| Entries |
| Document | Title | Date |
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| 20080199914 | Modified Alginates, Methods of Production and Use - Process for preparing a modified alginate polymers are disclosed. The processes comprise the steps of covalently attaching a modifying moiety to one or more unmodified monomeric subunits of an alginate polymer; and changing one or more unmodified mannuronic (M) monomeric subunits of the alginate polymer to one or more unmodified guluronic (G) monomeric sub-units by an enzymatic epimerization reaction performed in any order. Processes for preparing alginate gels, fiber, and compositions are also disclosed. Modified alginates in which only M monomeric subunits are modified, and alginate gels, fibers and compositions comprising the same, are disclosed. | 08-21-2008 |
| 20090023188 | Heparin/heparosan synthase from P. multocida and methods of making and using same - The presently claimed and disclosed invention relates, in general, to dual action heparin synthases and, more particularly, to dual action heparin synthases obtained from | 01-22-2009 |
| 20090155851 | NOVEL PROCESS FOR PREPARATION OF CHONDROITIN FRACTION - Provided are a method for producing a fraction containing more than 50% of CH represented by the general formula (1), which comprises at least the step of allowing a glucuronic acid donor, an N-acetylgalactosamine donor, a saccharide receptor, a chondroitin polymerase derived from the | 06-18-2009 |
| 20090155852 | Hyaluronan synthase genes and expression thereof in bacillus hosts - The present invention relates to a recombinant | 06-18-2009 |
| 20090246832 | PRODUCTION OF POLYSIALIC ACID CONTAINING GLYCOCONJUGATES USING A SELF-PRIMING POLYSIALYLTRANSFERASE - The invention relates to a fusion protein comprising a bifunctional sialytransferase and a poly-sialytransferase and methods to use the fusion proteins for production of poly-sialylated end products, e.g. oligosaccharides and glycoproteins. | 10-01-2009 |
| 20090305357 | CHONDROITIN POLYMERASE AND DNA ENCODING THE SAME - A chondroitin polymerase having such properties that it transfers GlcUA and GalNAc alternately to a non-reduced terminal of a sugar chain from a GlcUA donor and a GalNAc donor, respectively, and the like; and a process for producing the chondroitin polymerase. | 12-10-2009 |
| 20100086974 | HIGHLY PURE POLYSIALIC ACID AND PROCESS FOR PREPERATION THEREOF - The instant invention provides highly pure Polysialic acid and process for preparation thereof. | 04-08-2010 |
| 20100136630 | PRODUCTION OF LOW MOLECULAR WEIGHT HYALURONIC ACID - The present invention relates to methods for producing a hyaluronic acid with a desired average molecular weight in the range of 20,000-800,000 Dalton, the methods comprising the steps of:
| 06-03-2010 |
| 20110027831 | PRODUCTION OF SIALYLATED N-GLYCANS IN LOWER EUKARYOTES - The present invention relates to eukaryotic host cells which have been modified to produce sialylated glycoproteins by the heterologous expression of a set of glycosyltransferases, including sialyltransferase and/or trans-sialidase, to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. Novel eukaryotic host cells expressing a CMP-sialic acid biosynthetic pathway for the production of sialylated glycoproteins are also provided. The invention provides nucleic acid molecules and combinatorial libraries which can be used to successfully target and express mammalian enzymatic activities (such as those involved in sialylation) to intracellular compartments in a eukaryotic host cell. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. | 02-03-2011 |
| 20110059489 | METHOD FOR FERMENTATIVE PRODUCTION OF N-ACETYL-D-GLUCOSAMINE BY MICROORGANISM - N-Acetyl-D-glucosamine can be produced by cultivating a fungus capable of producing N-acetyl-D-glucosamine, such as | 03-10-2011 |
| 20110207178 | METHOD FOR PRODUCING HYALURONIC ACID - It is intended to provide a simple method for producing hyaluronic acid at a high yield. Further, it is also intended to provide a method for producing hyaluronic acid in a short period of time. The invention provides a method for producing hyaluronic acid including a step of culturing a microorganism having the capability to produce hyaluronic acid and a step of adding glutamine and arginine to a culture medium during late logarithmic growth phase of the microorganism. | 08-25-2011 |
| 20110244520 | Compositions and Methods for Bacterial Production of Chondroitin - The invention relates to the field of recombinant DNA technology for the production of chondroitin, including the production of chondroitin sulfate via a combination of recombinant bacterial fermentation and post-fermentation sulfation. | 10-06-2011 |
| 20110250647 | Corynebacterium Genus Microorganism Having Ability to Produce N-Acetyl Glucosamine and Method for Producing N-Acetyl Glucosamine or Glucosamine Using the Same - The present invention relates to a microorganism of the | 10-13-2011 |
| 20110262972 | Chondroitin Synthase, Method for Producing the Same and Method for Producing Saccharide Chain-Extended Chondroitin - A vector of the present invention has DNA encoding a protein or a product having the same effect as the protein, the protein containing an amino acid sequence from amino acid numbers 47 to 802 in SEQ. ID. NO:2. Expression of the DNA gives human chondroitin synthase. By using human chondroitin synthase, it is possible to produce a saccharide chain having a repeating disaccharide unit of chondroitin. The DNA or part thereof may be used as a probe for hybridization for the human chondroitin synthase. | 10-27-2011 |
| 20110287487 | HYALURONAN SYNTHASE GENES AND EXPRESSION THEREOF IN BACILLUS HOSTS - The present invention relates to a recombinant | 11-24-2011 |
| 20120009627 | PROCESS AND MATERIALS FOR PRODUCTION OF GLUCOSAMINE AND N-ACETYLGLUCOSAMINE - A biosynthetic method for producing glucosamine and N-acetylglucosamine is disclosed. Such a method includes the fermentation of a genetically modified microorganism to produce glucosamine and/or N-acetylglucosamine. Also disclosed are genetically modified microorganisms that are useful for producing glucosamine and N-acetylglucosamine. In addition, methods of recovering N-acetylglucosamine that has been produced by a fermentation process, including methods that result in N-acetylglucosamine of high purity, are described. Also disclosed is a method to produce glucosamine from N-acetylglucosamine. | 01-12-2012 |
| 20120028309 | Method for producing indole derivative - The present invention provides a method for in vitro producing an indole derivative in a one-pot reaction. The method for producing a rhamnosylated indolocarbazole compound includes the steps of transforming a plasmid carrying a gene encoding N-glycosyltransferase into a bacterial strain; expressing the gene encoding N-glycosyltransferase in the bacterial strain; lysing the bacterial strain to obtain a crude enzyme extract; and adding TDP-glucose, an indolocarbazole aglycone and a metal ion in the crude enzyme extract for performing an enzymatic reaction to form the rhamnosylated indolocarbazole compound. Alternatively, the method for producing an indole-3-carboxaldehyde analog includes the steps of transforming a plasmid carrying a gene encoding NokA of | 02-02-2012 |
| 20120064575 | CHEMO-ENZYMATIC APPROACH TO THE SYNTHESIS OF PIMECROLIMUS - Processes for preparing pimecrolimus starting from ascomycin, exploiting the selectivity characteristics of the purified enzymatic systems particularly regarding the selective functionalization of the hydroxyl groups present in position 24 and 33 of ascomycin. Such method represents the first example of chemoenzymatic synthesis for preparing pimecrolimus. | 03-15-2012 |
| 20120135470 | BIOTECHNOLOGICAL PRODUCTION OF CHONDROITIN - An innovative method is described for the production of chondroitin at high concentration, by fermentation of genetically mutated bacteria. | 05-31-2012 |
| 20120142058 | Conversion of Chitin into N-Acetylglucosamine, Glucosamine and Bioethanol - Compositions and methods are provided for converting chitin into N-acetylglucosamine, glucosamine and ethanol. The chitin may be used directly from the environment, for example, as occurs in invertebrate cuticles, fungal cells and/or algae. Mutant bacteria were created by knocking out or inactivating one or more genes preferably resulting in the chitin catabolic sensor maintaining an activated state. Methods are further provided for converting the N-acetylglucosamine into ethanol by means of a genetically engineered yeast strain which can be optionally co-cultivated with the Vibrionaceae to produce significant yields of ethanol. | 06-07-2012 |
| 20120149066 | Method for Producing Glucosamine by Culturing Microorganism with Low-cost Medium - A method for producing glucosamine with microorganism comprises of fermenting with a microorganism selected from the group consisting of | 06-14-2012 |
| 20130004995 | BETA 1,3-N-ACETYL-D-GALACTOSAMINE TRANSFERASE PROTEIN, NUCLEIC ACID ENCODING THE SAME AND METHOD OF EXAMINING CANCERATION USING THE SAME - The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with β1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them. | 01-03-2013 |
| 20130034878 | Chondroitin Synthase, Method for Producing The Same and Method for Producing Saccharide Chain-Extended Chondroitin - A vector of the present invention has DNA encoding a protein or a product having the same effect as the protein, the protein containing an amino acid sequence from amino acid numbers 47 to 802 in SEQ. ID. NO:2. Expression of the DNA gives human chondroitin synthase. By using human chondroitin synthase, it is possible to produce a saccharide chain having a repeating disaccharide unit of chondroitin. The DNA or part thereof may be used as a probe for hybridization for the human chondroitin synthase. | 02-07-2013 |
| 20130171696 | SYNTHESIS OF NEW SIALOOLIGOSACCHARIDE DERIVATIVES - The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an α-sialyl moiety and the other is H, X | 07-04-2013 |
| 20130189740 | PROCESS FOR THE PRODUCTION OF HYALURONIC ACID IN ESCHERICHIA COLI OR BACILLUS SUBTILIS - The present invention relates to a method for the production of hyaluronic acid (HA) in | 07-25-2013 |
| 20130196381 | CELL-BASED PRODUCTION OF NANULOSONATES - The present invention relates to the cell-based production of bacterial nonulosonates and their biosynthetic precursors. Specifically, the present invention provides recombinant cells for the production of pseudaminic acid, legionaminic acid, UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose, and UDP-2,4-diacetamido-2,4,6-trideoxy-α-D-glucopyranose. Methods for producing the sugars are also provided. | 08-01-2013 |
| 20130210077 | CSNR-DEFICIENT ACTINOBACTERIA FOR THE PRODUCTION OF AN ENZYME HAVING CHITOSANASE ACTIVITY - The present invention relates to genetically modified actinobacteria for the production of an enzyme having chitosanase activity. The genetically modified actinobacteria have a reduced (or abolished) activity of the CsnR polypeptide. Such reduced activity can be obtained by reducing the capacity of expressing the csnR gene, its corresponding transcript or expressing a dominant-negative CsnR polypeptide. Such genetically modified actinobacteria are less dependent (and, in some embodiment, totally independent) on the presence of chitosan in the culture medium for producing an enzyme having chitosanase activity. In addition, the genetically modified bacteria produce less proteases in the culture medium and ultimately provide a chitosanase end-product with higher purity. | 08-15-2013 |
| 20130266987 | METHOD AND AGENTS FOR PRODUCING N-ACETYLNEURAMINIC ACID (NEUNAC) - The invention relates to an isolated nucleic acid molecule comprising at least one promoter that is active in fungal cells of the | 10-10-2013 |
| 20130302855 | GENOMICS OF ACTINOPLANES UTAHENSIS - The present invention describes the DNA-sequence of the wild type genome as well as all genetic modifications which were introduced into the wild type-and further developed strains, based thereon. Thereby the first genotypic characterization of the developed strains, including the latest production strain, has been accomplished, accounting for the major part of the invention. Furthermore, on the basis of the determined DNA-sequences, potential genes were identified and account, combined with their functional annotation, for another part of the invention. In particular, the gene-and DNA-sequences, as well as protein-sequences derived there out, contribute to the invention which were affected by mutagenic modifications throughout the strain development process, potentially contributing to the increased production yield. | 11-14-2013 |
| 20140038235 | Methods For Producing Hyaluronan In A Recombinant Host Cell - The present invention relates to methods for producing a hyaluronic acid, comprising: (a) cultivating a | 02-06-2014 |
| 20140045218 | HYDROPHILIC MODIFICATION OF WATER INSOLUBLE POLYSACCHARIDE AS SURFACE-ACTIVE AGENTS - A surfactant produced by reacting naturally occurring polysaccharides that are not water soluble with a hydrophilic substituent on a carboxylic portion of the polysaccharide. In a second reaction, the surfactant is further substituted on a hydroxylic portion with a hydrophobic or lipophilic substituent, so as to make the reaction product both water soluble and capable of attracting oily material that is hydrophobic to be removed from a substrate by cleaning in water. Methods of making the surfactant and the follow-on reaction product are described. | 02-13-2014 |
| 20140099673 | PROCESS FOR THE PRODUCTION OF HYALURONIC ACID IN ESCHERICHIA COLI OR BACILLUS MEGATERIUM - The present invention relates to a method of producing hyaluronic acid (HA) in | 04-10-2014 |
| 20140120584 | PROCESS FOR THE CO-PRODUCTION OF CHITIN, ITS DERIVATIVES AND POLYMERS CONTAINING GLUCOSE, MANNOSE AND/OR GALACTOSE, BY THE FERMENTATION OF THE YEAST PICHIA PASTORIS - This invention concerns a process for the co-production of glucosamine polymers (chitin, chitosan or any of its derivatives) and polymers containing glucose, mannose and/or galactose, by the high cell density fermentation of the yeast | 05-01-2014 |
| 20140147891 | MUTANT ENDOGLYCOCERAMIDASES WITH ENHANCED SYNTHETIC ACTIVITY - The present invention relates to a novel endoglycoceramidase whose hydrolytic activity has been substantially reduced or eliminated, such that the enzyme is useful for synthesis of glycolipids from a monosaccharide or oligosaccharide and a ceramide. More specifically, the endoglycoceramidase is a mutant version of a naturally occurring endoglycoceramidase, preferably comprising a mutation within the active site or the nucleophilic site of the enzyme and more preferably comprising a substitution mutation of the Glu residue within the active site or the nucleophilic site. Also disclosed are a method for generating the mutant endoglycoceramidase and a method for enzymatically synthesizing glycolipids using this mutant enzyme. | 05-29-2014 |
| 20140206040 | STREPTOCOCCUS DYSGALACTIAE ID9103 AND METHOD FOR PRODUCTION OF HYALURONIC ACID USING THE SAME - Provided is a | 07-24-2014 |
| 20140349346 | NEW ACTINOMYCETE INTEGRATIVE AND CONJUGATIVE ELEMENT FROM ACTINOPLANES SP. SE50/110 AS PLASMID FOR GENETIC TRANSFORMATION OF RELATED ACTINOBACTERIA - The present invention is directed to an innate DNA sequence within the complete genome sequence of | 11-27-2014 |
| 20140349347 | SYNTHESIS OF N-ACETYL-D-NEURAMINIC ACID - Method of making NANA from NAM, which may itself be made from fructose. The NAM is treated with pyruvic acid or a pyruvate in the presence of a NANA aldolase having at least 70% sequence similarity or homology to the amino acid sequence of SEQ. ID. NO. 1. | 11-27-2014 |
| 20150010949 | CARBOHYDRATE BASED BINDER SYSTEM AND METHOD OF ITS PRODUCTION - The present invention relates to an aqueous carbohydrate based binder composition, comprising a carbohydrate component and an amine component, wherein the carbohydrate component comprises one or more pentose sugars, as well as to a method of its production. | 01-08-2015 |
| 20150031085 | Novel Leech Hyaluronidase and Its Application - The present invention provides a novel leech HAase and a method of producing low-molecular-weight HA oligosaccharides using the leech HAase. This invention successfully cloned the first leech HAase gene and provides a method for high-level expression of the leech HAase gene. By controlling the incubation condition, different HA oligosaccharides, particularly HA4, HA6, HA8 and HA10, can be selectively generated using the leech HAase. The large-scale expression of the leech HAase and the enzymatic production of specific HA oligosaccharides are not only useful for the cosmetic, healthcare and the medical industries but also can be a great help to polysaccharides chemical synthesis and cancer research. | 01-29-2015 |
| 20150111255 | PROCESS FOR MAKING CHITIN DERIVATIVES - Disclosed is a process comprising (1) forming an aqueous mixture comprising a microbial composition and solid chitin, wherein said microbial composition comprises one or more microbes that produce chitin digesting enzymes; and (2) fermenting the mixture for a time sufficient to enzymatically digest all or part of the chitin to form a fermented mixture comprising chitosan and glucosamine. In some embodiments, the chitin is derived from the biodegradation of chitin containing marine Arthropods. In other embodiments, the chitin is obtained from chitin containing fungi, filamentous fungi and yeast which is extracted via a chemical process. In yet another embodiment, the chitin is obtained by the biodegradation of chitin containing fungi, filamentous fungi, yeast and/or insects, preferably using HQE for the digestion. In some embodiments, the process is carried out with a solution that already contains chitosan and/or glucosamine such as HYTb, the aqueous fraction obtained from the biodegradation of chitin containing organisms. | 04-23-2015 |
| 20150344926 | Enzyme Hyaluronan-Lyase, Method of Production Thereof, Use Thereof and Method of Preparation of Low-Molecular Hyaluronan - The invention relates to an enzyme which is able to degrade hyaluronic acid and which is produced by fungi of the genus | 12-03-2015 |
| 20160032342 | Mutant Endoglycoceramidases with Enhanced Synthetic Activity - The present invention relates to a novel endoglycoceramidase whose hydrolytic activity has been substantially reduced or eliminated, such that the enzyme is useful for synthesis of glycolipids from a monosaccharide or oligosaccharide and a ceramide. More specifically, the endoglycoceramidase is a mutant version of a naturally occurring endoglycoceramidase, preferably comprising a mutation within the active site or the nucleophilic site of the enzyme and more preferably comprising a substitution mutation of the Glu residue within the active site or the nucleophilic site. Also disclosed are a method for generating the mutant endoglycoceramidase and a method for enzymatically synthesizing glycolipids using this mutant enzyme. | 02-04-2016 |
| 20160130622 | ACTINOMYCETE INTEGRATIVE AND CONJUGATIVE ELEMENT FROM ACTINOPLANES SP. SE50/110 AS PLASMID FOR GENETIC TRANSFORMATION OF RELATED ACTINOBACTERIA - The present invention is directed to an innate DNA sequence within the complete genome sequence of | 05-12-2016 |
| 20160145664 | SYNTHESIS OF SIALIC ACID IN PLANTS - A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase. | 05-26-2016 |
