Class / Patent application number | Description | Number of patent applications / Date published |
435178000 | Carrier is carbohydrate | 44 |
20090203103 | Induction and Stabilization of Enzymatic Activity in Microorganisms - The present invention is directed to methods for inducing desired activity in enzymes or microorganisms capable of producing the enzymes. The invention is further directed to methods of stabilizing activity in microorganisms. In specific embodiments, the invention provides methods for inducing and stabilizing nitrile hydratase activity, amidase activity, and asparaginase I activity. The invention further provides compositions comprising enzymes or microorganisms having induced and/or stabilized activity. | 08-13-2009 |
20090325263 | PREPARATION OF GLASSIFIED BIOLOGICAL REAGENTS - The invention related to a method of making a dried reagent preparation, comprising the steps of: providing an aqueous solution of at least one buffered biological reagent; mixing a glass forming filler material with the buffered reagent solution to form a mixture wherein the concentration of the filler material is sufficient to facilitate formation of a glassy, porous composition; dispensing the mixture in the form of substantially uniform droplets into wells of a multi-well container, wherein a single droplet is dispensed into each well; drying the droplets in the container to form the reagent preparation. The reagent preparation is water soluble and has a Tg sufficient for room temperature stability. | 12-31-2009 |
20110076737 | CARRIERS FOR IMMOBILIZATION AND REUSABILITY OF ENZYMES - This patent involves improvement of the thermal stability of natural polymers, “hydrogels”, to be used as supports for covalent immobilization of enzymes. The presence of the new functionality has been proved by FTIR. In brief, the new polymeric carrier has the main following advantages: • Natural polymer & friendly to the environment • Highly hydrophilic • Containing active groups for covalent immobilization of enzymes& antibodies Thermally stable (35-95° C.) Porous The modified carrier could be used for immobilization of enzymes on the industrial scale. The immobilized enzymes could be reused for tens of times, which will reduce the cost of the enzymes and their products. | 03-31-2011 |
20110124079 | Sorption reinforced catalytic coating system and method for the degradation of threat agents - Sorption reinforced catalytic coating system for the degradation of threat agents including a synzyme coating about a material configured for the degradation of the threat agents, the synzyme coating including bucket-shaped molecules configured for the sorption of the threat agents A binding agent is configured for synzyme immobilization to maximize loading and retention of the synzyme coating on the material. | 05-26-2011 |
20110183398 | MICROORGANISM-CAPTURING COMPOSITIONS AND METHODS - The invention relates to compositions, methods, devices, and kits for non-specifically isolating bacterial cells. The compositions comprise a solid support which has a surface comprising a combination of a carbohydrate and a biotin-binding protein, wherein the protein is covalently bonded to the carbohydrate, and wherein the protein is linked to the solid support via the carbohydrate; and at least one of 1) a plurality of bacterial cells non-specifically bound to the combination of the carbohydrate and the protein or 2) an amphiphilic glycoside of a steroid or triterpene. The methods, devices, and kits include at least one of these compositions. | 07-28-2011 |
20110217750 | Dendrimers and Dendrimer Applications - An activatable functionalised N | 09-08-2011 |
20110217751 | Alginate microbeads, method for forming the same and associated applications - This present invention relates to a method for forming alginate microbeads. The method includes using a needle connected to a vibrator to continuously spot tiny alginate microdroplets in an oil layer. Subsequently, the temporarily formed alginate microdroplets sink into a CaCl | 09-08-2011 |
20110269208 | CROSS-LINKED POLYMER NETWORK FORMED BY SEQUENTIAL CROSS-LINKING - The convention concerns methods for preparing a cross-linked polymer network comprising: forming a plurality of cross-links in a polymer network by (i) addition polymerization or (ii) ionic polymerization or (iii) partial radical polymerization of the polymer network to produce an intermediate polymer network, and forming further cross-links in the polymer network by radical polymerization of the intermediate polymer network to produce the cross-linked polymer network. | 11-03-2011 |
20110306110 | METHOD FOR THREE-DIMENSIONAL HIERARCHICAL CELL CO-CULTURE - A method for preparing a biomaterial comprising a gel layer which forms a core region, and cells (cover cells) which cover around the gel layer, said method comprising the steps of: | 12-15-2011 |
20120142069 | INTERPENETRATING BIOMATERIAL MATRICES AND USES THEREOF - The present invention relates to matrices (e.g., fibrin-alginate matrices; fibrin-alginate-matrigel matrices) for culture of cells, organs (e.g., ovary or fragment thereof), cells and cell aggregates (e.g., ovarian follicles, embryoid bodies), and tissues. In some embodiments, protease inhibitors e.g., aprotinin) are used to prevent the degradation of fibrin. | 06-07-2012 |
20120156749 | SEPARATING MATERIAL AND METHOD FOR COLLECTING CELL OR THE LIKE USING THE SAME - The present invention provides a novel material useful for selectively isolating a cell such as monocyte and the like or a protein from a body fluid and a production method thereof, a physiological material using the material and an isolation material using the physiological material, as well as a method of harvesting a cell such as monocyte and the like using the isolation material, a method of harvesting a protein and a method of preparing a dendritic cell. | 06-21-2012 |
20120208255 | APPARATUS AND PROCESS FOR PRODUCTION OF AN ENCAPSULATED CELL PRODUCT - A process for production of an encapsulated cell product, the process comprises the steps of concentrating cells from a propagation medium using a tangential flow filtration system. Mixing the concentrated cells with an encapsulation medium to form a cell encapsulation mixture. Polymerizing, gelling, or cross-linking the cell encapsulation mixture to form an encapsulated cell product. | 08-16-2012 |
20120270295 | NESTED CELL ENCAPSULATION - The invention relates to a method for encapsulating living cells and labels, as well as encapsulated labelled cells and kits for performing such encapsulation. The encapsulated cells may be useful in multiple parallel tissue culture experiments, where the labels in each microcapsule may be used to decipher a cells path through a series of culturing steps. | 10-25-2012 |
20120322133 | SEPARATING MATERIAL AND METHOD FOR COLLECTING CELL OR THE LIKE USING THE SAME - The present invention provides a novel material useful for selectively isolating a cell such as monocyte and the like or a protein from a body fluid and a production method thereof, a physiological material using the material and an isolation material using the physiological material, as well as a method of harvesting a cell such as monocyte and the like using the isolation material, a method of harvesting a protein and a method of preparing a dendritic cell. | 12-20-2012 |
20120329125 | GROUP CULTURE SYSTEM AND METHOD WITH HELPER EMBRYOS - Methods and systems for physically separating helper embryos from desired embryos in a group culturing technique in order to maintain the pedigree and genetic information of the desired embryos from different species, including cattle and human, and to provide the developmental benefits of group culturing. The separation of the groups of embryos can be the result of embedding one group of embryos in a gel or solid, or the groups can be physically separated by a membrane or other structure. | 12-27-2012 |
20130040356 | CYTOCOMPATIBLE ALGINATE GELS - The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy. | 02-14-2013 |
20130115673 | Methods of Screening Embryonic Progenitor Cell Lines - Aspects of the present invention include methods and compositions related to the production and use of numerous clonal lineages of embryonic progenitor cell lines derived from differentiating cultures of primordial stem cells with diverse molecular markers and having been cultured for >21 doublings of clonal expansion. The robustness of these clonally-purified lines, their ability to expand for >40 passages while maintaining their pattern of gene expression, lack of tumorigenicity, and their embryonic pattern of gene expression offers novel compositions and methods for modeling numerous differentiation pathways for the first time in vitro, and for the manufacture of purified product not existing in such a purified state in nature or using other manufacturing modalities. Representative progenitor cell lines described herein are capable of development into cutaneous adipocytes, blood-brain barrier cells, neuronal cells, or smooth muscle cells each with therapeutic potential. | 05-09-2013 |
20130122565 | INDUCTION AND STABILIZATION OF ENZYMATIC ACTIVITY IN MICROORGANISMS - The present invention is directed to methods for inducing desired activity in enzymes or microorganisms capable of producing the enzymes. The invention is further directed to methods of stabilizing activity in microorganisms. In specific embodiments, the invention provides methods for inducing and stabilizing nitrile hydratase activity, amidase activity, and asparaginase I activity. The invention further provides compositions comprising enzymes or microorganisms having induced and/or stabilized activity. | 05-16-2013 |
20130295637 | FIBROUS SUBSTRATES FOR CELL PROPAGATION AND DIFFERENTIATION - The present invention relates to a method of releasably encapsulating pluripotent embryonic stem cells in a degradable continuous polyionic fiber for tissue culture, wherein the encapsulated embryonic stem cells are able to maintain a pluripotent phenotype in tissue culture; the method comprising (a) contacting an aqueous solution of a polyanion with an aqueous solution of a polycation to form an interface between the aqueous solution of polyanion and the aqueous solution of polycation, and wherein the aqueous solution of polyanion or the aqueous solution of polycation or both the aqueous solution of polyanion and the aqueous solution of polycation comprises a suspension of pluripotent embryonic stem cells; (b) drawing a continuous polyionic fiber which comprises encapsulated pluripotent embryonic stem cells from the interface; (c) passing the continuous polyionic fiber comprising encapsulated pluripotent embryonic stem cells in a continuous process through a solution which reduces secondary complexation of the components of the polyionic fiber. | 11-07-2013 |
20130337528 | COMPOSITIONS FOR SEPARATION METHODS - This invention relates generally to the fields of separation and conversion technologies, and more particularly to materials for use in tangential-flow filtration techniques. The tangential-flow materials are useful in a wide range of separation and conversion processes, including those reliant on reverse osmosis, microfiltration, ultrafiltration, or nanofiltration semipermeable filtration membranes, and provide efficient methods for purifying or producing various target substances, including biopolymer particles for use in tangential-flow filtration. | 12-19-2013 |
20130344561 | LINKING METHODS, COMPOSITIONS, SYSTEMS, KITS AND APPARATUSES - In some embodiments, the disclosure relates generally to methods as well as related compositions, systems, kits and apparatus comprising linking proteins to target compounds and/or to locations of interest using tethers. For example, the tether can used to link the protein to a target compound, for example, to link an enzyme to a substrate. Similarly, the tether can be used to link the protein at or near a desired location on a surface. In one group of embodiments, the tether includes a polynucleotide and the target compound or location on the surface includes another polynucleotide that is capable of hybridizing to the tether. In such bodiments, the tether can be used to link the protein to the target compound or location using nucleic acid hybridization. | 12-26-2013 |
20140113347 | Biopolymer Composition for Encapsulating Cells, Method for Producing a Biopolymer Composition for Encapsulating Cells, Method for Promoting Cell Cytoprotection and Use of a Biopolymer Composition for Encapsulating Cells - The present invention relates to a biopolymer composition for encapsulating cells, containing alginate, at least one glycosaminoglycan compound, preferably chondroitin sulfate, and at least one component of the extracellular matrix, preferably laminin, and to the process for producing the biopolymer composition. Also disclosed are a method for promoting cytoprotection using this composition, and the use of this composition for preparing a medicament useful in cell transplantation. | 04-24-2014 |
20140127774 | Synthetically Functionalized Living Cells - Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells remain viable after attachment of the functional patch. The patch does not completely occlude the cellular surface from the surrounding environment. Functional payloads carried by the patch may include, for example, drugs or other small molecules, peptides, proteins, thermally responsive polymers, and nanoparticles, or any other material that can be incorporated in a polymer patch of subcellular dimensions. The patch can include one or more polyelectrolyte multilayers (PEMs). | 05-08-2014 |
20140127775 | APPARATUS AND PROCESS FOR FERMENTATION OF BIOMASS HYDROLYSATE - A process for converting biomass hydrolysate into biofuel, the process comprising the steps of: obtaining a biomass hydrolysate solution comprising monosaccharides; immobilizing | 05-08-2014 |
20140127776 | METHOD USING IMMOBILIZED ALGAE FOR PRODUCTION AND HARVEST OF ALGAL BIOMASS AND PRODUCTS - Compositions, articles, apparatus, methods and systems are provided for the growth of algae immobilized on a support in a gaseous environment supplying access to sources of carbon dioxide and light, and for subsequent harvesting and biomass processing. | 05-08-2014 |
20140134701 | BACTERIORHODOPSIN-CONTAINING BIOACTIVE GEL AND METHOD FOR FABRICATING THE SAME - The present invention discloses a bacteriorhodopsin-containing bioactive gel and a method for fabricating the same, wherein a thickening polymeric compound is suspended in water to form a base gel having appropriate glutinosity and suitable for skin, and wherein a bacteriorhodopsin-containing culture fluid, which is obtained via culturing halobacteria in a spent culture fluid, is integrated with the glutinous base gel to form the bacteriorhodopsin-containing bioactive gel. The bioactive gel of the present invention is abundant of vitamins, minerals, amino acids, etc. and thus very useful in beauty treatment and dermatological treatment. The present invention is also expected to have high commercial potential in many other fields. | 05-15-2014 |
20140335588 | APPARATUS AND PROCESS FOR PRODUCTION OF AN ENCAPSULATED CELL PRODUCT - A process for production of an encapsulated cell product, the process comprises the steps of concentrating cells from a propagation medium using a tangential flow filtration system. Mixing the concentrated cells with an encapsulation medium to form a cell encapsulation mixture. Polymerizing, gelling, or cross-linking the cell encapsulation mixture to form an encapsulated cell product. | 11-13-2014 |
20150010979 | METHOD FOR PREPARING IMMOBILIZED ANGIOGENIN - Stabilized angiogenin compositions and methods of preparing a stabilized angiogenin compositions by covalent immobilization on a naturally occurring substrate, such as a polysaccharide substrate, are disclosed. In particular, the polysaccharide substrate includes galactose-rich polysaccharide. | 01-08-2015 |
20150125924 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR - A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein. | 05-07-2015 |
20150315562 | Synthetically Functionalized Living Cells - Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells remain viable after attachment of the functional patch. The patch does not completely occlude the cellular surface from the surrounding environment. Functional payloads carried by the patch may include, for example, drugs or other small molecules, peptides, proteins, thermally responsive polymers, and nanoparticles, or any other material that can be incorporated in a polymer patch of subcellular dimensions. The patch can include one or more polyelectrolyte multilayers (PEMs). | 11-05-2015 |
20160053252 | REVERSIBLE SURFACE FUNCTIONALIZATION - Some embodiments described herein relate to a substrate comprising a silane functionalized surface for reversibly immobilizing a biological molecule of interest, such as oligonucleotides, polynucleotides, or protein. Methods for immobilizing the biological molecule and the use in DNA sequencing and other diagnostic applications are also disclosed. | 02-25-2016 |
20160201050 | ENCAPSULATING DEVICE AND ENCAPSULATING METHOD FOR ENCAPSULATING A SAMPLE IN A POLYMER CAPSULE | 07-14-2016 |
435179000 | Carbohydrate is cellulose or derivative thereof | 12 |
20090209019 | Bioartificial Renal Tubule - A bioartificial renal tubule is provided that forms an artificial kidney together with a bioartificial glomerulus suitable for continuous hemofiltration. The bioartificial renal tubule includes an artificial membrane having an inner surface coated with renal tubular epithelial cells and a vessel containing the artificial membrane. The cells are prevented by the use of a MEK inhibitor from being stratified and therefore form a confluent monolayer on the artificial membrane. The renal tubular epithelial cells are characterized in that the contact inhibition thereof is maintained by the use of the MEK inhibitor. The MEK inhibitor is preferably U0126. The attachment of cells capable of reproducing the function of a kidney allows dialysis to be continuously performed for 24 hours with high efficiency and also allows the ability of a renal tubule to reabsorb useful substances to be achieved. | 08-20-2009 |
20100136647 | METHOD FOR PRODUCTION OF CELL ATTACHMENT AND CULTURE SURFACES - The present invention relates to the field of adherent cell culture. More closely, the invention relates to a method for production of a cell attachment and culture surface, such as a microcarrier, comprising a guanidino-containing ligand, wherein the ligand is coupled via reaction involving a primary amine to the surface which is activated by activation groups such that the final molar ratio of grafted ligand and ungrafted activation groups is above 1.5. Preferably, the ligand density is above 0.5 mmol/g cell culture surface and the remaining activation groups after coupling is less than 0.6 mmol/g cell culture surface. The cell culture surface may be used for various purposes, primarily cell cultivation and virus production. | 06-03-2010 |
20110171713 | SORBENT FOR A DIALYSIS DEVICE - There is provided a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a layer of immobilized uremic toxin-treating enzyme particles intermixed with cation exchange particles. | 07-14-2011 |
20110281321 | Microbial Remediation System and Method - Methods and systems for effecting an environmental change by providing an effector composition that includes lignocellulosic particles with at least one absorbed microorganism species, wherein the lignocellulosic particles are preferably kenaf particles. The method steps include mixing at least one microorganism species with kenaf particles to form an effector composition and then dispersing the effector composition in the environment. | 11-17-2011 |
20120107900 | Electrospun Polymer Fibers Comprising Particles of Bacteria-Containing Hydrogels - The present invention provides electrospun polymer fibers comprising bacteria-containing hydrogel particles. Bacteria-containing hydrogel particles are produced by crosslinking water-soluble polymers to form hydrogels and mixing them with a bacteria suspension. The crosslinking is suitable to be carried out either chemically before the addition of the bacteria suspension or physically before or after this addition. Subsequently, these hydrogel particles are electrospun together with an electrospinnable polymer solution to form fibers or fibre non-wovens. | 05-03-2012 |
20120202261 | 3D TROPHOBLAST MATRIX FOR PREPARING ORGAN-SPECIFIC STEM CELLS - This disclosure relates generally to methods, apparatuses, and cellular compositions and cellular products that use a unique trophoblast-containing 3D matrix as a compartmental chamber for growing embryoid bodies that can be induced to differentiate into organ-specific cell types. | 08-09-2012 |
20130210111 | SUBSTRATE FOR IMMOBILIZING FUNCTIONAL SUBSTANCES AND METHOD FOR PREPARING THE SAME - A substrate having compounds disposed thereon for immobilizing a functional molecule, each compound having a chain including: a moiety R that is chemically coupled to the substrate, the moiety R being selected from the group consisting of an ether, ester, carbonyl, carbonate ester, thioether, disulfide, sulfinyl, sulfonyl, and carbonothioyl; and an epoxide-containing moiety that is coupled to the moiety R by a linker including at least one nucleophilic group. Methods of preparing the substrate and use of the substrate are also disclosed | 08-15-2013 |
20130309746 | BIODEGRADABLE IMMOBILIZED ENZYMES AND METHODS OF MAKING THE SAME - The present application discloses immobilized enzymes and immobilized enzyme materials comprising a crosslinked enzyme having a support material which includes a biomass material different than the biomass used to initially derive the enzyme. Optionally, the immobilized enzyme further includes a polymeric material and/or the biomass which was used to initially derive the enzyme. The resulting immobilized enzyme materials may be biodegradable. The present application also discloses methods of making and using the disclosed immobilized enzyme materials. | 11-21-2013 |
20130316431 | IMMOBILIZED ORGANOPHOSPHATE-DEGRADING ENZYMES AND METHODS OF MAKING THE SAME - The present application discloses immobilized enzymes and immobilized enzyme materials comprising a crosslinked organophosphate-degrading enzyme having a support material which includes a biomass material and/or a polymeric material. The resulting immobilized enzyme materials may be biodegradable. The present application also discloses methods of making and using the disclosed immobilized organophosphate hydrolase enzyme and enzyme materials. | 11-28-2013 |
20130337529 | Cell Culture - A method for determining the effect of a plurality of culture conditions on a cell, comprising the steps of: a) providing a first set of groups of cell units each comprising one or more cells, and exposing said groups to desired culture conditions; (b) pooling two or more of said groups to form at least one second pool; (c) subdividing the second pool to create a further set of groups of cell units; (d) exposing said further groups to desired culture conditions; (e) optionally, repeating steps (b)-(d) iteratively as required; and (f) optionally assessing the effect on a given cell unit of the culture conditions to which it has been exposed. | 12-19-2013 |
20140017761 | SUBSTRATE FOR IMMOBILIZING FUNCTIONAL SUBSTANCES AND METHOD FOR PREPARING THE SAME - A substrate having compounds disposed thereon for immobilizing a functional molecule, each compound having a chain including: a moiety R that is chemically coupled to the substrate, the moiety R being selected from the group consisting of an ether, ester, carbonyl, carbonate ester, thioether, disulfide, sulfinyl, sulfonyl, and carbonothioyl; and an epoxide-containing moiety that is coupled to the moiety R by a linker including at least one nucleophilic group. Methods of preparing the substrate and use of the substrate are also disclosed. | 01-16-2014 |
20150010980 | COMPOSITION FOR EMBEDDED MICROBIAL CULTURE - Disclosed is a composition for embedded three-dimensional microbial culture, the composition including nanofibrillar cellulose and at least one nutrient source. Also disclosed is a method for the manufacture of a composition for embedded three-dimensional microbial culture, the method including the steps of providing nanofibrillar cellulose, mixing the nanofibrillar cellulose with water and at least one nutrient source and optional additives to obtain a mixture, and optionally drying the mixture. | 01-08-2015 |