| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 435401000 | Support is a membrane | 28 |
| 20090068740 | AMORPHOUS CELL DELIVERY VEHICLE TREATED WITH PHYSICAL/PHYSICOCHEMICAL STIMULI - Provided are compositions and methods for in vitro generation and in vivo use of tissue for the repair of defective tissue, especially cartilage. Chondrocytes or other cells are cultured in vitro in a biodegradable amorphous carrier within the confines of a space bounded by a semi-permeable membrane with a molecular weight cut-off of greater than 100 kDa. The culture can be subjected to physical/physicochemical conditions that mimic in vivo conditions of the tissue in need of repair or replacement. In one embodiment the invention provides an amorphous preparation of chondrocytes and their extracellular products, suitable for injection. | 03-12-2009 |
| 20090233362 | Porous Scaffold, Method of Producing the Same and Method of Using the Porous Scaffold - A porous scaffold having pores for seeding cells characterized in that, in the outer peripheral face of the porous main body having the pores for seeding cells, a porous membrane having pores smaller than the cells is located. Thus, it is possible to provide a porous scaffold whereby the cells can be seeded at a high efficiency while preventing cell leakage and, moreover, even cells having little adhesiveness can be adhered. | 09-17-2009 |
| 20100055792 | EX VIVO GENERATED TISSUE SYSTEM - The present invention relates to methods of generating an ex vivo tissue-like system in a bioreactor system capable of supporting continuous production of, and output of cells and tissues and an ex vivo tissue system made therefrom. | 03-04-2010 |
| 20100159597 | CELL CULTURE MEMBRANE, CELL CULTURE KIT, POROUS MATERIAL, PRODUCTION METHOD FOR CELL CULTURE MEMBRANE AND PRODUCTION METHOD FOR POROUS MATERIAL - To produce a cell culture membrane having biocompatibility utilizing DNA of natural resources and a cell culture kit, the cell culture membrane having DNA ionically-cross-linked with calcium ions or magnesium ions is provided. To produce a porous material utilizing DNA, a production method for a cell culture membrane and a production method for a porous material, fine pores of 1 nm to 100 μm in diameter are prepared in the porous material. | 06-24-2010 |
| 20100216244 | Microfluidic Chip and Method Using the Same - Disclosed is a microfluidic chip and method using the same. The microfluidic chip comprises a substrate having a surface, and at least a tissue culture area formed on the surface of the substrate. The tissue culture area has a microfluidic channel formed by a plurality of connected geometrical structures (nozzle-type channels) having a predetermined depth. The microfluidic channel has an inlet and an outlet, which are at two ends of the microfluidic channel, for medium inputting and outputting, respectively. Additionally, at least an air-exchange hole is formed on the bottom of the microfluidic channel. By using the microfluidic chip for tissue culture, lateral flow speed and stress can be decreased, so as to prolong survival time of tissues (e.g. liver tissues). | 08-26-2010 |
| 20100233812 | MEMBRANE MADE OF A NANOSTRUCTURED MATERIAL - The present invention refers to a method of fabricating a membrane made of a nanostructured material and its use. | 09-16-2010 |
| 20110081721 | PROCESS FOR PRODUCING A TISSUE TRANSPLANT CONSTRUCT FOR RECONSTRUCTING A HUMAN OR ANIMAL ORGAN - A process for producing a tissue transplant construct for reconstructing a human or animal organ. The process may include the steps of: (a) isolation and two-dimensional cultivation of organ-specific tissue cells; (b) application of the organ-specific tissue cells to a biocompatible, collagen-containing membrane; and, (c) cultivation of the organ-specific tissue cells on the membrane with biochemical and mechanical stimulation of the organ-specific tissue cells. Tissue transplant constructs and methods for using tissue transplant constructs are also taught. | 04-07-2011 |
| 20110151565 | CELL SHEET HAVING GOOD DIMENSIONAL STABILITY, METHOD FOR PRODUCTION THEREOF, AND CELL CULTURE CARRIER FOR USE IN THE METHOD - It is an object of the present invention to provide a cell culture carrier for producing a cell sheet that can be readily detached from a cell culture carrier and is inhibited from contracting after being detached. | 06-23-2011 |
| 20110263022 | IRRADIATED MEMBRANE FOR CELL EXPANSION - A membrane for cultivating adherent or suspension cells, in particular adherent cells. The membrane permits adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma or beta rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. A method for preparing such an irradiated membrane for cultivating adherent or suspension cells. Methods of using such a membrane for cultivating adherent or suspension cells. | 10-27-2011 |
| 20110294215 | CULTURE SYSTEMS - A microplate is provided herein having a plate body with at least one well formed therein, the well having a first open end, a second end, an aperture being formed in the second end, and a side wall extending between the first end and the second end. The microplate further has a permeable membrane extending at least partially across the aperture formed in the second end. A microplate is provided with a permeable membrane which allows not only for removal of certain solutes from a solution (high or low molecular weight solutes), but also allows for separation of macromolecular mixtures and degradation of the membrane. The microplate is also provided with an integrated top assembly or integrated inserts. Also provided herein are methods of culturing systems in the microplates described. | 12-01-2011 |
| 20120034695 | TISSUE/CELL CULTURING SYSTEM AND RELATED METHODS - A system for culturing cells and/or tissue includes a tissue/cell culture chamber including a tissue/cell culture membrane, at least one collapsible valve fluidly coupled with the tissue/cell culture chamber, a pump fluidly coupled with the tissue/cell culture chamber, and a flow loop including the pump, chamber, and collapsible valve fluidly coupled together. | 02-09-2012 |
| 20120058560 | Bioreactor System - Bioreactors may be used for the cultivation of cells, in particular of adherent cells, and, in particular for the cultivation and propagation of cell cultures, and utilized in methods for the cultivation of cells. A particular area of application is the use of the bioreactors in the GMP-compliant, fully automatic cultivation and propagation of cells. | 03-08-2012 |
| 20130059382 | BIOMEDICAL MATERIALS FOR TISSUE ENGINEERING - In an embodiment of the disclosure, a biomedical material is provided. The biomedical material includes a biocompatible material having a surface and a carrier distributed over the surface of the biocompatible material, wherein both of the biocompatible material and the carrier have no charges, one of them has charges or both of them have charges with different electricity. The biomedical material is utilized for dentistry, orthopedics, wound healing or medical beauty and applied in the repair and regeneration of various soft and hard tissues. | 03-07-2013 |
| 20130143326 | ULTRATHIN PARYLENE-C SEMIPERMEABLE MEMBRANES FOR BIOMEDICAL APPLICATIONS - Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there. | 06-06-2013 |
| 20130236972 | Liver Sinusoid Model - A liver sinusoid model includes a generally planar substrate having first and second generally parallel microchannels formed therein. A microporous membrane is disposed between and separating the first and second generally parallel microchannels. A first layer of cells lines one side of the membrane in the first microchannel. The first layer of cells are all a first common cell type. A second layer of cells extends parallel to the first layer of cells in one of the first microchannel and the second microchannel. The second layer of cells is all of a second common cell type. A liver sinusoid bioreactor utilizing the inventive model is also disclosed. | 09-12-2013 |
| 20130244328 | METHOD OF CELL CULTURE - This invention provides a means for modifying surface properties of a cell culture substrate under specific conditions, to thereby regulate regions to which cells are allowed to adhere or are not allowed to adhere, depending on cell type. This invention relates to a method of cell culture comprising steps of: applying a positive potential to a conductive region of a substrate comprising a base material having a conductive region and a non-cell-adhesive membrane coupled thereto with the aid of silane, so as to separate the non-cell-adhesive membrane from the substrate; and culturing cells in a region from which the non-cell-adhesive membrane has been separated. | 09-19-2013 |
| 20130260465 | CULTURE SYSTEMS - A microplate is provided herein having a plate body with at least one well formed therein, the well having a first open end, a second end, an aperture being formed in the second end, and a side wall extending between the first end and the second end. The microplate further has a permeable membrane extending at least partially across the aperture formed in the second end. A microplate is provided with a permeable membrane which allows not only for removal of certain solutes from a solution (high or low molecular weight solutes), but also allows for separation of macromolecular mixtures and degradation of the membrane. The microplate is also provided with an integrated top assembly or integrated inserts. Also provided herein are methods of culturing systems in the microplates described. | 10-03-2013 |
| 20130302897 | DEFORMABLE TRANSPORTABLE BIOREACTOR CHAMBER - An apparatus and method is described for seeding and culturing cells on a sample. The apparatus includes a chamber in which the volume of the chamber may be adjusted without compromising the seal or sterility of the chamber. The apparatus enables the seeding of cells in a reduced volume and culturing of cells in an increased volume. Further, the apparatus enables application of forces, strains and torques to a sample during seeding, culturing or transportation of the sample. | 11-14-2013 |
| 20130337565 | Method and Apparatus for Patterning Cells - The present invention is directed to tissue engineering and, more particularly, to devices and methods that are used to pattern or deposit cells to simulate a tissue type in two dimensions or in three dimensions or a cell migration device, a materials testing device for cell proliferation, migration or cell seeder for the Bioflex® flexible bottom culture plates or comparable culture plates. The present invention operates by providing negative pressure to create multiple troughs or indentations for cells to attach and grow on or in the Bioflex® flexible bottom culture plates. The present invention is also directed to a device and method for simulating a tissue wound using the above devices. | 12-19-2013 |
| 20140065709 | MULTILAYERED CELL CULTURE APPARATUS - A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications. | 03-06-2014 |
| 20140178997 | SOFT TISSUE IMPLANTS AND METHODS FOR MAKING SAME - The present invention features soft tissue implants and methods for making same. The implants can includes a biocompatible film that is rendered porous due to the inclusion of uniformly or non-uniformly patterned cells, and the film has a thickness of less than about 0.015 inches in the event the starting material is non-porous and less than about 0.035 inches in the event the starting material is a microporous film. Multi-film implants can also be made. | 06-26-2014 |
| 20140212974 | CELL CULTURE MEMBRANE, CELL CULTURE SUBSTRATE, AND METHOD FOR MANUFACTURING CELL CULTURE SUBSTRATE - Provided is: a cell culture membrane, which is free from materials derived from living organisms, can easily be industrially mass-produced, exhibits superior long-term storage properties and chemical resistance, has excellent cell adhesion properties and long-term culture properties and is capable of replicating a cell adhesion morphology that is similar to that of collagen derived from living organisms and being used for conventional cell cultivation. Also provided are a cell culture substrate, and a method for manufacturing the cell culture substrate. In the present invention, as a cell adhesion layer, a polymer membrane represented by formula (I) is formed on the base of a cell culture substrate so as to have a membrane thickness equal to or greater than 0.2 μm (in the formula, R1 and R2 represent a —(CH | 07-31-2014 |
| 20150024495 | DEVICE AND METHOD FOR ENGINEERING LIVING TISSUES - A device for assembling aggregations of adherent cells includes a gripper moveable within an assembly vessel that fixes aggregations of adherent cells at a membrane of the gripper and, by movement of the gripper, assembles aggregations of cells on a separate membrane within the vessel, thereby creating a three-dimensional assembly of aggregations of cells that fuse and can be employed in surgical procedures as a unitary tissue of adherent cells. The aggregations of cells, as assembled, can assume three-dimensional configurations distinct from any one of the component aggregations of cells assembled. | 01-22-2015 |
| 20150093826 | CELL CULTURE CARRIER AND CELL CULTURE VESSEL - A cell culture carrier comprises an anodic oxide film having a plurality of micropores penetrating the anodic oxide film in a thickness direction, wherein an average density of the plurality of micropores is from 1 micropore/μm | 04-02-2015 |
| 20150093827 | CELL CULTURE CARRIER AND CELL CULTURE VESSEL - A cell culture carrier comprises an anodic oxide film having a plurality of micropores penetrating in a thickness direction from a front surface to a rear surface, wherein an average opening diameter A of a front surface-side opening portion of the plurality of micropores and an average opening diameter B of a rear surface-side opening portion thereof have different values from each other, and the plurality of micropores has a shape in which an average diameter increases or decreases toward the rear surface-side opening portion from the front surface-side opening portion. | 04-02-2015 |
| 20150147809 | CELL SEEDING DEVICE AND METHOD - Described is a device comprising an anchor, a tray including a well adapted to receive the anchor, and a cover adapted to engage the tray and cover the well. The device may be used to form a membrane-cell matrix having a substantially uniform distribution of the cells on the membrane in at least two dimensions. | 05-28-2015 |
| 20150147810 | ULTRATHIN PARYLENE-C SEMIPERMEABLE MEMBRANES FOR BIOMEDICAL APPLICATIONS - Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there. | 05-28-2015 |
| 20160177245 | T-CELL CULTURE DOUBLE BAG ASSEMBLY | 06-23-2016 |
