| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 436089000 | Amino acid or sequencing procedure | 46 |
| 20080213911 | Method of Analyzing C-Terminal Amino Acid Sequence of Peptide - An analyte peptide is selectively degraded sequentially by using an alkanoic anhydride (S | 09-04-2008 |
| 20080248585 | Protein/Peptide Sequencing By Chemical Degradation in the Gas Phase - A fast and sensitive method and device for protein sequencing are disclosed. The method uses a combination of Edman degradation chemistry and mass spectrometry to sequence proteins and polypeptides. A peptide degradation reaction is performed on a polypeptide or protein ion reactant in the gas phase. The reaction yields a first ion product corresponding to a first amino acid residue of the polypeptide or protein reactant and a polypeptide or protein fragment ion. The mass-to-charge ratio for the first ion product, or the polypeptide or protein fragment ion, or both, is then determined. The first amino acid residue of the polypeptide or protein reactant is then identified from the mass-to-charge ratio so determined. | 10-09-2008 |
| 20080261317 | Methods of Detecting Myocardial Ischemia and Myocardial Infarction - The disclosed methods address the identification of myocardial ischemia and myocardial infarction using metabolomics, as well as the identification of metabolic products whose differential expression over time is indicative of myocardial ischemia and/or myocardial infarction. | 10-23-2008 |
| 20080274556 | DETECTING ISOMERS USING DIFFERENTIAL DERIVATIZATION MASS SPECTROMETRY - Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second standard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more branched-chain amino acids in the sample. | 11-06-2008 |
| 20080318327 | Kit and Method for Mass Labelling - The present invention relates to a kit for mass labelling of peptides in two or more samples, comprising a set of mass tagging reagents for reaction at the N-terminals of the peptides and a set of mass balancing reagents for reaction at the C-terminals of the peptides, or vice versa, and wherein each mass tagging reagent in the set is matched with mass balancing reagent(s) in such a way that the sum of the masses from all matched mass tagging and mass balancing reagents is equal. The invention also relates to a method of using said mass labels and a database for use in said method. | 12-25-2008 |
| 20090017546 | FLUORESCENT ISOTOPE TAGS AND THEIR METHOD OF USE - The present invention provides novel reactive fluorescent compounds that incorporate stable isotopic (deuterium, 13-carbon, 15-nitrogen, 18-oxygen) substitutions. The invention includes the use of these compounds, in combination with non-isotopically substituted analogs, for the purification, identification and relative quantification of proteins, peptides, saccharides, metabolites, and other biologically important compounds by combining liquid chromatography (LC) and mass spectrometry (MS). Fluorescent labeling of target compounds in this manner provides orders-of-magnitude sensitivity enhancement over traditional stable isotope labels, and also affords the possibility of simultaneous multiplexed analysis due to the multiwavelength nature of different fluorophores. | 01-15-2009 |
| 20090124018 | MIX FOR QUALITY CONTROL OF THE MEDICINE "GLYCINE TABLETS FOR SUBLINGUAL APPLYING O.1G." AND ITS PREPARATION METHOD - The invention relates to the chemical-pharmaceutical industry and specifically to mix for quality control of the medicine “Glycine tablets for sublingual applying 0.1” and its preparation method. The method involves process of analysis by dissolution of 2.5 g of porphyrized tablets in 250 ml of purified water and light transmission spectrophotometer examination at a wave length of 700±2 in a cuvet with layer thickness of 10 mm relative to purified water Process of dissolution takes 20 minutes and is carried out at a temperature of 370° C. in the apparatus for dissolving determination at a paddle rotation speed of 150 rpm. After mix is dissolved it is allowed for 10 minutes then there are selected 4 ml for light transmission analysis. Mix for quality control includes water in a ratio 100:1 to porphyrized tablets, containing in one tablet 0.101 g microcapsules of non-agglomerated crystals of amino-acetic acid covered with polymeric film of water-soluble methylcellulose, MC-100 and 0.001 g of magnesium stearate. Mix light transmission coefficient is within the limits of 50 to 70% in comparison with purified water at a wave length 700±2 nm for 4 ml of mix and with layer thickness of 10 mm. | 05-14-2009 |
| 20090130770 | BIOMARKER FOR FARNESYL PATHWAY - The present invention relates to a novel biomarker which can be used to determine the extent of interference of a substance with the farnesyl pathway. | 05-21-2009 |
| 20090142851 | METHOD FOR SELECTIVELY RECOVERING C-TERMINAL PEPTIDE OF PROTEIN AND METHOD FOR DETERMINING AMINO ACID SEQUENCE OF C-TERMINAL PEPTIDE OF PROTEIN USING THE SAME - The present invention provides a method for specifically recovering a C-terminal peptide fragment, and a method for easily determining the sequence of a C-terminal peptide fragment, which is difficult to be determined by a conventional method, with the use of a mass spectrometer, in particular a method capable of de novo sequencing of a C-terminal peptide fragment. A method for selectively recovering a C-terminal peptide of a protein, comprising the steps of: in a cleavage product of a protein containing a C-terminal peptide fragment (A) having an α-amino group but not having an ε-amino group and the other peptide fragments (B) having an α-amino group and an ε-amino group, selectively modifying the α-amino groups to obtain a C-terminal peptide fragment modified (A′) and the other peptide fragments modified (B′); and separating the C-terminal peptide fragment modified (A′) from the modified cleavage product by allowing a carrier to hold the other peptide fragments modified (B′) via the ε-amino group. A method for determining the amino acid sequence of a C-terminal peptide of a protein, comprising the steps of: selectively recovering a C-terminal peptide of a protein by the above method; and determining the amino acid sequence by subjecting a recovered C-terminal peptide fragment to mass spectrometry measurement. | 06-04-2009 |
| 20090197345 | METHOD FOR QUANTIFICATION OF ALLERGENS - The invention relates to method for quantification of the absolute amount of allergen in an allergen sample comprising: a) providing a known amount of one or more allergen calibration standard peptide(s) having a sequence of amino acids which is identical with, and optionally unique for, a sequence to be found in the allergen to be quantified and optionally labelling said allergen calibration standard peptide(s), b) degrading the allergen sample to obtain a mixture of peptides, and optionally labelling said peptides with one or more labelling agent(s), wherein at least the peptides in the degraded allergen sample or the calibration standard peptides are labelled, and if both the peptides in the degraded allergen sample and the allergen calibration standard peptide(s) are labelled, the labelling agent(s) used for labelling the allergen calibration standard peptide(s) are different from the labelling agent(s) used for labelling the peptides of the degraded allergen sample, c) quantifying the absolute amount of allergen by correlating the amount of the allergen calibration standard peptide(s) with the amount of the corresponding peptide(s) of the degraded allergen sample by mass analysis. | 08-06-2009 |
| 20090246879 | Materials and Methods Relating to Nano-Tags and Nano-Brands - The invention relates to novel methods and materials for encoding and decoding information on individual molecules through the use of nano-tags, nano-barcodes, or modifications of a native molecule. | 10-01-2009 |
| 20100144047 | ELECTRODE FOR MOLECULAR SENSING AND METHOD FOR MOLECULAR SENSING - Molecular sensing of target molecules is performed by using an electrode for molecular sensing in which detecting molecules which can shift a surface potential of the electrode by an interaction with the target molecules are bound directly or via coupling molecules to surface hydroxyl groups on a conductive metal oxide. By this molecular sensing, specific target molecules can be detected selectively and stably with high accuracy. It is also possible to detect an enantiomer selectively and stably with high accuracy. The present invention can provide a chemical sensing system which is useful in fields such as medicines, environments and foods. | 06-10-2010 |
| 20100240139 | FREE RADICAL INITIATOR AND METHOD FOR PEPTIDE SEQUENCING USING THE SAME - The present invention relates to a free radical initiator and a method for peptide sequencing using the same. Compared with diazo or peroxy functionalized precursors, the precursors using the present compounds are chemically more robust and can generate radical species by homolytic cleavage upon thermal activation, enabling sequencing of more various peptides. In addition, the present invention makes it feasible to sequence peptides carrying disulfide bonds. | 09-23-2010 |
| 20100285597 | DETECTION OF FRAGMENTS OF NECTIN-1 FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE - Methods for diagnosing Alzheimer's Disease by detection of fragments of nectin-1 are described. Nectin-1 is shown to be a substrate for proteases associated with the onset of Alzheimer's Disease, including α-secretase, γ-secretase and BACE1 or a BACE1-like protease. The fragments produced by the action of these and other proteases on Nectin-1 can be used to diagnosis Alzheimer's Disease or a predilection towards Alzheimer's Disease. | 11-11-2010 |
| 20110045598 | METHODS FOR DETERMINING ENANTIOMERIC PURITY WITH IMPROVED CHIRAL SELECTORS - A strategy, or method, for the quantitative determination of enantiomeric purity that combines lin situ enantiomer diastereomerization', spectroscopy, and chemometric modeling. Spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-I”) regression. The PLS-I regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity. In this strategy, the guest-host complexation utilizes improved chiral selector molecules, including chiral amines and chiral alcohols such as phenylethylamine and 1,2-propanediol, that form ion pairs or covalent bonds with the chiral analytes. | 02-24-2011 |
| 20110111513 | MASS SPECTROMETRIC ANALYSIS - The disclosure provides a method for assaying for a target analyte, comprising providing a plurality of samples which may comprise the target analyte, wherein each sample is differentially labelled with a mass label or a combination of mass labels, wherein the mass labels are from a set of mass labels, wherein each mass label is an isobaric mass label comprising a mass spectrometrically distinct mass marker group, such that the samples can be distinguished by mass spectrometry and determining from the mass spectrum the quantity of the target analyte in each sample. | 05-12-2011 |
| 20110183428 | METHOD FOR ANALYZING C-TERMINAL AMINO ACID SEQUENCE OF PEPTIDE USING MASS SPECTROMETRY - The present invention provides a method for analyzing the C-terminal amino acid sequence of a peptide by using a reaction for successively releasing the C-terminal amino acids of the peptide, which method can suppress, when successively releasing the C-terminal amino acids of a peptide of long amino acid length, such a undesirable side reaction as cleavage of peptide bond in the intermediate position of the peptide and can carry out the chemical treatment thereof under widely applicable conditions; In the method, a dry sample of a peptide with long amino acid length is beforehand subjected to an N-acylation treatment; by using a reaction reagent where an alkanoic acid anhydride is combined with a small amount of a perfluoroalkanoic acid, successive release of C-terminal amino acids is conducted under mild conditions; a hydrolysis treatment is applied; then, selective fragmentization at site of arginine residue is performed by digestion by trypsin; thereafter, decreases in molecular weight are measured for the C-terminal side fragments derived from a series of reaction products with use of a MALDI-TOF-MS apparatus; thereby, the C-terminal amino acid sequence of the peptide sample is identified. | 07-28-2011 |
| 20110212531 | Mass Spectrometry-Based Protein Identification Method - A method of detection of amino acid sequences and/or identification of proteins and peptides is based on derivatization of peptides or proteins using compounds comprising two or more sulfonyl groups, and subsequent analysis of the derivatized analytes using a mass spectrometer in its negative mode of operation. | 09-01-2011 |
| 20120088308 | Detection Apparatus for Biological Materials and Methods of Making and Using the Same - Method that includes providing plurality of test sites each having first and second layers respectively including inorganic first and second surface sites forming parts of interior of a well, the surface sites having positions and thicknesses being configured for locating thereon portion of unidentified amino acid-containing molecules; exposing each of a first plurality of the test sites to a fluid containing a different one of plurality of pre-identified amino acid-containing molecules and determining bonding signatures onto each of first plurality of test sites; exposing each of second plurality of test sites to another fluid containing unidentified amino acid-containing molecule and determining bonding signatures onto second plurality of test sites; and comparing bonding signatures to determine or exclude identity of unidentified amino acid-containing molecule. | 04-12-2012 |
| 20120129265 | NEW BIOMARKERS FOR ASSESSING KIDNEY DISEASES - The present invention relates to a metabolic biomarker set for assessing kidney disease comprising at least two amino acids, at least two acylcarnitines and at least two biogenic amines. Moreover, the present invention relates to a method for assessing kidney disease in a mammalian subject which comprises obtaining a biological sample, preferably blood and/or urine, from the subject and measuring in the biological sample the amount of at least two amino acids, of at least two acylcarnitines and of at least two biogenic amines, as well as to a kit adapted to carry out the method. By employing the specific biomarkers and the method according to the present invention it becomes possible to more properly and reliably assess kidney disease. | 05-24-2012 |
| 20120156792 | REAGENTS FOR ELECTRON TRANSFER DISSOCIATION IN MASS SPECTROMETRY ANALYSIS - The invention provides improvements in reagents for use in electron transfer dissociation ionization techniques for use in mass spectrometry, particularly for sequencing peptides and proteins using mass spectrometric techniques involving electro-spray ionization and MS/MS characterization of fragment ions. The novel reagents used in the inventive methods allow for more effective determination of protein sequences, especially of long peptides or post-translationally modified protein fragments. Use of the polycyclic aromatic hydrocarbons azulene, homoazulene, and acenaphthylene, and homodimers and heterodimers thereof, are described. | 06-21-2012 |
| 20120208282 | Method For Normalization in Metabolomics Analysis Methods with Endogenous Reference Metabolites. - The present invention relates to the use of endogenous reference metabolites and a method for normalization of intensity data corresponding to amounts and/or concentrations of selected target metabolites in a biological sample of a mammalian subject, wherein said intensity data are obtained by a metabolomics analysis method with one or a plurality of endogenous reference metabolites, comprising carrying out at least one in vitro metabolomics analysis method of said selected target metabolites in said biological sample, simultaneously carrying out in the same sample a quantitative analysis of one or a plurality of endogenous reference metabolites or derivatives thereof, wherein said endogenous reference metabolites are such compounds in the biological sample which are present in the subject at an essentially constant level; and wherein said endogenous reference metabolites or derivatives thereof have a molecular mass less than 1500 Da. | 08-16-2012 |
| 20120238030 | Methods and Systems for Multiplex Analysis of Biomolecules by Liquir Chromatography-Mass Spectrometry - Multiplex analysis methods for rapid analysis of the presence or amount of two or more biomolecules in a sample are disclosed. Systems implementing such methods are further disclosed. | 09-20-2012 |
| 20120258544 | Plasmonic Force Manipulation in Nanostructures | 10-11-2012 |
| 20120276643 | Method for Specific Cleavage of N-CA Bond in Peptide Main Chain - The present invention provides a peptide degradation reagent with the following characteristics: 1) it has no marked toxicity such as carcinogenicity, 2) it does not produce metastable peaks resulting from excessive degradation property, 3) it does not produce multiply-charged ion peaks which are interference peaks, and 4) it can secure separation and sharpness of peaks. The present invention also provides a method for specifically cleaving N—Cα bonds on a peptide backbone using the above-described reagent, and a method of determining the amino acid sequence of a peptide utilizing this specific cleavage. A method for specifically cleaving N—Cα bonds on the backbone of a peptide, comprising irradiating the peptide with laser light in the presence of 5-amino salicylic acid. A method for determining the amino acid sequence of a peptide, comprising irradiating the peptide with laser light in the presence of 5-amino salicylic acid to thereby specifically cleave N—Cα bonds on the peptide backbone. A reagent for specifically cleaving N—Cα bonds on a peptide backbone; a hydrogen radical-releasing reagent; a matrix reagent for MALDI-ISD; a matrix for MALDI-ISD; a peptide ionization reagent for MALDI-ISD; and a kit for MALDI-ISD. | 11-01-2012 |
| 20120309096 | DETECTING SUCCINYLACETONE - This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry. | 12-06-2012 |
| 20140113378 | Method of evaluating fatty liver related disease, fatty liver related disease-evaluating apparatus, fatty liver related disease-evaluating method, fatty liver related disease-evaluating program product, fatty liver related disease-evaluating system, information communication terminal apparatus, and method of searching for prophylactic/ameliorating substance for fatty liver related disease - A method of evaluating fatty liver related disease includes (I) an obtaining step of obtaining amino acid concentration data on a concentration value of an amino acid in blood collected from a subject to be evaluated and (II) a concentration value criterion evaluating step of evaluating a state of a fatty liver related disease including at least one of fatty liver, NAFLD, and NASH in the subject, based on the amino acid concentration data of the subject obtained at the obtaining step. | 04-24-2014 |
| 20140127819 | METHOD OF EVALUATING NASH, NASH-EVALUATING APPARATUS, NASH-EVALUATING METHOD, NASH-EVALUATING PRODUCT, NASH-EVALUATING SYSTEM, INFORMATION COMMUNICATION TERMINAL APPARATUS, METHOD OF SEARCHING FOR PREVENTING/AMELIORATING SUBSTANCE FOR NASH - A method of evaluating NASH includes (I) an obtaining step of obtaining amino acid concentration data on a concentration value of an amino acid in blood collected from a subject to be evaluated and (II) a concentration value criterion evaluating step of evaluating a state of a hepatic fibrogenesis in a NASH in the subject, based on the amino acid concentration data of the subject obtained at the obtaining step. | 05-08-2014 |
| 20140141519 | Novel Reagent and Method Using the Same - A ninhydrin reagent for use in a method for analysing nitrogen-containing compounds, in particular visualising nitrogen-containing compounds by a colour forming reaction, is provided, the ninhydrin reagent comprising ninhydrin; an aqueous buffer; and a temperature-dependent reducing agent, which agent is inactive in the reduction of ninhydrin at a first temperature and active in reducing ninhydrin to hydrindantin at a second temperature, wherein the second temperature is higher than the first temperature. The reagent is particularly useful in the analysis of amino acids. | 05-22-2014 |
| 20140141520 | Method for Analysing Amino Acids and a Reagent for Use with the Same - A method for analysing one or more nitrogen-containing compounds, in which the one or more nitrogen-containing compounds are contacted with hydrindantin at an elevated temperature in a contact zone is provided, the method comprising contacting ninhydrin with one or more reducing agents in a heating zone at a first elevated temperature to produce a hydrindantin-containing mixture; and introducing the hydrindantin-containing mixture into the contact zone and contacting the hydrindantin-containing mixture with the nitrogen-containing compounds at a second elevated temperature. The method is particularly suitable for the analysis by visualisation of amino acids. | 05-22-2014 |
| 20140179011 | RAPID FLUORESCENCE TAGGING OF GLYCANS AND OTHER BIOMOLECULES WITH ENHANCED MS SIGNALS - Reagents comprising MS active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as N-glycans and uses thereof are taught and described. | 06-26-2014 |
| 20160033527 | SYSTEM AND METHOD FOR DETERMINING AMINO ACID SEQUENCE OF POLYPEPTIDE - This invention discloses systems and methods for determining the sequence of amino acids in a short peptide chain that constructs a protein. The protein is firstly hydrolyzed to various short peptides and amino acid enantiomers. Then, the systems and method are used to separate the short peptides and the amino acid enantiomers, identify qualitatively each of the amino acid enantiomers, and obtain the molecular mass signal for each of the peptides. After that, the identified amino acid enantiomers are used to construct any possible short peptides in an order from the smallest molecular weight dipeptide to higher molecular weight short peptides, and the correct short peptides is confirmed by matching the molecular weight obtained from the mass spectrometry measurement, then, the short peptides are combined to give a large peptide. The process is continued until the whole amino acid sequence of the peptide chain of protein can be determined. | 02-04-2016 |
| 20160139134 | METHOD FOR ANALYSIS OF COMPOUNDS WITH AMINO GROUP AND ANALYTICAL REAGENT THEREFOR - The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry. | 05-19-2016 |
| 20160146828 | CHEMISTRY, SYSTEMS AND METHODS OF TRANSLOCATION OF A POLYMER THROUGH A NANOPORE - Embodiments disclosed herein are directed to recognition tunneling systems, methods and devices, and more particularly, to chemical reactions for selectively labeling proteins and peptides and placing protein and/or peptides into, or onto a nanopore formed in a solid support and threading such in and/or through the nanopore, with such nanopores, in some embodiments, including a molecular motor to pull or otherwise force the protein/peptide through the nanopore. | 05-26-2016 |
| 436090000 | Alpha or beta amino acid | 12 |
| 20100210023 | Salivary metabolic biomarkers for human oral cancer detection - The present invention provides a novel oral cancer and periodontal disease salivary metabolome for use in the diagnosis or for providing a prognosis for oral cancer and periodontal disease in an individual. The present invention also provides novel methods of diagnosing or providing a prognosis for oral cancer or periodontal disease by detecting metabolites found in the saliva of an individual. Finally, the present invention provides kits for the detection of salivary metabolites useful in the diagnosis or prognosis of oral cancer and periodontal disease in an individual. | 08-19-2010 |
| 20110003393 | SYSTEMS AND METHODS FOR STUDYING INFLUENZA - The present invention generally relates to influenza and, in particular, to systems and methods for studying influenza viruses such as the influenza A virus. One aspect of the invention is generally directed towards systems and methods for determining the timescale dynamics of the tryptophan residue located in position 41 of the M2 proton channel of the influenza A virus, for instance, via nuclear magnetic resonance. This may be useful, for example, in determining whether a candidate drug is able to alter the dynamics of the tryptophan residue, and thus, whether the drug targets the M2 proton channel. | 01-06-2011 |
| 20110143444 | METHOD OF EVALUATING FEMALE GENITAL CANCER - According to the method of evaluating female genital cancer of the present invention, amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated is measured, and the state of female genital cancer including at least one of cervical cancer, endometrial cancer, and ovarian cancer in the subject is evaluated based on the concentration value of at least one of Thr, Ser, Asn, Gln, Pro, Gly, Ala, Cit, Val, Met, Ile, Leu, Tyr, Phe, His, Trp, Orn, Lys, and Arg contained in the measured amino acid concentration data of the subject. | 06-16-2011 |
| 20110143445 | Analysis of Amino Acids And Amine-Containing Compounds Using Tagging Reagents and LC-MS Workflow - A plurality of mass differential tagging reagents is used to label amine functionality in amine-containing compounds. The labeled analytes have distinct retention times on a reversed phase column, and distinct masses. Under high energy collision, reporter groups can be generated and the intensity or the peak area detected for each reporter group can be used for quantitation. One exemplary set of reagents includes a set of three different mass differential reagents comprising tagging weights of 140 atomic mass units, 144 atomic mass units, and 148 atomic mass units, respectively, with reporter groups of 113, 117, and 121 atomic mass units, respectively. A package including each of the mass differential reagents is also provided and can include separate respective containers, for example, one for each of the different reagents. The package can also include one or more standards each comprising a respective known concentration of a respective known amine-containing compound. | 06-16-2011 |
| 20110189780 | DETECTING ISOMERS USING DIFFERENTIAL DERIVATIZATION MASS SPECTROMETRY - Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second standard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more branched-chain amino acids in the sample. | 08-04-2011 |
| 20130023056 | EARLY DETECTION OF RECURRENT BREAST CANCER USING METABOLITE PROFILING - A monitoring test for recurrent breast cancer with a high degree of sensitivity and specificity is provided that detects the presence of a panel of multiplicity of biomarkers that were identified using metabolite profiling methods. The test is capable of detecting breast cancer recurrence about a years earlier than current available monitoring diagnostic tests. The panel of biomarkers is identified using a combination of nuclear magnetic resonance (NMR) and two dimensional gas chromatography-mass spectrometry (GC×GC-MS) to produce the metabolite profiles of serum samples. The NMR and GC×GC-MS data are analyzed by multivariate statistical methods to compare identified metabolite signals between samples from patients with recurrence of breast cancer and those from patients having no evidence of disease. | 01-24-2013 |
| 20140127820 | ANALYTE DETECTION USING NEAR-INFRARED FLUOROPHORES - Embodiments of compounds for selectively detecting an analyte are disclosed, along with methods and kits for detecting analytes with the compounds. The compounds are bridged viologen conjugates including at least one fluorophore according to the general structure | 05-08-2014 |
| 20140273253 | SYSTEM AND PROCESS FOR QUANTIFYING POTENTIALLY MINERALIZABLE NITROGEN FOR AGRICULTURAL CROP PRODUCTION - The invention is generally directed to a system and process for fluorometrically quantifying potentially mineralizable nitrogen for agricultural crop production. The soil analysis process measures potentially mineralizable nitrogen and calibrates the application of soil-based nitrogen for site or field specific management of nitrogen fertilizers for crops grown on a wide variety of soil textures including sandy loam, silt loam and clay soils. The spectrofluorometric system and process may be utilized for routine soil testing with a lower sample to sample variability, and the automation of the spectrofluorometric system and process allows for simultaneous determination of potentially mineralizable soil organic nitrogen, ammonium and nitrate. | 09-18-2014 |
| 20150064797 | METHOD FOR QUANTITATIVELY ANALYZING CYSTEINE AND CYSTINE AND REAGENT KIT FOR QUANTITATIVELY ANALYZING CYSTEINE AND CYSTINE - A method for quantitatively analyzing cysteine and cysteine includes a first step of adding a methyl-sulfurating agent to a sample that includes cysteine and cystine to obtain a methyl-sulfurated cysteine, a second step of adding a derivatizing agent to the methyl-sulfurated cysteine and the cystine to obtain a cysteine derivative and a cystine derivative, respectively, and a third step of quantifying the cysteine derivative and the cystine derivative. | 03-05-2015 |
| 20150309051 | ISOVALERYLGLYCINE AS BIOMARKER FOR THE PREDISPOSITON FOR WEIGHT GAIN AND OBESITY - The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to a new biomarker, its use and a method that allows it to diagnose the likelihood to resist diet induced weight gain, and/or to be susceptible to a diet induced weight gain. For example, the biomarker may be isovalerylglycine. | 10-29-2015 |
| 20150346221 | QUANTIFICATION METHOD FOR SULFUR-CONTAINING ORGANIC COMPOUND - Provided is a quantification method for a sulfur-containing organic compound. The quantification method may quantify the sulfur-containing organic compound without limitation. Preferably, the quantification method is more effective for quantifying organic compounds of which quantification is difficult to perform, such as a macromolecule such as a biomaterial, or the organic compound having a hygroscopic property or being present in a hydrated form, and significantly effectively quantifying high purity standard materials of peptide or protein among the biomaterials. | 12-03-2015 |
| 20160077103 | FLUORESCENCE DETECTION OF CYSTEINE AND HOMOCYSTEINE - Embodiments of probes for selectively detecting compounds having a thiol group and an amino group, e.g., cysteine and/or homocysteine, are disclosed, along with methods and kits for detecting the compounds in neutral media with the probes. The probes have a structure according to the general formula | 03-17-2016 |
