| Entries |
| Document | Title | Date |
|---|
| 20080305556 | CHEMICAL REACTION CARTRIDGE AND METHOD OF USING THE SAME - The invention provides a chemical reaction cartridge which can be treated with safety upon introduction of a sample into the cartridge and a method of using the same. An opening section of the chemical reaction cartridge is openable and closable by a rail fastener provided inside an elastic body. When the rail fastener is released, the elastic body can be opened across the entire width. The opening section provides the cartridge with an opening having a large sectional area, which is larger than a flow path and a chamber inside the cartridge, owing to elasticity of the elastic body. | 12-11-2008 |
| 20090053824 | Assay Device Processing Apparatus and Method - Assay device processing apparatus includes a rotatably mounted assay device vessel support; and a drive for rotating the support. The support is rotatable about a substantially horizontal first axis so that, upon rotation, an assay device vessel attached to the support can be inverted. | 02-26-2009 |
| 20090137061 | DETECTING MOLECULES - The invention relates to separating molecules, in particular, to proteins comprised in biological fluid such as serum, to purifying molecules and to producing antisera to molecules. | 05-28-2009 |
| 20090155926 | METHOD AND APPARATUS FOR DETECTING TRACE AMOUNTS OF SUBSTANCES - A method and apparatus for detecting trace amounts of a target substance carried by the object, by: applying to the object a flow of air which has been pre-heated, to dislodge substances carried by the object; collecting the heated air after applied to the object; and analyzing the collected heated air for the presence of the target substance. Preferably, a marker substance is introduced into the air before applied to the objects, and the collected heated air is analyzed also for the presence of the marker substance. | 06-18-2009 |
| 20090176315 | Microfluidic pl-based molecular sorting - This invention is directed to methods and devices for separating molecules in a sample, based on differences in their isoelectric point (pI). The methods and devices make use of a diffusion potential created in a microfluidic chamber when a buffered solution comprising molecules, which differ in terms of their isoelectric point (pI) values and a second buffer, which differs from the buffered solution in terms of its pH or salt concentration are introduced in the chamber. The diffusion potential, in turn, enables charge-based separation of the molecules. Applications and permutations of the methods and devices are described. | 07-09-2009 |
| 20090221092 | LIDDED MICROCHIP FOR ANALYSIS, SAMPLE PROCESSING METHOD FOR THE LIDDED MICROCHIP, AUTOMATIC SAMPLE PROCESSING METHOD FOR THE LIDDED MICROCHIP, AUTOMATIC SAMPLE PROCESSING APPARATUS BASED ON THE PROCESSING METHOD, AND SUBSTANCE ANALYZING APPARATUS TO WHICH THE AUTOMATIC SAMPLE PROCESSING METHOD IS APPLIED - The present invention provides a method of automating the operation to peel and remove a lid part adhered and fixed to the top surface of a substrate part, which composes a lidded “microchip”, after subjecting a sample liquid to be analyzed to an operation for electrophoretic separation. After subjecting the liquid sample to be analyzed to a desired operation of electrophoretic separation by utilizing a channel formed in the lidded microchip, aqueous solvent contained in the electrophoretically separated liquid sample held in the channel is frozen, and the end of the lid part sealing the groove-shaped channel formed on the substrate part is lifted up at a predetermined speed while keeping the whole electrophoretically separated sample in the frozen state, and peeled and removed from the substrate part under a condition to maintain the bend of a predetermined radius of curvature. | 09-03-2009 |
| 20090269854 | MICROCHIP - The capture rate of a target such as antigen and antibody in a sample is improved and the concentration of reaction product of a recognition substance is uniformized regardless of the position of a reaction field. By contacting microparticles and the sample using centrifugal force, the contact time of the target and the recognition substance is equalized regardless of the position in mixing chamber The microparticles and the sample are mixed evenly in the mixing chamber by changing the rotation direction and the concentration of reactant in a liquid mixture is uniform regardless of the position of the mixing chamber. When the liquid mixture having a uniform concentration is obtained, it is enough to extract a part of the liquid mixture and use the same for a process subsequent to a mixing process without the need of using all the liquid mixture. | 10-29-2009 |
| 20090269855 | Methods and compositions for mass spectrometry analysis - Methods and compounds are provided to improve the desorption and ionization of analyte for mass spectrometry analysis. More specifically, it is for laser desorption/ionization mass spectrometry. The method uses photon energy absorbing molecules that can bind with analyte either temporarily or permanently to improve the desorption and ionization of analyte. The photon energy absorbing molecules can be positively charged or negatively charged. | 10-29-2009 |
| 20090280573 | Structure for Introducing a Plurality of Solutions, Micro Fluidic Device Having Said Structure and Method for Introducing Solution - The present invention relates to a solution introducing structure for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel ( | 11-12-2009 |
| 20100047920 | DEVICE IMPROVING THE DETECTION OF A LIGAND - A device and method is disclosed for improving the detection of a ligand by a receptor by concentrating microbes by removing particulates from fluid-borne samples and/or causing selective aggregation of concentrated microbes. The device may be configured as a multipath valve capable purifying/concentrating a sample in one orientation and delivering the concentrated sample in another orientation. In one embodiment, the device includes a body that defines a plurality of chambers and pathways and supports a pathogen capture unit that houses a receptor that exhibits specificity for a ligand. In another embodiment, the capture unit houses a plurality of antibody coated generally spherical particles capable of binding to a ligand. | 02-25-2010 |
| 20100178711 | VIAL SYSTEM AND METHOD FOR PROCESSING LIQUID-BASED SPECIMENS - A vial-based system and method for handling and processing specimens of particulate matter-containing liquid directly in the vial. A processing assembly, which includes a stirrer and a particulate matter separation chamber, is releasably coupled to the inside of the vial cover. The processing assembly remains with the cover when the vial is opened to insert a specimen therein. Application of a particular external force to the closed vial detaches the processing assembly from the cover so that it remains in the vial, for access by automated or manual laboratory equipment, when the cover is subsequently removed. | 07-15-2010 |
| 20110104817 | INTEGRATED MICRO DEVICE, A METHOD FOR DETECTING BIOMARKERS USING THE INTEGRATED MICRO DEVICE, A METHOD FOR MANUFACTURING AN INTEGRATED MICRO DEVICE, AND AN INTEGRATED MICRO DEVICE ARRANGEMENT - Embodiments provide an integrated micro device. The integrated micro device comprises a substrate, a first microfluidic device disposed over a first surface of the substrate, a second microfluidic device disposed over a second surface of the substrate, and at least one via hole through the substrate connecting the first microfluidic device and the second microfluidic device. The second surface of the substrate is opposite to the first surface of the substrate. The first microfluidic device is monolithically integrated with the substrate, and the second microfluidic device is monolithically integrated with the substrate. | 05-05-2011 |
| 20120083046 | HYBRID DIGITAL AND CHANNEL MICROFLUIDIC DEVICES AND METHODS OF USE THEREOF - The present invention provides a hybrid digital and channel microfluidic device in the form of an integrated structure in which a droplet may be transported by a digital microfluidic array and transferred to a microfluidic channel. In one aspect of the invention, a hybrid device comprises a first substrate having a digital microfluidic array capable of transporting a droplet to a transfer location, and a second substrate having a microfluidic channel. The first and second substrates are affixed to form a hybrid device in which an opening in the microfluidic channel is positioned adjacent to the transfer location, so that a droplet transported to the transfer location contacts the channel opening and may enter the channel. The invention also provides methods of performing separations using a hybrid digital and channel microfluidic device and methods of assembling a hybrid digital microfluidic device. | 04-05-2012 |
| 20120115243 | SAMPLE PORT, MULTI-LAYER FILTER, SAMPLING METHOD, AND USE OF A SAMPLE PORT IN SAMPLING - The invention relates to a sample port, filter, and sampling method. The sample port according to the invention comprises a body equipped with an internal cavity and two plungers arranged moveably in this, which can be pressed against each other in the internal cavity, in order to compress a sample, and at least one of which plungers can be moved into a reactor, in order to collect a sample. The sample port also comprises a sample chamber, which is formed by the space remaining between the internal cavity and the plungers, and at least one sample-container connection connected in connection with the internal cavity, in order to collect the sample from sample chamber. In addition, the sample port has filter means adapted to at least either plunger for separating the liquid component of the sample from the solid component and means for leading the liquid component of the sample out of the sample chamber. | 05-10-2012 |
| 20120149127 | SAMPLE ANALYZER AND SAMPLE ANALYZING METHOD - The present invention is to present a sample analyzer for analyzing a target substance in a sample by carrying out a target substance separating process for separating a complex containing the target substance and a magnetic particle from other substances other than the complex. The sample analyzer executes the target substance separating process with respect to a second container held by a second holder with a second nozzle while executing the target substance separating process with respect to a first container held by a first holder with a first nozzle, and completes the target substance separating process with respect to the first container with the first nozzle and completes the target substance separating process with respect to the second container with the second nozzle. | 06-14-2012 |
| 20120164749 | Smart Hydrogel Particles for Biomarker Harvesting - Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid. | 06-28-2012 |
| 20120178178 | BIOSENSOR CARTRIDGE - A biosensor cartridge includes a plasma separator, a plasma metering chamber, a mixer, and a biosensor. | 07-12-2012 |
| 20120225490 | FILTERING DEVICE - A single use filtering device comprises a filter body formed at least in part of a filter medium configured to hold a sample during filtration and a fastening element configured for releasably mounting the filtering device to a holder. The fastening element being adapted to undergo an irreversible structural alteration during the mounting or removal of the filtering device from the holder to prevent remounting of the filtering device to the holder. | 09-06-2012 |
| 20120270331 | MICROFLUIDIC SYSTEM AND METHOD FOR AUTOMATED PROCESSING OF PARTICLES FROM BIOLOGICAL FLUID - A microfluidic system for automatically depleting particles not of interest from a biological sample, comprising: a sampling module configured to receive the sample; and one or more microfluidic protein and nucleic acid depletion modules fluidically coupled to the sampling module and comprising binding agents configured to selectively bind to abundant plasma proteins or nucleic acids. A method for automatically depleting particles not of interest from a sample, comprising: receiving the sample; subjecting the sample to a force that separates at least a portion of the particles not of interest from the sample, thereby isolating at least a portion of the target component; passing the isolated target copmonent into a chamber; circulating the isolated target component in the chamber; and selectively capturing proteins or nucleic acids with binding agents within the chamber. | 10-25-2012 |
| 20120270332 | MAGNETIC SAMPLE PURIFICATION - The invention relates to means for extracting magnetic particles (M) from a sample (S). The sample (S) is arranged adjacent to a liquid carrier (C), which is immiscible with it, in a configuration stable under the influence of gravity, and the magnetic particles (M) are moved by a magnetic field (B) from the sample (S) into the carrier (C). Preferably, the magnetic particles (M) are non-wetting with respect to the carrier (C) and will therefore form agglomerates in the carrier (C). | 10-25-2012 |
| 20120270333 | Apparatus and Methods for Controlling Application of a Substance to a Substrate - Apparatus and methods for controlling application of a substance to a substrate involve the use of a functional agent that helps determine the association of a substance with the substrate. The apparatus and methods may utilize jet technology to apply the functional agent directly to the substrate or to an intermediate surface. The substance may be biological substance or a chemical in nature. | 10-25-2012 |
| 20120276654 | USE OF FLUID ASPIRATION/DISPENSING TIP AS A MICROCENTRIFUGE TUBE - A fluid aspirating/dispensing member includes a sample cavity for sample acquisition and a sealable cavity that, once sealed, permits the separation of particles from the remainder of a fluid sample within the sample cavity after centrifugation or other separation means. The fluid aspirating/dispensing members, either individually or as part of an array, increase the efficiency of sample processing before analysis by a clinical analyzer. | 11-01-2012 |
| 20120282707 | SAMPLE PROCESSING CARTRIDGE AND METHOD OF PROCESSING AND/OR ANALYSING A SAMPLE UNDER CENTRIFUGAL FORCE - The present invention relates to a sample processing cartridge ( | 11-08-2012 |
| 20120301972 | CENTRIFUGATION APPARATUS, USE THEREOF AND CENTRIFUGATION METHOD - The present invention relates to a centrifuge apparatus ( | 11-29-2012 |
| 20130017620 | All-In-One Sample Preparation Device And Method - Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed. | 01-17-2013 |
| 20130210164 | REDUCING pH EXCURSIONS IN ION EXCHANGE CHROMATOGRAPHY - Provided are methods and compositions for reducing or eliminating pH excursions in cation and anion exchange chromatography. | 08-15-2013 |
| 20130244338 | FUNCTIONALIZATION OF A POROUS MEMBRANE WITH AN ADSORBED POLYACID - The disclosure relates to a process and related article for functionalizing a porous membrane by contacting the membrane with a polyacid polymer at low pH to stably adsorb a polyacid layer on the membrane pore surface. The resulting functionalized membrane is characterized by a high density of free acid groups, resulting in a higher specific capacity for its intended application. The process allows functionalization of porous membranes in a very simple, one-step process. Such functional membranes may find multiple uses, including rapid, selective binding of proteins for their purification or immobilization. | 09-19-2013 |
| 20130330834 | CARRIER-ENCLOSED TRANSFORMABLE CONTAINER, CARRIER-ENCLOSED TRANSFORMABLE CONTAINER PROCESSING APPARATUS, AND CARRIER-ENCLOSED TRANSFORMABLE CONTAINER PROCESSING METHOD - Provided are a carrier-enclosed transformable container, a carrier-enclosed transformable container processing apparatus, and a carrier-enclosed transformable container processing method about which a carrier to which various substances such as biogenic substances are bonded or bondable is held in a transformable container as the container to be in a substantially stationary state, thereby making it possible to make the handling of the carrier, measurement, and other treatments effective, speedy, and easy. The container is formed to have: a containing part which can contain liquid and gas at its inside surrounded by a wall face, a part of this wall face having a transformable wall face capable of undergoing a predetermined transformation without changing the entire internal surface area of the wall face substantially; an orifice part which is connected to the containing part and can undergo the inflow and outflow of a liquid sucked and discharged by the expansion and contraction of the inside by the transformation of the transformable wall face, respectively; and a carrier to which a predetermined substance enclosed in the containing part to be in a substantially stationary state is bonded or bondable. | 12-12-2013 |
| 20130337576 | MICROFLUIDIC SYSTEM, CARTRIDGE AND METHOD FOR PREPARING SAMPLE - A microfluidic system for preparing a sample containing an analyte of interest is provided. The microfluidic system includes a microfluidic cartridge and a magnetic element. The microfluidic cartridge includes a number of reservoirs, an immobilizer, a number of microfluidic flow channels and a number of microvalves. The microfluidic channels are coupled with the reservoirs and the immobilizer. The microvalves are positioned along the microfluidic flow channels. The magnetic element is positioned with respect to the immobilizer. The magnetic element is configured to generate a magnetic field to magnetically immobilize the analyte of interest in the immobilizer. The immobilizer is configured to flow one or more reagents therethrough to react with the analyte of interest. | 12-19-2013 |
| 20130337577 | Extraction Pipette - A solid-phase extraction pipette ( | 12-19-2013 |
| 20140011290 | COLLECTION OF LIQUID ANALYTICAL SAMPLES FOR CLINICAL ANALYTICAL PURPOSE AND DEVICE THEREOF - A method and analytical device for collecting a sample volume containing at least one analyte of interest from a liquid analytical sample having contaminants disposed at or near the sample surface. The liquid analytical sample is provided. A first pipetting device comprising a first pipetting needle aspirates from an upper region of the liquid analytical sample a portion comprising the contaminants and discards the portion. The first needle is washed with washing liquid. A second pipetting device comprising a second pipetting needle, or a disposable pipetting tip, aspirates the sample volume from the liquid analytical sample after the first pipetting device discards the aspirated portion and discharges the sample volume for analysis. The second needle is washed with washing liquid or disposed of. | 01-09-2014 |
| 20140038307 | REAGENT VESSEL INSERT, REAGENT VESSELS, METHOD FOR THE CENTRIFUGING OF AT LEAST ONE MATERIAL AND METHOD FOR THE PRESSURE TREATMENT OF AT LEAST ONE MATERIAL - A reagent vessel insert for a reagent vessel for a centrifuge and/or a pressure varying device includes an insert housing formed such that the reagent vessel insert is insertable in a reagent vessel for a centrifuge and/or for a pressure varying device. The reagent vessel insert also includes at least one agitating element arranged in at least one interior volume such that a place and/or position of the at least one agitating element is changeable with respect to the insert housing. The reagent vessel insert is configured such that at least one material filled into the at least one interior volume is agitatable and such that, during an adjustment, at least one subunit of the at least one agitating element contacting at least one holding structure, by which the at least one agitating element is held in at least one semi-stable place and/or at least one semi-stable position. | 02-06-2014 |
| 20140065721 | PRESSURE REACTOR FOR TREATING A SAMPLE FLUID - A pressure reactor for treating a sample fluid includes an oven, a sample line partly arranged in the oven, and a pressure line arranged in surrounding relation to the sample line and partly arranged in the oven. The sample line has an outlet opening into the pressure line. A contamination blocking apparatus is disposed in the pressure line for forming a contamination barrier which has at least one section arranged between the outlet opening and the oven and which delimits a contamination-free region in the pressure line. The outlet opening of the sample line is arranged in the contamination-free region of the pressure line. | 03-06-2014 |
| 20140179021 | HIGH THROUGHPUT MICROFLUIDIC DEVICE - A microfluidic element comprising at least one pair of plates, at least one of said plates having an open channel distributed on a surface that is adjacent the other plate in the pair. In use, said plates are releasably clamped together so as to form an enclosed, continuous microfluidic channel between the plates that is suitable for the passage of a fluid. | 06-26-2014 |
| 20140179022 | ROTATING SHIELDED MAGNETIC ACTUATOR - Magnetic actuators comprising at least one shielded rotatable magnet are presented. Systems comprising such magnetic actuators and methods for using such magnetic actuators to isolate magnetic particles in a fluid are also presented. | 06-26-2014 |
| 20140273267 | Methods of depleting antibodies directed towards major histocompatibility complex - The invention provides a method of depleting anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and removing at least the recombinant MHC molecules to which antibodies to said recombinant MHC molecules contained within the sample have bound. This method allows the depletion of one or more specific MHC particularly HLA allele antibodies from a sample. | 09-18-2014 |
| 20140349410 | METHOD FOR PROCESSING A FLUID AND FLUID PROCESSING DEVICE - The present invention relates to improved methods for processing fluids and to a fluid processing device ( | 11-27-2014 |
| 20150011012 | SPECIMEN CONCENTRATION CONTAINER AND SPECIMEN CONCENTRATING METHOD USING SAME - A specimen concentration container contains a specimen-containing liquid mixture, and the liquid mixture is concentrated in the specimen concentration container. The specimen concentration container includes: a tubular container main body including an upper surface on which an upper surface opening portion is formed; an upper surface opening portion communicating with an inside of the container main body; a specimen concentration portion formed at a bottom portion side of the container main body and containing the concentrated liquid mixture; and a specimen lid provided in the container main body and configured to cover the upper surface opening portion. | 01-08-2015 |
| 20150011013 | APPARATUS, SYSTEM, AND METHOD FOR COLLECTING A TARGET MATERIAL - This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a processing vessel, such as an Eppendorf tube, a syringe or a test tube, and a collector. The collector is sized and shaped to fit into a primary vessel, such as a test tube. The collector funnels the target material from the suspension through a cannula and into the processing vessel. The cannula extends into a cavity at a first end of the collector that holds the processing vessel. The collector includes a funnel at a second end in fluid communication with the cannula. In one implementation, the processing vessel includes at least one displacement fluid to be expelled, such that the at least one displacement fluid pushes the target material into the collector. | 01-08-2015 |
| 20150017737 | APPARATUS AND METHOD FOR SEPARATING PLASMA FROM BLOOD AND DELAYED WETTING - Devices and methods are disclosed herein for separating a supernate from a suspension. The apparatus consists of a sample zone, a controllable gate, and an analysis zone. The sample zone holds the suspension. The analysis zone passively transports a supernate formed from the suspension by capillary transport. A controllable gate prevents the suspension in the sample zone from flowing into the analysis zone. The controllable gate can be triggered after the supernate has separated from the suspension to allow the supernate to flow into the analysis zone. | 01-15-2015 |
| 20150050746 | METHODS FOR FABRICATING HIGH ASPECT RATIO PROBES AND DEFORMING HIGH ASPECT RATIO NANOPILLARS AND MICROPILLARS - Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described. | 02-19-2015 |
| 20160250630 | METHOD AND DEVICE FOR TRANSFERRING PART OF A LIQUID HOUSED IN A CONTAINER | 09-01-2016 |
