| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 435690500 | Lymphokines or monokines | 36 |
| 20110177556 | Nucleic Acids Encoding Chimeric CD154 Polypeptides - The present invention provides for an isolated polynucleotide sequence encoding a chimeric CD154, comprising a first nucleotide sequence encoding an extracellular subdomain of non-human CD154, preferably murine CD154, that replaces a cleavage site of human CD154, and a second nucleotide sequence encoding an extracellular subdomain of human CD154 that binds to a human CD154 receptor. The present invention also provides for the chimeric CD154 that is encoded by the above-described polynucleotide sequence, an expression vector and a genetic vector comprising the polynucleotide sequence, a host cell comprising the expression vector or the genetic vector, a process for producing the chimeric CD154, and methods for utilizing the expression vectors and genetic constructs containing the chimeric CD154 polynucleotide sequences. | 07-21-2011 |
| 435690510 | Interferons | 17 |
| 20090011465 | INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES - The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids. | 01-08-2009 |
| 20090017500 | INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES - The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids. | 01-15-2009 |
| 20090017501 | INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES - The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids. | 01-15-2009 |
| 20090017502 | INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES - The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids. | 01-15-2009 |
| 20090042252 | INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES - The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids. | 02-12-2009 |
| 20090123974 | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules - Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines. | 05-14-2009 |
| 20090170165 | METHOD FOR RECOMBINANT PRODUCTION IN CHO CELLS - We describe a | 07-02-2009 |
| 20090253179 | Mammalian Cell Lines for Increasing Longevity and Protein Yield from a Cell Culture - Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene, can survive longer in culture, resulting in extension of the state and yield of protein biosynthesis. Such transfected cells exhibit maximal cell densities that equal or exceed the maximal density achieved by the parent cell lines. Transfected cells can also be pre-adapted for growth in serum-free medium, greatly decreasing the time required to obtain protein production in serum-free medium. In certain methods, the pre-adapted cells can be used for protein production following transformation under serum-free conditions. The method preferably involves eukaryotic cells, more preferably mammalian cells. | 10-08-2009 |
| 20090258394 | METHOD FOR THE PRODUCTION OF HIGH-LEVEL SOLUBLE HUMAN RECOMBINANT INTERFERON ALPHA IN E. COLI AND VECTORS USEFUL FOR SUCH A PRODUCTION - A method for the production of high-level soluble human recombinant interferon alpha protein (rhuIFNα) in | 10-15-2009 |
| 20100003721 | HUMAN INTERFERON-BETA MUTEIN - The present invention relates to a human interferon-beta mutein. In particular, the present invention relates to the human interferon-beta mutein having one or two additional sugar chains compared to natural human interferon-beta. | 01-07-2010 |
| 20100028951 | PRODUCTION OF GLYCOPROTEINS WITH MODIFIED FUCOSYLATION - Methods are disclosed for genetically engineering host cells that lack an endogenous pathway for fucosylating N-glycans of glycoproteins to be able to produce glycoproteins with fucosylated N-glycans. | 02-04-2010 |
| 20110151515 | PRODUCTION OF FC-FUSION POLYPEPTIDES IN EUKARYOTIC ALGAE - Methods and compositions are disclosed to engineer plastids comprising heterologous genes encoding immuno-activating domains fused to an extracellular domain (ECD) of a receptor or surface glycoprotein, a growth factor or an enzyme and produced within a subcellular organelle, such as a chloroplast. The immuno-activating domains may include those regions of a protein capable of modulating the interaction between immune effector cells via proteins containing stereoselective binding domains and specific ligands, such as the Fc regions of antibodies. The present disclosure also demonstrates the utility of plants, including green algae, for the production of complex multi-domain fusion proteins as soluble bioactive therapeutic agents. | 06-23-2011 |
| 20120064573 | METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES - The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins. | 03-15-2012 |
| 20120301922 | NOVEL P. PASTORIS PASTORIS PROMOTERS, AND THE USE THEREOF TO DIRECT EXPRESSION OF PROTEINS IN YEAST, PREFERABLY USING A HAPLOID MATING STRATEGY - Novel promoters which are derived from | 11-29-2012 |
| 20120309057 | METHOD FOR PRODUCING INTERFERON ALPHA 5 - A process for producing an interferon alpha 5 (IFNa5) protein by expression in an IFNa5 producing | 12-06-2012 |
| 20140308706 | RECOMBINANT FUSION INTERFERON FOR ANIMALS - A recombinant fusion interferon for animals. The recombinant fusion interferon comprises an animal interferon and a Fc region of an animal immunoglobulin G (IgG). The animal interferon and the Fc region of the animal immunoglobulin G can be further joined by a linker. A polynucleotide that encodes the recombinant fusion interferon for animals, a method for producing the recombinant fusion interferon, and the use of the recombinant fusion interferon. | 10-16-2014 |
| 20220136025 | METHODS FOR HARVESTING MAMMALIAN CELL CULTURES - The invention provides methods and materials for culturing mammalian cells and harvesting recombinant protein. | 05-05-2022 |
| 435690520 | Interleukins | 18 |
| 20080268503 | Method for Achieving High-Level Expression of Recombinant Human Interleukin-2 Upon Destabilization of the Rna Secondary Structure - The present invention provides a method for achieving high-level expression of the therapeutically important lymphokine (human IL-2). The method comprises of identifying the secondary structure in the 5′ region of human IL-2 mRNA, modifying the 5′ region of the human IL-2 DNA sequence to produce a new DNA sequence wherein the mRNA transcribed from the modified human IL-2 DNA sequence has the predicted 5′ secondary structure destabilized with increased free energy compared to that of the secondary structure of the mRNA transcribed from the native DNA sequence without altering the sequence of the encoded amino acids; and using this modified DNA sequence of human IL-2 for high level recombinant expression in a microbial host for large scale production. This method is also applicable to other expression host like yeasts and mammalian cells. | 10-30-2008 |
| 20090011466 | CONCATAMERIC IMMUNOADHESION MOLECULE - Disclosed are concatameric proteins comprising two soluble domains, in which the C-terminus of a soluble domain of a biologically active protein is linked to the N-terminus of an identical soluble domain or a distinct soluble domain of a biologically active protein. Also, the present invention discloses dimeric proteins formed by formation of intermolecular disulfide bonds at the hinge region of two monomeric proteins formed by linkage of a concatamer of two identical soluble extracellular regions of proteins involving immune response to an Fc fragment of an immunoglobulin molecule, their glycosylated proteins, DNA constructs encoding the monomeric proteins, recombinant expression plasmids containing the DNA construct, host cells transformed or transfected with the recombinant expression plasmids, and a method of preparing the dimeric proteins by culturing the host cells. Further, the present invention discloses pharmaceutical or diagnostic compositions comprising the dimeric protein or its glycosylated form. | 01-08-2009 |
| 20090104664 | Use of Molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells - The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein. | 04-23-2009 |
| 20090117618 | Expression system for preparing IL-15/FC fusion protein and its use - The invention relates to an expression system containing one or more nucleic acid(s) comprising at least one nucleic acid for an interleukin 15/Fc (IL-15/Fc) fusion protein, at least one promotor, at least one nucleic acid for a CD5 leader and, where appropriate, at least one nucleic acid for a selectable marker gene; to a nucleic acid comprising the components of the said expression system and to a host cell containing the expression system or the nucleic acid. Furthermore, the invention relates to a process for preparing an IL-15/Fc fusion protein, using the expression system, and to the use of the expression system, the nucleic acid, the host cell or the CD5 leader for expression in host cells. | 05-07-2009 |
| 20090137005 | IL-12 for Expression in Mammalian Cell - The present invention provides for nucleic acids improved for the expression of interleukin-12 (IL-12) in mammalian cells. The invention further provides for methods of expressing IL-12 in mammalian cells by transfecting the cell with a nucleic acid sequence encoding an improved IL-12 sequence. | 05-28-2009 |
| 20090142806 | INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR - The present invention provides isolated and purified polynucleotides and polypeptides related to the IL-17F signaling pathway. The invention also provides antibodies to IL-17F homodimers and IL-17A/IL-17F heterodimers, and methods of isolating and purifying members of the IL-17 family, including IL-17A/IL-17F heterodimers, from a natural source. The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating and/or preventing disorders related to IL-17F signaling, i.e., IL-17F-associated disorders, including, but not limited to, inflammatory disorders, such as autoimmune diseases (e.g., arthritis (including rheumatoid arthritis), psoriasis, systemic lupus erythematosus, and multiple sclerosis), respiratory diseases (e.g., COPD, cystic fibrosis, asthma, allergy), transplant rejection (including solid organ transplant rejection), and inflammatory bowel diseases or disorders (IBDs, e.g., ulcerative colitis, Crohn's disease). The present invention is further directed to novel therapeutics and therapeutic targets, and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of disorders related to IL-17F signaling. | 06-04-2009 |
| 20090233333 | Methods for preventing gluconoylation of proteins - The present invention relates to methods of preventing glyconoylation of polypeptides produced in micororganisms. | 09-17-2009 |
| 20090269811 | IL-1 RELATED POLYPEPTIDES - The present invention is directed to novel polypeptides having homology to the IL-1-like family of proteins and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention. | 10-29-2009 |
| 20100003722 | PRODUCTION AND PURIFICATION OF IL-29 - The expression vectors and methods using an | 01-07-2010 |
| 20100184146 | PLASMID FOR EXPRESSING THIOREDOXIN FUSION PROTEIN AND METHOD FOR PRODUCING TARGET PROTEIN USING SAME - The present invention provides a plasmid for expressing a thioredoxin fusion protein comprising thioredoxin as a fusion partner, an | 07-22-2010 |
| 20110124048 | Methods for Effectively Coexpressing IL-12 and IL-23 - Disclosed is a method for coexpressing IL-12 (interleukin-12) and IL-23 (interleukin-23), which comprises the steps of: (a) preparing vectors comprising monocistronic expression constructs of each of nucleotide sequences encoding the p35 subunit, the p40 subunit and the p19 subunit, or preparing a vector comprising a polycistronic expression construct of nucleotide sequences encoding the p35 subunit, the p40 subunit and the p19 subunit; (b) transforming the expression constructs into a host cell; and (c) culturing the transformed host cell to obtain IL-12 and IL-23, a vector for coexpressing IL-12 and IL-23, and a pharmaceutical anti-tumor composition comprising the vectors. | 05-26-2011 |
| 20110129876 | Constructs and Methods for the Production and Secretion of Polypeptides - Described herein are molecules, constructs and methods for the production and secretion of polypeptides of interest by host cells, preferably bacterial host cells, and more particularly gram positive bacteria. In particular, the present invention is related to a polynucleic acid encoding a fusion protein and to uses thereof for the secretion of heterologous or homologous polypeptides of interest by a bacterial host cell, preferably | 06-02-2011 |
| 20120015403 | PRODUCTION AND PURIFICATION OF IL-29 - The expression vectors and methods using an | 01-19-2012 |
| 20130143270 | PRODUCTION AND PURIFICATION OF IL-29 - The expression vectors and methods using an | 06-06-2013 |
| 20140377807 | METHOD FOR PRODUCING POLYPEPTIDE FRAGMENT WITH HIGH EFFICIENCY, WHICH IS SUITABLE FOR NCL METHOD - A method for efficiently manufacturing a polypeptide fragment suitable for the NCL method includes a step of reacting a polypeptide containing a first polypeptide fragment having cysteine at the N-terminal and a second polypeptide fragment linked via an intervening sequence -Cys-W-(His)n-Z-Met- with CNBr to obtain a first polypeptide fragment having cysteine at the N-terminal and a third polypeptide fragment, and a step of sequentially reacting the third polypeptide fragment with a compound represented by the following formula (I) and a compound represented by the following formula (II) to obtain a second polypeptide fragment having the C-terminal modified. | 12-25-2014 |
| 20150031083 | Adenoviral-based biological delivery and expression system for use in the treatment of Osteoarthritis - The invention relates to an adenoviral-based biological delivery and expression system for use in the treatment or prevention of osteoathritis in human or mammalian joints by long-term inducible gene expression of human or mammalian interleukin-1 receptor antagonist (Il-1Ra) in synovial cells, comprising a helper-dependent adenoviral vector containing a nucleic acid sequence encoding for human or mammalian interleukin-1 receptor antagonist (Il-1Ra), left and right inverted terminal repeats (L ITR and R ITR), the adenoviral packaging signal and non-viral, non-coding stuffer nucleic acid sequences, wherein the expression of the human or mammalian interleukin-1 receptor antagonist (Il-1Ra) gene within synovial cells is regulated by an inflammation-inducible promoter. | 01-29-2015 |
| 20160102128 | CODON OPTIMIZED IL-15 AND IL-15R-ALPHA GENES FOR EXPRESSION IN MAMMALIAN CELLS - The present invention provides for nucleic acids improved for the expression of interleukin-15 (IL-15) in mammalian cells. The invention further provides for methods of expressing IL-15 in mammalian cells by transfecting the cell with a nucleic acid sequence encoding an improved IL-15 sequence. | 04-14-2016 |
| 20160194369 | METHODS AND COMPOSITIONS FOR CO-EXPRESSION OF POLYPEPTIDES OF INEREST AND IL6 | 07-07-2016 |
