| Entries |
| Document | Title | Date |
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| 20080227204 | PROCESS FOR PRODUCING CYTOTOXIC LYMPHOCYTE - The present invention relates to a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one of induction, maintenance and expansion of a cytotoxic lymphocyte in the presence of fibronectin, a fragment thereof or a mixture thereof. | 09-18-2008 |
| 20080261308 | DRY POWDER CELL CULTURE PRODUCTS AND METHODS OF PRODUCTION THEREOF - The present invention relates to nutritive medium, medium supplement, media subgroup and buffer formulations. The present invention provides powder nutritive medium, medium supplement and medium subgroup formulations, e.g., cell culture medium supplements (including powdered sera such as powdered fetal bovine serum (FBS)), medium subgroup formulations and cell culture media comprising all of the necessary nutritive factors that facilitate the in vitro cultivation of cells. The invention further provides powder buffer formulations that produce particular ionic and pH conditions upon reconstitution with a solvent. The invention provides methods for production of media, media supplement, media subgroup and buffer formulations, and also provides kits and methods for cultivation of prokaryotic and eukaryotic cells, particularly bacterial cells, yeast cells, plant cells and animal cells (including human cells) using these dry powder nutritive media, media supplement, media subgroup and buffer formulations. | 10-23-2008 |
| 20080274546 | ARTIFICIAL PHYSIOLOGICAL SALT SOLUTION AND MANUFACTURING METHOD FOR SAME - An artificial physiological salt solution, wherein the active hydrogen reaction value is 0.01 to 1, the pH is 4.0 to 7.9 and the osmotic pressure is 260 mOsm/L to 2560 mOsm/L, as well as a manufacturing method for the same are provided as a novel artificial physiological salt solution, which has active oxygen eliminating activity and anti-inflammation effects, and can be appropriately used in a multitude of applications such as organ cleaning solutions (cleaning solutions for the eyes, cleaning solutions for the nose and the like), artificial infusions, artificial amniotic fluid, protective solutions, cell/tissue cultures and the like, as well as a manufacturing method for the same. | 11-06-2008 |
| 20080286868 | METAL BINDING COMPOUNDS AND THEIR USE IN CELL CULTURE MEDIUM COMPOSITIONS - The present invention is directed generally to metal binding compounds which may be added to cell culture media to replace factors required for cultivation of the cells (e.g. transferrin) which are of animal or human origin. More specifically, the invention is directed to metal binding compounds or complexes thereof comprising one or more transition element cations (such as ferrous or ferric ions), which are added to cell and tissue culture medium compositions. The metal binding compounds may be added to the media alone or may be first complexed with a transition metal ion. The invention is also directed to methods of use of such compositions, including, for example, methods for the cultivation of eukaryotic cells, particularly animal cells, in vitro. The invention also relates to compositions comprising such culture media and one or more cells, and to kits comprising one or more of the above-described compositions. The compositions of the present invention obviate the need for naturally derived metal-binding proteins, such as transferrin and ceruloplasmin, which may contain blood-borne pathogens. | 11-20-2008 |
| 20080293140 | PROPAGATION AND/OR DERIVATION OF EMBRYONIC STEM CELLS - Embryonic stem (ES) cells are cultured in the presence of a compound which selectively inhibits propagation or survival of cells other than ES cells. The ES cells have not been genetically altered. Instead, the compound inhibits a signalling pathway which is essential for propagation of differentiated cells but is not essential for propagation of ES cells—hence ES cells are selectively maintained in the culture. | 11-27-2008 |
| 20080311660 | Dry powder cell culture products and methods of production thereof - The present invention relates to nutritive medium, medium supplement, media subgroup and buffer formulations. The present invention provides powder nutritive medium, medium supplement and medium subgroup formulations, e.g., cell culture medium supplements (including powdered sera such as powdered fetal bovine serum (FBS)), medium subgroup formulations and cell culture media comprising all of the necessary nutritive factors that facilitate the in vitro cultivation of cells. The invention further provides powder buffer formulations that produce particular ionic and pH conditions upon reconstitution with a solvent. The invention provides methods for production of media, media supplement, media subgroup and buffer formulations, and also provides kits and methods for cultivation of prokaryotic and eukaryotic cells, particularly bacterial cells, yeast cells, plant cells and animal cells (including human cells) using these dry powder nutritive media, media supplement, media subgroup and buffer formulations. | 12-18-2008 |
| 20090061518 | System and Method for Dispensing Dehydrated Culture Media Powder - An improved system and method for dispensing dehydrated culture media (DCM) powder into containers for preparation as a culture media. The manual and automated systems and methods operate to dispense DCM powder, as well as liquid, into vessels or media preparation instruments in a manner to avoid DCM dust inhalation by persons in the surrounding area and contamination of equipment and surfaces in the surrounding area. | 03-05-2009 |
| 20090291501 | Rapid Dissolve Media - A method for producing a palletized material includes mixing a media powder with a treated water ( | 11-26-2009 |
| 20100022004 | MODIFIED RECONSTITUTED BASEMENT MEMBRANE COMPOSITION FOR ASSAY SYSTEM - A modified reconstituted extracellular matrix composition is provided herein. The composition includes an extracellular matrix and at least one exogenous component selected from heparin, fibronectin and laminin. The composition may have a basic pH. Additionally, provided herein is a cell culturing system including a substrate and a coating thereon of the composition to assess potential stimulators and/or inhibitors for their effects on various cell cultures while increasing the signal dynamic range. | 01-28-2010 |
| 20100120150 | METHOD FOR PREPARING SERUM AND SERUM PREPARATION APPARATUS - A method for preparing serum and a serum preparation apparatus is provided that can give a large amount of serum with high culture efficiency regardless of freshness of blood used. In a method for preparing serum from blood containing at least platelets, a platelet processing step is provided in which platelet membrane in the blood is destroyed. After the platelet processing step, a deposition step for depositing thermolabile protein in blood and a removal step for removing the thermolabile protein, which has been deposited in the deposition step, are preferably provided. | 05-13-2010 |
| 20100197022 | AUTOMATED LIQUID MANUFACTURING SYSTEM - A method for continuously preparing a medium formulation mixes a diluent with a plurality of chemically incompatible concentrate solutions in such a manner that none of the ingredients of the concentrate solutions chemically react in an adverse manner. The method utilizes a static mixing chamber to add the concentrate solutions to the diluent stream sufficiently in advance of one another so that adverse chemical reactions do not occur. The method also adjusts a pH level of the diluent prior to adding any of the concentrate solutions to the diluent. | 08-05-2010 |
| 20100221836 | SOL-GEL MATERIALS FOR CELLULAR MODULATION - A modified sol-gel material and method of making the same is provided herein. More particularly, sol-gels disclosed herein have been modified to have one or more bioactive peptides covalently bound to the surface of the sol-gel. In one embodiment the peptide presenting sol-gels are prepared as thin film coatings and in a further embodiment the sol-gels are combined with living cells. The present disclosure is also directed to a novel one vessel reaction process for preparing the sol-gel-based peptide material. | 09-02-2010 |
| 20100248368 | BIOMATERIAL - A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation. | 09-30-2010 |
| 20110027890 | MATERIAL FOR CELL CULTURE - A ligand construct containing at least two, identical or different, ligand molecules which are capable of binding to a cell surface receptor, the ligand molecules being coupled via a spacer, wherein the ligand construct has at least one functional group for binding substrates. According to the ligand construct of the present invention, the immobilization of the ligand construct to various artificial substrates is facilitated, so that an artificial matrix can be easily prepared on an optimal substrate, whereby cells can be stably cultured. | 02-03-2011 |
| 20110027891 | MAMMALIAN CELL CULTURE MEDIA WHICH COMPRISE SUPERNATANT FROM COHN FRACTIONATION STAGES AND USE THEREOF - The present invention relates to mammalian cell culture media which comprise supernatant from some of the fractions of human plasma fractionation according to the Cohn method, more specifically, the supernatant of fractions I and II+III. When said supernatant is added as a culture medium supplement it provides various nutrients and factors for the effective maintenance and/or proliferation of the cultured mammalian cells. In addition, the present invention relates to the preparation process and use of said medium in the culture of mammalian cells. | 02-03-2011 |
| 20110053271 | IRRADIATION INDUCED GRAFTING OF POLYSACCHARIDES TO CELL CULTURE VESSELS - A method for grafting a polysaccharide to a surface of a cell culture article includes (a) contacting the surface of the article with the polysaccharide in a dry form; and (b) exposing the surface of the article and contacted dry polysaccharide to ionizing radiation to graft the polysaccharide to the surface of the article. In addition to grafting the polysaccharide to the surface, the ionizing radiation may serve to sterilize the article. | 03-03-2011 |
| 20110081722 | ANIMAL PROTEIN-FREE MEDIA FOR CULTIVATION OF CELLS - The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating cells, such as recombinant cells or cells infected with a virus, and for producing biological products by cell culture processes. | 04-07-2011 |
| 20110104804 | MIXING DEVICE - A mixing device for mixing a first and second material together to create an output mixture. The device includes a first chamber containing the first material coupled to a mixing chamber defined between a rotor and a stator. The rotor is disposed inside the stator and rotates therein about an axis of rotation. The first chamber houses an internal pump configured to pump the first material from the first chamber into the mixing chamber. The pump may be configured to impart a circumferential velocity into the first material before it enters the mixing chamber. At least one of the rotor and stator have a plurality of through-holes through which the second material is provided to the mixing chamber. Optionally, a second chamber is coupled to the mixing chamber. The second chamber may house an internal pump configured to pump the output material from the mixing chamber into the second chamber. | 05-05-2011 |
| 20110129926 | DRY POWDER CELL CULTURE PRODUCTS AND METHODS OF PRODUCTION THEREOF - The present invention relates to nutritive medium, medium supplement, media subgroup and buffer formulations. The present invention provides powder nutritive medium, medium supplement and medium subgroup formulations, e.g., cell culture medium supplements (including powdered sera such as powdered fetal bovine serum (FBS)), medium subgroup formulations and cell culture media comprising all of the necessary nutritive factors that facilitate the in vitro cultivation of cells. The invention further provides powder buffer formulations that produce particular ionic and pH conditions upon reconstitution with a solvent. The invention provides methods for production of media, media supplement, media subgroup and buffer formulations, and also provides kits and methods for cultivation of prokaryotic and eukaryotic cells, particularly bacterial cells, yeast cells, plant cells and animal cells (including human cells) using these dry powder nutritive media, media supplement, media subgroup and buffer formulations. | 06-02-2011 |
| 20110244573 | Method For The Supply Of Growth Components To Cell Cultures - The present invention provides a method for improving the preparation and use of growth media by the uses of specific pellet formulations, which especially are tablets of different sizes, which contain the growth medium or parts thereof and are sterilized with the standard methods of pharmaceutical technology. Specifically these pellet formulations are applied to control a cell culture in a way that the adaptation phase is shorter or that the growth is controlled by a release of certain components at a certain time and in a certain concentration during the process, and nutrients (e.g., nitrogen) can be packed into the cultivation vessel in amounts sufficient for high cell densities without the risk of intoxication of the organism. | 10-06-2011 |
| 20110250690 | Microfluidic Embryo and Gamete Culture Systems - A robotic microfluidic incubator system has a thin transparent sidewall and close proximity of the embryo/oocyte/cultured cells to the sidewall allow close approach of a side view microscope with adequate focal length for mid to high power. This arrangement permits microscopic examination of multiple culture wells when arranged in rows (linear or along the circumference of a carousel). Manual or automated side to side movement of the linear well row, or rotation of the carousel, allows rapid inspection of the contents each well. Automated systems with video capability also allow remote inspection of wells by video connection or Internet connection, and automated video systems can record oft-hours inspections or time lapse development in culture (i.e. embryo cell division progression, or axon growth in neuron cell cultures). | 10-13-2011 |
| 20110275155 | ENTRAPPED STEM CELLS AND USES THEREOF - The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells. | 11-10-2011 |
| 20120034696 | Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures - Particular aspects provide compositions comprising an electrokinetically altered oxygenated aqueous fluid, wherein the oxygen in the fluid is present in an amount of at least 25 ppm. In certain aspects, the electrokinetically altered oxygenated aqueous fluid comprises electrokinetically modified or charged oxygen species present in an amount of at least 0.5 ppm. In certain aspects the electrokinetically altered oxygenated aqueous fluid comprises solvated electrons stabilized by molecular oxygen, and wherein the solvated electrons present in an amount of at least 0.01 ppm. In certain aspects, the fluid facilitates oxidation of pyrogallol to purpurogallin in the presence of horseradish peroxidase enzyme (HRP) in an amount above that afforded by a control pressure pot generated or fine-bubble generated aqueous fluid having an equivalent dissolved oxygen level, and wherein there is no hydrogen peroxide, or less than 0.1 ppm of hydrogen peroxide present in the electrokinetic oxygen-enriched aqueous fluid. | 02-09-2012 |
| 20120045835 | PORTABLE DEVICE BASED ON IMMOBILIZED CELLS FOR THE DETECTION OF ANALYTES - The present invention relates to a portable device for the detection of analytes, in particular toxic substances, comprising at least a whole-cell biosensor with cells immobilized onto a transparent and inert matrix that allows the maintenance of cell vitality. The matrix comprises a mixture of collagen and/or its enzyme degradation derivatives, a proteoglycan and a mixture of vinyl polymer and an optionally modified polysiloxane, and an orthosilicate. The biosensor can be a genetically modified cell that expresses luciferase as reporter gene. | 02-23-2012 |
| 20120045836 | Enzyme-Based Fed-Batch Technique In Liquid Cultures - The present invention is generally in the field of continuous and high-cell-density cultivation in laboratory- or large-scale liquid shaken cultures. More particularly it relates to a method of enzyme-based fed-batch (EnBase) for liquid microbial prokaryotic or eukaryotic cell cultivation having the possibility to manipulate the growth rate of the cultured organisms by a controlled enzymatic release of the growth-limiting substrate-monomer from substrate-polymers or substrate-oligomers. | 02-23-2012 |
| 20120088303 | PEPTIDE FRACTIONS PROMOTING GROWTH AND SYNTHESIS OF DESIRED PRODUCT(S) INTO CELL AND/OR TISSUE CULTURE - The invention relates to preparing and/or supplementing a cell or tissue culture medium. In particular, said invention relates to a serum-free and/or protein-free cell culture medium comprising peptide fractions isolated from rapseeds, in particular rapseeds cakes. A method for the production of a cell culture comprising said peptide fractions and for the use thereof is also disclosed. | 04-12-2012 |
| 20120107936 | CULTURED PANCREAS ISLETS - Methods of preparing pancreatic islets that may comprise pancreatites are provided. The methods may involve subjecting a pancreas and/or pieces thereof to disruption, such as, for example, an enzyme digest, and seeding the recovered cellular product comprising islets in a culture medium comprising at least a detectable amount of endocrine tissue and/or exocrine tissue. | 05-03-2012 |
| 20120156783 | AUTOMATED LIQUID MANUFACTURING SYSTEM - A method for continuously preparing a medium formulation mixes a diluent with a plurality of chemically incompatible concentrate solutions in such a manner that none of the ingredients of the concentrate solutions chemically react in an adverse manner. The method utilizes a static mixing chamber to add the concentrate solutions to the diluent stream sufficiently in advance of one another so that adverse chemical reactions do not occur. The method also adjusts a pH level of the diluent prior to adding any of the concentrate solutions to the diluent. | 06-21-2012 |
| 20120196367 | METHOD FOR CULTURING CELLS ON CULTURE MEDIUM - A method for culturing a number of cells includes the following steps. A culture medium is provided. The culture medium has a carbon nanotube structure and a hydrophilic layer. The hydrophilic layer is formed on a surface of the carbon nanotube structure. A polar layer is formed on a surface of the hydrophilic layer away from the carbon nanotube structure. The cells are seeded and cultured on the polar layer. | 08-02-2012 |
| 20120196368 | CULTURE MEDIUM - A culture medium includes a carbon nanotube structure and a hydrophilic layer. The culture medium is capable of culturing at least one neuron. The hydrophilic layer has a polar surface and is located on a surface of the carbon nanotube structure. The polar surface is located on a surface of the hydrophilic layer away from the carbon nanotube structure, and has a polarity attracted to a polarity of the at least one neuron. | 08-02-2012 |
| 20120196369 | METHOD FOR FORMING CULTURE MEDIUM - A method for forming a culture medium includes the following steps. A carbon nanotube structure is provided. A hydrophilic layer is formed on a surface of the carbon nanotube structure. The hydrophilic layer is polarized to form a polar surface on the hydrophilic layer. A number of neurons are formed on the polar surface of the hydrophilic layer. | 08-02-2012 |
| 20120276630 | DRY POWDER CELLS AND CELL CULTURE REAGENTS AND METHODS OF PRODUCTION THEREOF - The present invention relates generally to nutritive medium, medium supplement, media subgroup and buffer formulations. Specifically, powdered nutritive medium, supplement, subgroup formulations, cell culture media comprising all of the necessary nutritive factors for in vitro cell cultivation, buffer formulations that produce particular ionic and pH conditions upon reconstitution with a solvent are provided. Particularly, methods of production of these media, supplement, subgroup, buffer formulations and kits, and methods for the cultivation of prokaryotic and eukaryotic cells using these dry powdered nutritive media, supplement, subgroup and buffer formulations are provided. Methods of producing sterile, powdered media or supplement (e.g., powdered FBS, powdered transferrin, powdered insulin, powdered organ extracts, powdered growth factors), media subgroup and buffer formulations by gamma irradiation are provided. Methods for producing dry cell powders, comprising spray-drying a cell suspension, and cells, media, media supplement, media subgroup and buffer powders produced by these methods are provided. | 11-01-2012 |
| 20120276631 | METHODS FOR CONTROLLING THE GALACTOSYLATION PROFILE OF RECOMBINANTLY-EXPRESSED PROTEINS - The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose. | 11-01-2012 |
| 20130034904 | CULTURE MEDIUM - A culture medium is used for culturing neural cells. Each neural cell includes a neural cell body and at least one neurite branched from the neural cell body. The culture medium includes a substrate and a carbon nanotube structure located on the substrate. The carbon nanotube structure includes a number of carbon nanotube wires spaced apart from each other. A distance between adjacent carbon nanotube wires is greater than or equal to diameters of the neural cell bodies. The carbon nanotube wires are capable of guiding extending directions of the neurites. | 02-07-2013 |
| 20130034905 | METHOD FOR MAKING CULTURE MEDIUM - A method for making a culture medium for culturing neural cells is provided. Each neural cell includes a neural cell body and at least one neurite branched from the neural cell body. The method includes the following steps. An original carbon nanotube structure is provided. The original carbon nanotube structure includes at least one drawn carbon nanotube film including a number of carbon nanotubes joined end to end by van der Waals force. The carbon nanotubes are substantially oriented along a same direction. A carbon nanotube structure including a number of carbon nanotube wires spaced from each other is formed from the original carbon nanotube structure. A distance between adjacent carbon nanotube wires is larger than or equal to a diameter of the neural cell body, the carbon nanotube wires are capable of guiding extending directions of the neurites. The carbon nanotube structure is fixed on a substrate. | 02-07-2013 |
| 20130084640 | ANIMAL CELL CULTURE MEDIA COMPRISING NON ANIMAL OR PLANT DERIVED NUTRIENTS - The present invention provides serum-free cell culture media formulations which are capable of supporting the in vitro cultivation of animal cells. The media comprise at least one nutrient of non-animal derivation, such as at least one plant peptide and/or at least one non-animal or plant lipid and/or fatty acid. The media may further optionally comprise an enzymatic digest or extract of yeast cells. The present invention also provides methods of cultivating animal cells in vitro using these cell culture media formulations. In addition, the media of the present invention can be used for growth of animal cells for virus production. | 04-04-2013 |
| 20130109094 | Dry powder cell culture products and methods of production thereof | 05-02-2013 |
| 20130267027 | DRY GRANULATED CELL CULTURE MEDIA - The present invention relates dry granulated cell culture media which do not comprise peptones or tryptones, especially to dry granulated cell culture media formulations that support the growth of mammalian, and/or insect and/or plant cells. The present invention further relates to the production of these dry granulated cell culture media and their use. | 10-10-2013 |
| 20130337566 | RESPONSIVE CELL CULTURE HYDROGEL - The present invention provides devices, compositions and methods for maintaining conditions in a cell culture and for measurement of conditions in the cell culture. In particular, the invention provides hydrogel materials, apparatus and methods for several non-invasive techniques of maintaining optimal or near-optimal nutrient and pH levels in cell cultures. | 12-19-2013 |
| 20140065710 | METHODS TO CONTROL PROTEIN HETEROGENEITY - The instant invention relates to the field of protein production, and in particular to compositions and processes for controlling and limiting the heterogeneity of proteins expressed in host cells. | 03-06-2014 |
| 20140120620 | Culturing solution and method of using the same, which solution is used for in-vitro support of the growth of fertilized oocytes though embryonic development to the implantation stage - This invention relates to a media solution, which has been shown to be a stabilized balance of growth media, which may contain a combination of proteins, insulin, growth hormones, and/or steroids to assist an embryo to grow from the retrieval stage through the return implantation. The media has shown consistent, improved results and overall embryonic outcome and may be used for culturing the embryos through each stage of growth, will reduce shock and stress to the embryos during the culturing process. | 05-01-2014 |
| 20150011004 | Systems and Methods for Expanding High Density Non-Adherent Cells - Embodiments described herein generally relate to systems and methods for promoting the expansion of high density non-adherent cells through the use of a cell growth chamber, a mass transfer device, and a fluid circulation loop. Improved cell growth is achieved in the cell growth chamber by using a chamber having a particular orientation and shape, e.g., conical, to create a media-rich reservoir for growing cells. By placing the chamber in a vertical position, the force of media flow along the chamber walls is substantially equal and opposite to the gravitational force on the cells. The interaction of these forces maintains the non-adherent cells in suspension. The use of the cell growth chamber in conjunction with the mass transfer device and fluid circulation loop(s) creates efficiencies by relying on the cumulative and combined features of the devices. | 01-08-2015 |
| 20150017726 | MEDIA FOR STEM CELL PROLIFERATION AND INDUCTION - The present application discloses a cell culture media for growth, maintenance and induction of reversion to a less mature state of a cell comprising a MUC1* activating ligand. | 01-15-2015 |
| 20150064785 | CELL CULTURE MEDIA AND METHODS - Compositions and methods are described for preparing media, feeds, and supplements. Such methods and medias may display increased stability of labile components and may use, for example, microsuspension and/or encapsulation technologies, chelation, and optionally, coating and/or mixing the labile compounds with anti-oxidants. The compositions may withstand thermal and/or irradiation treatment and have reduced virus number. These techniques may result in product with extended shelf-life, extended release of their internal components into culture, or in product that can be added aseptically into a bioreactor using minimal volumes. The compositions and methods may optimize the bioproduction workflow and increase efficiency. | 03-05-2015 |
| 20150064786 | IN VITRO MODEL FOR NEURONAL DEATH - This invention demonstrates the formation of a novel polarized membrane lipid raft signaling module in neurons, in response to several diverse neurotoxic stimuli. This polarization occurs well before neurons commit to die, and is an early mechanism in death signaling. The formation of this signaling module is dependent on cholesterol for its formation and provides a mechanistic explanation for the protective effects of cholesterol depleting drugs in several non-neural models of cell death. As such, the formation of the signaling module lends itself as a novel screen for the identification of new drugs and therapeutics which would retard its formation and protect against neuronal injury and death. | 03-05-2015 |
| 20150329826 | MATERIALS AND METHODS FOR CELL CULTURE - Methods and compositions for improved cell growth and serum-reduced or -free cell culture media. | 11-19-2015 |
| 20150337258 | CELL CULTURE MEDIA - The present invention relates to cell culture media comprising inorganic ester derivatives of tyrosine and/or cysteine. The poor solubility of tyrosine and the often non-sufficient stability of cysteine in cell culture media is overcome by substituting them with an inorganic ester derivative, e.g. with a phosphorylated derivative. | 11-26-2015 |
| 20150353882 | APPARATUS FOR CULTURING CELLS AND METHOD FOR CULTURING CELLS - An apparatus for culturing cells using a culture medium, including: a replacer that replaces the culture medium in a culture vessel held by a holder; a measurer that measures a pH of the culture medium in the culture vessel; and an instructor that instructs the replacer to replace the culture medium in the culture vessel, wherein the instructor gives an instruction when the pH measured by the measurer is less than a predetermined pH threshold at a first replacement of the culture medium, and gives an instruction when the pH measured by the measurer is less than the predetermined pH threshold and the interval is less than an interval of a previous replacement of the culture medium at second and subsequent replacements of the culture medium. | 12-10-2015 |
| 20160060392 | BIODEGRADABLE NETWORK POLYMERS FOR REGENERATIVE MEDICINE AND TISSUE ENGINEERING - The disclosure relates to biodegradable polyether network polymers crosslinked via ester linkages, to substrates, implants and scaffolds comprising the biodegradable polyether network polymers, to methods for preparing such network polymers, implants and scaffolds, and to methods of using substrates, implants and scaffolds comprising the network polymers, particularly for culturing cells and regenerating tissue. | 03-03-2016 |
| 20160083433 | TEMPLATE-DIRECTED GAMMAPNA SYNTHESIS PROCESS AND GAMMAPNA TARGETING COMPOUNDS - Described herein are recognition modules that bind specifically to a template nucleic acid and which ligate together in a reducing environment to produce a gamma peptide nucleic acid (γPNA) oligomer. Also provided are methods of synthesizing a γPNA oligomer on a template using the recognition modules. | 03-24-2016 |
| 20160115442 | COMPOSITION FOR CULTURING SANAL AND SANAL CULTURING METHOD USING THE SAME - Provided are a sanal culturing composition and a method for culturing sanal using the same. | 04-28-2016 |
| 20160145565 | CELL CULTURE MEDIA - The present invention relates to cell culture media comprising polymer embedded components. Some components show poor stability in dry powder cell culture media. Others are hygroscopic. Such components can be embedded into polymers to increase stability and reduce clumping | 05-26-2016 |
