| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 435113000 | Methionine; cysteine; cystine | 67 |
| 20080274516 | Psod Expression Units - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 11-06-2008 |
| 20080286841 | PGRO EXPRESSION UNITS - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 11-20-2008 |
| 20080311632 | Methods for Producing Methionine by Culturing a Microorganism Modified to Enhance Production of Cysteine - A method of producing methionine, derivatives or precursors thereof comprising culturing a microorganism modified to enhance production of cysteine in a culture medium comprising a source of carbon and a source of sulfur and recovering methionine from the culture medium. A microorganism for fermentative production of methionine or its derivatives in which production of methionine or derivatives thereof, wherein the microorganism enhances production of cysteine. | 12-18-2008 |
| 20090004705 | PSOD Expression Units - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 01-01-2009 |
| 20090029424 | Recombinant enzyme with altered feedback sensitivity - The present invention relates to the use of recombinant homoserine transsuccinylase enzymes with altered feedback sensitivity (MetA*) and possibly recombinant S-adenosyl methionine synthetase enzymes with reduced activity (MetK*) for the production of methionine, its precursors or derivatives thereof. | 01-29-2009 |
| 20090053778 | Microorganisms for producing sulfur-containing compounds - The present invention relates to microorganisms and methods for producing at least one sulfur-containing compound. | 02-26-2009 |
| 20090170170 | P2-10 expression units - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 07-02-2009 |
| 20090246836 | Pgro expression units - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 10-01-2009 |
| 20090291478 | METHOD FOR PRODUCING AN L-AMINO ACID - An L-amino acid is produced by culturing a bacterium of the Enterobacteriaceae family which has an L-amino acid-producing ability in a medium containing fatty acids as the carbon source, particularly fatty acids which have been subjected to emulsification or homogenization, to thereby produce and accumulate the L-amino acid in a culture medium; and collecting the L-amino acid from the culture medium. | 11-26-2009 |
| 20090298135 | Method for fermentative production of L-methionine - A microorganism strain suitable for fermentative production of L-methionine and preparable from a starting strain, which comprises increased activity of a yjeH gene product or of a gene product of a yjeH homolog, compared to the starting strain. | 12-03-2009 |
| 20090298136 | Methionine producing recombinant microorganisms - This invention relates to methionine producing recombinant microorganisms. Specifically, this invention relates to recombinant strains of | 12-03-2009 |
| 20090298137 | MICROORGANISM AND PROCESS FOR THE PREPARATION OF L-METHIONINE - The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented. | 12-03-2009 |
| 20090311756 | Microorganisms with a Reactivation System for cob(I)Alamin-Dependent Methionine Synthase - The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme. | 12-17-2009 |
| 20090325243 | Method for producing amino acids using glycerol - The present invention relates to an amino acid-producing microorganism capable of simultaneously utilizing glycerol as a carbon source, a method for preparing the microorganism, and a method for producing amino acids using the microorganism. According to the present invention, amino acids can be efficiently produced using a byproduct of biodiesel production, glycerol, thereby substituting a cheaper material for the conventional fermentation materials such as glucose. | 12-31-2009 |
| 20090325244 | METHOD OF INCREASING GENE EXPRESSION USING MODIFIED CODON USAGE - The present invention relates to a method of increasing the amount of at least one polypeptide in the host cell by expressing a modified nucleotide sequence encoding for a polypeptide in a host cell with said modified nucleotide sequence being derived from a different non-modified nucleotide sequence encoding for a polypeptide of identical amino acid sequence such that the codon usage of the modified nucleotide sequence is adjusted to the codon usage of abundant proteins in the host cell. | 12-31-2009 |
| 20100003727 | Coryneform Bacteria with Formate-THF-Synthetase and/or Glycine Cleavage Activity - The present invention relates to microorganisms, in particular | 01-07-2010 |
| 20100009416 | Process for the Preparation of L-Methionine - The present invention relates to microorganisms and processes for the efficient preparation of L-methionine. In particular, the present invention relates to processes in which the amount of serine available for the metabolism of the microorganism is increased. | 01-14-2010 |
| 20100035307 | Methionine Synthases with Reduced Product Inhibition - The present invention relates to nulceotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof being modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host cells comprising such nucleotide sequences. Furthermore, the present invention relates to methods for producing methionine in host organisms by making use of such nucleotide sequences. | 02-11-2010 |
| 20100041107 | METHOD OF REDUCING GENE EXPRESSION USING MODIFIED CODON USAGE - The present invention is directed to a method of reducing the amount of at least one polypeptide in a host cell by expressing a nucleotide sequence encoding for the polypeptide in the host cell wherein the nucleotide sequence uses codons that are rarely used according to the codon usage of the host organism. Furthermore, the present invention relates to nucleotide sequences encoding for a polypeptide with a codon usage that has been adjusted to use codons that are only rarely used according to the codon usage of the host organism. The present invention further relates to the use of such sequences and methods for producing fine chemicals such as amino acids, sugars, lipids, oils, carbohydrates, vitamins, cofactors etc. | 02-18-2010 |
| 20100041108 | METHOD FOR PRODUCING L-METHIONINE BY FERMENTATION - The present invention provides a method for producing L-methionine by culturing a microorganism in a medium to produce and accumulate L-methionine in the medium, and collecting the L-methionine from the medium, where the microorganism is deficient in a repressor of L-methionine biosynthesis system and has L-methionine productivity. | 02-18-2010 |
| 20100047879 | PRODUCING METHIONINE WITHOUT N-ACYL-METHIONINE - The present invention relates to a method for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulphur. The microorganism and/or the culture medium and/or the process parameters were modified in a way that the accumulation of the by-product N-acyl-methionine (NAM) is reduced. The isolation of methionine or its derivatives from the fermentation medium is also claimed. | 02-25-2010 |
| 20100047880 | PRODUCTION OF N-ACYLATED SULPHUR-CONTAINING AMINO ACIDS WITH MICROORGANISMS HAVING ENHANCED N-ACYLTRANSFERASE ENZYMATIC ACTIVITY - The present invention claims an isolated polypeptide having L-amino-acid-N-acyl transferase enzymatic activity and a modified microorganism in which this enzyme is overexpressed. Substrates of said enzyme include mainly methionine and their derivatives or analogs. Overexpression in sulphur-containing amino acid producing microorganisms permits the production of large amounts of N-acylated sulphur-containing amino acids. The isolation of the N-acylated sulphur-containing amino acids from the fermentation medium is also claimed. | 02-25-2010 |
| 20100047881 | Microorganisms with Deregulated Vitamin B12 System - The present invention relates to microorganisms with improved efficiency of vitamin B12 utilization. | 02-25-2010 |
| 20100062498 | POLYPEPTIDE BEING CAPABLE OF INCREASING THE PRODUCTION OF L-METHIONINE, A MICROORGANISM THAT OVEREXPRESSES SAID POLYPEPTIDE AND A PROCESS OF PREPARING L-METHIONINE IN HIGH YIELD USING SAME - The present invention relates to a polypeptide capable of increasing the production of L-methionine in a microorganism. In particular, the present invention relates to an YgaZ and YgaH polypeptide or a complex thereof, referred to herein as YgaZH polypeptide, which are novel putative L-methionine exporters, polynucleotides encoding the same, a recombinant vector comprising the polynucleotide, a microorganism transformed with the recombinant vector, and a method for producing L-methionine and/or S-adenosyl-methionine, comprising the steps of culturing the transformed microorganism to produce L-methionine and/or S-adenosyl-methionine, and isolating L-methionine and/or S-adenosyl-methionine. The transformed microorganism of the present invention produces L-methionine in a high yield, thereby being used for medicinal and pharmaceutical industries and feed industry, in particular, animal feeds | 03-11-2010 |
| 20100093045 | L-CYSTEINE PRODUCING MICROORGANISM AND A METHOD FOR PRODUCING L-CYSTEINE - L-cysteine is produced by culturing an | 04-15-2010 |
| 20100159537 | ESCHERICHIA COLI STRAINS THAT OVER-PRODUCE L-THREONINE AND PROCESSES FOR THEIR PRODUCTION - The invention relates to novel bacterial strains and constructs as well as methods for production of L-amino acids, including but not limited to L-threonine. Such novel bacterial strains may be characterized by, for instance, | 06-24-2010 |
| 20100184164 | Microorganism Producing L-Methionine Precursor And Method Of Producing L-Methionine And Organic Acid From The L-Methionine Precursor - The present invention relates to a method for producing L-methionine and organic acid comprising the following steps: Step 1) preparing a strain producing L-methionine precursor and producing L-methionine precursor by the fermentation of the strain; Step 2) producing L-methionine and organic acid by the enzyme reaction process with the L-methionine precursor as a substrate, and microorganism strains used in each step. | 07-22-2010 |
| 20100216196 | L-CYSTEINE-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING L-CYSTEINE - The present invention provides a bacterium belonging to the family Enterobacteriaceae, which is able to produce L-cysteine and has been modified to increase the activity of the protein encoded by the dsbA gene. This bacterium is cultured in a medium, and L-cysteine, L-cystine, a derivative or precursor thereof or a mixture thereof can be collected from the medium. | 08-26-2010 |
| 20100233765 | L-CYSTEINE-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING L-CYSTEINE - The present invention provides a bacterium belonging to the family Enterobacteriaceae, which is able to produce L-cysteine, and has been modified to decrease activity of the YdjN protein, or the activities of the YdjN and the FliY protein. This bacterium is cultured in a medium, and L-cysteine, L-cystine, a derivative or precursor thereof, or a mixture of these can be collected from the medium. | 09-16-2010 |
| 20100248311 | INCREASING METHIONINE YIELD - Process for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulfur. The microorganism and/or the culture medium are modified in such way that the methionine/carbon source yield is increased. The isolation of methionine or its derivates from the fermentation medium is also described. | 09-30-2010 |
| 20110033902 | L-CYSTEINE-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING L-CYSTEINE - L-Cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has L-cysteine-producing ability and has been modified so that the activity of a protein encoded by a tolC gene, for example, a protein defined in the following (a) or (b), is increased in a medium, and by collecting L-cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof from the medium:
| 02-10-2011 |
| 20110117614 | Production Process for Methionine Using Microorganisms with Reduced Isocitrate Dehydrogenase Activity - The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of methionine. | 05-19-2011 |
| 20110183383 | Compositions and Methods of Producing Methionine - Described herein are microorganisms that produce methionine and related products from endogenous genes in a transsulfuration pathway, as well as from exogenous genes providing a direct sulfhydrylation pathway. Novel genes that are useful for methionine and SAMe production are disclosed. | 07-28-2011 |
| 20110207184 | MICROORGANISM PRODUCING L-METHIONINE PRECURSOR AND THE METHOD OF PRODUCING L-METHIONINE PRECURSOR USING THE MICROORGANISM - The present invention relates to a microorganism producing L-methionine precursor, O-acetylhomoserine, and a method of producing L-methionine precursor using the microorganism. | 08-25-2011 |
| 20110318792 | NOVEL METHOD FOR UTILIZATION OF MICROBIAL MUTANT - The object of the present invention is to provide a microbial mutant capable of producing S-adenosylmethionine (hereinafter referred to as SAM) in a large amount with no change in growth characteristics and a method of efficiently producing SAM by incubating the microbial mutant. | 12-29-2011 |
| 20120190080 | O-PHOSPHOSERINE SULFHYDRYLASE MUTANTS AND METHOD FOR PRODUCTION OF CYSTEINE USING THE SAME - Disclosed is an O-phosphoserine sulfhydrylase (OPSS) mutant which has a | 07-26-2012 |
| 20120190081 | MICROORGANISM PRODUCING O-PHOSPHOSERINE AND METHOD OF PRODUCING L-CYSTEINE OR DERIVATIVES THEREOF FROM O-PHOSPHOSERINE USING THE SAME - The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein. | 07-26-2012 |
| 20120190082 | MICROORGANISM PRODUCING O-PHOSPHOSERINE AND METHOD OF PRODUCING L-CYSTEINE OR DERIVATIVES THEREOF FROM O-PHOSPHOSERINE USING THE SAME - The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein. | 07-26-2012 |
| 20120190083 | MICROORGANISM PRODUCING O-PHOSPHOSERINE AND METHOD OF PRODUCING L-CYSTEINE OR DERIVATIVES THEREOF FROM O-PHOSPHOSERINE USING THE SAME - The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and the activity of PhnC, PhnD, and PhnE is reduced, and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having these reduced and enhanced properties noted above are also provided herein. | 07-26-2012 |
| 20120190084 | Process for the Fermentative Preparation of Sulphur-Containing Amino Acids - Disclosed herein is a process for the fermentative preparation of sulphur-containing amino acids chosen from the group of L-methionine, L-cysteine, L-cystine, L-homocysteine and L-homocystine, comprising the steps: a) provision of a microorganism of the family Enterobacteriaceae or of a microorganism of the family Corynebacteriaceae which has an increased thiosulphate sulphurtransferase activity compared with the particular starting strain; b) fermentation of the microorganism from a) in a medium which contains an inorganic source of sulphur chosen from the group of salt of dithiosulphuric acid or a mixture of a salt of dithiosulphuric acid and a salt of sulphuric acid, a fermentation broth being obtained, and c) concentration of the sulphur-containing amino acid in the fermentation broth from b). | 07-26-2012 |
| 20120231511 | PREPARATION METHOD FOR BIO-FUEL MATERIALS AND BIO-CHEMICALS - Disclosed is a preparation method for bio-fuel materials and bio-chemicals comprising the following steps: preparing a medium comprising fermentation waste generated in an alcohol production process; inoculating a first microorganism into the medium; and culturing the medium wherein the first microorganism was inoculated. More specifically, the preparation method for bio-fuel materials and bio-chemicals comprises the following steps: fermenting hexoses from a mixture of pentoses and hexoses to produce an ethanol fermentation broth; separating and purifying the ethanol fermentation broth; preparing a medium comprising the fermentation waste produced in the separation and purification step; inoculating a first microorganism into the medium; and culturing the medium wherein the first microorganism was inoculated. | 09-13-2012 |
| 20120237986 | METHOD FOR PRODUCING AN L-CYSTEINE, L-CYSTINE, A DERIVATIVE OR PRECURSOR THEREOF OR A MIXTURE THEREOF USING A BACTERIUM OF ENTEROBACTERIACEAE FAMILY - The present invention provides a method for producing L-cysteine, L-cystine, a derivative or precursor thereof or a mixture thereof using a bacterium of Enterobacteriaceae family which has been modified to have enhanced expression of the genes involved in the process of sulphur assimilation. | 09-20-2012 |
| 20120252076 | METHOD FOR PRODUCING L-CYSTEINE - A method for producing L-cysteine and the like is provided by developing a novel technique for improving bacterial L-cysteine-producing ability. The method includes the steps of culturing a bacterium belonging to the genus | 10-04-2012 |
| 20120252077 | USE OF INDUCIBLE PROMOTERS IN THE PRODUCTION OF METHIONINE - The present invention relates to use of inducible promoters in the production of methionine by fermentation. The present invention concerns a method for the production of methionine, its precursors or derivatives in a fermentative process comprising the following steps:
| 10-04-2012 |
| 20120288901 | Method of Producing Methionine in Corynebacteria by Over-Expressing Enzymes of the Pentose Phosphate Pathway - The present invention relates to a method of producing methionine in Coryneform bacteria in which enzymes of the pentose phosphate pathway are over-expressed. The present invention also relates to Coryneform bacteria for producing methionine in which at least two enzymes of the pentose phosphate pathway are over-expressed. | 11-15-2012 |
| 20120288902 | L-CYSTEINE-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING L-CYSTEINE - An L-cysteine-producing bacterium is provided, as well as a method for producing L-cysteine etc. using the bacterium by developing a novel technique for improving L-cysteine-producing ability of a bacterium. By culturing a bacterium belonging to the family Enterobacteriaceae, which has L-cysteine-producing ability and is modified so that activity of a protein encoded by the yciW gene, for example, a protein defined by the following (A) or (B), is reduced, in a medium, and collecting L-cysteine, L-cystine, a derivative thereof, or a mixture thereof from the medium, these compounds are produced: (A) a protein having the amino acid sequence shown in SEQ ID NO: 2, (B) a protein having the amino acid sequence shown in SEQ ID NO: 2, but which includes substitution, deletion, insertion, or addition of one or several amino acid residues, reduction of which activity in the bacterium results in improvement in the L-cysteine-producing ability. | 11-15-2012 |
| 20120288903 | INCREASING METHIONINE PRODUCTION BY OVEREXPRESSING SUCCINATE DEHYDROGENASE - The present invention relates to a process for improving the production of methionine by culturing a microorganism modified for enhancing the expression of genes involved in succinate dehydrogenase synthesis. The microorganisms were modified in a way that the methionine/carbon source yield is increased. The isolation of methionine from the fermentation medium is also claimed. | 11-15-2012 |
| 20120288904 | STRAINS AND METHOD FOR THE PRODUCTION OF METHIONINE - The present invention relates to a method for the production of methionine using modified strains with attenuated transformation of threonine. This can be achieved by reducing threonine transformation into glycine, and/or by reducing its transformation to α-ketobutyrate. The invention also concerns the modified strains with attenuated transformation of threonine. | 11-15-2012 |
| 20120295315 | Nucleic acid encoding a cobalamin-dependent methionine synthase polypeptide - The present invention relates to nulceotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof being modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host cells comprising such nucleotide sequences. Furthermore, the present invention relates to methods for producing methionine in host organisms by making use of such nucleotide sequences. | 11-22-2012 |
| 20130122556 | PROCESS FOR PRODUCING SULFUR-CONTAINING alpha- AMINO ACID COMPOUND - The present invention provides a novel process for producing a sulfur-containing α-amino acid compounds such as methionine. A process for producing a sulfur-containing α-amino acid compound (Compound 2) comprising a step of reacting a specific sulfur-containing amino alcohol compound (Compound 1) with the following transformants and others: (a) both a transformant in which has been introduced into a microorganism cell a gene of an enzyme capable of converting the Compound 1 into a corresponding sulfur-containing α-amino aldehyde compound (Compound 3) (Capability A) and a transformant in which has been introduced into a microorganism cell a gene of an enzyme capable of converting the Compound 3 into a corresponding Compound 2, (b) a transformant in which has been introduced into a microorganism cell both a gene of an enzyme which has Capability A and a gene of an enzyme which has Capability B, or (c) a transformant in which has been introduced into a microorganism cell a gene of an enzyme which has both Capability A and Capability B. | 05-16-2013 |
| 20130137148 | PROCESS FOR PRODUCING SULFUR-CONTAINING ALPHA-AMINO ACID COMPOUND - The present invention provides a novel process for producing a sulfur-containing α-amino acid compound such as methionine. A process for producing a sulfur-containing α-amino acid compound represented by the formula (2): wherein R | 05-30-2013 |
| 20130143279 | PROCESS FOR PRODUCING METHIONINE - The present invention relates to a process for producing methionine, comprising a first step of reacting 2-amino-3-buten-1-ol with methanethiol, and a second step of oxidizing 2-amino-4-methylthio-1-butanol obtained in the first step. The present invention also relates to a process for producing 2-amino-4-methylthio-1-butanol, comprising a step of reacting 2-amino-3-buten-1-ol with methanethiol. | 06-06-2013 |
| 20130164793 | SULFUR-CONTAINING AMINO ACID-PRODUCING BACTERIUM AND METHOD FOR PRODUCING SULFUR-CONTAINING AMINO ACID - A novel technique for improving the production by bacteria of amino acids that contain sulfur has been developed, and thereby a sulfur-containing amino acid-producing bacterium, and a method for producing a compound such as a sulfur-containing amino acid are provided. A sulfur-containing amino acid, a related substance thereof, or a mixture of these can be produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has a sulfur-containing amino acid-producing ability and has been modified so that the activity of the protein encoded by the yeeE gene, for example, the protein of the following (A) or (B), is increased in a medium, and collecting a sulfur-containing amino acid, a related substance thereof, or a mixture of them from the medium: (A) a protein having the amino acid sequence of SEQ ID NO: 14, (B) a protein having the amino acid sequence of SEQ ID NO: 14 but which includes one or several amino acid substitutions, deletions, insertions, or additions, and when the intracellular activity of this protein is increased, the ability of the bacterium to produce a sulfur-containing amino acid is improved. | 06-27-2013 |
| 20130183726 | METHODS FOR PRODUCING METHIONINE BY CULTURING A MICROORGANISM MODIFIED TO ENHANCE PRODUCTION OF CYSTEINE - A method of producing methionine, derivatives or precursors thereof includes culturing a modified microorganism in a culture medium comprising a source of carbon and a source of sulfur; and recovering methionine from the culture medium, wherein said modified microorganism has an increased expression of cysE gene encoding serine acetyltransferase, metH gene encoding methionine synthase and metF gene encoding 5,10-methylenetetrahydrofolate reductase compared to expression of the cysE, metH and metF genes in an unmodified microorganism. | 07-18-2013 |
| 20130183727 | INCREASING NADPH AVAILABILITY FOR METHIONINE PRODUCTION - The present invention is related to a microorganism for the production of methionine, wherein said microorganism is modified to enhance the transhydrogenase activity of PntAB. In a preferred aspect of the invention, the activity of the transhydrogenase UdhA is attenuated in said microorganisms. The invention also related to a method for producing methionine by fermentation. | 07-18-2013 |
| 20130260424 | Compositions and Methods of Producing Methionine - Described herein are microorganisms that produce methionine and related products from endogenous genes in a transsulfuration pathway, as well as from exogenous genes providing a direct sulfhydrylation pathway. Novel genes that are useful for methionine and SAMe production are disclosed. | 10-03-2013 |
| 20130273614 | NOVEL O-ACETYLHOMOSERINE SULFHYDRYLASE OR MUTANT PROTEIN THEREOF, AND METHOD FOR CONVERTING TO METHIONINE USING THE SAME - The present invention relates to a novel protein having O-acetylhomoserine sulfhydrylase activity, a mutant protein thereof, a polynucleotide encoding the same, a recombinant vector comprising the polynucleotide, a microorganism transformed with the recombinant vector, and a method for producing methionine or acetic acid using the protein. The production method of the present invention has the advantage of producing L-methionine and acetic acid cost-effectively through having higher conversion rate and reduced reaction time compared to the existing methods, and it can minimize the amount of enzyme homogenate added when using the mutant protein, thereby easily producing L-methionine and acetic acid at high yield. | 10-17-2013 |
| 20140080186 | METHOD FOR PRODUCING L-CYSTINE BY FERMENTATION UNDER CONTROLLED OXYGEN SATURATION - The invention relates to a method for producing L-cystine by fermenting a microorganism strain in a fermentation medium, in which method L-cystine is precipitated in an amount of at least 70% relative to the total cysteine, characterized in that the O | 03-20-2014 |
| 20140134680 | MICROORGANISM FOR METHIONINE PRODUCTION WITH ENHANCED GLUCOSE IMPORT - The present invention is related to a recombinant microorganism for improved methionine production comprising modifications to produce methionine from glucose as main carbon source by fermentation, and modifications to improve glucose import, wherein the glucose import is improved by modifying the expression of at least one gene selected from ptsG, sgrT sgrS and dgsA. | 05-15-2014 |
| 20140141474 | METHOD FOR PRODUCTION OF NATURAL L-CYSTEINE BY FERMENTATION - A method for the production of natural L-cysteine by fermentation in a production fermenter in which a microorganism strain is cultured in a fermentation medium, characterized in that the fraction of the compounds L-cysteine, L-cystine and thiazolidine in the fermentation medium is controlled in a targeted manner by an iron concentration of a maximum of 8 mg/l in the fermentation medium. | 05-22-2014 |
| 20150322469 | Process For The Fermentative Preparation Of Sulphur-Containing Amino Acids - The invention relates to a process for the fermentative preparation of sulphur-containing amino acids chosen from the group of L-methionine, L-cysteine, L-cystine, L-homocysteine and L-homocystine, comprising the steps:
| 11-12-2015 |
| 20150337346 | ASPARAGINIC ACID KINASE III MUTANT AND HOST CELLS AND USE THEREOF - Provided in the present invention is an asparaginic acid kinase, and the 340 | 11-26-2015 |
| 20160024541 | Compositions and Methods of Producing Methionine - Described herein are microorganisms that produce methionine and related products from endogenous genes in a transsulfuration pathway, as well as from exogenous genes providing a direct sulfhydrylation pathway. Novel genes that are useful for methionine and SAMe production are disclosed. | 01-28-2016 |
| 20160115507 | NOVEL O-PHOSPHOSERINE EXPORT PROTEIN AND THE METHOD OF PRODUCING O-PHOSPHOSERINE USING THE SAME - The present invention relates to a novel isolated polypeptide having the ability to export O-phosphoserine (OPS) that is a precursor of L-cysteine, a vector comprising the polynucleotide, an OPS-producing microorganism having enhanced activity of the polypeptide, a method of producing OPS using the microorganism, and a method for preparing cysteine or its derivatives, which comprises reacting OPS, produced by the above method, with a sulfide in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism that expresses OPSS. | 04-28-2016 |
| 20160160249 | INCREASING METHIONINE YIELD - Process for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulfur. The microorganism and/or the culture medium are modified in such way that the methionine/carbon source yield is increased. The isolation of methionine or its derivates from the fermentation medium is also described. | 06-09-2016 |
| 20160177351 | MICROORGANISM FOR METHIONINE PRODUCTION WITH ENHANCED METHIONINE EFFLUX | 06-23-2016 |
| 20160177352 | MICROORGANISM FOR METHIONINE PRODUCTION WITH IMPROVED METHIONINE SYNTHASE ACTIVITY AND METHIONINE EFFLUX | 06-23-2016 |
