delivery channel delivers fluid into the wells. The well of the microfluidic device comprises a gas-permeable membrane that forms the floor, well, or at least a portion of the floor or wall of the well. In preferred embodiments, the well is cylindrical. | 04-28-2016 |
| 20160139035 | DIGITAL CONTROL OF ON-CHIP MAGNETIC PARTICLE ASSAY - An assay system and method for use in the field of chemical testing is disclosed. The assay system can be used for filtering whole blood for testing on an integrated circuit containing digital control functionality. | 05-19-2016 |
