| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 436066000 | HEMOGLOBIN, MYOGLOBIN, OR OCCULT BLOOD | 34 |
| 20080227208 | Devices and Methods for Detection of Occult Blood - The present invention relates to devices and methods for the detection of occult blood in a test sample. These devices and methods can detect the presence of one or more of the following components of occult blood: hemoglobin, transferrin, hemoglobin-haptoglobin complex, and albumin. Methods for the detection of occult blood in a test sample include the following steps: exposing said test sample to two or more of the following antibodies: anti-hemoglobin antibodies, anti-hemoglobin-haptoglobin-complex antibodies, anti-transferrin antibodies, and anti-albumin antibodies or one or more of the following antibodies: anti-hemoglobin-haptoglobin-complex antibodies, anti-transferrin antibodies, and anti-albumin antibodies; determining the level of reactions between the antibodies and their corresponding components of occult blood that may be in the test sample; and deciding on the presence of occult blood. The devices of this invention can have two or more of test areas containing two or more of the following antibodies: anti-hemoglobin antibodies, anti-transferrin antibodies, anti-hemoglobin-haptoglobin complex antibodies, and anti-albumin antibodies or one or more of test areas containing one or more of the following antibodies: anti-transferrin antibodies, anti-hemoglobin-haptoglobin complex antibodies, and, anti-albumin antibodies. The devices and methods of this invention are simple and produce rapid responses. | 09-18-2008 |
| 20080241940 | FECAL SAMPLING DEVICE AND METHOD - A specimen sampling device according to one embodiment has a first panel, a second panel, a sheet between the first and second panels for receiving the collected samples and a movable area creating metering apertures through which samples are received. The movable area is movable from a collection position, in which it is adjacent the sheet, to a test position, in which it is spaced away from the sheet. A method of obtaining a fecal sample is also disclosed. | 10-02-2008 |
| 20080248581 | Method for performing correction of blood glucose assay bias using blood hemoglobin concentration - A device and method for determining a correction factor for correcting the blood glucose assay bias based on sample hematocrit interference in a testing device using the blood hemoglobin concentration. The hemoglobin assay and the glucose assay may be performed using a single combination monitoring device. | 10-09-2008 |
| 20090117660 | Devices and methods for sample collection and analysis - The present invention provides devices, methods, and kits for the collection of a solid or semi-solid sample and analysis for the presence, absence, or quantity of an analyte. The invention provides a collection slide having a first card and a second card. The first card has a sample collection area. The first and second cards have orifices allowing the passage of fluid through the sample collection area, and the cards are hingeably connected to each other. The invention also provides an assay device having a housing with a test element, a results window, and a docking area for receiving and engaging the collection slide. In one embodiment the collection slide and device can be used to detect the presence of fecal occult blood (human hemoglobin) in a stool sample. Many other embodiments are described herein. | 05-07-2009 |
| 20090263905 | DETECTION TEST ASSEMBLY FOR DETECTING THE PRESENCE OF A SUBSTANCE IN A SAMPLE - A detection test assembly for detecting the presence of a substance preferably a blood substance in a feces sample comprising feces diluted in buffer solution or water is described. The blood substance is detected by acceptors having binding properties for the substance or that may be specifically bound by the substance. Said assembly comprises a reaction field having a mobile first acceptor with visualization properties and a detection field comprising a test field connected to and located downstream from the reaction field having an immobilized second acceptor. After direct application of a prepared feces sample to the assembly, first acceptor forms a complex with blood substance, flows to test field and binds to or is bound by immobilized second acceptor. Accumulation of first acceptor in the test field results in the formation of a visualizable line such as color different from the color of the test field itself. The detection test assembly includes at least two positive internal controls. | 10-22-2009 |
| 20100159605 | Method of Correction of Particle Interference to Hemoglobin Measurement - A method of correction of particle interference to hemoglobin measurement of a blood sample on a hematology analyzer is provided. The method includes mixing an aliquot of a blood sample with a lytic reagent to lyse red blood cells and forming a sample mixture; measuring absorbance of the sample mixture at a predetermined wavelength of a hemoglobin chromogen formed in the sample mixture, and obtaining an apparent hemoglobin concentration of the blood sample using obtained absorbance; measuring concentration and size of cellular particles remaining in the sample mixture; removing contribution of the cellular particles to the apparent hemoglobin concentration using the concentration and the size of the cellular particles to obtain a corrected hemoglobin concentration of the blood sample; and reporting the corrected hemoglobin concentration of the blood sample. | 06-24-2010 |
| 20100197027 | AN INDICATING FIBER - A fiber, an articles formed from a fiber and methods of making the fiber and associate article are disclosed. In one embodiment, the fiber comprises a synthetic polymer and a color-changing indicator. The color-changing indicator is dispersed throughout the synthetic polymer. The color-changing indicator reacts in the presence of a stimulus to produce a color change. | 08-05-2010 |
| 20100285595 | MYOGLOBIN AS EARLY PREDICTOR OF MYOCARDIAL INFARCTION - The present invention relates to a method for diagnosing myocardial infarction in a subject who suffers from acute coronary syndrome and has a cardiac troponin level, which is detectable, but lower than the level that is considered as being indicative for a myocardial infarction. Moreover, the present invention relates to a method for identifying a subject being susceptible to cardiac intervention, wherein the subject suffers from acute coronary syndrome and has a cardiac troponin level which is detectable, but lower than a level that is considered as being indicative for a myocardial infarction. The methods of the present invention are based on the determination of myoglobin and, optionally, Heart-type fatty acid binding protein (H-FABP) in a sample of said subject and comparing the amount of myoglobin and, optionally, H-FABP to reference amounts. Also comprised by the present invention are kits or devices to carry out the methods of the present invention. | 11-11-2010 |
| 20110229974 | METHOD AND A KIT FOR DETERMINING HUMAN OR ANIMAL BLOOD ON A SURFACE - A method for detecting human or animal blood traces on a surface is described. The method is fundamentally based on the reaction of luminol and includes the preliminary operation of atomizing an inorganic powder suspension, such as titania, silica, alumina, hydroxyapatite, or the like, onto the surface to be investigated, after which a luminol composition is atomized thereon, which comprises a luminol compound, a peroxidic oxidising agent and an alkaline agent in an amount providing a pH within the range of 10 to 14. Furthermore, a kit for carrying out the detection method of the invention is described. | 09-22-2011 |
| 20110263031 | Process, Portable Equipment and Device for In Vitro, One-Step Photometric Determination of Hemoglobin Concentration in a Diluted Blood Sample - A process, portable equipment and device for in vitro photometric determination of hemoglobin concentration in diluted blood. The present invention allows its use in field anemias prospection programs. The present invention has a light source ( | 10-27-2011 |
| 20120040466 | Analytical Method of Hemoglobin - A method for analyzing hemoglobin in a sample by separation analysis while suppressing the denaturation of the hemoglobin includes separating hemoglobin in the presence of at least one of a sulfurous acid compound and a dithionous acid compound. | 02-16-2012 |
| 20120135529 | Detection of Occult Blood in Feces or Urine - The present invention relates to an improved method, reagents and kit for the detection of fecal or urine occult blood. The reagents are either supplied as solutions in small vials or incorporated into a matrix that is treated, impregnated, or imprinted with the test reagents that are capable of undergoing a chromagenic reaction. The method elucidates false positives from dietary sources, oxidants in the toilet water supply and is specific for blood. A stabilized chromogenic solution is disclosed which contains phemolphthalin in a deoxygenated, basic solution. The chromagenic solution either in a liquid or matrix form is placed into the toilet water following urination or defecation. A few moments are allowed to occur for observation of the matrix turning from colorless to a hot-pink. A hot pink color is indicative of a false positive. If no color change occurs, an oxidizing solution is added to the toilet water. If a change from colorless to a hot-pink occurs in less than thirty seconds then this test is positive and specific for occult blood in this fecal and/or urine specimen. Typically, the oxidizing solution is hydrogen peroxide. Hemoglobin or a porphyrin solution can be added to a separate matrix or | 05-31-2012 |
| 20130130391 | METHOD OF ANALYZING HEMOGLOBINS - An object of the present invention is to provide a method for analyzing hemoglobins which can accurately separate hemoglobins in a short time by liquid chromatography. | 05-23-2013 |
| 20130196443 | APPARATUS AND METHOD FOR DATING A BODY OR BODY SAMPLE - A method and apparatus for dating a dating a body sample, such as blood, includes taking at least one spectroscopic measurement ( | 08-01-2013 |
| 20140004612 | SPECIMEN ANALYZING METHOD AND SPECIMEN ANALYZING APPARATUS | 01-02-2014 |
| 20140162369 | METHOD FOR MEASURING HEMOGLOBINS - The present invention aims to provide a method of measuring hemoglobins which can measure hemoglobins in a short time at high accuracy. The present invention also aims to provide a method of measuring hemoglobin A1c, a method of simultaneously measuring hemoglobin A1c and hemoglobin F, a method of simultaneously measuring hemoglobin A1c and hemoglobin A2, and a method of simultaneously measuring hemoglobin A1c and abnormal hemoglobins, each utilizing the above-mentioned method of measuring hemoglobins by liquid chromatography. The present invention relates to a method of measuring hemoglobins by liquid chromatography. A column used in the method is filled with, as a column-packing material, cation-exchangeable particles including cross-linked polymer particles having a cation-exchange-group-containing polymer bonded to the surface of the cross-linked polymer particles, and the column shows a pressure value of 9.8×10 | 06-12-2014 |
| 20140193921 | TEST APPARATUS AND TARGET MEASUREMENT METHOD USING THE SAME - A test apparatus and method for measuring a concentration of a target by correcting for an impact of hemoglobin are provided. The target measurement method includes measuring an absorbance of hemoglobin in a sample, measuring an absorbance of a target in the sample, determining variation of the absorbance of the target according to the measured absorbance of the hemoglobin, and correcting the absorbance of the target by subtracting the determined variation of the absorbance of the target from the measured absorbance of the target. | 07-10-2014 |
| 20140256051 | DECARBOXYLATION DOSIMETRY - Methods and apparatuses of the present disclosure provide accurate and precise radiation dosimetry based on decarboxylation of a reactant upon exposure to ionizing radiation. The decarboxylation reaction yields carbon dioxide and stable end products, which can be detected and measured, and correlated to determine an amount of radiation exposure. The reactants include carboxyl acids, such as amino acids and others occurring naturally in mammals. The dosimetry may be performed in real-time or retrospectively by assaying a sample of tissue from a patient. Also disclosed is a device which detects and measures radiation dosages based on decarboxylation of a reactant contained therein. | 09-11-2014 |
| 20150024503 | METHOD OF ANALYZING HEMOGLOBINS - An object of the present invention is to provide a method for analyzing hemoglobins which can accurately separate hemoglobins in a short time by liquid chromatography. | 01-22-2015 |
| 20150140670 | KITS AND METHODS FOR DETERMINING PHYSIOLOGIC LEVEL(S) AND/OR RANGE(S) OF HEMOGLOBIN AND/OR DISEASE STATE - Diagnostic kits and methods configured to rapidly and non-invasively determine physiologic levels of hemoglobin. A diagnostic kit may include a chamber pre-filled with an indicator, the indicator solution including a tetramethylbenzidine (TMB) solution, the indicator being configured to change color; a collection device configured to collect a test sample from a subject. The kit may also include a hemoglobin physiologic level identifier legend, the legend indicating 1) at least one color of the indicator and 2) a physiologic level and/or range of the hemoglobin and/or disease state associated with the color. | 05-21-2015 |
| 20160123998 | Devices, Systems, and Methods for Measuring Blood Loss - Devices, systems, and methods for measuring the blood loss of a subject during a medical procedure. Blood and other fluids are received within a container, and a blood measurement device determines the hemoglobin concentration of the fluid within the container. The blood measurement device can also calculate the estimated blood loss of the subject based upon the determined hemoglobin concentration and the volume of the fluid within the container and the patient's hemoglobin. | 05-05-2016 |
| 20160184826 | REAGENT SUPPLYING DEVICE - Provided are a reagent supply method and device capable of using up a reagent in a container without a remnant to the extent possible, and supplying the reagent to an analysis device without mixing air bubbles even when the remaining amount of the reagent is extremely small. The reagent supply device includes: at least one reagent container including: a container body for storing a liquid reagent; and a reagent supply port arranged on the container body; and a support member for supporting the at least one reagent container so that the reagent supply port is positioned on a lower side of the container body. The reagent supply port is sealed by a plug including at least one nozzle penetration portion. The at least one nozzle penetration portion is formed of a material having a Shore hardness of from A5° to A90°. | 06-30-2016 |
| 436067000 | Glycosylated hemoglobin | 12 |
| 20090042307 | Hydrophilic Polymer Microparticle, Filler for Ion Exchange Liquid Chromatography, and Method for Production of Filler for Ion Exchange Liquid Chromatography - An object of the present invention is to provide a hydrophilic polymer microparticle which shows reduced swelling in an aqueous medium and has an excellent dispersibility in an aqueous medium, a filler for ion-exchange liquid chromatography which can effectively suppress non-specific adsorption of protein and the like, a method for analyzing glycosylated hemoglobin using the filler for ion-exchange liquid chromatography, a method for production of a filler for ion-exchange liquid chromatography that can maintain suppressive effects on swelling, non-specific adsorption and the like for a long period of time, a filler for ion-exchange liquid chromatography produced by the method for production of a filler for ion-exchange liquid chromatography, and a filler for ion-exchange liquid chromatography for glycosylated hemoglobin analysis. | 02-12-2009 |
| 20090053816 | HEMOGLOBIN-BASED METHODS FOR PROPHYLAXIS, DIAGNOSIS AND/OR TREATMENT OF RETINAL DISORDERS - The presently disclosed subject matter provides methods of diagnosing retinal disorders in subjects by measuring hemoglobin and modified hemoglobin in the subjects. The presently disclosed subject matter further provides methods of treating retinal disorders in subjects by decreasing hypoxia in retinal tissue of the subjects through modulation of hemoglobin levels and activities in the retinal tissue. | 02-26-2009 |
| 20090176309 | Fluorescent Assay - A method and apparatus to estimate the concentration of a non-fluorescent substance (e.g. haemoglobin) in a fluorescent assay by separately estimating the non time dependent alteration attributed to inherent filter effects from the time dependent alteration caused by the assay chemistry. Such a method obviates the requirement for a separate photometric or other measurement thereby simplifying the methodology and associated instrumentation. | 07-09-2009 |
| 20090317912 | Method of Measuring Glycated Hemoglobin Concentration - The present invention relates to a method and an apparatus that measure the concentration of glycated hemoglobin by an optical technique. A wavelength in which the molecular extinction coefficient of oxyhemoglobin agrees or substantially agrees with the molecular extinction coefficient of deoxyhemoglobin is adopted as a measurement wavelength. Preferably, the measurement wavelength is set at from 417 to 421 nm. In the present invention, the concentration of glycated hemoglobin is measured by making use of column chromatography and of using a sample prepared from red blood cells in blood. | 12-24-2009 |
| 20100197028 | METABOLIC MARKERS OF DIABETIC CONDITIONS AND METHODS OF USE THEREOF - Novel methods for assessing the state of a diabetic condition of a subject are described, comprising determining the amount of a metabolite in a sample from a body fluid or tissue of the subject. The methods may be used, for example, in diagnosing and monitoring insulin resistance, prediabetes, or the response to a drug which alters a diabetic condition. | 08-05-2010 |
| 20100291691 | METHOD OF MEASURING GLYCATED HEMOGLOBIN CONCENTRATION AND CONCENTRATION MEASURING APPARATUS - When the concentration of glycated hemoglobin is measured, a plurality of wavelengths are selected as measurement wavelengths from the wavelength range of 400 to 450 nm. Preferably, by use of a liquid chromatography, at least the light of different peak wavelengths in the wavelength range of 415 to 430 nm are continuously or intermittently received to obtain a three dimensional chromatogram having as variables the wavelength, the elution time and the amount of detection. The concentration of glycated hemoglobin is calculated based on this three dimensional chromatogram. | 11-18-2010 |
| 20100311174 | DETERMINATION OF GLYCATED PROTEIN - The present invention provides methods for quantitation of glycated protein in a biological sample using a solid support matrix by making a first bound protein measurement total bound protein under conditions where both glycated and non-glycated protein bind to the support in making a second bound protein measurement under conditions where glycated protein is bound to the support and non-glycated protein is not substantially bound. Diagnostic devices and kits comprising the methods of the present invention are also provided | 12-09-2010 |
| 20100323450 | SYSTEM FOR QUANTITATIVE MEASUREMENT OF GLYCOHEMOGLOBIN AND METHOD FOR MEASURING GLYCOHEMOGLOBIN - The present invention provides a device for simultaneously detecting hemoglobin and glycohemoglobin in blood, comprising a lateral flow assay strip, a laser-induced epifluorescence detection device, and an LED detection device, and a simple method for simultaneously quantifying hemoglobin and glycohemoglobin in blood by an immunological method using the same. | 12-23-2010 |
| 20110136241 | TYPE II DIABETES MOLECULAR BIOPROFILE AND METHOD AND SYSTEM OF USING THE SAME - Molecular bioprofiles comprising biologically correlated and relevant analytes that impact the biological state of a human health condition compared to a control population are provided. These molecular bioprofiles are useful in several ways including but not limited to, monitoring a disease or condition's progression, evaluating the impact of an agent or compound on a disease or condition, evaluating the impact of a lifestyle change on a disease or condition and assessing the risk of the disease or condition to a subject. Type II diabetes molecular bioprofiles are of particular interest. | 06-09-2011 |
| 20110195508 | SYSTEMS AND METHODS FOR HEMOGLOBIN ANALYSIS - Systems and methods for hemoglobin analysis. At least one embodiment of a stabilizing system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a glycosylated hemoglobin (HbA1c) in a body fluid and a detection agent capable of detecting the HbA1c. | 08-11-2011 |
| 20130157373 | SYSTEMS AND METHODS FOR HEMOGLOBIN ANALYSIS - Systems and methods for hemoglobin analysis. At least one embodiment of a stabilizing system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a glycosylated hemoglobin (HbA1c) in a body fluid and a detection agent capable of detecting the HbA1c. | 06-20-2013 |
| 20140065714 | METHOD OF IDENTIFYING GLYCATED PROTEIN IN SAMPLE AND DEVICE FOR THE GLYCATED PROTEIN - Provided is a method and device for identifying glycated protein in a sample using a matrix including a boronic acid moiety that binds glycated proteins. | 03-06-2014 |
