| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 506027000 | Liquid-phase synthesis (i.e., wherein all library building blocks are in liquid phase or in solution during library creation) or particular method of cleavage from the liquid support used | 43 |
| 20090023604 | Scavenger supports and the use thereof in a process for the extraction of metals - There is provided a process for removing metal from solution wherein a solution comprising a metal is contacted with a scavenger support, whereby the scavenger support binds to at least some of the metal in solution thereby decreasing the amount of metal in solution, characterised in that the scavenger support comprises a functionalised support comprising pendant groups selected from 1,3-ketoesters or 1,3-ketoamides or mixtures thereof attached to a support wherein a number of the pendant groups are reacted with an amine. Scavenger supports comprising a functionalised support comprising pendant 1,3-ketoester or 1,3-ketoamide groups of formula 1: wherein R | 01-22-2009 |
| 20090023605 | OLIGONUCLEOTIDE SYNTHESIZER - An apparatus for high-throughput combinatorial synthesis of organic molecules including a reaction vessel for containing a combinatorial chemistry synthetic reaction, a liquid dispenser for dispensing the liquid, a liquid aspirator and an adjustment mechanism. The reaction vessel includes an ingress aperture allowing a liquid to enter into an interior of the vessel and an egress aperture for aspirating the liquid from the vessel. The liquid dispenser dispenses liquid through the ingress aperture. The liquid aspirator aspirates liquid through the egress aperture and includes a rotor for carrying the vessel and orbiting the vessel about an axis of rotation. The rotor is oriented generally in a horizontal plane and includes an adjustment mechanism for adjusting the angle of the vessel relative to the horizontal plane in response to the centrifugal force generated by orbiting the vessel about the axis or rotation. A method of combinatorial synthesis of organic molecules is also disclosed. | 01-22-2009 |
| 20090042742 | Attachment of molecules to surfaces - The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density. | 02-12-2009 |
| 20090143249 | BIOARRAY CHIP REACTION APPARATUS AND ITS MANUFACTURE | 06-04-2009 |
| 20090163383 | SYSTEMS AND METHODS FOR MONITORING AND CONTROLLING COMBINATORIAL PROCESSES - Method for monitoring and controlling a combinatorial process are presenting including: receiving a substrate; executing the combinatorial process, wherein the combinatorial process includes an in-line chemical preparation; analyzing the in-line chemical preparation for conformance with a corresponding in-line chemical preparation parameter using an in-line chemical analysis; and if the in-line chemical preparation is out of conformance with the corresponding in-line chemical preparation parameter, adjusting the in-line chemical preparation to conform with the corresponding in-line chemical preparation parameter utilizing a replenishing chemical preparation. In some embodiments, methods further include: performing a post-chemical mechanical planarization (CMP) clean before executing the combinatorial process, wherein the combinatorial process is a pre-clean; and depositing a capping layer after the pre-clean. | 06-25-2009 |
| 20090192050 | PARALLEL PREPARATION OF HIGH FIDELITY PROBES IN AN ARRAY FORMAT - The present invention provides massively parallel oligonucleotide synthesis and purification for applications that utilize large collections of defined high-fidelity oligonucleotides (e.g., from about 10 | 07-30-2009 |
| 20090270278 | Methods and compounds for making arrays - Arrays and methods of making an array are described. A plurality of beads, each bead comprising a group of compounds, each compound of said group attached to a bead through a photocleavable linker are brought in proximity (or contact) with another surface, and exposed to electromagnetic radiation. Illuminating the beads with radiation causes at least a portion of the compounds to be photocleaved from the beads and transferred to the surface to form a plurality of transferred groups of compounds on said surface, at least a portion of which is positioned in different locations on said surface. | 10-29-2009 |
| 20100029512 | FORMING SAMPLE COMBINATIONS USING LIQUID BRIDGE SYSTEMS - The present invention generally relates to methods of constructing liquid bridges and methods of forming predetermined combinations of samples using liquid bridges. | 02-04-2010 |
| 20100087337 | High Throughput Fabrication of Nanoparticles - This application provides a high throughput method of making nanoparticles is provided that utilizes plates comprising wells (e.g., 96-well plates). | 04-08-2010 |
| 20100152065 | PRODUCTION METHOD OF PARTICLE ARRAY - A method of producing a particle array is disclosed, comprising allowing monodisperse particles to be arrayed in an aqueous medium containing a monomer to form a colloidal crystal exhibiting a structural color and then polymerizing the monomer to form a polymer. | 06-17-2010 |
| 20100179074 | METHODS AND APPARATUS FOR FLUID DELIVERY AND REMOVAL OF MICRON SCALE STRUCTURES - Methods and apparatus for the fluid delivery and removal of micron scale structures that increase the efficiency of such fluid delivery and removal. An exemplary method for fluid delivery of a micron scale structure includes providing a silicon device that comprises a plurality of wells. Each of the wells includes a bottom wall, a side wall, a top opening and a plurality of protrusions that extend into the interior of the well. A plurality of micron scale structures are delivered into the wells using a fluid. The fluid is then removed from the wells, whereby spaces between the protrusions facilitate flow and removal of the fluid. The protrusions then retain the plurality of micron scale structures in the wells. | 07-15-2010 |
| 20100210479 | METHOD OF SYNTHESIS AND TESTING OF COMINATORIAL LIBRARIES USING MICROCAPSULES - Methods for use in the synthesis and identification of molecules which bind to a target component of a biological system or modulate the activity of a target are described. | 08-19-2010 |
| 20100285996 | SEGMENTED PROCESS APPARATUS FOR MICROPLATE AND SEGMENTED PROCESS METHOD FOR MICROPLATE - An object is to provide a highly effective segmented process apparatus for a microplate using a standard microplate without increasing the scale of the apparatus, as well as a method for processing a microplate. The apparatus includes: a predetermined microplate provided with a number of wells are set in array; one or more nozzle heads provided with a number of nozzles set in array; a suction and ejection mechanism for sucking and ejecting a gas via the nozzles; and a moving means which allows relative movement between the microplate and the nozzle heads, wherein tips of all of the nozzles provided on each nozzle head are provided in such a manner that the tips can be inserted into the wells in a portion of the microplate all together, and the row intervals and column intervals of the nozzles in array are respectively same as the row intervals and column intervals of the wells in array. | 11-11-2010 |
| 20110092392 | SYSTEM FOR FORMING AN ARRAY OF EMULSIONS - System, including apparatus and methods, for forming an array of emulsions. The system may comprise a plate including an array of emulsion production units. Each unit may include at least one first input well, a second input well, and an output well connected to the first and second input wells by channels that form a droplet generator. The system also may comprise a vacuum or pressure source configured to be connected operatively to wells of the plate to form a pressure drop between the input wells and the output well of each unit that is capable of driving a first fluid and a second fluid from respective first and second input wells of such unit and through the droplet generator, for collection as an emulsion in the output well of such unit. | 04-21-2011 |
| 20110143965 | OLIGONUCLEOTIDE SYNTHESIZER - An apparatus for high-throughput combinatorial synthesis of organic molecules including a reaction vessel for containing a combinatorial chemistry synthetic reaction, a liquid dispenser for dispensing the liquid, a liquid aspirator and an adjustment mechanism. The reaction vessel includes an ingress aperture allowing a liquid to enter into an interior of the vessel and an egress aperture for aspirating the liquid from the vessel. The liquid dispenser dispenses liquid through the ingress aperture. The liquid aspirator aspirates liquid through the egress aperture and includes a rotor for carrying the vessel and orbiting the vessel about an axis of rotation. The rotor is oriented generally in a horizontal plane and includes an adjustment mechanism for adjusting the angle of the vessel relative to the horizontal plane in response to the centrifugal force generated by orbiting the vessel about the axis or rotation. A method of combinatorial synthesis of organic molecules is also disclosed. | 06-16-2011 |
| 20110218123 | CREATION OF LIBRARIES OF DROPLETS AND RELATED SPECIES - The present invention is generally related to systems and methods for producing a plurality of droplets. The droplets may contain varying species, e.g., for use as a library. In some cases, the fluidic droplets may be rigidified to form rigidified droplets (e.g., gel droplets). In certain embodiments, the droplets may undergo a phase change (e.g., from rigidified droplets to fluidized droplets), as discussed more herein. In some cases, a species may be added internally to a droplet by exposing the droplet to a fluid comprising a plurality of species. | 09-08-2011 |
| 20120035082 | Synthesis of Oligomers in Arrays - Systems, including apparatus and methods, for synthesis of oligomers in arrays. | 02-09-2012 |
| 20120329680 | Metal (III) Complex Of Biuret-Amide Based Macrocyclic Ligand As Green Oxidation Catalyst - The present invention discloses metal (III) complex of a biuret-amide based macrocyclic ligand as green catalysts that exhibit both excellent reactivity for the activation of H | 12-27-2012 |
| 20130143774 | METHODS AND COMPOSITIONS FOR GENERATING POLYNUCLEIC ACID FRAGMENTS - Provided are methods and compositions for the generation of broad size distributions of polynucleic acid fragments from larger polynucleic acids. The invention provides unbiased polynucleic acid fragments, i.e. fragments representative of all portions of the larger polynucleic acids. The methods are amendable to automation and are cost-effective. The methods comprise contacting the polynucleic acid sample with a reducing agent and a transition metal in a solvent to form a mixture. An exemplified reducing agent is sodium ascorbate, and an exemplified transition metal is copper. | 06-06-2013 |
| 20130165348 | METHOD AND DEVICE FOR SYNTHESIZING PROTEIN FROM DNA MOLECULE CAPTURED IN MICROCHAMBER - Provided are a method and a device for synthesizing proteins from DNA molecules captured in microchambers, whereby the distance between microchambers can be shortened, thereby allowing the density of arrays to be increased. Microchambers ( | 06-27-2013 |
| 20130217601 | IN VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS - The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention. | 08-22-2013 |
| 20140051604 | MICROFLUIDIC DROPLET QUEUING NETWORK - A multi-port liquid bridge ( | 02-20-2014 |
| 20140142001 | ORGANO-CASCADE CATALYSIS: ONE-POT PRODUCTION OF CHEMICAL LIBRARIES - A method for production of a chemical library is provided, where the method involves: reacting, in a single vessel, a) a plurality, x, of aldehydes and/or ketones; and b) either (i) a plurality, y, of nucleophiles, (ii) a plurality, z, of electrophiles or both (i) and (ii); in the presence of c) a cascade catalyst capable of catalyzing reaction between said plurality of aldehydes and/or ketones and said plurality of nucleophiles, said plurality of electrophiles or both; to obtain a mixture of x-y β-nucleophile substituted aldehydes and/or ketones, x•z α-electrophile substituted aldehydes and/or ketones or x•y•z β-nucleophile substituted, α-electrophile substituted aldehydes and/or ketones; and the chemical libraries thus produced. | 05-22-2014 |
| 20140162907 | METHOD OF PRODUCING A SET OF MHC MOLECULES - The present invention relates to a method of producing a set of MHC molecules, and more precisely to a method of producing a set of MHC molecules which differ in their peptide bound in the binding groove. The method allows for parallel and rapid synthesis of different MHC molecules at high yields for each molecule. | 06-12-2014 |
| 20140179565 | POST-SYNTHESIS PROCESSING SYSTEM FOR SUPPORTED OLIGONUCLEOTIDES, AND METHOD - A system is provided that can include: a plurality of retainment regions, where each retainment region is adapted to retain a respective type of an oligonucleotide supported on a respective support; a mixture retainment region; a handling device; a control unit adapted to control the handling device; and a separating unit adapted to simultaneously separate different supported oligonucleotides from their respective supports. A method is provided that can include: pooling together a plurality of supported oligonucleotides to form a mixture; and simultaneously separating the oligonucleotides of the supported oligonucleotides in the mixture from their supports. A method for facilitating genetic analysis is also provided and can include: receiving from a user a request for one or more genetic analysis assays; formulating each assay; and providing to the user the one or more assay; wherein the formulating can include pooling together into a mixture retainment region a plurality of different supported oligonucleotides and simultaneously separating the different oligonucleotides from their respective supports. | 06-26-2014 |
| 20150126411 | SYSTEMS AND METHOD FOR HIGH-THROUGHPUT TESTING - The systems and methods described herein relate to a high-throughput flow apparatus. The apparatus is used with an array of wells, and is configured to impart a predetermined shear stress on cells cultured within each of the wells of the array of wells. The apparatus includes a plurality of mechanical tips. The plurality of mechanical tips each includes a head with a hemispheroid shape. The apparatus also includes a motor associated with at least one of plurality of mechanical tips. The motor is configured to drive the plurality of mechanical tips to impart the shear stress pattern in each of the wells. | 05-07-2015 |
| 20150292988 | FLUIDIC DEVICES, SYSTEMS, AND METHODS FOR ENCAPSULATING AND PARTITIONING REAGENTS, AND APPLICATIONS OF SAME - The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization. | 10-15-2015 |
| 20150321163 | METHOD FOR MAINTAINING HETEROGENEOUS CONCENTRATIONS OF MOLECULES IN EMULSION DROPLETS - The present invention provides a method for maintaining heterogeneous concentrations of transitory target molecules in emulsion droplets by using one of a number of means to associate them to other, non-transitory molecules within the emulsion droplets contained in a microfluidic device. The present invention further provides a method for ensuring that the concentration and speciation of molecules will remain constant when stored in emulsion droplets. This results in emulsion droplets having heterogeneous concentrations of molecules, thereby improving the performance and applicability of droplet-based microfluidics. | 11-12-2015 |
| 20150336069 | CREATION OF LIBRARIES OF DROPLETS AND RELATED SPECIES - The present invention is generally related to systems and methods for producing a plurality of droplets. The droplets may contain varying species, e.g., for use as a library. In some cases, the fluidic droplets may be rigidified to form rigidified droplets (e.g., gel droplets). In certain embodiments, the droplets may undergo a phase change (e.g., from rigidified droplets to fluidized droplets), as discussed more herein. In some cases, a species may be added internally to a droplet by exposing the droplet to a fluid comprising a plurality of species. | 11-26-2015 |
| 20150336072 | CREATION OF LIBRARIES OF DROPLETS AND RELATED SPECIES - The present invention is generally related to systems and methods for producing a plurality of droplets. The droplets may contain varying species, e.g., for use as a library. In some cases, the fluidic droplets may be rigidified to form rigidified droplets (e.g., gel droplets). In certain embodiments, the droplets may undergo a phase change (e.g., from rigidified droplets to fluidized droplets), as discussed more herein. In some cases, a species may be added internally to a droplet by exposing the droplet to a fluid comprising a plurality of species. | 11-26-2015 |
| 20160033370 | TRIPHASIC FLUID HANDLING - Aspects of the present disclosure include methods of moving a target fluid in a triphasic fluid arrangement from a vessel into a tube and systems and devices for practicing the same. | 02-04-2016 |
| 20160122802 | DROPLET STORAGE METHOD - A method of storing a stream of droplets at least some of which comprise one or more single nucleotides and/or oligonucleotides, and a droplet fluid is provided. It is characterised by the step of introducing each droplet sequentially onto a surface of a substrate at a corresponding unique location and further characterised in that the stream of droplets is prepared by a process which includes the steps of generating an ordered stream of nucleotides from the analyte by progressive pyrophosphorolysis or exo nucleolysis and capturing each nucleotide in a corresponding droplet. The method can advantageously be used in association with microdroplet droplet sequencers and an analysis unit in which the sequence of nucleotides in a precursor polynucleotide analyte is determined using fluorescence spectroscopy. A device for carrying out the method is also described. | 05-05-2016 |
| 20160129443 | DEVICE AND METHOD FOR EXTRACTING INDIVIDUAL PICOLITER DROPLETS FROM MICROFLUIDIC EMULSIONS FOR FURTHER ANALYSIS AND SCALE-UP - The disclosure relates to a method and a system for the isolation of picoliter droplets from a continuous stream of carrier fluid in a microfluidic system. In particular the disclosure relates to a system that comprises a sorter, a detector and a collector. The sorter serves for a selection of picoliter droplets with a desired content based upon an optical signal obtained from the picoliter droplets. The selected picoliter droplets are guided towards the detector that comprises a detection channel that is arranged perpendicular to a light beam. By means of a photodetector that is aligned with the optical axis of the light beam the passage of the picoliter droplets can be detected. The collector comprises multiple wells and the detection of the passage of the picoliter droplets results in a relative movement of the detector and a collector such that the picoliter droplet is isolated by depositing it into one of said wells. The disclosure moreover relates to a method that uses such a system to isolate individual picoliter droplets. In particular the disclosure relates to a method that allows for an analysis and/or further processing of the content of the picoliter droplets that have been isolated from a microfluidic system by depositing them into a well. | 05-12-2016 |
| 506028000 | Involving an encoding step | 4 |
| 20100099581 | LOCALIZED TEMPERATURE CONTROL FOR SPATIAL ARRAYS OF REACTION MEDIA - Individual temperature control in multiple reactions performed simultaneously in a spatial array such as a multi-well plate is achieved by thermoelectric modules with individual control, with each module supplying heat to or drawing heat from a single region within the array, the region containing either a single reaction vessel or a group of reaction vessels. | 04-22-2010 |
| 20100222238 | Asymmetrical Adapters And Methods Of Use Thereof - A pair of asymmetrical, partially double-stranded oligonucleotide adapters are provided wherein the pair of adapters comprise a first asymmetrical oligonucleotide adapter comprising a single-stranded 3′ overhang and a second asymmetrical double-stranded oligonucleotide adapter comprising a single-stranded 5′ overhang and at least one blocking group on the strand of said second asymmetrical oligonucleotide adapter that does not comprise the 5′ overhang. Also provided are a pair of double-stranded Y oligonucleotide adapters and a pair of double-stranded bubble oligonucleotide adapters and methods of using said asymmetrical adapters for amplification of at least one double stranded nucleic acid molecule, wherein the amplification produces a plurality of amplified nucleic acid molecules having a different nucleic acid sequence at each end are also described. Also provided is a method for exponentially amplifying one strand in a double-stranded nucleic acid molecule. Also provided are methods for preparing libraries of paired tags using COS-linkers. Also provided are cleavable adapters comprising an affinity tag and a cleavable linkage, wherein cleaving the cleavable linkage produces two complementary ends. Methods of using the cleavable adapters to produce a paired tag library are also described. | 09-02-2010 |
| 20150353924 | GENERATION OF LIBRARY OF SOLUBLE RANDOM POLYPEPTIDES LINKED TO mRNA - Methods and compositions are provided for producing libraries of soluble random polypeptides. In the methods, the fraction of hydrophilic residues in the polypeptide is controlled so as to maintain the solubility of the polypeptide constructs. | 12-10-2015 |
| 20160053306 | METHOD FOR THE SYNTHESIS OF A BIFUNCTIONAL COMPLEX - Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes. | 02-25-2016 |
| 506029000 | Using a particular method of attachment to the liquid support | 6 |
| 20090054265 | Chemical Screening System Using Strip Arrays - Arrays of distinct chemically reactive materials used for assaying or screening are assembled by arranging premanufactured strips, each having a linear array of chemically reactive materials on its surface, into a frame to be exposed to a substance to be analyzed. The strips provide great flexibility in generating different types of arrays while still permitting efficiencies to be gained by batch processing of each strip type. The arrays further provide for novel read-out and reaction promotion techniques making use of the ability of the strips to direct and received energy to and from particular sites. | 02-26-2009 |
| 20110195869 | APPARATUS FOR SYNTHESIZING MICROARRAY PROBE, AND METHOD OF SYNTHESIZING MICROARRAY PROBE USING THE APPARATUS - An apparatus for synthesizing a microarray probe, the apparatus including a capillary nozzle, and a method of synthesizing a microarray probe by using the apparatus. The probe is efficiently synthesized by using the apparatus. | 08-11-2011 |
| 20130252852 | Oligonucleotides Related to Lipid Membrane Attachment - A method of forming a lipid membrane attached linker comprises contacting a lipid membrane with an oligonucleotide having a first strand and a second strand of nucleic acid and two or more hydrophobic anchoring moieties located in its terminal ends. The two strands are hybridized to each other in a duplex section in a manner that the first strand terminal end is not a part of the duplex section and free from a hydrophobic anchoring moiety and the two or more hydrophobic anchoring moieties are covalently attached to the adjacent terminal ends of the first strand and the second strand of said oligonucleotide, thereby accomplishing a direct attachment of the oligonucleotide by the moieties on the same membrane. | 09-26-2013 |
| 20140018264 | REDUCING ADAPTER DIMER FORMATION - Provided herein is a method of reducing adapter dimer formation comprising contacting a sample comprising target nucleic acid sequences with 5′ and 3′ adapters in the presence of one or more hairpin oligonucleotides. Also provided is a method of preparing a library of nucleic acid sequences comprising contacting first adapter oligonucleotides with a sample comprising target nucleic acid sequences under conditions to form first ligation products, contacting the sample with one or more hairpin oligonucleotides that binds to the first adapter oligonucleotides, and contacting the sample with second adapter oligonucleotides under conditions to bind to the first ligation products and form second ligation products, wherein the second ligation products form the library of nucleic acid sequences. | 01-16-2014 |
| 20150377870 | SOLID PHASE LABELING METHOD - The invention provides for the labeling of antibodies with a fluorescent label, using a solid support comprising an affinity for an Fc portion of an antibody. Thus, the invention provides a method for labeling an antibody or fragment thereof with a fluorescent label, comprising the steps of immobilizing an antibody on the solid support and covalently coupling a fluorescent label to the immobilized antibody, as well as a kit for performing such method. | 12-31-2015 |
| 20160018396 | Methods and Compositions for Phototransfer - Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface. | 01-21-2016 |
