Class / Patent application number | Description | Number of patent applications / Date published |
435016000 | Involving transaminase | 15 |
20090298106 | Methods for Monitoring Immunosuppressant Drug Levels, Renal Function, and Hepatic Function Using Small Volume Samples - Systems and methods are provided for monitoring a immunosuppressant drug level and renal function, hepatic function, or a combination thereof in a patient, comprising obtaining a small volume blood sample from the patient; determining the level of at least one immunosuppressant drug in the small volume blood sample and determining the level of a second immunosuppressant drug or analyzing the renal function, the hepatic function, or a combination thereof in the patient. In some embodiments, the immunosuppressant drug levels are determined using a liquid chromatography tandem mass spectrometry (LC-MS/MS) procedure. Also provided are kits for use in any of the systems and methods described herein. | 12-03-2009 |
20100112618 | Measurement of the Activity of a Kynurenine-Converting Enzyme and/or a Kynurenic-Acid, Anthranilic-Acid and/or 3-Hydroxykynurenine-Producing Enzyme - The present invention relates to a method of measuring the activity of a kynurenine-converting enzyme and/or a kynurenic-acid-, anthranilic-acid- and/or 3-hydroxykynurenine-producing enzyme, the method comprising the step of measuring the activity in the presence of an interfering sample, preferably selected from a CSF (cerebrospinal fluid) or serum, and detecting the conversion of kynurenine and/or kynurenic acid and/or anthranilic acid and/or 3-hydroxykynurenine. | 05-06-2010 |
20100255518 | Highly sensitive system and methods for analysis of troponin - The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin. | 10-07-2010 |
20110003322 | CELL-ENZYME BASED BIOSENSORS - The invention relates to a sensor ( | 01-06-2011 |
20110189709 | METHOD FOR DETECTING HEPATIC INJURY DUE TO ANTITHYROID DRUG - The present invention relates a detecting method of distinguishing a temporary liver function test abnormalities by a thyrotoxicosis from a drug-induced hepatic injury by an antithyroid drug using a blood test and the likes, which is performed in a simple manner and with specificity. In the course of treating Graves' disease using an antithyroid drug, it is possible to differentiate a temporary liver function test abnormalities resulted from a thyrotoxicosis from a drug-induced hepatic injury resulted from the antithyroid drug, and therefore to detect the drug-induced hepatic injury with specificity by assaying a level of OCT in a body sample from a patient. In other words, it is possible to diagnose as a drug-induced hepatic injury if a blood OCT level in the sample from the patient is elevated compared to a level prior to administering the antithyroid drug or a blood OCT level from normal persons. Meanwhile, if the OCT level is not changed in spite of elevated levels of transaminases in the sample, it is possible to continue the treatment without discontinuing the drug administration since liver function test abnormalities in this case can be judged as temporary abnormalities owing to metabolic alteration, not as a drug-induced hepatic injury. | 08-04-2011 |
20110269162 | UBIQUITIN PROTEASOME SYSTEM PROFILING FOR DIAGNOSIS OF CHRONIC LIVER DISEASE - Provided herein are methods for the diagnosis, staging, prognosis, or management of liver disease, e.g. chronic liver disease, and other diseases using profiles of the ubiquitin-proteasome system determined from acellular body fluids or cell-containing samples. Further provided are methods of predicting response to therapy in certain populations of patients with liver disease. | 11-03-2011 |
20120156706 | PROCESS FOR THE IDENTIFICATION AND PREPARATION OF A (R)-SPECIFIC OMEGA-TRANSAMINASE - The present invention relates to processes for the screening, preparation and characterization of (R)-selective ω-transaminases, to transaminases obtained thereby and their uses in various transamination processes. | 06-21-2012 |
20120164671 | METHODS FOR MONITORING IMMUNOSUPPRESSANT DRUG LEVELS, RENAL FUNCTION, AND HEPATIC FUNCTION USING SMALL VOLUME SAMPLES - Systems and methods are provided for monitoring a immunosuppressant drug level and renal function, hepatic function, or a combination thereof in a patient, comprising obtaining a small volume blood sample from the patient; determining the level of at least one immunosuppressant drug in the small volume blood sample and determining the level of a second immunosuppressant drug or analyzing the renal function, the hepatic function, or a combination thereof in the patient. In some embodiments, the immunosuppressant drug levels are determined using a liquid chromatography tandem mass spectrometry (LC-MS/MS) procedure. Also provided are kits for use in any of the systems and methods described herein. | 06-28-2012 |
20140206025 | Use Of Detection Of Aspartate Transaminase And Lactate Dehydrogenase In Early Evaluation Of Clinical Efficacy Of Antitumor Intervention Measure - The present invention relates to a method for early evaluation of clinical efficacy of antitumor intervention measure, comprising evaluating the efficacy of the antitumor intervention measure by assaying whether the content of a tumor-damaging biomarker(s) in the blood of a patient having tumor rises as compared to the baseline level before treatment within a time window after the patients receives at least one antitumor intervention measure. In preferable embodiments, the tumor-damaging biomarker(s) is selected from a group consisting of Alanine Aminotransferase (ALT), Aspartate Transaminase (AST), Lactate Dehydrogenase (LDH); said tumor is multiple myeloma; said antitumor intervention measure is the administration of CPT alone or the administration of CPT in combination with thalidomide. | 07-24-2014 |
20140234883 | USE OF PHOTOCLEAVABLE COMPOUNDS - Use of photochemically cleavable compounds in course of one or multi-photon irradiation experiments. | 08-21-2014 |
20140242622 | METHODS OF DETECTING TEST ELEMENTS HAVING DEGRADED TEST CHEMICALS AS WELL AS APPARATUSES INCORPORATING THE SAME - An analytical apparatus is disclosed for detecting at least one analyte in a sample, where in an analyte measurement at least an electrical or optical property changeable by presence of the analyte at least one test chemical of a test element is recorded, and where the analytical apparatus also can perform at least one quality measurement on the at least one test chemical such as an intrinsic luminescence, which is recorded and from the intrinsic luminescence a conclusion is drawn on a quality of the test chemical and thus the test element. Methods also are disclosed for detecting at least one analyte in a sample that include a quality measurement of the at least one test chemical of the test strip. | 08-28-2014 |
20140329262 | TESTING SYSTEM AND METHOD FOR TESTING - This invention relates to a testing system for assessing the level of a biochemical marker, comprising a disposable device ( | 11-06-2014 |
20150140586 | DEVICE FOR ONLINE MEASUREMENT OF NEUROTRANSMITTERS USING ENZYMATIC REACTORS - The invention relates to a device and a method for measuring neurotransmitters in the brain dialysate of mammals using enzymatic reactors specific to a certain neurotransmitter, which generate fluorescent derivatives when mixed. The mixture is introduced into an incubation chamber and passes through a temperature controlling system in order to set it to the optimum enzymatic reaction temperature, and the fluorescent derivative generated is passed through a flow fluorescence cell located inside the incubation chamber, where the liquid is impacted with a laser light source via an optical fibre. The fluorescence emitted is captured by a fluorescence detector that sends it to a processing system in order to obtain the corresponding values. | 05-21-2015 |
20160054342 | IN-VITRO DIAGNOSTIC APPARATUS AND IN-VITRO DIAGNOSTIC TEST METHOD - An in-vitro diagnostic apparatus includes a controller configured to set a test result reference range corresponding to a condition of a testee, among test result reference ranges corresponding to a plurality of conditions, with respect to a test item of a test object, and generate a user interface screen including the set test result reference range; and a display configured to display the user interface screen. | 02-25-2016 |
20180024153 | DISEASE SEVERITY INDEX FOR ASSESSMENT OF CHRONIC LIVER DISEASE | 01-25-2018 |