Class / Patent application number | Description | Number of patent applications / Date published |
436034000 | RATE OF REACTION DETERMINATION | 27 |
20080206876 | INSTRUMENTS FOR THE SELECTIVE AND DIRECT DETECTION OF FREE METALS IN FLUIDS AND METHODS TO DIAGNOSE METAL-RELATED DISEASES AND DETERMINE PHARMACOLOGIC DOSING REGIMENS - Instruments for the selective and direct detection of free metals in fluids and methods to diagnose metal-related diseases and determine pharmacologic dosing regimens are disclosed. | 08-28-2008 |
20080227206 | METHOD AND SYSTEM FOR DETERMINATION OF MOLECULAR INTERACTION PARAMETERS - A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface. An analytical system for carrying out the method, a computer program, a computer program product and a computer system for performing the method are also disclosed. | 09-18-2008 |
20090142846 | METHODS FOR MEASURING BIOCHEMICAL REACTIONS - Methods for measuring biochemical reactions and analysis of reaction products by controlling dispersion of reagents within fluid streams such that the measuring of the biochemical reaction is substantially free of a measurable dispersion artifact. Controlling dispersion of reagents within fluid streams can include flowing multiple fluid streams each including reaction reagents into contact through a mixing region to laterally mix the fluid streams and then passing the merged, laterally mixed fluid stream through a controlled dispersion element to axially disperse the reaction reagents merged fluid stream. Controlling dispersion of reagents within fluid streams can include controlling flow rates of multiple fluid streams each including reaction reagents to create a concentration gradient that is substantially free of a measurable dispersion artifact. The biochemical reaction can occur in a microfluidic chip. | 06-04-2009 |
20090191637 | Method and apparatus for determining anticoagulant therapy factors - Methods and apparatus are disclosed for determining a new anticoagulant therapy factors for monitoring oral anticoagulant therapy to help prevent excessive bleeding or deleterious blood clots that might otherwise occur before, during or after surgery. New anticoagulant therapy factors maybe based upon the time to maximum acceleration from the time of reagent injection (TX) into a plasma sample, Embodiments include methods and apparatus for determining an anticoagulant therapy factor without requiring use of a mean normal prothrombin time determination or ISI, and may be carried out with the patient sample and a coagulation reagent. | 07-30-2009 |
20090305424 | Microfluidic Flow Devices For Determining Parameters of Physical and/or Chemical Transformations - Microfluidic flow devices for determining parameters of a physical and/or chemical transformation include a body ( | 12-10-2009 |
20100022008 | COMPOSITIONS AND METHODS FOR DETECTING NERVE AGENTS - The present invention provides methods and compositions for detecting, identifying and measuring the abundance of chemical nerve agents. Methods and compositions of the present invention are capable of providing selective detection of phosphorous based nerve agents, such as nerve agents that are esters of methyl phosphonic acid derivatives incorporating a moderately good leaving group at the phosphorus. Selectivity in the present invention is provided by a sensor composition having an alpha (α) effect nucleophile group that undergoes specific nucleophilic substitution and rearrangement reactions with phosphorus based nerve agents having a tetrahederal phosphorous bound to oxygen. The present invention includes embodiments employing a sensor composition further comprising a reporter group covalently linked to the alpha effect nucleophile group allowing rapid optical readout of nerve agent detection events, including direct visual readout and optical readout via spectroscopic analysis. | 01-28-2010 |
20100136697 | APPARATUS AND METHOD OF MEASURING CONCENTRATION OF FUEL - An apparatus of measuring concentration of fuel including a catalyst layer, a diffusion layer, a fuel chamber, a reactive gas chamber, and a sensor is provided. The diffusion layer is connected to the catalyst layer. The fuel chamber is suitable for containing a fuel. The diffusion layer is between the fuel chamber and the catalyst layer. The reactive gas chamber is suitable for containing a reactive gas. The catalyst layer is between the reactive gas chamber and the diffusion layer. The fuel diffuses to the catalyst layer via the diffusion layer such that a combustion reaction of the fuel and the reactive gas is conducted in the catalyst layer to consume the reactive gas and generate a gaseous product. The sensor is disposed on the reactive gas chamber for measuring the concentration of the reactive gas or the concentration of the gaseous product in the reactive gas chamber. | 06-03-2010 |
20100323449 | HIGH THROUGHPUT CATALYTIC PROCESS DEVELOPMENT METHOD - A method for investigating longitudinally dependent properties of the composite catalyst bed of a laboratory scale plug flow reactor, comprises the steps of: supplying fresh reactant feed to the inlet of said composite catalyst bed; sampling and measuring the amounts of fresh reactant feed and amounts and characteristics of reaction products and byproducts at a plurality of positions along the length of said catalyst bed; based on the amounts of fresh reactant feed and amounts and characteristics of reaction products and byproducts at said plurality of positions, determining information concerning longitudinal gradients occurring in the composite catalyst bed of said plug flow reactor. | 12-23-2010 |
20110183422 | MEASUREMENT OF CURING - A method for increasing productivity and quality in production of cured polymer by a real time measurement of the progress of curing, in a mould cavity, which being filled with a compound to be cured, wherein a signal is generated by a wave at an ultrasonic or equivalent frequency, which is transmitted through the mould cavity, the time for the wave to pass through the compound in the mould and back is detected, and the detected signal being analyzed in a suitable data processing computer , to establish a graph showing a relationship between the time for the wave to pass through the compound in the mould and back, and the time of the curing of the compound. The graph is used to determine a feature of the compound by identifying at least one specific parameter of the graph, and using said parameter to control the production. | 07-28-2011 |
20110207229 | METHOD AND DEVICE FOR DETERMINING THE AMOUNT OF MAGNETICALLY LABELED TARGET COMPONENTS - The invention relates to a method and a device ( | 08-25-2011 |
20120045838 | CUSTOMIZED MOLECULARLY IMPRINTED POLYMER (MIP) UNITS - A method of manufacturing at least one customized MIP unit including: (a) providing at least one MIP unit having a surface including at least one target binding site configured to resemble a target molecule and surface-bound chargeable groups; (b) contacting the MIP unit(s) from the step (a) with at least one template molecule in a first solvent allowing the template molecule(s) to bind to the MIP unit(s); (c) passivating the surface-bound chargeable groups on the MIP unit(s) by adding a passivating agent; and (d) removing the template molecule(s) by washing in a second solvent, wherein the passivating agent binds to the surface of the unit(s) through bonds which remain stable upon washing in the second solvent. | 02-23-2012 |
20120142112 | ELECTROLUMINESCENT DIODE SENSOR - A senor uses a transduction mechanism of attenuating electroluminescence. Luminescence from a light emitting diode is attenuated as a consequence of direct interaction of an analyte and a electroluminescent material, An electroluminescent diode sensor (EDS) is fabricated in a way that allows the electroluminescent material in the diode to be exposed to gaseous, liquid or solid sample(s) which may affect the luminescence intensity of the diode, | 06-07-2012 |
20120295357 | APPARATUS AND METHOD FOR QUANTIFYING BINDING AND DISSOCIATION KINETICS OF MOLECULAR INTERACTIONS - The present invention relates to an apparatus for quantifying the binding and dissociation kinetics of molecular interactions of small molecular bio materials with high sensitivity almost without the influence of a change in the reflective index resulting from a buffer solution by making polarized incident light incident on the binding layer of a bio material, formed in a thin dielectric film, so that the polarized incident light satisfies a p-wave non-reflecting condition and a quantifying method using the same. | 11-22-2012 |
20130071935 | Dual Inlet Microchannel Device And Method For Using Same - A dual inlet microchannel device and a method for using the device to perform a flow-through kinetic assay are described. A microplate having an array of the dual inlet microchannel devices and in particular their specially configured flow chambers is also described. Several embodiments of the dual inlet microchannel devices and specially configured flow chambers are also described. | 03-21-2013 |
20130330827 | In Vitro Methodology for Predicting in Vivo Absorption Time of Bioabsorbable Polymeric Implants and Devices - A novel in vitro methodology for predicting the in vivo behavior, such as absorption time or mechanical strength retention, of biodegradable polymeric implants and medical devices. The present invention provides a novel in vitro methodology, hydrolysis profiling, for studying the degradation of absorbable polymers. Accuracy and reproducibility have been established for selected test conditions. Data from this in vitro method are correlated to in vivo absorption data, allowing for the prediction of accurate in vivo behaviors, such as absorption times. | 12-12-2013 |
20140057356 | ESTIMATING DIFFUSION COEFFICIENT FOR A RESERVOIR STIMULATION FLUID - The subject disclosure relates to matrix acidizing. More specifically, systems and methods are described for estimating a diffusion coefficient for an acid fluid used to stimulate a subterranean reservoir wherein a spent acid is formulated that includes one or more by-products of the reaction between the fluid and rock. A rock sample, such as in the form of a rotating disk is exposed to spent acid under elevated pressure and temperature conditions while the fluid is sampled and analyzed. A diffusion coefficient for the spend acid is estimated. | 02-27-2014 |
20140147921 | MICROSECOND TIME-RESOLVED MASS SPECTROMETRY - A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization ( | 05-29-2014 |
20140212979 | DIFFUSION BASED METAL OXIDE GAS SENSOR - A measuring device is provided for determining the type and/or concentration a gaseous analyte from a set of analytes in a gaseous carrier. It comprises a housing having a passage to a cavity. A gas sensor with a heated metal-oxide sensing layer is arranged in the cavity. In order to gain a better understanding of the type of the analyte, diffusion effects are exploited by taking into account that the diffusion process through the passage as well as the catalytic reaction rate at the metal-oxide sensing layer depend on the type of the analyte. These material parameters can be determined by taking several measurements in a non-steady state of the concentration of the analyte within the cavity or while varying the reaction rate. | 07-31-2014 |
20140377874 | Method for Determining the Propensity for Calcification - The present invention relates to a method for determining the propensity of a fluid for calcification characterized by the following steps: (i) adding a soluble calcium salt and a soluble phosphate salt to a sample of said fluid; (ii) incubating said sample at conditions allowing the formation of calciprotein particles (CPPs); and (iii) determining one or more of the following: (a) the rate of the formation of primary and/or secondary CPPs; (b) the amount of primary and/or secondary CPPs; and/or (c) the rate of the transition of primary CPPs into secondary CPPs, wherein an increase in one or more of (a), (b) and/or (c) of step (iii) indicates an increased propensity of said fluid for calcification. | 12-25-2014 |
20150064794 | BIORELEVANT COMPOSITIONS - This application relates to a homogeneous biorelevant composition for preparing fasted state biorelevant media having a surface tension between 25 mN/m and 50 mN/m for simulating fasted state gastric and fasted state upper small intestinal fluids of mammalian species, especially humans, dogs, etc. comprising at least one bile salt, eg. sodium taurocholate or sodium taurodeoxycholate; at least one phospholipid, especially 60-99 wt % phosphatidylcholine (PC), enzyme digested diacylphospholipids containing 50-90 wt % of monoacyl-PC; or mixtures thereof; and at least one fatty acid or monovalent salt of the fatty acid, such as sodium oleate. The application also relates to an aqueous biorelevant media composed of surfactants occurring in the gastrointestinal tract of mammals, in particular when prepared from above homogeneous biorelevant composition. | 03-05-2015 |
20150316531 | Automated Analyzer and Automated Analysis Method - Provided is technology for blood clotting reactions capable of analyzing a blood clotting reaction with a high degree of precision, by precisely detecting and removing noise, regardless of the location where the noise is generated in the light intensity data. This automated analyzer approximates, with an approximation curve, time series data for transmitted light intensity or scattered light intensity of light emitted onto a sample, and, in this process, removes abnormal data points that deviate from the approximation curve (see | 11-05-2015 |
20150338375 | MICROSECOND TIME-RESOLVED MASS SPECTROMETRY - A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization ( | 11-26-2015 |
20160025614 | METHOD AND APPLICATION OF GaPO4 CRYSTAL MICROBALANCE TO HIGH ACID CRUDE CORROSION TESTING - A new technique to measure corrosion rates in naphthenic crudes in a high temperature environment has been designed using a gallium phosphate (GAPO) crystal microbalance. The technique is highly sensitive and can measure instantaneous corrosion rates. Due to the high temperature stability of the GAPO crystals, this technique can be used to measure in the laboratory dynamic naphthenic acid corrosion rates of iron at the high temperatures that are prevalent in various locations in oil and gas production and refining facilities, therefore opening a new and more accurate method to study naphthenic corrosion. | 01-28-2016 |
20160116408 | CORRECTION FOR OSMOTIC PRESSURE VARIATIONS IN CHEMO-OPTICAL SENSOR SPOTS - The present invention relates to a method for optically determining the concentration of a gas, using at least two luminescent dyes, the first being in-sensitive to the concentration of a gas with respect to the luminescence response (reference dye) and the second being sensitive to the concentration of a gas with respect to the luminescence response (indicator dye), wherein said dyes show different luminescence decay times so that the resultant phase angle is indicative for the concentration of a gas, characterized in that the detected luminescent amplitude of the reference dye at a first moment in time is utilized to correct for sensitivity changes after said moment. The present invention also relates to a corresponding method for quality assessment of the measurement of an optical sensor for determining the concentration of a gas. | 04-28-2016 |
20160154004 | DEVICE AND METHOD FOR DETERMINING REACTION KINETICS | 06-02-2016 |
20160169810 | SELECTIVE DETECTION OF ALKENES OR ALKYNES | 06-16-2016 |
20160178527 | MEASURING THE RATE OF RELEASE OF METAL IONS | 06-23-2016 |