| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 436166000 | Including reagent preparation | 20 |
| 20080261323 | Photo-Swichable Surfaces with Controllable Physico-Chemical Properties - Photochromic materials, such as spiropyran dyes, are disclosed that can be used for high-density optical storage and molecular switches. According to the disclosure these compounds can be used as transducers in optical sensors. When the spiropyran dye absorbs UV light it switches to the merocyanine form, and this structure has an active binding site for cations. When cations bind to the site, the resulting colored complex has a new absorption band in the visible spectrum. By shining white or green light on the colored complex, the dye is reverted to the closed spiropyran form, and the cation is released. The disclosure optimizes the immobilization of the spiropyran dye onto a polymer substrate via long chain alkyl groups. These long chain alkyl linkers enable the dye to reversibly form the preferred merocyanine (2):(1) cation sandwich complex. | 10-23-2008 |
| 20080286880 | Methods and Systems for Nanoparticle Enhancement of Signals - Methods and systems for utilizing metal nanoparticles to enhance optical (UV, visible, and IR, as appropriate) signals from a reporting entity are presented. The methods and systems of this invention do not require the nanoparticles to be attached or adhered to a surface, assembled in a matrix or coated with a spacer coating. | 11-20-2008 |
| 20080293153 | Photolabile System with Instantaneous Fluorescence Reporting Function - A method of photofragmentation is provided comprising: providing a masked fluorescent molecule having a masking group bonded to a fluorescent molecule through a photolabile covalent bond; exposing the masked fluorescent molecule to cleaving photoradiation, producing an unmasked fluorescent molecule; detecting the fluorescence of the unmasked fluorescent molecule. The photolabile covalent bond disrupts the conjugation of the fluorescent molecule, causing the fluorescence to be masked. When the photolabile covalent bond is broken, the conjugation is restored, resulting in an increase in fluorescence of the fluorescent molecule as compared to the masked fluorescent molecule. | 11-27-2008 |
| 20080318336 | Labels, Their Production Process And Their Uses - The present invention relates to labels capable of forming a covalent or non-covalent bond with a target molecule, consisting of a dye to which there is bonded in a covalent manner by one or more carbons of its chemical structure:
| 12-25-2008 |
| 20090004753 | LABELING REAGENTS AND METHODS OF THEIR USE - The present disclosure is directed to a reactive ester agent capable of conjugating a reporter molecule to a carrier molecule or solid support. The reactive ester agent has the general formula: | 01-01-2009 |
| 20090053823 | Liquid Reagent of Color Former and Method of Stabilizing The Same - A liquid reagent in which a methylene blue compound color former is stably stored in a liquid state; and a method of stabilizing a methylene blue compound color former in a liquid state. A methylene blue compound color former is stabilized by causing it to coexist with either a quaternary ammonium compound having a C | 02-26-2009 |
| 20090124021 | Device for Containing, Reacting and Measuring, and Method of Containing, Reacting and Measuring - The invention relates to a device for containing, reacting and measuring, and a method of containing, reacting and measuring, and provides a device for containing, reacting and measuring, and a method of containing, reacting and measuring which is also able to effectively and quickly perform the reaction processing, measuring and identification. The invention comprises; a transparent container section having a liquid inlet/outlet and which is able to contain a base member with various substances for detection having predetermined chemical structures fixed at respective fixed positions which are arranged in a predetermined condition, and with each of the chemical structures associated with each of the fixed positions, a drawing and discharging section which is able to draw and discharge the liquid into and from the container section via the inlet/outlet, and a measuring device which is able to receive light from the contained base member, external to the container section and in a condition associated with the fixed position. | 05-14-2009 |
| 20090155923 | Photometric Measuring Method for a Sample Liquid, A Photometric Measuring Device, and a Mixing Container for a Photometric Measuring Device - The invention relates to a mixing container ( | 06-18-2009 |
| 20090269853 | TRIOXYETHYLENE GOLD NANOCLUSTERS FUNCTIONALIZED WITH A SINGLE DNA - A method of making a nanoclusters functionalized with a single DNA strand comprising the steps of providing nanoclusters, combining said nanoclusters with thiolated DNA, incubating said nanoclusters and thiolated DNA mixture, combining said mixture with a solution comprising ethanol and dichloromethane; separating said mixture into an aqueous phase and an organic phase, mixing said aqueous phase with a solution comprising dicholormethane and NaCl, and separating the mixture into an aqueous phase and an organic phase; wherein said organic phase comprises said nanoclusters functionalized with a single DNA strand. Further, provided is a nanocluster functionalized with a single DNA strand comprising a nanocluster, said nanocluster being functionalized with a single DNA strand, said DNA strand having a length of about 10 to about 50 bases. | 10-29-2009 |
| 20090311796 | MICROFLUIDIC ANALYTICAL DEVICE FOR ANALYSIS OF CHEMICAL OR BIOLOGICAL SAMPLES, METHOD AND SYSTEM THEREOF - An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. The liquid processing unit comprises a mixing chamber for mixing a sample with a reagent, a sample dosing chamber for delivering a defined volume of the sample to the mixing chamber, and a reagent channel for delivering the reagent to be mixed with the sample, wherein the mixing chamber also serves as a detection chamber. | 12-17-2009 |
| 20100009458 | DETECTION METHOD, DETECTION APPARATUS, AND SAMPLE CELL AND KIT FOR DETECTION - A sensor-chip includes a sensor-portion having at least a metal-layer deposited on a surface of a dielectric-plate. A fluorescent-label binding-substance in an amount corresponding to the amount of a detection-target-substance in a liquid-sample binds onto the sensor-portion. The amount of the detection-target-substance is detected based on the amount of light generated by excitation of a fluorescent-label in the fluorescent-label binding-substance. A fluorescent-substance the charge state of which changes in the liquid-sample according to the pH of the liquid-sample, and which contains a plurality of fluorescent-dye-molecules enclosed by a material that transmits fluorescence output from the fluorescent-dye-molecules, is used as the fluorescent-label. With the fluorescent-label binding-substance bound to the sensor-portion, the fluorescent-label is attracted to the sensor-portion by adjusting the pH of the sample-liquid to neutralize the charge state of the fluorescent-substance, thereby attracting the fluorescent-label onto the sensor-portion. In this state, the amount of the detection-target-substance is detected. | 01-14-2010 |
| 20100311183 | MAGNETIC BEAD ACTUATION USING FEEDBACK FOR FTIR BIOSENSOR - The invention provides a method for controlling actuation of label particles in a biosensor device, in particular a biosensor device using frustrated total internal reflection. By applying a predetermined actuation force on the label particles and determining the effect of the applied actuation force in a binding volume or surface of a sensor cartridge of the biosensor device, a feedback control of the actuation force is applied. Furthermore, a biosensor device is provided which is adapted for forming the method according to the invention. | 12-09-2010 |
| 20110086431 | Methods for Altering Surface Characteristics of Microspheres - Various methods for altering surface characteristics of a microsphere are provided. One method includes coupling an enolic acid to the microsphere to modify the surface characteristics of the microsphere. The surface characteristics may include charge density and/or pKa. A reagent can be coupled to the microsphere via the enolic acid. The reagent may include a biomolecule. The modified surface characteristics may increase a stability of the reagent when the reagent is coupled to the microsphere. The modified surface characteristics may also improve performance of an assay carried out with the microsphere. Another embodiment relates to a microsphere that includes an enolic acid coupled to a polymer core of the microsphere such that the enolic acid modifies surface characteristics of the microsphere. A reagent can be coupled to the microsphere via the enolic acid. | 04-14-2011 |
| 20120231550 | APPARATUS AND METHOD FOR PRECONCENTRATING AND TRANSFERRING ANALYTES FROM SURFACES AND MEASUREMENT THEREOF USING SPECTROSCOPY - A system and method for capturing a target analyte in advance of performing spectroscopic analysis to determine the existence of the target analyte from a source contacted with a collection substrate. The collection substrate is fabricated of a material selected to have an affinity for the target analyte, sufficiently transparent in a spectral region of interest and capable of immobilizing the target analyte thereon in a manner that limits scattering sufficient to obscure spectral analysis. The collection substrate may be coated with a material selected to react with, bind to, or absorb the target analyte. The method optionally includes the step of transferring the captured target analyte to a second substrate, which may be an optical substrate. The target analyte may be captured to the collection substrate by one or more of wiping, dabbing or swabbing a target analyte carrier with the collection substrate. | 09-13-2012 |
| 20130196447 | MICROFLUIDIC ELEMENT FOR THOROUGHLY MIXING A LIQUID WITH A REAGENT - A microfluidic element for thoroughly mixing a liquid with a reagent used for the analysis of the liquid for an analyte contained therein and a method thereof are disclosed. The microfluidic element has a substrate and a channel structure. The channel structure includes an elongate mixing channel and an output channel. The mixing channel has an inlet opening and an outlet opening, and is implemented to mix the reagent contained therein with the liquid flowing through the inlet opening into the mixing channel. The outlet opening of the mixing channel is in fluid communication to the output channel. The outlet opening is positioned closer to the middle of the length of the mixing channel than the inlet opening. | 08-01-2013 |
| 20150140678 | METHOD FOR STABILIZING QUANTUM-DOTS - Disclosed herein is a method for stabilizing quantum dots. The method comprises introducing a first monomer into a mini emulsion system. The first monomer is a crosslinking polymer. A second monomer is added to the system so as to stabilize the quantum dots. Also disclosed is a method of increasing the brightness of the quantum dots by adding a redox initiator system at a low temperature to reduce fluorescence quenching. | 05-21-2015 |
| 20150309060 | Apparatus and Method for Automated Analysis - An automated analyzer is offered which can dilute an analyte repeatedly without contamination due to carry-over and thus can yield reliable analysis results. The analyzer has an analyte turntable for holding analyte containers in which analyte is stored, a dilution turntable for holding dilution containers for storing a diluent, a dilution probe for aliquotting a liquid between two containers held on these two turntables, respectively, a diluent vessel for storing a diluent, and a diluent supply mechanism for supplying the diluent into the diluent vessel. The dilution probe has a function of aliquotting the diluent stored in the diluent vessel into the dilution containers held on the dilution turntable. The diluent vessel has a diluent discharging mechanism for discharging the diluent from inside the diluent vessel. | 10-29-2015 |
| 20150323522 | Physicochemical Modification and Application of Alginate Gels for the Controlled Release of Reagents in Classical Solution Assays and Microfluidic Assays - A reagent assay in accordance with the present disclosure has a porous alginate core containing a first reagent, a first polysaccharide layer coating the alginate core and having a second reagent, and at least one polysaccharide core comprising a hydration seal and coating the first polysaccharide layer. | 11-12-2015 |
| 20150362436 | METHOD FOR MEASURING CONCENTRATION OF DISSOLVED SUBSTANCE - A reagent includes a coloring agent allowing a measured solution to develop a color transmitting a region component light for a dissolved-substance concentration measurement selected from three region component lights of red, green, and blue obtained by transmitting a light including a visible light region to the measured solution colored by addition of the reagent to the sample, and dividing a light of the visible light region of a transmitted light thereof into roughly three portions. Based on the transmitted light from the measured solution with the coloring agent added, an absorbance of the region component light for the dissolved-substance concentration measurement, and an absorbance A | 12-17-2015 |
| 20160161417 | Super-Sensitive and Stable Gold Nanoparticles - A medium comprising AuNPs and a pre bonded ascorbic acid and sodium borohydride (AA-BH) capped onto larger number of the AuNPs in the medium, wherein the pre bonded AA-BH prevents aggregation of the AuNPs in the medium is provided in the present disclosure. In one embodiment, the method for synthesizing AuNPs and capping of the same with AA-BH is provided. In another embodiment, infrared light absorption characteristics at different wavelengths are determined for the synthesized AuNPs which represents the capping of AA-BH onto them. The AuNPs synthesized in the present disclosure are more stable and capable to sense lower concentration of various substances. | 06-09-2016 |
