| Entries |
| Document | Title | Date |
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| 20080206840 | CYTOTOXIN-BASED BIOLOGICAL CONTAINMENT - Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including | 08-28-2008 |
| 20080248553 | Production of Bioavailable Folic Acid - The invention provides a process of producing bio-available folate, i.e., folic acid having an increased proportion of monoglutamyl folate and a decreased proportion of polyglutamyl folate, by culturing food-grade microorganisms containing an active heterologous or homologous polyglutamyl hydrolase activity or containing increased activities of folate biosynthesis enzymes. The genes encoding the polyglutamyl hydrolase and the folate biosynthesis enzymes may be of various origin, e.g. from rodents or other mammals including man. Also provided is a foodstuff, especially a dairy product containing such monoglutamyl folate-producing microorganisms. | 10-09-2008 |
| 20080254528 | Baculovirus Expression System - Described herein are baculovirus vectors, host cells containing the baculovirus vectors, methods of using the baculovirus vectors for cloning genes, and kits containing the baculovirus vectors. | 10-16-2008 |
| 20080280346 | System For the Production of Dimeric Proteins Based on the Transport System of Hemolysin of Escherichia Coli - The system comprises a DNA construct comprising: a) a first nucleic acid sequence containing the nucleotide sequence coding for a product of interest; b) a second nucleic acid sequence containing the nucleotide sequence coding for a dimerization domain; and c) a third nucleic acid sequence containing the nucleotide sequence coding for | 11-13-2008 |
| 20080286852 | Electroporation of Mycobacterium and Overexpression of Antigens in Mycobacteria - Recombinant | 11-20-2008 |
| 20080293124 | Multimeric Oxidoreductases - The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof. | 11-27-2008 |
| 20080293125 | ENGINEERED MICROORGANISMS FOR PRODUCING ISOPROPANOL - In an embodiment, there is disclosed a recombinant microbial host cell having each of the DNA molecules encoding a polypeptide or group of polypeptides that catalyze the conversion: | 11-27-2008 |
| 20080318302 | PCB-Degrading recombinant bacterium, product for the bioremediation and method of bioremediation - A recombinant bacterium capable to completely degrade or mineralize pollutants such as polychlorobiphenyls (PCBs), which corresponds to | 12-25-2008 |
| 20090011490 | IMMUNOGENIC MINICELLS AND METHODS OF USE - The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject. | 01-08-2009 |
| 20090029443 | COMPOSITIONS AND METHODS FOR ENHANCED BACTERIAL EXOPOLYSACCHARIDE PRODUCTION - The present invention provides nucleic acid sequences and variants thereof capable of modulating exopolysaccharide production in | 01-29-2009 |
| 20090053791 | Methods and composition for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs - This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo. | 02-26-2009 |
| 20090075358 | VECTORS FOR TRANSFORMATION OF PLANT CELLS - Vectors for transformation of plants contain a minimum set of transfer machinery genes, such as vir genes from | 03-19-2009 |
| 20090148925 | Single chain class I major histocompatibility complexes - A recombinant polypeptide and nucleic acid constructs capable of expressing the recombinant polypeptide are provided. The recombinant polypeptide comprises a chimeric polypeptide including an antigenic peptide being capable of binding a human MHC class I, a functional human β-2 microglobulin and a functional human MHC class I heavy chain. | 06-11-2009 |
| 20090155886 | NUCLEIC ACIDS AND POLYPEPTIDES SPECIFIC FOR PATHOGENIC STRAINS OF THE NEISSERIA GENUS - The invention concerns nucleic acids coding for polypeptides specific of the | 06-18-2009 |
| 20090155887 | Vaccine Composition - The present invention provides a hyperblebbing non-typeable | 06-18-2009 |
| 20090186398 | Increased Bacterial CoA and Acetyl-CoA Pools - Methods of increasing the cellular pool of A-CoA and thus driving the metabolic pathways in the direction of A-CoA containing metabolites by overexpressing rate limiting enzymes in A-CoA synthesis. Methods of increasing intracellular levels of CoA and A-CoA through genetic engineering of bacterial strains in conjunction with supplementation with precursor molecules. | 07-23-2009 |
| 20090215151 | Two-Step Immunization Procedure Against Chlamydia Infection - A host is immunized against infection by a strain of | 08-27-2009 |
| 20090263885 | Process for producing trans-4-hydroxy-L-proline - The present invention is directed to a process for producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus | 10-22-2009 |
| 20090286303 | PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED) AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF - The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized | 11-19-2009 |
| 20100003738 | PLASMID CURING - The present invention relates to plasmid curing, and particularly to efficient and stress-free methods for displacing resident or endogenous plasmids from a host cell, such as a bacterium. The invention extends to method of displacing a plasmid comprising a post-segregational killing system from a host cell, the method comprising introducing a recombinant nucleic acid molecule into a host cell harbouring a plasmid comprising a post-segregational killing (PSK) system, characterised in that the recombinant nucleic acid molecule is adapted to neutralise the toxic effects of the plasmid's post-segregational killing system, and wherein the nucleic acid molecule is also adapted to outcompete or inhibit replication of the plasmid. The invention further extends to recombinant nucleic acid molecules that can be used in this method, as well as further uses of the methods and nucleic acid molecules of the invention. | 01-07-2010 |
| 20100003739 | Selection of ADH In Genetically Modified Cyanobacteria For The Production Of Ethanol - The present invention discloses genetically-modified cyanobacteria with ethanol-production capabilities enhanced over the currently-reported art, and methods of making such cyanobacteria. The invention provides a genetically modified photoautotrophic, ethanol producing host cell comprising an overexpressed pyruvate decarboxylase enzyme converting pyruvate to acetaldehyde and an overexpressed Zn2+ dependent alcohol dehydrogenase enzyme converting acetaldehyde to ethanol. | 01-07-2010 |
| 20100047900 | Novel l-Lysine-inducible promoter - Disclosed is a novel L-lysine-inducible promoter nucleic acid molecule. Also disclosed are a vector containing the nucleic acid molecule, a host cell transformed with the vector, and a method of inducing expression of a target gene using the L-lysine-inducible promoter nucleic acid molecule. | 02-25-2010 |
| 20100120124 | SYSTEMS, METHODS AND MICRORGANISMS FOR ANTIBODY PRODUCTION WITH TYPE III SECRETION SYSTEM - Exemplary embodiments disclosed herein include a microorganism that produces, secretes and injects recombinant antibodies into eukaryote cells said the described microorganisms can be used to prepare pharmaceutical compositions for the treatment of human or veterinary diseases. | 05-13-2010 |
| 20100120125 | BACTERIAL BIOMINERALIZATION OF CONTAMINANTS - The various embodiments of the present disclosure relate generally to bacterial biomineralization of contaminants and, more particularly, to methods, systems and compositions for the biomineralization of soil and water contaminants, such as metals and radionuclides. In one aspect of the present invention, a method for the in situ biomineralization of a soil contaminant comprises: providing a plurality of bacteria to a soil comprising at least one contaminant, wherein at least one bacterium expresses a phosphatase; providing a phosphate-rich material to the soil; reacting at least one bacterium expressing a phosphatase with the phosphate-rich material in the presence of the contaminant; and immobilizing the contaminant in the soil. | 05-13-2010 |
| 20100124777 | Bacterium producing L-glutamic acid and method for producing L-glutamic acid - L-Glutamic acid is produced by culturing a coryneform bacterium having L-glutamic acid producing ability, in which trehalose synthesis ability is decreased or deleted by, for example, disrupting a gene coding for trehalose-6-phosphate synthase, a gene coding for maltooligosyltrehalose synthase, or both of these genes to produce and accumulate L-glutamic acid in the medium, and collecting the L-glutamic acid from the medium. | 05-20-2010 |
| 20100209998 | CELL-PERMEABILISING PEPTIDES AND POLYPEPTIDES FOR MICROBIAL CELLS - Signal peptides and polypeptides from | 08-19-2010 |
| 20100209999 | PHAGE OMRU POLYNUCLEOTIDES AND POLYPEPTIDES AND USES THEREOF - The invention encompasses phage φmru including phage induction, phage particles, and the phage genome. Also encompassed are phage polypeptides, as well as polynucleotides which encode these polypeptides, expression vectors comprising these polynucleotides, and host cells comprising these vectors. The invention further encompasses compositions and methods for detecting, targeting, permeabilising, and inhibiting microbial cells, especially methanogen cells, using the disclosed phage, polypeptides, polynucleotides, expression vectors, or host cells. | 08-19-2010 |
| 20100221812 | PRODUCTION OF GENETICALLY MODIFIED ACTINOMYCETES BY RECOMBINATION - The present invention relates to the recombinant modification of microorganisms, in particular actinomycetes. This is effected with the use of the recombination systems Dre-rox and Cre-lox. The present invention provides novel nucleotide sequences for the recombinases of the abovementioned recombination systems. Here, synthetic genes which have the codons preferred by actinomycetes and can therefore be used in these host organisms were produced. | 09-02-2010 |
| 20100297736 | Genetically Modified Photoautotrophic Ethanol Producing Host Cells, Method For Producing The Host Cells, Constructs For The Transformation Of The Host Cells, Method For Testing A Photoautotrophic Strain For A Desired Growth Property And Method Of Producing Ethanol Using The Host Cells - The invention provides genetically modified photoautotrophic ethanol producing host cells. Ethanol production is controlled by an inducible promoter. Promoters utilized may be endogenous or heterologous, and genetic modification may be obtained by extrachromosomal means or chromosomal insertion. | 11-25-2010 |
| 20100317084 | RECOMBINANT BACTERIA COMPRISING VECTORS FOR EXPRESSION OF NUCLEIC ACID SEQUENCES ENCODING ANTIGENS - The invention encompasses a recombinant bacterium that comprises at least one vector capable of expressing a nucleic acid sequence encoding an antigen. In particular, the bacterium comprises at least one chromosomally encoded essential nucleic acid that is altered so that it is not expressed, and at least one extrachromosomal vector. | 12-16-2010 |
| 20110081707 | LACTOBACILLUS ACIDOPHILUS NUCLEIC ACID SEQUENCES ENCODING CARBOHYDRATE UTILIZATION-RELATED PROTEINS AND USES THEREFOR - Carbohydrate utilization-related and multidrug transporter nucleic acids and polypeptides, and fragments and variants thereof, are disclosed in the current invention. In addition, carbohydrate utilization-related and multidrug transporter fusion proteins, antigenic peptides, and anti-carbohydrate utilization-related and anti-multidrug transporter antibodies are encompassed. The invention also provides vectors containing a nucleic acid of the invention and cells into which the vector has been introduced. Methods for producing the polypeptides and methods of use for the polypeptides of the invention are further disclosed. | 04-07-2011 |
| 20110111481 | ENABLING THE USE OF LONG dsRNA FOR GENE TARGETING IN MAMMALIAN AND OTHER SELECTED ANIMAL CELLS - The present invention provides a method of enabling the use of long dsRNA for gene silencing in mammalian cells through bacteria, preferably non-pathogenic or therapeutic strains of bacteria. DNA that encodes long double-strand RNAs are transformed into bacteria and processed in the bacterial cells into a mixture of smaller RNA duplexes and then released into the cytoplasm of the target cells, resulting in modulation of gene expression in the target cells. The methods overcome the incompatibility between long strong dsRNA and mammalian cells by eliminating, or mitigating, the non-specific innate immune response. The eukaryotic cells can be mammalian cells or avian cells. The gene of interest can be a mammalian, avian, bacterial, eukaryotic, or viral gene. | 05-12-2011 |
| 20110111482 | High Viscosity Xanthan Polymer Preparations - Increasing the molecular length of xanthan polymer makes a higher viscosity xanthan composition. Xanthan with higher specific viscosity characteristics provides more viscosity at equivalent concentration in food, industrial and oilfield applications. Methods for increasing the viscosity of xanthan include inducing particular key genes and increasing copy number of particular key genes. | 05-12-2011 |
| 20110124088 | Expression vector for expressing recombinant protein in Cyanobacterium - The present invention provides a universal vector for expressing a protein in a Cyanobacterium that includes an erythromycin promoter and a homologous recombination DNA fragment, and further provides a transformed | 05-26-2011 |
| 20110171721 | Targeted Gene Deletions for Polysaccharide Slime Formers - The present invention provides improved polysaccharides (e.g., gellan and diutan) produced by mutant gene R | 07-14-2011 |
| 20110189757 | TRANSFECTION VECTOR - The present invention relates to a novel secretory signal, a novel plasmid containing the secretory signal, a transformed anaerobic bacterium transformed with said plasmid, a gene transfer carrier consisting of said anaerobic bacterium, and a pharmaceutical composition containing said carrier. | 08-04-2011 |
| 20110189758 | TRANSFECTION VECTOR - The present invention relates to a novel secretory signal, a novel plasmid containing the secretory signal, a transformed anaerobic bacterium transformed with said plasmid, a gene transfer carrier consisting of said anaerobic bacterium, and a pharmaceutical composition containing said carrier. | 08-04-2011 |
| 20110207203 | Methods and Compositions for the Recombinant Biosynthesis of N-Alkanes - The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules. | 08-25-2011 |
| 20110223649 | RECOMBINANT CELL TRANSFORMED BY AN ARABIDOPSIS THALIANA ATPASE ATHMA1 SEQUENCE - This invention corresponds to a bacteria or preferably a yeast, which in its natural state presents a reduced tolerance to heavy metals, but when genetically transformed following this invention, with a vegetal-origin gene, presents high tolerance to heavy metals. Specifically, the cell in the invention is transformed with a vector that allows the expression of the AtHMA-1 gene of | 09-15-2011 |
| 20110281334 | TARGETED GENE DELETIONS FOR POLYSACCHARIDE SLIME FORMERS - The present invention provides improved polysaccharides (e.g., gellan and diutan) produced by mutant gene M or gene N | 11-17-2011 |
| 20110281335 | ETHANOL PRODUCTION IN MICROORGANISMS - The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth medium. | 11-17-2011 |
| 20110287520 | SALMONELLA MARKER VACCINE - The present invention relates to a | 11-24-2011 |
| 20120045820 | NEW ANTIBIOTIC-SENSITIVE LACTIC ACID BACTERIA STRAINS - Many probiotic Bifidobacteriacea contains an active tetW that renders the cells resistant to tetracycline. This may present a risk of a horizontal transfer of functional antibiotic genes. The present invention relates to a method of obtaining novel tetracycline-sensitive strains of the genus of Bifidobacteriacea ( | 02-23-2012 |
| 20120142080 | LIVE BACTERIAL VACCINES FOR VIRAL INFECTION PROPHYLAXIS OR TREATMENT - A live bacterium, having a DNA construct stabilized against transduction of other bacteria, having a promoter sequence and encoding a fusion peptide, comprising a bacterial secretion peptide portion and a non-bacterial immunogenic polypeptide portion, having a nucleotide sequence coding for the non-bacterial immunogenic polypeptide portion which has at least one codon optimized for bacterial expression. The bacterium has a secretion mechanism which interacts with at least the bacterial secretion peptide portion to cause a secretion of the fusion peptide from the bacterium, and a genetic virulence attenuating mutation. The bacterium is adapted to act as an animal vaccine, to transiently infect a tissue of the animal, and cause an immunity response to the non-bacterial immunogenic polypeptide portion in the animal to a non-bacterial organism associated with the non-bacterial immunogenic polypeptide portion. | 06-07-2012 |
| 20120202270 | Producing an immune response for reducing the risk of developing brucellosis - This invention relates to unique antigens in a brucellosis vaccine which Provide an immune response against bacteria which cause brucellosis in cattle and other animals. The vaccine specifically uses L7L12, 85A, Bp26 and/or LeuB and may or may not include GFP with any combination of polypeptides | 08-09-2012 |
| 20120202271 | Method producing an immune response for reducing the risk of developing brucellosis - This invention relates to unique antigens in a brucellosis vaccine which Provide an immune response against bacteria which cause brucellosis in cattle and Other animals. The vaccine specifically uses Bp26 and LeuB expressed to create the immunity. | 08-09-2012 |
| 20120244601 | RIBOSWITCH BASED INDUCIBLE GENE EXPRESSION PLATFORM - The present disclosure provides a synthetic translation regulator, as well as gene expression cassettes and gene expression constructs comprising the synthetic translation regulator. The present disclosure further provides genetically modified bacterial host cells comprising a subject synthetic translation regulator; and methods of regulating gene expression in such host cells. | 09-27-2012 |
| 20120252099 | IMMUNOGENIC MINICELLS AND METHODS OF USE - The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject. | 10-04-2012 |
| 20120258521 | METHODS AND GENETICALLY ENGINEERED MICRO-ORGANISMS FOR THE COMBINED PRODUCTION OF PDO, BDO AND PHP BY FERMENTATION - The present invention relates to genetically engineered micro-organisms for the combined production of 1,3-propanediol (PDO), 2,3-butanediol (BDO), and polyhydroxypropionic acid (PHP) by fermentation. In particular, the invention relates to a genetically engineered micro-organism suitable for combined production of PDO, BDO and PHP by fermentation, characterized in that: compared with corresponding wild-type starting micro-organism, the D-lactate dehydrogenase gene in the genetically engineered micro-organism is deleted or functionally inactivated, and the genetically engineered micro-organism comprises a heterogenous polynucleotide encoding the Coenzyme A-dependent Aldehyde dehydrogenase and a heterogenous polynucleotide encoding the Polyhydroxyalkanoate synthase. Methods for the construction of such micro-organisms, and methods for combined production of PDO, BDO and PHP by fermentation of a genetically engineered bacterium are also taught. | 10-11-2012 |
| 20120276615 | RECOMBINANT BACTERIUM CAPABLE OF REMOVING MERCURY (II) SPECIES, CADMIUM (II) AND COPPER (II) IN PRESENCE OF OTHER HEAVY METALS FROM POLLUTED SITES, PRODUCT FOR THE BIOREMEDIATION, PROCESS OF OBTAINING THE PRODUCT AND METHOD OF BIOREMEDIATION - A heavy metal-resistant recombinant bacterium capable to remove mercury (II) species, cadmium and copper (II) in presence of other heavy metals from polluted sites, which corresponds to | 11-01-2012 |
| 20120301950 | BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL HEXANES AND PENTANES FROM CARBOHYDRATE FEEDSTOCKS - Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes. | 11-29-2012 |
| 20130017593 | Biological Synthesis of Difunctional Hexanes and Pentanes from Carbohydrate Feedstocks - Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes. | 01-17-2013 |
| 20130023035 | REGULATION OF TOXIN AND ANTITOXIN GENES FOR BIOLOGICAL CONTAINMENT - The present invention relates to the regulation of a toxin and/or antitoxin genes in a genetically engineered microorganism, such as cyanobacterial or eukaryotic algal strains, in particular for preventing unintentional and/or uncontrolled spread of the microorganisms. The present invention also includes methods of controlling the growth and/or survival of the engineered microorganism | 01-24-2013 |
| 20130045525 | METHOD OF CANCER TREATMENT - A method and composition for treating cancer comprising administering to a patient an effective amount of attenuated | 02-21-2013 |
| 20130059363 | Isolated Nucleic Acids for Producing High Viscosity Diutan Gums and Methods - The production of a diutan polysaccharide exhibiting increased viscosity properties as compared with previously produced polysaccharide of the same type of repeating units. Such an improved diutan polysaccharide is produced through the generation of a derivative of | 03-07-2013 |
| 20130078706 | METHOD OF TRANSFORMING CELLS - Use of an isolated | 03-28-2013 |
| 20130084621 | PLASMID VECTOR - The object is to provide a technique for modifying a bacterium belonging to the genus | 04-04-2013 |
| 20130122573 | Live Vaccine Strain - A strain of | 05-16-2013 |
| 20130203153 | TARGETED GENE DELETIONS FOR POLYSACCHARIDE SLIME FORMERS - The present invention provides improved polysaccharides (e.g., gellan and diutan) produced by mutant gene 1 | 08-08-2013 |
| 20130224838 | RECOMBINANT MICROORGANISMS AND USES THEREFOR - The invention provides, inter alia, methods for the production of acetone, isopropanol and/or precursors of acetone and/or isopropanol by microbial fermentation of substrates comprising CO, genetically modified microorganisms of use in such methods, nucleic acids suitable for preparation of genetically modified microorganisms, a novel alcohol dehydrogenase and nucleic acids encoding same. | 08-29-2013 |
| 20130224839 | Recombinant Microorganism and Methods of Production Thereof - The invention relates to a recombinant carboxydotrophic acetogenic microorganism capable of producing one or more products by fermentation of a substrate comprising CO, wherein the microorganism has an increased tolerance to ethanol versus a parental carboxydotrophic acetogenic microorganism. The invention also provides, inter alia, methods for the production of ethanol and one or more other products from a substrate comprising CO using the recombinant carboxydotrophic acetogenic microorganism. | 08-29-2013 |
| 20130244307 | COMPOSITIONS RELATING TO A MUTANT CLOSTRIDIUM DIFFICILE TOXIN AND METHODS THEREOF - In one aspect, the invention relates to an immunogenic composition that includes a mutant | 09-19-2013 |
| 20130323819 | EXPRESSION OF ANTIBODY OR A FRAGMENT THEREOF IN LACTOBACILLUS - Described herein are methods and compositions for expressing an antibody or a fragment thereof in a microorganism and use of the microorganism to treat or prevent a pathogenic infection in a mammal. | 12-05-2013 |
| 20130323820 | Recombinant microorganisms and uses therefor - Terpenes are valuable commercial products used in a diverse number of industries. Terpenes may be produced from petrochemical sources and from terpene feed-stocks, such as turpentine. However, these production methods are expensive, unsustainable and often cause environmental problems including contributing to climate change. Microbial fermentation provides an alternative option for the production of terpenes. One or more terpenes and/or precursors can be produced by microbial fermentation of a substrate comprising CO. Recombinant microorganisms may be used in such methods. Carboxydotrophic, acetogenic, recombinant microorganisms can be used in such methods. The recombinant microorgnsims may contain exogenous mevalonate (MVA) pathway enzymes and/or DXS pathway enzymes, for example. | 12-05-2013 |
| 20130330809 | Recombinant microorganisms and uses therefor - Carboxydotrophic acetogenic microorganisms do not produce MEK and/or 2-butanol. They lack the biosynthesis pathways to make these products. In addition, they produce the intermediate (R,R)-2,3-butanediol whereas the production of MEK and 2-butanol requires production of the intermediate (R,S)-2,3-butanediol. Nonetheless, the production of MEK and/or 2-butanol can be accomplished using recombinant microorganisms adapted to express or overexpress key enzymes in the MEK and/or 2-butanol biosynthesis pathways. Such microorganisms, such as the carboxydotrophic acetogen | 12-12-2013 |
| 20130337544 | METHODS AND COMPOSITION FOR THE IDENTIFICATION OF ANTIBIOTICS THAT ARE NOT SUSCEPTIBLE TO ANTIBIOTIC RESISTANCE - Compositions are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with predetermined levels of ribosome function. The compositions of the present invention may be used to identify antibiotics to treat a large number of human pathogens through the use of genetically engineered rRNA genes from a variety of species. The invention further provides novel plasmid constructs to be used in the methods of the invention. | 12-19-2013 |
| 20130337545 | MINICELL BASED DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS - Minicells are used to deliver biologically active compounds including radioisotopes, polypeptides, nucleic acids, small molecules, drug molecules, and chemotherapeutic agents. In some cases, the minicell displays ligands or binding moieties that target the minicell to a desired host cell. | 12-19-2013 |
| 20140186928 | Recombinant Microorganism and Methods of Production Thereof - The invention relates, inter alia, to novel genetically modified microorganisms capable of using CO to produce 1-butanol and/or a precursor thereof, novel methyltransferases and nucleic acids encoding same, methods for producing genetically modified microorganisms using said novel methyltransferases, and methods of producing 1-butanol and/or a precursor thereof by microbial fermentation. | 07-03-2014 |
| 20140206064 | BACTERIAL METHODS - A bacterial spore comprising a modified prkC protein, wherein the extracellular domain of the modified prkC protein binds an agent which is not bound by the extracellular domain of the wild-type prkC protein, and wherein the agent is a germinant that stimulates germination of the bacterial spore, or a bacterial spore comprising a modified gerA protein, wherein the gerA protein has been modified such that the spore undergoes germination in the presence of a germinant which does not stimulate germination of a bacterial spore comprising wild-type gerA protein. | 07-24-2014 |
| 20140206065 | Uracil-Requiring Moorella Bacteria and Transforming-Gene-Introduced Moorella Bacteria - The present invention provides uracil-requiring Moorella bacteria obtained by destroying a gene coding for orotidine-5-phosphate decarboxylase; and transforming-gene-introduced Moorella bacteria obtained by introducing a gene coding for orotidine-5-phosphate decarboxylase and a transforming-gene to a chromosome of the uracil-requiring Moorella bacteria. The present invention was accomplished by uracil-requiring Moorella bacteria, comprising an MTA-D-pF strain that is obtained by destroying a gene coding for orotidine-5-phosphate decarboxylase on a chromosome of Moorella bacteria. | 07-24-2014 |
| 20140220661 | LIVE BACTERIAL VACCINES FOR PROPHYLAXIS OR TREATMENT OF INFECTION - A live bacterium, having a DNA construct stabilized against transduction of other bacteria, having a promoter sequence and encoding a fusion peptide, comprising a bacterial secretion peptide portion and a non-bacterial immunogenic polypeptide portion, having a nucleotide sequence coding for the non-bacterial immunogenic polypeptide portion which has at least one codon optimized for bacterial expression. The bacterium has a secretion mechanism which interacts with at least the bacterial secretion peptide portion to cause a secretion of the fusion peptide from the bacterium, and a genetic virulence attenuating mutation. The bacterium is adapted to act as an animal vaccine, to transiently infect a tissue of the animal, and cause an immunity response to the non-bacterial immunogenic polypeptide portion in the animal to a non-bacterial organism associated with the non-bacterial immunogenic polypeptide portion. | 08-07-2014 |
| 20140242672 | Lactobacillus Mutant, Nucleotide Sequence for Lactobacillus Mutant and Primers for Nucleotide Sequence of Lactobacillus Mutant - The present invention relates to a lactobacillus mutant, a nucleotide sequence for lactobacillus mutant, and primers for nucleotide sequence of | 08-28-2014 |
| 20140248687 | METHODS FOR EXPRESSING POLYPEPTIDES IN HYPERTHERMOPHILES - Provided herein are genetically engineered archaea. A genetically engineered archaea includes a heterologous polynucleotide that has a promoter operably linked to a coding region, where the coding region encodes a polypeptide having optimal activity below the optimum growth temperature (T | 09-04-2014 |
| 20140342436 | Targeted Gene Deletions for Polysaccharide Slime Formers - The present invention provides improved polysaccharides (e.g., gellan and diutan) produced by mutant gene R, M or N | 11-20-2014 |
| 20150017704 | Cyanobacterium sp. Host Cell and Vector for Production of Chemical Compounds in Cyanobacterial Cultures - A cyanobacterial host cell, | 01-15-2015 |
| 20150050718 | METHOD FOR PRESERVING ENZYME - The problem is to provide a method for inexpensively and simply preserving an enzyme of a microbial biomass obtained by culturing and improve the enzyme activity during preservation. Provided is a method for preserving nitrile hydratase, characterized in that microbes having nitrile hydratase activity are cultured while being protected from light, and the resulting biomass is crushed using a high-pressure homogenizer and preserved while being protected from light. | 02-19-2015 |
| 20150125932 | Modified Organisms for Producing Gums - The production of a diutan polysaccharide exhibiting increased viscosity properties as compared with previously produced polysaccharide of the same type of repeating units. Such an improved diutan polysaccharide is produced through the generation of a derivative of | 05-07-2015 |
| 20150307873 | BACTERIAL ENGINEERING - Described is a process for producing a mutant bacterium which exhibits improved survival and/or growth under a selected growth condition, the process comprising the steps of: (a) generating a pool of mutant bacteria by transposon mutagenesis with an activating transposon (TnA), wherein the TnA comprises a promoter capable of increasing transcription of a gene at or near its insertion site; (b) growing bacteria from the mutant pool under the selected growth condition and under one or more reference conditions to produce two or more test cultures; and (c) comparing the distribution of TnA insertions between test cultures to identify a first class of genes which are disadvantageous for growth and/or survival under the selected growth condition and a second class of genes which are advantageous for growth and/or survival under the selected growth condition. | 10-29-2015 |
| 20150344837 | MINIMAL BACTERIAL GENOME - The present invention relates, e.g., to a minimal set of protein-coding genes which provides the information required for replication of a free-living organism in a rich bacterial culture medium, wherein (1) the gene set does not comprise the 100 genes listed in Table 2; and/or wherein (2) the gene set comprises the 382 protein-coding genes listed in Table 3 and, optionally, one of more of: a set of three genes encoding ABC transporters for phosphate import (genes MG410, MG411 and MG412; or genes MG289, MG290 and MG291); the lipoprotein-encoding gene MG185 or MG260; and/or the glycerophosphoryl diester phosphodiesterase gene MG293 or MG385. | 12-03-2015 |
| 20150353971 | BIOREFINERY SYSTEM, METHODS AND COMPOSITIONS THEREOF - The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C | 12-10-2015 |
| 20160032294 | CHLOROGLOEOPSIS SP. HOST CELL FOR PRODUCING ETHANOL AND METHOD FOR PRODUCING ETHANOL USING THE SAME - One embodiment of the invention provides a genetically enhanced | 02-04-2016 |
| 20160053271 | Engineered Organisms for Production of Novel Lipids - The present disclosure provides engineered microorganisms, engineered biosynthetic pathways, methods of producing lipid compounds using genetically engineered microorganisms, and the products synthesized by those organisms. In particular, the disclosure provides genetically engineered microorganisms for the production of multi-methyl branched fatty acids (MMBFAs) and MMBFA esters (wax esters) derived from these fatty acids. In addition, the disclosure provides methods for producing acylglycerols with one of more of their acyl substituents being an MMBFA, and methods for producing alcohols derived from MMBFAs (fatty alcohols). | 02-25-2016 |
| 20160068801 | SALMONELLA-BASED VECTORS FOR CANCER IMMUNOTHERAPY TARGETING WILMS' TUMOR GENE WT1 - The present invention relates to an attenuated mutant strain of | 03-10-2016 |
| 20160152943 | ALKALINE MICROBIAL ENHANCED OIL RECOVERY | 06-02-2016 |
| 20160152989 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF (2-HYDROXY-3METHYL-4-OXOBUTOXY) PHOSPHONATE | 06-02-2016 |
| 20160160243 | Biological Production of Multi-Carbon Compounds from Methane - Multi-carbon compounds such as ethanol, n-butanol, sec-butanol, isobutanol, tert-butanol, fatty (or aliphatic long chain) alcohols, fatty acid methyl esters, 2,3-butanediol and the like, are important industrial commodity chemicals with a variety of applications. The present invention provides metabolically engineered host microorganisms which metabolize methane (CH | 06-09-2016 |
| 20160185835 | IMMUNE SYSTEM MEDIATOR - The present invention discloses an isolated nucleic acid molecule encoding an ISRAA polypeptide comprising at least 70% homology to the sequence represented by the nucleotide sequence SEQ ID NO: 1. Also disclosed is a recombinant expression vector comprising said nucleic acid molecule and an isolated polypeptide molecule encoded by said nucleic acid molecule. | 06-30-2016 |
