| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 436514000 | INVOLVING DIFFUSION OR MIGRATION OF ANTIGEN OR ANTIBODY | 22 |
| 20080241962 | Micromachined Diagnostic Device with Controlled Flow of Fluid and Reaction - This invention relates to a micromachined microfluidics diagnostic device that comprises one or multiple assaying channels each of which is comprised a sample port, a first valve, a reaction chamber, a second valve, a fluid ejector array, a third valve, a buffer chamber, a capture zone and a waste chamber. Each of these device components are interconnected through microfluidic channels. This invention further relates to the method of operating a micromachined microfluidic diagnostic device. The flow of fluid in the microchannels is regulated through micromachined valves. The reaction of sample analytes with fluorescent tags and detection antibodies in the reaction chamber are enhanced by the micromachined active mixer. By ejecting reaction mixture onto the capture zone through micromachined fluid ejector array, the fluorescent tagged analytes bind with capturing antiodies on capture zone. The fluid ejector array further ejects buffer fluid to wash away unbound fluorescent tags. | 10-02-2008 |
| 20080286881 | COMPOSITIONS AND METHODS FOR COMBINING REPORT ANTIBODIES - Compositions are disclosed. One embodiment of a composition comprises a first antibody having an affinity for an antigen and a second antibody having an affinity for the first antibody, wherein at least one antibody is conjugated to a marker, and wherein the antigen is not present in the composition. Further disclosed are methods of using compositions according to the invention for analyzing a biological sample by antibody profiling for identifying forensic samples or detecting the presence of an analyte. In embodiments of the invention, the analyte is a drug, such as marijuana, cocaine, methamphetamine, methyltestosterone, or mesterolone. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, may be coupled to a test for identity such that the results of the assay may be positively correlated to the subject's identity. | 11-20-2008 |
| 20090017561 | Labelled silica nanoparticles for immunochromatographic reagent, immunochromatographic reagent, immunochromatographic test strip using the same, and immunochromatographic fluorescence-detecting system or radiation-detecting system - Labelled silica nanoparticles for immunochromatographic reagent, comprising silica nanoparticles containing a labelled substance. | 01-15-2009 |
| 20090181470 | MEASUREMENT KIT AND AN IMMUNOCHROMATOGRAPHY METHOD - It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of the developing directions. | 07-16-2009 |
| 20090181471 | ASSAY DEVICE AND PROCESS FOR THE TESTING OF FLUID SAMPLES - An assay device for testing of liquid samples for drugs of abuse has a transparent container for retaining a liquid sample. A backing member is within the container and is curved so that its front surface corresponds to the curvature of the container wall. Immunoassay test strips are on the front face of the backing and are visible through the container wall. Each test strip is enclosed in a transparent pocket which has a bottom opening through which the bottom portion of the test strip protrudes to contact the liquid sample within the container. The liquid then flows upwardly through the test strip to react with reagents within the test strip. | 07-16-2009 |
| 20090215199 | Caffeine Detection Via Internally-Referenced Two Part Assay - Methods, compositions, and apparatus for detecting the presence of caffeine in a liquid sample are provided. In certain embodiments, an internally referenced competitive assay allows a very precise determination of a threshold value of caffeine for use in semiquantitative types of ligand-receptor assays. By using a detection means that participates in two assays, sensitivity is doubled in the maximum sensitivity range and the range can be adjusted to match the predicted concentration range of an analyte. This format and the materials described herein allow the assay to complete within three minutes. In addition, this format accommodates common attributes of liquid samples for detecting caffeine, such as the inclusion of milk or sugar in a coffee-type beverage. | 08-27-2009 |
| 20090253219 | POSITIVE DETECTION LATERAL-FLOW APPARATUS AND METHOD FOR SMALL AND LARGE ANALYTES - Methods and devices for the detection and/or quantification of an analyte in a sample are provided. These are positive detection methods and devices, in that the more analyte is present in the sample, the stronger the signal that is provided. Devices of the invention include a mobilization zone including a mobile or mobilizable detectable analyte analog, a sample application area, primary and secondary capture areas each including an immobilized binding partner having a binding affinity for the analyte being tested for a detectable analyte analog. The mobilization zone, sample application area, primary and secondary capture area are in fluid continuous contact with each other. In these devices, the first immobilized binding partner has an equal or lower apparent affinity for the analyte than it has for the detectable analyte analog. Methods of this invention involve introducing a sample (which is suspected of containing the analyte to be tested for) to a device such as those described herein, and permitting the sample to migrate from the application area to and through the first and secondary binding zones. A detectable tracer conjugate is also permitted to migrate through the device, usually slightly behind the sample so that any analyte in the sample contacts the first binding partner before the conjugate. Results of such methods are read based on the presence and/or intensity of the detectable signal given by conjugate that binds in the second capture area. | 10-08-2009 |
| 20090258439 | IMMUNOCHROMATOASSAY METHOD AND IMMUNOCHROMATOASSAY KIT - An immunochromatoassay method that allows high detection sensitivity measurement. The method including the steps of: permeating an analyte solution that includes a visibly labeled second binding substance that specifically binds to a detection target substance into a test area of a chromatography medium provided with a first binding substance that specifically binds to the detection target substance, simultaneously with or after the permeation of the analyte solution into the test area, permeating a visual recognition aid solution into the chromatograph medium, the solution having a refractive index whose refractive index difference Δn from that of the chromatograph medium is −0.1=Δn=0.1, and visually observing the test area while the visual recognition aid solution is permeated in the test area. | 10-15-2009 |
| 20090269857 | Instruments for detecting low-molecular weight substance - To provide the following instruments 1 and 2 as a low-molecular-weight substance detection instrument employing immunochromatography capable of detecting conveniently and sensitively detecting a low-molecular weight substance such as an environmental pollutant (e.g., a dioxin), as a target substance contained in a test sample:
| 10-29-2009 |
| 20090280576 | Analyte assaying by means of immunochromatography with lateral migration - The invention relates to a device for determining an analyte in a liquid sample. The inventive device consists of: a capillary action means, involving lateral migration, defining a reference capillary action direction and comprising a liquid sample deposit area and an analyte-detection area which is disposed downstream of the deposit area; a first analyte-specific binding reagent which is conjugated to a visible and/or measurable marker and which is free to migrate when wet by means of capillary action in the above-mentioned capillary actions means along the reference direction; and a second analyte-specific binding reagent which is immobilized in the detection area. The invention is characterized in that the detection area comprises the analyte or an analogue of the analyte, which is immobilized and disposed at a distance from the second specific binding reagent. | 11-12-2009 |
| 20100029014 | Micromachined diagnostic device with controlled flow of fluid and reaction - This invention relates to a micromachined microfluidics diagnostic device that comprises one or multiple assaying channels each of which is comprised a sample port, a first valve, a reaction chamber, a second valve, a fluid ejector array, a third valve, a buffer chamber, a capture zone and a waste chamber. Each of these device components are interconnected through microfluidic channels. This invention further relates to the method of operating a micromachined microfluidic diagnostic device. The flow of fluid in the microchannels is regulated through micromachined valves. The reaction of sample analytes with fluorescent tags and detection antibodies in the reaction chamber are enhanced by the micromachined active mixer. By ejecting reaction mixture onto the capture zone through micromachined fluid ejector array, the fluorescent tagged analytes bind with capturing antiodies on capture zone. The fluid ejector array further ejects buffer fluid to wash away unbound fluorescent tags. | 02-04-2010 |
| 20100062543 | Polyelectrolytic Internal Calibration System of a Flow-Through Assay - A flow-through assay for detecting the quantity of an analyte residing in a test sample is provided. The flow-through assay contains a porous membrane that is in fluid communication with probe conjugates that contain a specific binding member and a detectable probe. The porous membrane also defines a detection zone and a calibration zone. The calibration zone contains a polyelectrolyte substantially non-diffusively immobilized on the porous membrane. The polyelectrolyte is capable of generating a detectable calibration signal that can be readily compared (visually, quantitatively, and the like) to a detection signal to determine the amount of analyte in the test sample. | 03-11-2010 |
| 20100190268 | Assay Device, System and Method - A system for treating a blood sample ( | 07-29-2010 |
| 20100267166 | DIAGNOSTIC DETECTION DEVICE - The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device comprises a labeled conjugate comprising a binding member reactive with a first epitope of the analyte and a label comprising a gold colloid, preferably having a mean particle size of 50 nm to 100 nm. In further embodiments, the device comprises a capture component comprising polymerized streptavidin. The diagnostic device is particularly useful in the preparation of pregnancy test kits. | 10-21-2010 |
| 20100267167 | DEVICE FOR DETECTION OF MOLECULES IN BIOLOGICAL FLUIDS - Disclosed is a test device and a method for qualitatively and/or quantitatively measuring the concentration of an analyte in a biological fluid sample. The test device includes a housing defining a sample port, a test well containing a stirrer and a conjugate, and a test strip disposed within the housing. The test well is also defined by being located between the sample port and the test strip. Fluid flows from the test well onto the test strip, which has a trapping zone which binds the analyte and allows for its detection. A control zone may also be included. The test device is generally adapted to use a sandwich assay. Also disclosed is a system comprising the test device and a signal sensing device; and a method for using the test device. | 10-21-2010 |
| 20110053291 | METHOD FOR ANALYZING SAMPLE SOLUTION AND APPARATUS FOR ANALYZING SAMPLE SOLUTION - Disclosed is a method for analyzing a sample solution, including introducing a sample solution | 03-03-2011 |
| 20110195525 | Method of use and Apparatus for an Enhanced Lateral Flow Rapid Test Device - An immunoassay test membrane strip that is able to quickly tell the experimenting user the results of the presence of a specific antibody. The present invention makes use of a membrane strip that is broken into different sections. The user applies a specimen and a dilution buffer to the membrane strip. The specimen and the labeled conjugate solution travel through the membrane strip through capillary action. The membrane strip will provide the user with visual results on the presence of the antibody that the specimen is being tested for and a visual result of the validity of the test. | 08-11-2011 |
| 20110201131 | ANTIBODY DETECTION METHOD INVOLVING OLIGONUCLEOTIDE ENHANCED COLLOIDAL GOLD SIGNAL - The present invention refers to a rapid immunochromatographic test device for antibody detection, comprising at least a first and a second conjugate releasing pad, wherein the first conjugate pad comprises a gold conjugated protein linked first oligonucleotide and a gold conjugated anti-antibody, and the second conjugate pad comprises a gold conjugated protein linked second oligonucleotide, which second oligonucleotide is complementary to the first oligonucleotide. The present invention further refers to a use of such test device for antibody detection in urine or saliva, e.g. HIV antibody. Embodiments of the test device are a test strip and a detection cup. The present invention also refers to a method for manufacturing such test device. | 08-18-2011 |
| 20120225496 | ORGANIC COLORED MICROPARTICLES, DIAGNOSTIC REAGENT KIT CONTAINING THE SAME, AND IN VITRO DIAGNOSIS METHOD - Provided are an immunochromatography kit that is highly sensitive and capable of multicoloration, and organic colored microparticles that are ideal as an element of the immunochromatography kit. Organic colored microparticles having an average grain size between 10 and 1,000 nm and a color intensity between 1.0 and 5.0 are prepared using cellulose as the starting material. When the organic colored microparticles are used as a label in an immunochromatography kit, the immunochromatography kit is of a high sensitivity than conventional technology. The immunochromatography kit is also capable of multicoloration and is useful for rapid diagnosis. | 09-06-2012 |
| 436515000 | Through a gel (e.g., Ouchterlony technique, etc.) | 3 |
| 20110177618 | Multi-Directional Microfluidic Devices and Methods - Multi-directional microfluidic devices and methods for using the same are provided. Aspects of the invention include microfluidic devices that are configured to subject a sample to two or more directionally distinct flow fields, and include a separation medium and a binding medium, where the binding medium is in fluid communication with the separation medium. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays. | 07-21-2011 |
| 436516000 | Immunoelectrophoresis | 2 |
| 20090181472 | LABELED MOLECULE FOR PROGNOSING TUMOR GRADE OF HEAD NECK CANCER AND METHOD FOR THE SAME - The present invention discloses a labeled molecule for prognosing the tumor grade of head neck cancer and a method for the same, wherein a 78-kDA glucose regulated protein (GRP78) is adopted as a labeled molecule of head neck cancer. GRP78 is much more overexpressed in head neck cancer cells than in non-cancer cells. GRP78 also has relation with tumor size, tumor depth and tumor metastasis. Therefore, the present invention uses GRP78 overexpression as a reference for tumor grading of head neck cancer. | 07-16-2009 |
| 20150050749 | METHOD FOR IDENTIFICATION AND DETECTION OF MUTANT GENE USING INTERCALATOR - The invention provides a method for detection of mutant-type DNA or/and wild-type DNA by contacting at least one of a single-stranded DNA having a substituted nucleotide, a deficient nucleotide region, or an inserted nucleotide region (mutant-type DNA), or/and a wild-type single-stranded DNA corresponding to the mutant-type DNA (wild-type DNA) with a probe hybridizing with both single-stranded DNAs, to form a hybrid with the mutant-type DNA (mutant-type hybrid) or/and a hybrid with the wild-type DNA (wild-type hybrid) (at least one of the obtained mutant-type hybrid and wild-type hybrid has a loop structure), (2) contacting the obtained mutant-type hybrid or/and wild-type hybrid with an intercalator, and (3) detecting the presence or absence of the mutant-type DNA or/and the wild-type DNA by separating the conjugate of mutant-type hybrid and intercalator or/and the conjugate of wild-type hybrid and intercalator. | 02-19-2015 |
