Class / Patent application number | Description | Number of patent applications / Date published |
435459000 | Involving particle-mediated transfection (i.e., biolistic transfection) | 8 |
20090068745 | COMPOSITIONS AND METHODS FOR PERFORMING REVERSE GENE THERAPY - The invention relates to compositions and methods for reverse gene therapy, wherein a gene therapy vector encoding a gene product (e.g. a protein) which is usually only expressed in cells of an abnormal tissue is delivered to a cell of an animal afflicted with a disease or disorder to alleviate the disease or disorder. In one embodiment, a plasmid vector encoding HERG (A561V) protein is delivered to a cell of an animal afflicted with re-entrant atrial flutter-mediated cardiac arrhythmia. | 03-12-2009 |
20090098653 | Transgenomic Mitochondria, Transmitochondrial Cells and Organisms, and Methods of Making and Using - The invention provides transgenomic mitochondria, transmitochondrial cells and organisms, and the materials and methods for making such mitochondria, cells, and organisms. | 04-16-2009 |
20090130762 | Activation of HCV-specific T cells - The invention provides a method of activating hepatitis C virus (HCV)-specific T cells, including CD4 | 05-21-2009 |
20090233367 | Method of Transferring Substance Into Cell - There is provided a method by which multiple types of substances desired to be transferred into cells can be continuously transferred into multiple types of cells by a convenient procedure, a cell in which the substance desired to be transferred into cells has been taken up by this method, and an apparatus for transferring a substance into cells by this method. The foregoing objects can be achieved by electrospraying cells with a liquid free from the substance to be transferred into cells while the cells are kept in contact with the substance to be transferred into cells, or first electrospraying cells with a liquid free from the substance to be transferred into cells and then bringing the cells into contact with the substance to be transferred into cells. | 09-17-2009 |
20120135526 | LOW-PRESSURE BIOLISTIC BARRELS - Low pressure biolistic barrels and biolistic devices including the same are provided. Aspects of the biolistic barrels include the presence of one or more pressure-reducing elements. Also provided are kits which include the biolistic barrels, as well as methods of delivering a molecule to a target site with the biolistic barrels and devices that include the same. The devices and methods described herein find use in a variety of applications, including in vivo and in vitro high-precision delivery applications. | 05-31-2012 |
20140106456 | APPARATUS FOR INTRODUCING BIOLOGICAL MATERIAL, METHOD OF INTRODUCING BIOLOGICAL MATERIAL AND MAGNETIC SUPPORT FOR INTRODUCING BIOLOGICAL MATERIAL - The invention relates to an apparatus for introducing a biological material, a method of introducing a biological material, and a magnetic support for introducing a biological material with the object of providing an apparatus for introducing a biological material, a method of introducing a biological material, and a magnetic support for introducing a biological material whereby a biological material can be efficiently introduced into a host. | 04-17-2014 |
20140295558 | METHOD AND APPARATUS FOR DELIVERY OF MOLECULES TO CELLS - The present invention is concerned with a system and method for introducing a substance into cells. The system has an assembly including a plurality of elongate non-hollow nanoneedles forming a nanoneedle array or patch for delivering the substance into the cells, at least some of the nanoneedles have a non-uniform diameter with a wider upper end, a narrower lower end for penetration into the cells and a length from substantially 200 nm to 100 um. The lower end has a diameter from substantially 20-436 nm. Adjacent nanoneedles are spaced apart by substantially 5-50 um. The nanoneedles are made from a material selected from the group consisting of diamond, cubic boron nitride, carbon nitride, boron nitride, boron carbon nitride, metal borides and essentially boron materials, allowing the nanoneedles to maintain sufficient thinness and yet adequate rigidity during penetration. The nanoneedles are applied onto the cells grown on substrates at a preferred rate from 1 to 5 m/s. Alternatively, the nanoneedles are applied onto the cells grown on substrates by centrifugation force from 0.5 to 10 nN. Yet alternatively, the cells suspended in a fluid are applied to the nanoneedle array at a rate of 1 to 10 m/s. | 10-02-2014 |
20150315608 | MITOCHONDRIAL EXPRESSION VECTOR AND METHOD FOR THE TRANSFORMATION OF MITOCHONDRIA - The invention relates to a mitochondrial expression vector which may comprise a gene to be expressed and/or a selection marker and a mitochondrial region, and a method for inserting a DNA to be expressed into mitochondria of mammalian cells, wherein the method may comprise the steps: (i) construction of a mitochondrial expression vector or a mitochondrial genome, (ii) reversible induction of megamitochondria and (iii) transfection of the megamitochondria by means of a physical transfection method. | 11-05-2015 |