| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 436536000 | INVOLVING IMMUNE COMPLEX FORMED IN LIQUID PHASE | 27 |
| 20080199973 | HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS - In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydrophobicity of the acridinium ring system to produce a more soluble label which can be attached to an antibody at higher loading before precipitation and aggregation problems are encountered. Additional compounds described herein contain linkers derived from short peptides and tetraethylene oxide which increase aqueous solubility due to hydrogen bonding with water molecules. The present invention also embraces reagents for multiple acridinium labeling for signal amplification composed of a peptide bearing several acridinium esters with sulfonate groups at regularly spaced intervals for increased solubility. The invention also embraces assays employing the above-described compounds. | 08-21-2008 |
| 20080213920 | DIAGNOSTIC DETECTION DEVICE - The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device comprises a labeled conjugate comprising a binding member reactive with a first epitope of the analyte and a label comprising a gold colloid, preferably having a mean particle size of 50 nm to 100 nm. In further embodiments, the device comprises a capture component comprising polymerized streptavidin. The diagnostic device is particularly useful in the preparation of pregnancy test kits. | 09-04-2008 |
| 20080213921 | Immunoassay Methods - The invention generally relates to the field of diagnostic or prognostic assays and in particular relates to assays for the detection of antibodies in a sample comprising patient bodily fluid, wherein such antibodies are used as biological markers of a disease state or disease susceptibility. The assay is based on cross-titration of both the patient bodily fluid to be tested for the antibody and an antigen used to detect the antibody by specific binding. | 09-04-2008 |
| 20080220539 | Apparatus and Method for Determining an Analyte in a Fluid - The invention relates to an apparatus and a method for determining an analyte in a fluid. Provided in the device is a stirring zone formed in an optionally microfluidic three-dimensional structure, into which stirring zone a sample of the fluid can be introduced and in which there is a stirring device which can be operated in a contactless manner and is optionally designed as a microstirrer, the stirring device being configured so as to stir the sample of fluid introduced into the stirring zone and being loaded with at least one reagent which reacts with the analyte. The invention also provides a stirring device which can be operated in a contactless manner and is optionally designed as a microstirrer, the stirring device being loaded with the at least one reagent which reacts with the analyte. | 09-11-2008 |
| 20080227220 | Lateral Flow Binding Assay - Provided is a test device, a test method and a test kit for the detection of the presence or absence of an analyte in a fluid sample, based on a device comprising a backing with a first end (A) and a second end (B) and consecutively going from first end (A) to second end (B): (a) a sample receiving section attached to one side of the backing; (b) an analyte detection section attached to said one side of the backing comprising a capture site; (c) an absorption section attached to said one side of the backing; (d) a reaction section; wherein the sample receiving section is in fluid contact with the analyte detection section, which is in fluid contact with the absorption section and wherein there is no fluid contact between the reaction section and any of the other sections. | 09-18-2008 |
| 20080241965 | METHODS FOR VALIDATING THE PRESENCE OF AND CHARACTERIZING PROTEINS DEPOSITED ONTO AN ARRAY - A method of determining if proteins have been transferred from liquid-phase protein fractions to an array comprising staining the array with a total protein stain and imaging the array, optionally comparing the staining with a standard curve generated by staining known amounts of a known protein on the same or a similar array; a method of characterizing proteins transferred from liquid-phase protein fractions to an array including staining the array with a post-translational modification-specific (PTM-specific) stain and imaging the array and, optionally, after staining the array with a PTM-specific stain and imaging the array, washing the array, re-staining the array with a total protein stain, imaging the array, and comparing the imaging with the PTM-specific stain with the imaging with the total protein stain; stained arrays; and images of stained arrays. | 10-02-2008 |
| 20080241966 | Apparatuses and methods for detecting an analyte - A method and apparatus for detecting an analyte includes a sensor chamber for detecting an analyte, an analyte feed chamber, a distributor, and a controller for controlling the transport medium flow. The distributor includes an annular channel with four connections with a switchable isolating device between two connections. The controller controls the distributor for flushing the transport medium fed from the distributor to the sensor chamber without passing through the analyte feed chamber and for measuring the transport medium fed from the distributor to the sensor chamber while passing through the analyte feed chamber. | 10-02-2008 |
| 20080293164 | Fluorescent Methods and Materials for Directed Biomarker Signal Amplification - Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule. | 11-27-2008 |
| 20080311680 | Method for detecting high antigen concentration and device therefor - A method for detecting high antigen concentration is disclosed. The method enables the mobile-phase antibody, in the presence of excessive amount of antigen, to form the antibody-antigen-antibody sandwich with the immobilized solid-phase antibody effectively in a rapid lateral flow chromatographic immunoassay. The mobile-phase and/or immobilized solid-phase antibody are treated with soluble coatings to generate a delaying mechanism, so that antigen-antibody binding occurs only when both phases of antibodies and antigen are in very close proximity. A user friendly immunoassay device with a sample over-flow mechanism also facilitates such antigen-antibody binding. | 12-18-2008 |
| 20090029484 | Novel Hemopoietin Receptor Protein, NR12 - A novel hemopoietin receptor gene (NR12) was successfully isolated by extracting motifs conserved among the amino acid sequences of known hemopoietin receptors and by using the predicted sequence. The NR12 gene encodes two forms of proteins, a transmembrane type and a soluble type. The expression of the NR12 gene was detected in tissues containing hematopoietic cells. NR12 is a novel hemopoietin receptor molecule involved in the regulation of immune system and hematopoiesis in vivo. Thus, NR12 is useful in the search for novel hematopoietic factors that functionally bind to the NR12 receptor, and in the development of therapeutic drugs for diseases associated with immunity or hematopoiesis. | 01-29-2009 |
| 20090042319 | Biosensor Detection By Means Of Droplet Driving, Agitation, and Evaporation - Methods of improving microfluidic assays are disclosed. Assays can be improved (better signal to noise ratio) by using sessile drop evaporation as an analyte concentration step (enhanced signal) and repeated passes of wash droplets as a means to reduce non-specific binding (noise reduction). In addition multiple massively parallel analyses improve the statistical precision of the analyses. | 02-12-2009 |
| 20090053831 | Tyrosine phosphorylation sites - The invention discloses 405 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above. | 02-26-2009 |
| 20090061536 | Si/Si3N4 SYSTEM NANOSIZED PARTICLES, BIOSUBSTANCE LABELING AGENT EMPLOYING THE NANOSIZED PARTICLES, AND METHOD OF MANUFACTURING THE NANOSIZED PARTICLES - An objective is to provide Si/Si | 03-05-2009 |
| 20090104717 | System to Reduce Incubation Time in Immunological Testing Using Enhanced Microwaves - A system for shortening incubation times on immunoassays employs energy that is applied to the assays. Energy is applied in careful gradations so that chemical bonds are not broken. If polyclonal antibodies, as opposed to monoclonal antibodies, are worked with, then because the bonds are stronger, cooling is employed in combination with the extra energy delivered. | 04-23-2009 |
| 20090111197 | HYBRID DEVICE - A hybrid device ( | 04-30-2009 |
| 20090191650 | ANTIBODY SPECIFIC FOR MUTANT PRESENILIN 1 AND METHOD OF USE THEREOF - The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the construction of transgenic animals expressing the mutant genes. | 07-30-2009 |
| 20090258442 | Reagents for the detection of protein phosphorylation in carcinoma signaling pathways - The invention discloses nearly 474 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Kinase, Adaptor/Scaffold proteins, Phosphatase, G protein Regulator/Guanine Nucleotide Exchange Factors/GTPase Activating Proteins, Cytoskeleton Proteins, DNA Binding Proteins, Phospholipase, Receptor Proteins, Enzymes, DNA Repair/Replication Proteins, Adhesion Proteins, and Proteases, as well as other protein types. | 10-15-2009 |
| 20100015728 | Assay Device and Method - A method for detecting an analyte can include binding an analyte with a first reagent which is associated with a magnetic particle, allowing analyte to interact with an excess amount of a second reagent capable of interacting with the analyte, and magnetically separating a portion of analyte-bound second reagent from excess second reagent. After the magnetic separation, the interaction of the analyte and the second reagent can be disrupted to produce a detectable form of the second reagent, which can be detected. A device and system suited to performing the method are also described. | 01-21-2010 |
| 20100029017 | Mono-chlorinated hydroxycoumarin conjugates - The present invention provides fluorescent biopolymers that are amino acid polymers conjugated to multiple mono-chlorinated 3-carbonyl-7-hydroxy-coumarin dyes, and methods of their use. The fluorescent biopolymers containing multiple mono-chlorinated 3-carbonyl-7-hydroxy-coumarin dyes generally exhibit superior fluorescence properties compared to biopolymers labeled with multiple non-chlorinated hydroxycoumarin dyes. The fluorescent biopolymers of the invention in which the amino acid polymer is an antigen-specific antibody are particularly useful for analyzing cells by flow cytometers that are equipped with a violet laser as an excitation source due to their strong absorption at 405 nm and high fluorescence quantum yield. | 02-04-2010 |
| 20100068827 | Stabilized Standards for Busulfan Immunoassay - Use of busulfan amide as stabilized standards in immunoassays for quantifying the amount of busulfan in samples of human biological fluids, methods for carrying out said immunoassay and kits for use in said immunoassay. | 03-18-2010 |
| 20100112727 | SINGLE MOLECULE ASSAYS - The present invention provides single molecule analyses of species of use in analytical, diagnostic or prognostic assays. In exemplary embodiments, the assays utilize samples prepared by novel methods, affording assays of unexpected sensitivity and robustness. The method is described in a non-limiting manner by reference to cytokine assays. | 05-06-2010 |
| 20110104826 | CALIBRATION OF FLUIDIC DEVICES - The present invention provides methods of calibrating a fluidic device useful for detecting an analyte of interest in a bodily fluid. The invention also provides methods for assessing the reliability of an assay for an analyte in a bodily fluid with the use of a fluidic device. Another aspect of the invention is a method for performing a trend analysis on the concentration of an analyte in a subject using a fluidic device. | 05-05-2011 |
| 436537000 | Signal modification or steric inhibition | 3 |
| 20080227221 | Fluorescence Polarization-Based Homogeneous Assay For Aflatoxins - A homogeneous assay for determining the aflatoxin content in agricultural products uses the technique of fluorescence polarization. A solvent is used to extract aflatoxins from a sample of the agricultural product. A mixture is prepared by combining the extract with a tracer and with a monoclonal antibody specific for aflatoxin. The tracer is able to bind to the monoclonal antibody to produce a detectable change in fluorescence polarization. The tracer is prepared by conjugating an aflatoxin oxime to a suitable fluorophore. The fluorescence polarization of the mixture is measured. The aflatoxin concentration of the mixture may be calculated using a standard curve obtained by measuring the fluorescence polarization of a series of aflatoxin solutions of known concentration. | 09-18-2008 |
| 20090053832 | SIMULTANEOUS ASSAY FOR DETERMINING DRUGS - A method and kits for assaying a sample of a human or mammalian bodily fluid to simultaneously determine whether one or more of a plurality of drugs and/or metabolites thereof are present in said sample and optionally to perform a semi-quantitative assay for said drug or drugs, comprising:
| 02-26-2009 |
| 20100124790 | PORTABLE OPTICAL BIOSENSOR MEASURING APPARATUS AND MEASUREMENT METHOD THEREOF - Provided is a portable optical biosensor measuring apparatus. The portable optical biosensor measuring apparatus includes a light emitting unit emitting a light having a first line width, an optical biosensor receiving an output light from the light emitting unit, and a peak wavelength detector detecting one peak wavelength having a second line width from a light from the optical biosensor. The first line width is greater than the second line width, and the optical biosensor provides the peak wavelength according to an antigen-antibody reaction. | 05-20-2010 |
| 436538000 | Separation of immune complex from unbound antigen or antibody | 2 |
| 436541000 | Absorbent column, particles or resin strip | 1 |
| 20090269859 | Mobile Bead Configuration Immunoaffinity Column and Methods of Use - It has been discovered that a column configuration which allows for suspension of the beads, such as a mobile bead, during washing results in significantly lower levels of background and hence more sensitive levels of quantitation. The present invention provides columns, kits, and methods for more sensitive detection of a toxin or other analyte. | 10-29-2009 |
| 436542000 | Involving radioactive labeling | 1 |
| 20080241967 | Radioimmunoassay using nanoparticle-antibody conjugates - A radioimmunoassay method for determining the quantity of an analyte of interest in a sample is disclosed. The analyte of interest may be an antigen or other chemical entity. A known antibody to the antigen or other entity is employed and is conjugated to a functionalized nanoparticle. Because of the high surface area presented by the present nanoparticle—antibody conjugates, the present radioimmunoassay method is particularly suited for the qualitative and quantitative analysis of low molecular weight chemicals. | 10-02-2008 |
